Article
Biophysics
Xin Yang, Qiang Wang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Pingbo Chen, Congming Li, Lei Wang, Guohai Lu, Yaozeng Xu
Summary: In this study, a simply immersing method was used to fabricate dual-functional PEEK with antibacterial properties and enhanced bone integration. The modified PEEK demonstrated favorable biosafety, accelerated cell adhesion, and distribution, as well as wide antibacterial capabilities. The PEEK-PDA-Mn/Ag composite showed antibacterial and osseointegration-enhancing abilities in vivo.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Materials Science, Multidisciplinary
Richard Drevet, Hicham Benhayoune
Summary: This article provides a summary of over three decades of scientific knowledge on the electrodeposition of calcium phosphate coatings. Electrodeposition is a low-temperature process designed to make metallic bone implants bioactive in a physiological environment. The process involves electrochemical reactions, pH modification, and precipitation of the calcium phosphate coating. However, the deposition process also generates undesired dihydrogen bubbles due to the reduction of water in the electrolyte solution. To address this issue, the use of pulsed current has been suggested as an alternative to traditional direct current, resulting in reduced bubble accumulation and improved properties of the electrodeposited coating. Furthermore, electrodeposition offers the possibility of incorporating ionic substituents into the calcium phosphate lattice to enhance the biological performance of bone implants.
Review
Chemistry, Physical
Nansi Lopez-Valverde, Antonio Lopez-Valverde, Juan Manuel Aragoneses, Bruno Macedo de Sousa, Maria Joao Rodrigues, Juan Manuel Ramirez
Summary: A meta-analysis of preclinical studies on unmodified experimental animals showed that there is no significant difference in bone-to-implant contact between implants coated with Ca-P and implants with etched surfaces. Further well-designed studies with larger sample sizes are needed to confirm these findings.
Article
Materials Science, Ceramics
Yessie W. Sari, Annisa Tsalsabila, Noviyan Darmawan, Yuliati Herbani
Summary: This study investigated the effects of surface-modified gold nanoparticles with different amino acids on the formation of hydroxyapatite. The results showed that aspartic acid modification of the gold nanoparticles promoted the crystallization of hydroxyapatite with a smaller crystallite size and a higher Ca/P ratio, which is beneficial for bone substitute applications.
CERAMICS INTERNATIONAL
(2022)
Article
Materials Science, Ceramics
Yessie W. Sari, Annisa Tsalsabila, Angga Saputra, Nur Aisyah Nuzulia, Yuliati Herbani
Summary: Surface modification of biomaterials affects the surface reactivity of implantable materials and induces the formation of apatite-like layers. This study investigates the bioactivity and surface reactivity of modified biomaterials (calcium-deficient hydroxyapatite [CDHA] on amino acid-capped AuNPs [AA-AuNPs]) by immersing them in simulated body fluid (SBF). The results show that AA-AuNPs, capped with charged and polar uncharged amino acids, are capable of inducing biomimetic hydroxyapatite formation. The presence of hydroxyapatite peaks in XRD patterns confirms the formation of hydroxyapatite after immersion in SBF. Furthermore, longer immersion time leads to nucleation and growth of hydroxyapatite, as indicated by changes in crystal structure. The surface modification of AA-AuNPs significantly affects the orientation of hydroxyapatite crystals and the presence of charged amino acids contributes to nucleation and growth, while polar uncharged amino acids only contribute to growth. The study highlights the bioactivity of CDHA-modulated AA-AuNPs in hydroxyapatite formation for bone tissue regeneration.
CERAMICS INTERNATIONAL
(2023)
Article
Engineering, Biomedical
Xiaogang Wang, Yuanman Yu, Luli Ji, Zhen Geng, Jing Wang, Changsheng Liu
Summary: Calcium phosphate-based materials, commonly used in bone graft substitutes, play a crucial role in bone healing. Recent studies have shown that osteoclast behaviors can greatly influence osteogenesis, with an appropriate Ca/P ratio promoting osteoclast differentiation and bone healing. This suggests the potential of manipulating osteoclast-mediated osteogenesis for improving osseointegration in materials.
BIOACTIVE MATERIALS
(2021)
Article
Multidisciplinary Sciences
Tao Wang, Jiaxiang Bai, Min Lu, Chenglong Huang, Dechun Geng, Gang Chen, Lei Wang, Jin Qi, Wenguo Cui, Lianfu Deng
Summary: In this study, a dual-effect coating was designed to modulate the osteoimmune microenvironment and enhance bone regeneration. The coating, which immobilized immunomodulatory metal ions and osteoinductive growth factors, significantly increased the recruitment of M2 macrophages and upregulated the expression of M2 cytokines. This led to improved bone-implant mechanical fixation and new bone ingrowth.
NATURE COMMUNICATIONS
(2022)
Review
Biotechnology & Applied Microbiology
Yuchen Zhang, Tianyu Shu, Silin Wang, Zhongbo Liu, Yilong Cheng, Ang Li, Dandan Pei
Summary: The report reviewed the complex and tight relationship between bone healing response and CaP-based biomaterials, with emphasis on in vivo degradation mechanisms of such materials and their osteoinductive properties mediated by immune responses, osteoclastogenesis and osteoblasts. A deep understanding of the interaction between biological healing process and biomaterials is crucial for optimizing the design of CaP-based biomaterials and effective strategies for customization.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Jian-Tong Cui, Xin-Yuan Wang, Xiao-Dan Mu, Meng Huang, Ya-Di Wang, Qiang Luo, Hui-Xia He
Summary: This study establishes a sustainably releasing system of exosomes-fibrin combinate loaded on tantalum-coating titanium implants. The system has potential effects on osseointegration between tantalum coating titanium implants and the surrounding bone tissue. The study demonstrates that the exosome sustained-release system with fibrin loading on the tantalum coating successfully promotes adhesion, proliferation, and osteogenic differentiation of BMSCs, and significantly enhances the osseointegrative capacity of the implants in vivo.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Veterinary Sciences
Daniel Cardoso Garcia, Larissa Eckmann Mingrone, Marcelo Jorge Cavalcanti De Sa
Summary: This study summarized the clinical and experimental studies using β-TCP as a bone substitute, showing promising results in bone integration with predictable, sustainable and adequate new bone formation. However, there is a lack of information on its application in veterinary medicine, and more research is needed to evaluate its osseoconductive and osseointegrative characteristics in animals.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Chemistry, Physical
Sergej Zankovic, Michael Seidenstuecker, Wolf C. Prall, Johannes Loos, Franziska Maderer, Mike Oberle, Sergio H. Latorre, Pia Schilling, Bianca Riedel, Anke Bernstein
Summary: An ex vivo organ model using human bone was developed to evaluate the initial osseointegration behavior of implant materials, showing that cells can remain viable for up to 28 days in the model. The geometry of test substrates influences the number of cells grown onto the substrate, offering an alternative for in vitro tests and animal models for testing implant materials.
Review
Engineering, Biomedical
Ilijana Kovrlija, Janis Locs, Dagnija Loca
Summary: Octacalcium phosphate (OCP) has significant advantages as a precursor to biologically formed apatite and is utilized as a carrier for biologically active substances in bone regeneration. However, research on drug delivery systems with OCP is still in its pioneering stage, and comprehensive data is lacking to fully understand the benefits it can bring. Further studies are needed to explore the potential of OCP in drug delivery systems for bone tissue engineering.
ACTA BIOMATERIALIA
(2021)
Review
Engineering, Biomedical
Jiajun Luo, Matthew Walker, Yinbo Xiao, Hannah Donnelly, Matthew J. Dalby, Manuel Salmeron-Sanchez
Summary: This review explores the effective physical approach of nanotopography in biomaterial cell manipulation and its interactions with protein adsorption. Advances in creating nanotopographical features to guide cell behaviors and the cellular mechanotransductive pathways initiated by nanotopography are summarized in this review.
BIOACTIVE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Masako Fujioka-Kobayashi, Hiroki Katagiri, Niklaus P. Lang, Jean-Claude Imber, Benoit Schaller, Nikola Saulacic
Summary: The aim of this study was to investigate the effect of synthetic bone substitutes in combination with deproteinized bovine bone mineral on bone formation. The results showed that the combination of alpha-TCP and DBBM resulted in similar levels of new bone formation compared to the negative control. Micro-CT analysis indicated resorption of the combined materials, but without any change in volume.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Shukufe Amukarimi, Iman Mobasherpour, Sorosh Abdollahi, Peiman Brouki Milan, Masoud Mozafari
Summary: Thanks to prophylactic antibiotics, the risk of wound infection in orthopedic surgeries has significantly decreased. This study focuses on the effectiveness of a new biodegradable antibiotic-loaded coating on the surface of a magnesium implant. The results show that the coating is biocompatible, antibacterial, and has improved corrosion resistance, making it potentially suitable for bone regeneration applications.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Nanoscience & Nanotechnology
Jelle Penders, Michelle Stolzoff, Daniel J. Hickey, Martin Andersson, Thomas J. Webster
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2017)
Article
Pharmacology & Pharmacy
Lukas Boge, Anita Umerska, Nada Matougui, Helena Bysell, Lovisa Ringstad, Mina Davoudi, Jonny Eriksson, Katarina Edwards, Martin Andersson
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2017)
Article
Engineering, Biomedical
Emma Westas, Mariko Hayashi, Francesca Cecchinato, Ann Wennerberg, Martin Andersson, Ryo Jimbo, Julia R. Davies
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2017)
Article
Polymer Science
Jelle Penders, Anand K. Rajasekharan, Mats Hulander, Martin Andersson
MACROMOLECULAR RAPID COMMUNICATIONS
(2017)
Article
Materials Science, Biomaterials
Maria Pihl, Ellen Bruzell, Martin Andersson
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2017)
Article
Cell Biology
Jaime S. Marques Filho, Jorge Gobara Jr, Gustavo Vargas da Silva Salomao, Laura M. Sumita, Jamil A. Shibli, Renato G. Viana, Humberto O. Schwartz Filho, Claudio Sergio Pannuti, Paulo Henrique Braz-Silva, Debora Pallos
MEDIATORS OF INFLAMMATION
(2018)
Article
Multidisciplinary Sciences
Antiope Lotsari, Anand K. Rajasekharan, Mats Halvarsson, Martin Andersson
NATURE COMMUNICATIONS
(2018)
Article
Materials Science, Biomaterials
Mats Hulander, Hakon Valen-Rukke, Gustav Sundell, Martin Andersson
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2019)
Article
Biochemistry & Molecular Biology
Anna Peterson, Ida Ostergren, Antiope Lotsari, Abhijit Venkatesh, Johannes Thunberg, Anna Strom, Ramiro Rojas, Martin Andersson, Lars A. Berglund, Antal Boldizar, Christian Mueller
Article
Chemistry, Multidisciplinary
Anand K. Rajasekharan, Christoffer Gyllensten, Edvin Blomstrand, Marianne Liebi, Martin Andersson
Article
Biochemistry & Molecular Biology
Kristin Hyltegren, Mats Hulander, Martin Andersson, Marie Skepoe
Article
Chemistry, Multidisciplinary
Adrian Rodriguez-Palomo, Viviane Lutz-Bueno, Xiaobao Cao, Roland Kadar, Martin Andersson, Marianne Liebi
Summary: The study shows that in regions with high extensional flow, the material is oriented perpendicular to the flow, while in regions with high enough shear rate, the material is oriented in the flow direction. A flow-induced morphological transition from aligned lamellae toward multilamellar vesicles is observed in the lamellar phase with different shear rates.
Article
Materials Science, Biomaterials
Saba Atefyekta, Edvin Blomstrand, Anand K. Rajasekharan, Sara Svensson, Margarita Trobos, Jaan Hong, Thomas J. Webster, Peter Thomsen, Martin Andersson
Summary: The covalent immobilization of antimicrobial peptides (AMPs) in amphiphilic hydrogels increases long-term stability and shows high antibacterial activity. The AMP-hydrogels are non-toxic to human fibroblasts and retain their antimicrobial activity up to 48 hours in human blood serum.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Article
Nanoscience & Nanotechnology
Annija Stepulane, Anand Kumar Rajasekharan, Martin Andersson
Summary: This study presents a coating technique that improves the antibacterial properties of polydimethylsiloxane (PDMS), a commonly used biomaterial in medical devices, and also provides drug delivery capabilities. The coating, composed of cross-linked triblock copolymers and an antimicrobial peptide, effectively kills Staphylococcus aureus and Staphylococcus epidermidis and shows sustained drug release profiles.
ACS APPLIED BIO MATERIALS
(2022)
Correction
Chemistry, Multidisciplinary
Anand K. Rajasekharan, Martin Andersson
CRYSTAL GROWTH & DESIGN
(2018)