Journal
JOURNAL OF DENTAL RESEARCH
Volume 90, Issue 4, Pages 495-500Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0022034510391792
Keywords
iNOS; periapical lesion; ROS
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Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [CNPq473597/2006-3]
- CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)
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Nitric oxide (NO) and reactive oxygen species (ROS) are key molecules in resistance to pathogens. Little is known about their role in pathogenesis of periapical lesions. To address this issue, we induced periapical lesions in mice lacking nitric oxide synthase (iNOS(-/-)) or phagocyte oxidase (PHOX-/-). iNOS(-/-) mice expressed higher levels of IL-1 beta, TNF-alpha, RANK, RANKL, and MCP-1 than C57BL/6 and PHOX-/-. Apical thickening of the periodontal ligament was also greater in iNOS(-/-) compared with other groups. Interestingly, ROS production did not interfere in periapical lesion progression, but seemed to be essential for the appearance of multinucleated TRAP-positive cells. Thus, periapical lesion progression in iNOS(-/-) was associated with an imbalance of pro-inflammatory cytokines (IL-1 beta and TNF-alpha), bone-resorptive modulators (RANK and RANKL), and MCP-1. We conclude that NO, but not ROS, controls progression of bone resorption in a murine experimental model of apical periodontitis.
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