Advanced BMP Gene Therapies for Temporal and Spatial Control of Bone Regeneration

Gene therapy approaches to regenerating bone

(2012) Nadav Kimelman Bleich et al.   ADVANCED DRUG DELIVERY REVIEWS

Co-expression of BMPs and BMP-inhibitors in human fractures and non-unions

(2012) Peter Kloen et al.   BONE

Vascular tissues are a primary source of BMP2 expression during bone formation induced by distraction osteogenesis

(2012) Hidenori Matsubara et al.   BONE

Bmp signaling regulates a dose-dependent transcriptional program to control facial skeletal development

(2012) M. Bonilla-Claudio et al.   DEVELOPMENT

Doxycycline Counteracts Bone Morphogenic Protein 2–Induced Osteogenic Mediators

(2012) Manoj Muthukuru et al.   JOURNAL OF PERIODONTOLOGY

Spatiotemporal control of gene expression by a light-switchable transgene system

(2012) Xue Wang et al.   NATURE METHODS

An Evolutionarily Conserved Enhancer Regulates Bmp4 Expression in Developing Incisor and Limb Bud

(2012) Dolrudee Jumlongras et al.   PLoS One

Bmp Indicator Mice Reveal Dynamic Regulation of Transcriptional Response

(2012) Anna L. Javier et al.   PLoS One

A Wnt-Bmp Feedback Circuit Controls Intertissue Signaling Dynamics in Tooth Organogenesis

(2012) D. J. O'Connell et al.   Science Signaling

Spatiotemporal delivery of bone morphogenetic protein enhances functional repair of segmental bone defects

(2011) Yash M. Kolambkar et al.   BONE

Combinatorial roles for BMPs and Endothelin 1 in patterning the dorsal-ventral axis of the craniofacial skeleton

(2011) C. Alexander et al.   DEVELOPMENT

The transcriptome of fracture healing defines mechanisms of coordination of skeletal and vascular development during endochondral bone formation

(2011) Rachel Grimes et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Self-complementary AAV2.5-BMP2-coated Femoral Allografts Mediated Superior Bone Healing Versus Live Autografts in Mice With Equivalent Biomechanics to Unfractured Femur

(2011) Cemal Yazici et al.   MOLECULAR THERAPY

“Same Day” Ex-vivo Regional Gene Therapy: A Novel Strategy to Enhance Bone Repair

(2011) Mandeep S Virk et al.   MOLECULAR THERAPY

An Intermediate Level of BMP Signaling Directly Specifies Cranial Neural Crest Progenitor Cells in Zebrafish

(2011) Jennifer A. Schumacher et al.   PLoS One

A Synthetic Optogenetic Transcription Device Enhances Blood-Glucose Homeostasis in Mice

(2011) H. Ye et al.   SCIENCE

Phosphatidylserine immobilization of lentivirus for localized gene transfer

(2010) Seungjin Shin et al.   BIOMATERIALS

Bone morphogenetic protein 2 stimulates endochondral ossification by regulating periosteal cell fate during bone repair

(2010) Yan Yiu Yu et al.   BONE

BMP signaling induces digit regeneration in neonatal mice

(2010) L. Yu et al.   DEVELOPMENT

Modulation of BMP signaling by Noggin is required for the maintenance of palatal epithelial integrity during palatogenesis

(2010) Fenglei He et al.   DEVELOPMENTAL BIOLOGY

Wound healing and blastema formation in regenerating digit tips of adult mice

(2010) Warnakulasuriya Akash Fernando et al.   DEVELOPMENTAL BIOLOGY

Osteoblast Precursors, but Not Mature Osteoblasts, Move into Developing and Fractured Bones along with Invading Blood Vessels

(2010) Christa Maes et al.   DEVELOPMENTAL CELL

rhBMP-2 Induces Transient Bone Resorption Followed by Bone Formation in a Nonhuman Primate Core-Defect Model

(2010) Howard J. Seeherman et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Differential Shh, Bmp and Wnt gene expressions during craniofacial development in mice

(2009) Katiucia Batista Silva Paiva et al.   ACTA HISTOCHEMICA

The use of reactive polymer coatings to facilitate gene delivery from poly (ɛ-caprolactone) scaffolds

(2009) Wei-Wen Hu et al.   BIOMATERIALS

Local gene delivery from ECM-coated poly(lactide-co-glycolide) multiple channel bridges after spinal cord injury

(2009) Laura De Laporte et al.   BIOMATERIALS

BMP2 is essential for post natal osteogenesis but not for recruitment of osteogenic stem cells

(2009) M.V. Bais et al.   BONE

Immunolocalization of BMPs, BMP antagonists, receptors, and effectors during fracture repair

(2009) Yan Yiu Yu et al.   BONE

BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation

(2009) K. N. Retting et al.   DEVELOPMENT

Image-guided, noninvasive, spatiotemporal control of gene expression

(2009) R. Deckers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mesenchyme-dependent BMP signaling directs the timing of mandibular osteogenesis

(2008) A. E. Merrill et al.   DEVELOPMENT

Effect of bone morphogenetic protein signaling on development of the jaw skeleton

(2008) Diane Hu et al.   DEVELOPMENTAL DYNAMICS

Real time monitoring of BMP Smads transcriptional activity during mouse development

(2008) Rui M. Monteiro et al.   GENESIS

Regional and cellular localisation of BMPs and their inhibitors’ expression in human fractures

(2008) Francois N. K. Kwong et al.   INTERNATIONAL ORTHOPAEDICS

Disruption of BMP Signaling in Osteoblasts Through Type IA Receptor (BMPRIA) Increases Bone Mass*

(2008) Nobuhiro Kamiya et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Spatially patterned gene expression for guided neurite extension

(2008) Tiffany Houchin-Ray et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Altered relative expression of BMPs and BMP inhibitors in cartilaginous areas of human fractures progressing towards nonunion

(2008) Francois N.K. Kwong et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Engineering graded tissue interfaces

(2008) J. E. Phillips et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA