Review
Cell Biology
Bo Li, Takehito Ouchi, Yubin Cao, Zhihe Zhao, Yi Men
Summary: MSCs can be found in mammalian teeth from various dental sources, with similar multipotent potential and immunomodulatory functions, showing promising applications in injury repair and disease treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yafei Yuan, Lipei Shen, Tiankun Liu, Lin He, Dan Meng, Qingsong Jiang
Summary: In this study, researchers developed a novel scaffold material for bone tissue engineering by encapsulating bone marrow mesenchymal stem cells (BMSCs) in alginate chitosan alginate (ACA) microcapsules and compounding them with calcium phosphate bone cement (CPC). The results showed that cells protected by microcapsules had better viability, proliferation, and adhesion compared to cells directly combined with CPC. The composite scaffold also exhibited better new bone formation function and degradability. These findings suggest that BMSCs encapsulated in ACA microcapsules combined with CPC composite scaffolds have promising applications in bone tissue engineering.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Zhi Zhou, Yunshan Fan, Yingying Jiang, Sheng Shi, Chao Xue, Xinyu Zhao, Shuo Tan, Xin Chen, Chaobo Feng, Yancheng Zhu, Jiajun Yan, Zifei Zhou, Yunfei Zhao, Junjian Liu, Feng Chen, Shisheng He
Summary: Inspired by bone biomineralization, a biomimetic strategy is achieved for the preparation of mineralized ALP nanoparticles. This approach significantly enhances bone marrow mesenchymal stem cell proliferation and osteogenic differentiation, and can be applied for constructing mineralized protein-based bioactive materials for tissue regeneration.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Veronika Smolinska, Michaela Debreova, Martina Culenova, Maria Csobonyeiova, Andrey Svec, Lubos Danisovic
Summary: Healing of articular cartilage defects is challenging and traditional reparative approaches are limited. Mesenchymal stromal cells have been extensively studied and proven to have therapeutic effects on articular cartilage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
David A. Hart, Norimasa Nakamura
Summary: After injuries to musculoskeletal tissues, an inflammatory response occurs to promote endogenous repair, but it often results in functionally inferior scar tissue. Injuries in adults no longer have the anabolic processes that contribute to growth and maturation, which can lead to degenerative conditions such as osteoarthritis. Researchers have been exploring cellular therapies, such as Platelet-rich Plasma and mesenchymal stem/medicinal signaling cells, to enhance tissue repair and regeneration. However, implanting these cells or engineered constructs into an inflammatory adult environment may compromise their potential for regeneration. Therefore, it may be necessary to neutralize the inflammatory environment and create an anabolic environment for optimal outcomes.
Article
Engineering, Biomedical
Shuangpeng Jiang, Guangzhao Tian, Zhen Yang, Xiang Gao, Fuxin Wang, Juntan Li, Zhuang Tian, Bo Huang, Fu Wei, Xinyu Sang, Liuqi Shao, Jian Zhou, Zhenyong Wang, Shuyun Liu, Xiang Sui, Quanyi Guo, Weimin Guo, Xu Li
Summary: This study confirms that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration. The promoting effect may be related to the polarization of macrophages and inhibition of inflammatory response by hWJMSC-Exos. Additionally, hWJMSC-Exos contain miRNAs that can promote hyaline cartilage regeneration.
BIOACTIVE MATERIALS
(2021)
Review
Medicine, Research & Experimental
Mengyuan Wang, Ying Li, Hongqiao Wang, Meng Li, Xiaomin Wang, Rongzhen Liu, Daijun Zhang, Wenhua Xu
Summary: Corneal epithelial defects and excessive wound healing can cause severe complications. Stem cells offer a promising solution for regenerating the corneal epithelium and treating severe corneal epithelial injury. Biological scaffolds such as the amniotic membrane, fibrin, and hydrogels provide the necessary signals for stem cell proliferation and differentiation. Researchers have evaluated these scaffolds as potential therapeutic interventions for corneal disorders, identifying both benefits and drawbacks. This study provides a comprehensive overview of the history and use of stem cells in corneal repair, focusing on biological scaffolds used in stem cell transplantation and innovative materials under investigation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Engineering, Biomedical
Liaobing Xin, Xiaowen Zheng, Jianmin Chen, Sentao Hu, Yilun Luo, Qunzi Ge, Xiaoying Jin, Lie Ma, Songying Zhang
Summary: This study explores an acellular biomaterial called SDF-1 alpha/E7-modified collagen scaffold (CES), which enables near-complete endometrium regeneration and fertility restoration by mobilizing endogenous MSCs. The results demonstrate that CES can overcome the traditional limitations of cell-based therapies and serve as a clinically feasible and cell-free strategy with high therapeutic efficiency for IUA treatment.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Engineering, Biomedical
N. Contessi Negrini, A. Angelova Volponi, C. A. Higgins, P. T. Sharpe, A. D. Celiz
Summary: Developmental TE is a novel paradigm aiming to obtain tissues and organs with correct biomorphology and biofunctionality by mimicking the morphogenetic processes leading to the tissue/organ generation in the embryo. Successful applications have been reported for ectodermal appendages such as teeth, hair follicles and glands, with a focus on accurate selection of cell sources, scaffolds, and cell culture configurations to replicate in vivo morphogenetic cues.
MATERIALS TODAY BIO
(2021)
Review
Cell Biology
Cangwei Liu, Hao Guo, Ce Shi, Hongchen Sun
Summary: Short root anomaly (SRA) can cause tooth loss and affect patients' health. Dental implants have limitations compared to natural tooth roots, and tissue engineering-mediated root regeneration offers a more natural function. This article reviews the roles of Bone Morphogenetic Proteins (BMPs) in tooth root development and regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
Sandra Stamnitz, Agnieszka Krawczenko, Urszula Szalaj, Zaneta Gorecka, Agnieszka Antonczyk, Zdzislaw Kielbowicz, Wojciech Swieszkowski, Witold Lojkowski, Aleksandra Klimczak
Summary: FGF-2 and BMP-2 enhance the osteogenic differentiation potential of MSCs grown on a scaffold, making them promising tools for bone regeneration. This was confirmed through in vitro and in vivo experiments.
Review
Biochemistry & Molecular Biology
Giulia Battafarano, Michela Rossi, Viviana De Martino, Francesco Marampon, Luca Borro, Aurelio Secinaro, Andrea Del Fattore
Summary: Bone is a regenerative organ with self-renewal ability, but impaired bone healing may require medical intervention using natural or synthetic bone grafts for regeneration. Tissue engineering relies on the combination of cells, growth factors, and scaffold materials, with various materials and cell types being investigated for bone regeneration strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Liaobing Xin, Cheng Wei, Xiaomei Tong, Yangyang Dai, Dong Huang, Jianmin Chen, Lie Ma, Songying Zhang
Summary: Stem cell-derived apoptotic bodies (ABs) have been shown to promote endometrial regeneration through immunomodulation, cell proliferation, and angiogenesis. Incorporating ABs into hyaluronic acid hydrogel can effectively reduce fibrosis and promote endometrial regeneration in mouse and rat models, leading to fertility restoration.
BIOACTIVE MATERIALS
(2022)
Review
Biotechnology & Applied Microbiology
Qian Zhang, Yixin Hu, Xuan Long, Lingling Hu, Yu Wu, Ji Wu, Xiaobing Shi, Runqi Xie, Yu Bi, Fangyuan Yu, Pinxue Li, Yu Yang
Summary: Cartilage regeneration relies on cellular-ECM interactions. Traditional tissue engineering methods have not been able to replicate the physiological structure of natural cartilage, but recent advances in ECM-based scaffolds show promise in improving cartilage regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Paul Humbert, Meadhbh A. Brennan, Julien De Lima, Regis Brion, Annie Adrait, Celine Charrier, Benedicte Brulin, Valerie Trichet, Yohann Coute, Frederic Blanchard, Pierre Layrolle
Summary: Osteoclasts play a key role in bone regeneration, and apoptosis is found to be important for the effectiveness of MSCs. Experimental results show that apoptotic secretion of MSCs can inhibit the development of inflammatory multinucleated giant cells.
SCIENTIFIC REPORTS
(2021)
Article
Cell & Tissue Engineering
Fatima N. Syed-Picard, Yiqin Du, Kira L. Lathrop, Mary M. Mann, Martha L. Funderburgh, James L. Funderburgh
STEM CELLS TRANSLATIONAL MEDICINE
(2015)
Article
Cell & Tissue Engineering
Fatima N. Syed-Picard, Yiqin Du, Andrew J. Hertsenberg, Rachelle Palchesko, Martha L. Funderburgh, Adam W. Feinberg, James L. Funderburgh
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2018)
Article
Pathology
Mildred C. Embree, Tina M. Kilts, Mitsuaki Ono, Colette A. Inkson, Fatima Syed-Picard, Morten A. Karsdal, Ake Oldberg, Yanming Bi, Marian F. Young
AMERICAN JOURNAL OF PATHOLOGY
(2010)
Article
Engineering, Biomedical
Fatima N. Syed-Picard, Thottala Jayaraman, Raymond S. K. Lam, Elia Beniash, Charles Sfeir
Correction
Cell Biology
Michael J. Smietana, Fatima N. Syed-Picard, Jinjin Ma, Tatiana Kostrominova, Ellen M. Arruda, Lisa M. Larkin
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2010)
Article
Dentistry, Oral Surgery & Medicine
Fatima N. Syed-Picard, Gaurav A. Shah, Bernard J. Costello, Charles Sfeir
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2014)
Article
Cell Biology
Sayan Basu, Andrew J. Hertsenberg, Martha L. Funderburgh, Michael K. Burrow, Mary M. Mann, Yiqin Du, Kira L. Lathrop, Fatima N. Syed-Picard, Sheila M. Adams, David E. Birk, James L. Funderburgh
SCIENCE TRANSLATIONAL MEDICINE
(2014)
Article
Physiology
Avik Basu, Kristi Rothermund, Meer N. Ahmed, Fatima N. Syed-Picard
FRONTIERS IN PHYSIOLOGY
(2019)
Article
Chemistry, Analytical
Utku M. Sonmez, Adam Wood, Kyle Justus, Weijian Jiang, Fatima Syed-Picard, Philip R. LeDuc, Pawel Kalinski, Lance A. Davidson
Article
Cell & Tissue Engineering
Meer N. Ahmed, Delin Shi, Matthew T. Dailey, Kristi Rothermund, Michelle D. Drewry, Tia C. Calabrese, Xinyan T. Cui, Fatima N. Syed-Picard
Summary: This study demonstrates the use of DPC sheets as vehicles for NTF delivery that could augment the current methods for treating PNIs to accelerate regeneration and enhance the functional outcome.
TISSUE ENGINEERING PART A
(2021)
Article
Dentistry, Oral Surgery & Medicine
Kristi Rothermund, Tia C. Calabrese, Fatima N. Syed-Picard
Summary: This study demonstrates the use of scaffold-free dental pulp stem cell constructs as models for oral diseases and highlights the diverse effects of lipopolysaccharide (LPS) derived from different bacterial species on the differentiation and function of dental pulp stem cells.
JOURNAL OF ENDODONTICS
(2022)
Meeting Abstract
Ophthalmology
Fatima N. Syed-Picard, Yiqin Du, Rachelle Palchesko, Martha L. Funderburgh, Andrew Hertsenberg, Adam W. Feinberg, James L. Funderburgh
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2015)
Meeting Abstract
Ophthalmology
Fatima N. Syed-Picard, Mary Mann, Martha L. Funderburgh, Kira L. Lathrop, James L. Funderburgh
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2014)
Meeting Abstract
Ophthalmology
Martha Funderburgh, Fatima Syed-Picard, Charles Sfeir, James Funderburgh
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2013)