Article
Biotechnology & Applied Microbiology
Jinjin Lu, Rui Li, Shilei Ni, Yuandong Xie, Xinchen Liu, Kai Zhang, Yi Li
Summary: The synthesized MCDs in this study achieved efficient odontoblastic differentiation of hDPSCs in vitro, improving the cell differentiation capacity by promoting the expression of odontoblast genes and proteins, and enhancing the process through autophagy mechanism.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Nunthawan Nowwarote, Stephane Petit, Francois Come Ferre, Florent Dingli, Victor Laigle, Damarys Loew, Thanaphum Osathanon, Benjamin P. J. Fournier
Summary: The study identified the matrisome of ECM proteins derived from human DPSCs and found that it can regulate mineralization, even in cells which do not respond to mineralization assaults like GF.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
C. Liu, J. Yu, B. Liu, M. Liu, G. Song, L. Zhu, B. Peng
Summary: The study investigated the effects of BACH1 on the proliferation and odontoblastic differentiation of hDPSCs in vitro. Manipulation of BACH1 expression may provide an opportunity to promote the regenerative capacity of hDPSCs.
Article
Chemistry, Physical
Ji-Young Yune, Donghee Lee, Sin-Young Kim
Summary: The aim of this study was to determine the osteogenic and dentinogenic potential of commercially distributed MTA and HCSCs when applied in combination with Emdogain gel on human dental pulp stem cells (hDPSCs). The presence of Emdogain resulted in greater cell viability, and higher alkaline phosphatase activity was detected in the Emdogain-supplemented groups in the early days of cell culture. Overall, the cytotoxicity and osteogenic/odontogenic potential of HCSCs were similar to that of ProRoot MTA.
Article
Dentistry, Oral Surgery & Medicine
Xia Qi, Chunyan Liu, Guohua Li, Dalia Al-Alfe, Susan Paurazas, Mazin Askar, Dongru Yang, Zheng Zhou
Summary: THC did not inhibit the vitality of HDPCs and significantly increased cell division at low doses, but reduced proliferation at higher concentrations. The expression of odonto/osteogenic marker genes was up-regulated in the presence of cannabinoids, leading to increased collagen synthesis and mineralized calcium nodule formation. THC-induced odonto/osteogenesis occurred via MAPK signaling mediated by CB1 and CB2 receptors, suggesting cannabinoids may be used in HDPC regeneration and as a pulp-capping agent.
JOURNAL OF ENDODONTICS
(2021)
Article
Biochemistry & Molecular Biology
Cristina- Bucchi, Ella Ohlsson, Josep Maria de Anta, Melanie Woelflick, Kerstin Galler, Maria Cristina Manzanares-Cespedes, Matthias Widbiller
Summary: Pluripotent stem cells derived from the amnion show the ability to adhere to dentin and mineralize in vitro, but exhibit unfavorable proliferation behavior and fail to undergo odontoblastic transition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Igor Paulino Mendes Soares, Giovana Anovazzi, Caroline Anselmi, Maria Luisa Leite, Debora Lopes Salles Scheffel, Diana Gabriela Soares, Carlos Alberto de Souza Costa, Josimeri Hebling
Summary: The study investigated the biological effects of treating EWSLs with resin infiltration components on odontoblast-like cells and human dental pulp cells. The results showed that RICs reduced cell viability, ALP activity, and MN formation, while upregulating inflammatory cytokines and downregulating mineralization-related genes. Among the RICs, the Etch component had the most detrimental effects.
Article
Cell & Tissue Engineering
Tianyi Xin, Qian Li, Rushui Bai, Ting Zhang, Yanheng Zhou, Yuehua Zhang, Bing Han, Ruili Yang
Summary: A novel frameshift mutation of SATB2 was identified in a Chinese patient with SATB2-associated syndrome (SAS) exhibiting tooth agenesis. Mechanistically, SATB2 regulates osteo/odontogenesis of human dental pulp stem cells through the Wnt/beta-catenin signaling pathway by regulating DKK1 and histone demethylase JHDM1D.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Medicine, General & Internal
Somyeong Hwa, Hyun-Jin Lee, Youngkyung Ko, Jun-Beom Park
Summary: This study evaluated the effects of an enamel matrix derivative on cell viability, osteogenic differentiation, and mineralization using human gingiva-derived stem cell spheroids. The results showed that the enamel matrix derivative promoted osteogenic differentiation and increased mineralization in stem cell spheroids.
MEDICINA-LITHUANIA
(2023)
Article
Cell & Tissue Engineering
Francesca Agriesti, Francesca Landini, Mirko Tamma, Consiglia Pacelli, Carmela Mazzoccoli, Giovanni Calice, Vitalba Ruggieri, Giuseppe Capitanio, Giorgio Mori, Claudia Piccoli, Nazzareno Capitanio
Summary: This study investigated the metabolic and redox changes occurring during osteoblastic differentiation of human dental pulp stem cells (hDPSCs) and the impact of reactive oxygen species (ROS) signaling. The results showed that redox signaling, likely mediated by peroxide species, influenced the osteogenic expansion and differentiation of hDPSCs, shaping their metabolic phenotype changes and improving their efficiency in bone regeneration and repair.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Layla Panahipour, Sara Botta, Azarakhsh Oladzad Abbasabadi, Zohreh Afradi, Reinhard Gruber
Summary: Epithelial cells in periodontitis patients express increased chemokines, indicating their involvement in the inflammatory process. Enamel matrix derivative (EMD) has potential anti-inflammatory activity and can reduce chemokine expression in oral epithelial cells through TGF-β signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Guo Liu, Ying Yang, Kyung-San Min, Bin-Na Lee, Yun-Chan Hwang
Summary: In this study, it was found that icariin can enhance the odontogenic differentiation of HDPCs by activating the MAPK signaling pathway. This finding is significant for dentin regeneration.
MEDICINA-LITHUANIA
(2022)
Review
Chemistry, Physical
Alice Alberti, Luca Francetti, Silvio Taschieri, Stefano Corbella
Summary: Enamel matrix derivative (EMD) has shown promising results in promoting bone regeneration and osseointegration in combination with titanium implants. However, further randomized clinical trials are needed to assess its efficacy for peri-implant bone defects and peri-implantitis treatment protocols.
Article
Biotechnology & Applied Microbiology
Hanxin Xu, Fen Xu, Jiajia Zhao, Caixia Zhou, Jiarong Liu
Summary: The study demonstrates that autologous platelet-rich plasma (PRP) can enhance migration, proliferation, and osteogenic differentiation of dental pulp cells, and this process is strengthened by activating autophagy. Inhibiting autophagy weakens the effects of PRP on cells, while an autophagy activator enhances the promoting effects of PRP.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jiahui Fu, Jianfeng Chen, Wenjun Li, Xiaomin Yang, Jingyan Yang, Huixin Quan, Haitao Huang, Gang Chen
Summary: The supplementation of laminins to DPEM enhances odontogenic differentiation of cells and contributes to the formation of the odontoblast layer in dental pulp regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Food Science & Technology
Yuan-ting Zhu, Shao-lan Zhang, Qian Ma, Yong Zuo, Rui-tong Li, Jian-xia Yang, Rui-yu Zhu, Li-hong Ge
Summary: The research investigated the metabolic characteristics of inulin in the probiotic L. plantarum QS7T derived from Sichuan pickle, showing its efficient utilization of inulin as a carbon source. Genomic and transcriptomic analysis revealed the molecular mechanisms involved in inulin consumption by the strain QS7T, including the upregulation of genes associated with carbohydrate metabolism and transport.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Geochemistry & Geophysics
Lina Ge, Fu Yi, Changbo Du, Junxia Zhou, Zhenglong Cui, Tao Wang, Yu Wang
Summary: The heterogeneous development of strain fields in hard and brittle raw coal material and soft plastic briquette coal material under uniaxial compression is evaluated using digital image correlation. A material damage constitutive model based on the statistical indicator of strain field is established. The results show that there are differences in the yield stage and failure mode between raw coal and briquette coal, and the progress of strain localization can reflect the damage and destruction process of materials.
Article
Chemistry, Inorganic & Nuclear
Lihong Ge, Wei Lai, Yilin Deng, Jian Bao, Bo Ouyang, Huaming Li
Summary: This study investigates how the in situ dissolution of MoO42- in CoMoO4 boosts surface reconstruction, leading to the formation of Co3O4/CoMoO4 and CoOOH/CoMoO4 heterostructures. The surface reconstruction has positive effects on the catalytic activities of oxygen evolution reaction and hydrogen evolution reaction.
INORGANIC CHEMISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Shuo Gao, Li-Hong Ge, Yu-Ming Zhao, Pei Li, Yao-Yin Li, Wei Zhao
Summary: miR-143-3p maintains the stemness of hSCAPs and negatively modulates their differentiation by directly targeting NFIC. Inhibition of miR-143-3p may represent a potential strategy to promote the regeneration of damaged tooth roots.
INTERNATIONAL ENDODONTIC JOURNAL
(2022)
Article
Food Science & Technology
Lihong Ge, Yuli Huang, Qian Ma, Yu Wang, Rui Yang, Xinyu Yang, Yan Chen, Yuzhi Miao, Yong Zuo
Summary: Dipping grass carp fillets in certain acid solutions can effectively mitigate fish softening, inhibit cathepsin activity, and improve lysosome stability, thus protecting myosin and actin from degradation and dissociation and enhancing muscle tissue integrity.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Quantum Science & Technology
Wei-Feng Zhou, Li-Li Ge, Zi-Xin Huang, Li-Zhen Jiang, Xiao-yu Chen
Summary: In this article, we provide necessary and sufficient conditions for the full separability of four-qubit GHZ and W mixed states using entanglement witnesses. We also present a method for constructing optimal product states.
QUANTUM INFORMATION PROCESSING
(2022)
Article
Immunology
Xueqing Wu, Shanshan Zhao, Yan Jiang, Xi Xiang, Lihong Ge, Qiong Chen, Yanfei Wang, Jorge E. Vidal, Yunsong Yu
Summary: This study evaluated the impact of interrupted PCV availability on pneumococcal pneumonia and genetic variation of Streptococcus pneumoniae. The findings showed that interrupted PCV availability affected the prevalence of pneumococcal disease and pneumococcal genome variation.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Oncology
Zhuo Liu, Liyuan Ge, Lei Liu, Xun Zhao, Kewei Chen, Yuxuan Li, Abudureyimujiang Aili, Min Lu, Xinlong Pei, Dengyang Han, Shudong Zhang, Lulin Ma
Summary: This study retrospectively analyzed 19 cases of retroperitoneal tumor with venous tumor thrombus and proposed a new tumor thrombus grading system. The study concluded that retroperitoneal tumor resection and removal of venous tumor thrombi are safe and effective for the treatment of such diseases.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Zonglong Wu, Yimeng Song, Yaqian Wu, Liyuan Ge, Zhuo Liu, Tan Du, Shudong Zhang, Lulin Ma
Summary: This study identified metastasis-related genes in clear cell renal cell carcinoma (ccRCC) and constructed a metastasis-associated prognostic gene signature. Kinesin family member 23 (KIF23) was identified as a prognostic marker in ccRCC patients, and inhibition of KIF23 expression reduced ccRCC cell proliferation, migration, and invasion.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pediatrics
Shi-Qi Chen, Li-Juan Ge, Guo-Qing Chen, Wen-Juan He, Juan-Juan Guo, Yan Li, Lin Shi, Yan-Li Cheng
Summary: This study found a high incidence of language development disorder in children in Ningxia, with neonatal factors being the primary cause. The majority of affected children had definite intrauterine and perinatal high-risk factors or neonatal diseases.
TRANSLATIONAL PEDIATRICS
(2022)
Article
Environmental Sciences
Ke Zhao, Liya Ge, Grzegorz Lisak
Summary: A simple method to synthesize BiONS without the use of halogens or other metalloids was developed and successfully applied in developing a palladium sensor, demonstrating its potential for on-site process control of complex industrial samples.
ENVIRONMENTAL POLLUTION
(2022)
Article
Computer Science, Information Systems
Xiaoqiang Jia, Li Ge, Yunfei Li, Jun Liu, Biying Zhou
Summary: Network Function Virtualization (NFV), as a key technology for next-generation communication, provides resource flexibility and improved network performance. The resource scheduling for Virtual Network Function Service Chain (VNF-SC) mapping is a crucial challenge in NFV. A multiobjective model was established to optimize the service path construction problem, and the proposed algorithm showed superior performance in simulation experiments.
WIRELESS COMMUNICATIONS & MOBILE COMPUTING
(2022)
Review
Dentistry, Oral Surgery & Medicine
Jing Zou, Qin Du, Lihong Ge, Jun Wang, Xiaojing Wang, Yuqing Li, Guangtai Song, Wei Zhao, Xu Chen, Beizhan Jiang, Yufeng Mei, Yang Huang, Shuli Deng, Hongmei Zhang, Yanhong Li, Xuedong Zhou
Summary: Early childhood caries (ECC) is a significant chronic disease that affects the oral health of children, and is closely related to changes in the oral microbiome. Improving parental oral health awareness, establishing early dental care, and developing individualized caries management plans are crucial for lifelong oral health.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2022)
Article
Engineering, Environmental
Yuhui Liu, Yaning Lu, Shuang Zhang, Xiaoyan Li, Zhibin Zhang, Liya Ge, MengYu Chang, Yunhai Liu, Grzegorz Lisak, Sheng Deng
Summary: In this study, an amphiphilic ligand NND was successfully synthesized and used to enhance the adsorption capacity of MoS2 particles for UO22+ by replacing H2O through hydrogen bonding. The NND-modified MoS2 showed higher adsorption capacity and stronger stability under extreme conditions.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Oncology
Zhuo Liu, Liyuan Ge, Xun Zhao, Min Lu, Abudureyimujiang Aili, Yuxuan Li, Guodong Zhu, Peng Hong, Xiaojun Tian, Shumin Wang, Hongxian Zhang, Cheng Liu, Zhenshan Ding, Shudong Zhang, Lulin Ma
Summary: This study investigated the clinicopathological features and prognosis of type-2 papillary renal cell carcinoma associated with venous tumor thrombi. The results showed that type-2 papillary renal cell carcinoma differs from clear cell renal carcinoma in terms of imaging manifestation and pathological characteristics. The prognosis of type-2 papillary renal cell carcinoma patients was worse than that of clear cell renal carcinoma patients.
CLINICAL MEDICINE INSIGHTS-ONCOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Chang Zeng, Pei Hu, Colin P. Egan, Brian E. Bergeron, Franklin Tay, Jingzhi Ma
Summary: The study compared the bacteria debridement efficacy of the first and second generations of sonic root canal irrigant activation systems. The results showed that activation of 2% NaOCl with either EndoActivator or SmartLite Pro EndoActivator significantly reduced the overall intracanal bacterial load compared to syringe-side-vented needle delivery. However, delivering 2% NaOCl for 5 minutes using the syringe-side-vented needle produced better bacteria debridement than either sonic agitation system.
JOURNAL OF DENTISTRY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Alaa Husni Qari, Raghad Mohammed Alharbi, Shahd Saud Alomiri, Banan Nasser Alandanusi, Lina Ayman Mirza, Mohammad Hasan Al-Harthy
Summary: The study compares the experience of patients seen using teledentistry with traditional Orofacial Pain and TMD visits. Results indicated a borderline difference in effectively using teledentistry for follow-ups among different age groups, but no significant differences were found in patients' experience between virtual and conventional visits. This suggests that high-quality dental care services can be provided remotely without adversely affecting patient experience or quality of care.
JOURNAL OF DENTISTRY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Giovanna Iezzi, Barbara Zavan, Morena Petrini, Letizia Ferroni, Tania Vanessa Pierfelice, Ugo D'Amora, Alfredo Ronca, Emira D'Amico, Carlo Mangano
Summary: This study characterized the surface topography and evaluated the biological responses of various cells to a novel 3D-printed dental implant. The surface of the implant showed a highly interconnected porous architecture and roughness, leading to good adhesion and growth of human oral osteoblasts, gingival fibroblasts, mesenchymal stem cells, and monocytes. These findings suggest that this 3D-printed implant has excellent potential for clinical applications.
JOURNAL OF DENTISTRY
(2024)
