Article
Biochemistry & Molecular Biology
Rabia Javed, Farwa Rais, Muhammad Kaleem, Bushra Jamil, Muhammad Arslan Ahmad, Tianhao Yu, Saba Waqar Qureshi, Qiang Ao
Summary: This study presents the utilization of chitosan capped CuO nanoparticles in the healthcare system, showing enhanced antibacterial, antioxidant, cytotoxic, and antidiabetic activity compared to CuO nanoparticles. The amalgamation of these nanoparticles into dentine bonding agents results in efficient remedy against secondary caries, with significant reduction of harmful bacteria. Additionally, the synthesized CuO nanoparticles and CuO-Chitosan nanoparticles exhibit promising potential in drug delivery and nanotheranostics.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Caio Luiz Lins-Candeiro, Luiz Renato Paranhos, Nilson Ferreira de Oliveira Neto, Rafael Antonio Oliveira Ribeiro, Carlos Alberto de-Souza-Costa, Fernanda Rodrigues Guedes, Washington Henrique Themoteo da Silva, Ana Paula Turrioni, Paulo Cesar de Freitas Santos Filho
Summary: This study evaluated the transdentinal cytotoxic effects of enzymatic agents for chemomechanical carious tissue removal on human dental pulp cells. The results showed that the Brix3000 (TM) enzymatic agent did not cause indirect cytotoxic effects on pulp cells, regardless of the application time. In contrast, Papacarie Duo (TM) reduced viability and increased ROS production by pulp cells.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Nur Sahin, Suna Saygili, Merve Akcay
Summary: This study evaluated the success of three different pulp-capping materials in one-stage indirect pulp treatment of primary teeth. While the clinical and radiographic success rates were similar among the materials, the histological examination showed that resin-based materials like TheraCal LC may negatively impact pulp status. Resin-free calcium silicate-based materials seem to be more favorable in long-term success of indirect pulp treatment in young-age groups.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Shaqayeq Ramezanzade, Tudor Laurentiu Dascalu, Bulat Ibragimov, Azam Bakhshandeh, Lars Bj
Summary: This study aimed to evaluate the impact of providing artificial intelligence (AI)-based radiographic information to dental students on their ability to predict pulp exposure compared to standard radiographic and clinical information. The results showed that the AI model outperformed the students in all groups, with an F1-score of 0.71 (P < 0.001). The students' F1-score in the groups with AI predictions (G(X-ray+AI) and G(X-ray+clinical data+AI)) was slightly higher than the groups without AI predictions (G(X-ray) and G(X-ray+clinical data)), but the difference was only marginally significant (P = 0.054).
JOURNAL OF DENTISTRY
(2023)
Article
Medicine, General & Internal
Pratima Panda, Shashirekha Govind, Sanjit Kumar Sahoo, Satabdi Pattanaik, Rachappa M. Mallikarjuna, Triveni Nalawade, Sanjay Saraf, Naseer Al Khaldi, Salma Al Jahdhami, Vinay Shivagange, Amit Jena
Summary: The study examined the effects of different pulp capping agents on human dental pulp stem cells. The results showed that platelet-rich fibrin (PRF) had the highest cell viability and the greatest potential to enhance cell proliferation and differentiation. On the other hand, Tetric N-Bond was found to be ineffective as a pulp capping agent. Overall, PRF was the most effective in maintaining the viability of human dental pulp stem cells compared to the other tested materials.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell & Tissue Engineering
L. L. E. Whitehouse, N. H. Thomson, T. Do, G. A. Feichtinger
Summary: Research in dental regeneration is focusing on dental-pulp capping, with natural biomimetic scaffolds showing potential advantages over manufactured materials. Further exploration of synergistic peptide use and tailored scaffold development is needed for the successful application in dental-pulp capping.
EUROPEAN CELLS & MATERIALS
(2021)
Article
Dentistry, Oral Surgery & Medicine
N. Ballal, H. F. Duncan, D. B. Wiedemeier, N. Rai, P. Jalan, V Bhat, V. S. Belle, M. Zehnder
Summary: In this study, it was found that the levels of neutrophil gelatinase 9 (MMP-9)/total protein (TP) and NaOCl lavage significantly influenced pulp survival in cariously exposed and directly capped teeth, while mild preoperative discomfort did not have an impact.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Kim R. Ekstrand, Thais Cordeschi, Ninoska Abreu-Placeres
Summary: This study examined the relationship between the features of root caries lesions classified by ICCMS (TM) and the depth of the lesions towards the pulp, showing high validity in terms of reproducibility and accuracy of the scoring system. The results demonstrated that the ICCMS (TM) system can effectively evaluate the depth of root caries lesions towards the pulp.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Engineering, Biomedical
Matthew J. Osmond, Melissa D. Krebs
Summary: The study introduces a potential regenerative pulp capping agent by embedding calcium phosphate nanoparticles in carboxymethyl-chitosan and a diglycidyl ether polymer hydrogel, demonstrating promising potential for restoring tooth function and healthy dentin tissue.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2021)
Article
Dentistry, Oral Surgery & Medicine
Florin Eggmann, Thomas J. W. Gasser, Hanjo Hecker, Mauro Amato, Roland Weiger, Lucia K. Zaugg
Summary: Partial pulpotomy showed favorable short and medium-term outcomes in teeth with carious pulp exposure, with no significant differences in pulp survival rates among different age groups.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Chawan Manaspon, Chavin Jongwannasiri, Sujin Chumprasert, Noppadol Sa-Ard-Iam, Rangsini Mahanonda, Prasit Pavasant, Thantrira Porntaveetus, Thanaphum Osathanon
Summary: The study found that ProRoot(R) MTA and Biodentine(TM) have favorable in vitro biocompatibility and bioactive properties on human dental pulp stem cells, suggesting their superior regenerative potential compared with DyCal(R) and TheraCal(TM).
Article
Dentistry, Oral Surgery & Medicine
Domenico Ricucci, Isabela N. Rocas, Flavio R. F. Alves, Pedro H. Cabello, Jose F. Siqueira Jr
Summary: This study evaluated the long-term outcome of direct pulp capping in mature teeth. The success rate of the procedure was high, especially within the first 10 years after treatment. The quality of the coronal restoration was the main factor influencing the treatment outcome.
JOURNAL OF ENDODONTICS
(2023)
Article
Chemistry, Multidisciplinary
Cristina Gabriela Puscasu, Corina Laura Stefanescu, Rodica Maria Murineanu, Mircea Grigorian, Lucian Cristian Petcu, Elena Dumea, Liliana Sachelarie, Radu Andrei Puscasu
Summary: The study revealed that carious dental pulp specimens of type 2 diabetic patients showed fibrotic transformation, calcifications, arteriosclerosis, and inflammatory infiltrate. Dentists need to be cautious in treating this condition.
APPLIED SCIENCES-BASEL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Marwa Mohamed Ahmed Lotfy Baraka, Lucia Cevidanes, Magda Tekeya, Niveen Bakry, Antonio Ruellas, Tatiana Botero, Erika Benavides, Margherita Fontana
Summary: This study aimed to evaluate radiographic changes after indirect pulp capping (IPC) using silver diamine fluoride (SDF) with or without potassium iodide (KI) and resin modified glass ionomer cement (RMGIC) in deep carious young permanent molars using cone beam computed tomography (CBCT). The results showed no significant differences among the three groups regarding tertiary dentin formation (volume and grey level intensity), increase in root length, and prevention of secondary caries and periapical radiolucency.
Article
Materials Science, Ceramics
Ensanya A. Abou Neel, Soumya Sheela, Fatma Mousa AlGhalban, Andi Arjuna, Ifty Ahmed
Summary: This study investigated the morphology, chemistry, thermal characteristics, cytocompatibility, and osteogenic potential of solid and porous phosphate-based glass microspheres for potential use as pulp-capping materials. Through various tests, it was found that both solid and porous GMs showed good compatibility with dental pulp stem cells and could support cell attachment, spreading, and viability. However, cells grown in GMs' extracts showed higher viability but less mineralization compared to direct contact with GMs. Therefore, both types of GMs have potential applicability as pulp-capping materials.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2023)
Review
Dentistry, Oral Surgery & Medicine
Falk Schwendicke, Sascha Rudolf Herbst
Summary: This review introduces the main concepts of health economic analysis, systematically reviews the existing economic literature on endodontic treatments, and suggests further action for the community. The identified evidence on the health economics of endodontic therapies is limited and has some limitations. However, maintaining pulpal vitality is preferred over root canal treatment for cost-effectiveness, retaining teeth is usually more cost-effective than extraction and replacement, and endodontic retreatment may be clinically indicated but not always cost-effective and should be carefully considered.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ana Cristina Mafla, Falk Schwendicke
Summary: The aim of this study was to estimate disease pattern clusters and co-occurrences of oral signs and symptoms in a Colombian population. A cross-sectional study was carried out through a telephone survey among 1155 people. Age-specific clustering of signs and symptoms and diagnostic patterns were present in this Colombian cohort.
INTERNATIONAL DENTAL JOURNAL
(2023)
Review
Medicine, General & Internal
Lubaina T. Arsiwala-Scheppach, Akhilanand Chaurasia, Anne Mueller, Joachim Krois, Falk Schwendicke
Summary: Machine learning is increasingly used in dental research and application. This study aimed to compile and evaluate studies using machine learning in dentistry, focusing on methodological quality and reporting standards. The findings showed that machine learning is commonly employed for classification tasks in different clinical fields. Forty-two different metrics were used to evaluate model performances, with accuracy, sensitivity, precision, and intersection-over-union being the most common. The study identified a significant risk of bias and moderate adherence to reporting standards, highlighting the need for a minimum (core) set of outcome and outcome metrics for comparison across studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Marcus Cebula, Gerd Goestemeyer, Joachim Krois, Vinay Pitchika, Sebastian Paris, Falk Schwendicke, Susanne Effenberger
Summary: The present study conducted a meta-analysis to evaluate the certainty of evidence for resin infiltration of proximal carious lesions in primary and permanent teeth. The results showed that resin infiltration can effectively arrest caries lesions in both primary and permanent teeth. However, the certainty of evidence remains unclear due to the high or unclear risk of bias in the included trials.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Stella Danek, Martha Buettner, Joachim Krois, Falk Schwendicke
Summary: To reach more vaccine recipients, high-income countries have introduced mass vaccination centers for COVID-19. Understanding user experiences of these structures can help improve their design and increase patient satisfaction and vaccine uptake.
Editorial Material
Dentistry, Oral Surgery & Medicine
Falk Schwendicke, Martha Buettner
BRITISH DENTAL JOURNAL
(2023)
Editorial Material
Dentistry, Oral Surgery & Medicine
Martha Buettner, Falk Schwendicke
BRITISH DENTAL JOURNAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
W. Park, F. Schwendicke, J. Krois, J. -K. Huh, J. -H. Lee
Summary: This study evaluated the efficacy of deep learning in identifying and classifying different types of dental implant systems using a large-scale multicenter data set. Deep learning outperformed dental professionals in accuracy and required less reading and classification time. The results suggest that deep learning can be used successfully as a decision support aid for the identification and classification of dental implant systems encountered in clinical practice.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Medicine, General & Internal
Hossein Mohammad-Rahimi, Shankeeth Vinayahalingam, Erfan Mahmoudinia, Parisa Soltani, Stefaan J. Berge, Joachim Krois, Falk Schwendicke
Summary: Using super-resolution algorithms, low-resolution images can be converted to high-quality images. This study compared deep learning-based super-resolution models with a conventional approach for enhancing the resolution of dental panoramic radiographs. The LTE model outperformed other models, showing significant improvements in the quality of panoramic radiographs compared to low-resolution images.
Article
Dentistry, Oral Surgery & Medicine
Lisa Schneider, Roman Rischke, Joachim Krois, Aleksander Krasowski, Martha Buettner, Hossein Mohammad-Rahimi, Akhilanand Chaurasia, Nielsen S. Pereira, Jae-Hong Lee, Sergio E. Uribe, Shahriar Shahab, Revan Birke Koca-Unsal, Gurkan Unsal, Yolanda Martinez-Beneyto, Janet Brinz, Olga Tryfonos, Falk Schwendicke
Summary: This study demonstrates the effectiveness of Federated Learning (FL) in dentistry, showing that it can train high-performance and generalizable deep learning models without sharing sensitive data. FL outperformed Local Learning (LL) in tooth segmentation on panoramic radiographs and proved to be a valuable alternative when data pooling is not feasible.
JOURNAL OF DENTISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Falk Schwendicke, Lisa Bombeck
Summary: This study assessed the cost-effectiveness of near-infrared-light-transillumination (NILT) for school-based caries screening and found that NILT may provide limited effectiveness gains and cost savings in the modelled populations. However, in countries other than Germany, NILT may have higher cost-effectiveness.
JOURNAL OF DENTISTRY
(2023)
Article
Medicine, General & Internal
Sascha Rudolf Herbst, Vinay Pitchika, Joachim Krois, Aleksander Krasowski, Falk Schwendicke
Summary: This study aimed to identify factors associated with the presence of apical lesions (AL) in panoramic radiographs and evaluate their predictive value. The results showed that the presence of AL was higher in root-canal treated teeth, those with crowns, and molars. Less-complex machine learning models, such as decision tree, performed better in predicting AL.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Stella Danek, Dmitrij Achelrod, Ole Wichmann, Falk Schwendicke
Summary: This qualitative study examined the role of mass vaccination centers in the COVID-19 vaccination campaign in Germany and explored their optimal deployment. The study found that these centers played an essential role in terms of controllability, throughput, accessibility, and openness. Unlike regular vaccination structures, public administration had direct authority over these centers, allowing for prioritization and documentation of vaccine access. The deployment of vaccination centers should be guided by vaccine availability, demand, logistics, and local capacities to ensure effective and equitable access. Improvements in capacity use, scalability, and flexibility of governmental vaccination structures are necessary for future pandemics.
Article
Dentistry, Oral Surgery & Medicine
Gerd Goestemeyer, Mareike Preus, Karim Elhennawy, Falk Schwendicke, Sebastian Paris, Haitham Askar
Summary: In this study, the diagnostic accuracy of radiographic evaluation, visual-tactile assessment, laser-fluorescence, and near-infrared-light transillumination were evaluated for proximal root caries lesions. The results showed that near-infrared-light transillumination was not applicable for detecting proximal root caries, while laser-fluorescence and visual-tactile assessment were more accurate than radiographic evaluation for detecting these lesions.
CLINICAL ORAL INVESTIGATIONS
(2023)
