Article
Biotechnology & Applied Microbiology
Shaoping Li, Yundeng Xiaowen, Yuqing Yang, Libo Liu, Yifan Sun, Ying Liu, Lulu Yin, Zhiyu Chen
Summary: In this study, a multifunctional structurally optimized hydrogel scaffold was designed and analyzed. The scaffold showed a multi-network microstructure, bone tissue-matched properties, and desirable drug-release function. It demonstrated excellent performance in improving cell viability, promoting cell osteogenic differentiation, and regulating the inflammatory microenvironment. The synergistic osteogenic and anti-inflammatory functions of aspirin and nano-hydroxyapatite were also verified.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Rui-Chian Tang, Lily Shang, Philip O. Scumpia, Dino Di Carlo
Summary: Researchers have developed a novel crescent-shaped hydrogel scaffold with a microporous structure that allows for improved cell infiltration and expansion. With the use of microfluidic fabrication, the size of the cavities in the scaffold can be adjusted, leading to enhanced cellular network formation in vitro and in vivo. The results suggest that this new scaffold has the potential for superior functionality in tissue engineering applications.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Beibei Liu, Jiannan Wu, Xiaodi Sun, Qingxun Meng, Jian Zhang
Summary: A GelMA/HAMA dual network hydrogel loaded with osteogenic growth peptide (OGP) was developed to provide long-term sustained release of OGP for effective bone regeneration and rebuilding. The hydrogel polymers showed suitable physical characteristics, porosity structure, and biocompatibility. In vitro experiments demonstrated that the GelMA/HAMA-OGP hydrogel promoted cell proliferation, adhesion, and increased osteogenic-related gene and protein expression. This study offers a fresh perspective on bone regeneration therapy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Hongwei Pan, Wanxin Li, Yue Qu, Simei Li, Ayixiemu Yusufu, Jia Wang, Lihua Yin
Summary: This study successfully developed a series of injectable hydrogels for bone defect repair caused by trauma or tumor. The hydrogels exhibited excellent mechanical properties and biodegradability, and could provide a favorable microenvironment for the growth and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs).
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Article
Biophysics
Deepak Patil, Sushma Kumari, Kaushik Chatterjee
Summary: This study presents an innovative spin-coating setup to generate nanotopography on 3D-printed polymer scaffolds, which exhibit excellent bactericidal and osteogenic activities. The nanostructured PLA surface showed a high bactericidal effect on P. aeruginosa and S. aureus, while also supporting pre-osteoblast attachment and proliferation. This work has important implications for engineering next-generation 3D printed bioactive tissue scaffolds.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Cigdem Cetin Genc, Hilal Deniz Yilmaz, Burak Karaca, Fadime Kiran, Yavuz Emre Arslan
Summary: A novel biomimetic osteogenic bioscaffold was fabricated in this study by enriching therapeutic hydrocolloid quince seed mucilage with needle-like nano-hydroxyapatite crystals. The bioscaffold showed excellent physical and chemical properties, supporting osteogenic development. Experimental validation demonstrated its potential in in vitro osteogenic differentiation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Jasmine L. King, Roopali Shrivastava, Pooja D. Shah, Panita Maturavongsadit, Soumya Rahima Benhabbour
Summary: Bone fractures are a common problem in the elderly and have a significant impact on the economy worldwide. Traditional methods for repairing bone defects have limitations, leading to the investigation of injectable hydrogel scaffolds as an alternative approach. This study demonstrated that a chitosan-based hydrogel scaffold can promote the differentiation of preosteoblasts and support new bone growth, with high mechanical strength and cell viability.
Article
Cell Biology
Ali Salehi, Mohammad A. Mobarhan, Javad Mohammadi, Hosein Shahsavarani, Mohammad Ali Shokrgozar, Atefeh Alipour
Summary: The study investigated the characteristics of decellularized cabbage leaves and their potential for promoting bone differentiation, as demonstrated by enhanced osteogenic differentiation of BM-MSCs on the scaffold. These results suggest that decellularized cabbage leaves have great potential for tissue engineering applications in bone regeneration.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Rui Du, Bin Zhao, Kun Luo, Man-Xi Wang, Quan Yuan, Lei-Xiao Yu, Ke-Ke Yang, Yu-Zhong Wang
Summary: In this study, a bioactive and shape memory bone scaffold was fabricated using a four-dimensional fused deposition modeling technique. The scaffold utilized a poly(e-caprolactone) segment with a transition temperature near body temperature as the molecular switch for shape memory effect, and a poly(propylene fumarate) segment for improving regulation effect on osteogenesis. The experimental results demonstrated that the scaffold could quickly adapt to defect geometry through shape change, and significantly promote bone regeneration.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Ling Wang, Ting Li, Zihan Wang, Juedong Hou, Sitian Liu, Qiao Yang, Liu Yu, Weihong Guo, Yongjie Wang, Baolin Guo, Wenhua Huang, Yaobin Wu
Summary: Developing an injectable anisotropic scaffold with precise topographic cues plays a critical role in volumetric muscle loss repair. In this study, researchers prepared monodisperse remote magnetic controlled short nanofibers (MSNFs) and designed an injectable MSNF/Gel nanofiber/hydrogel scaffold. This scaffold showed the ability to guide 3D cellular alignment and organization through remote magnetic field control. The MSNF/Gel anisotropic scaffolds successfully recreated the topographical features of orbicular and bipennate muscles, leading to enhanced aligned myofiber formation and improved functional recovery in animal models.
Article
Biochemistry & Molecular Biology
Senthilguru Kulanthaivel, Tarun Agarwal, V. S. Sharan Rathnam, Kunal Pal, Indranil Banerjee
Summary: The study developed an efficient hMSC encapsulation system using bivalent cobalt doped nano-hydroxyapatite and gum tragacanth as angiogenic-osteogenic components. Experimental results showed that the encapsulation system supported hMSC growth, reduced reactive oxygen species production, promoted osteogenic differentiation marker expression, and enhanced vascular formation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Environmental
Zhen Geng, Xiaogang Wang, Yuanman Yu, Luli Ji, Jing Wang, Changsheng Liu
Summary: The study developed a pH-responsive NP-BP system that effectively inhibits osteoclastic bone resorption and subchondral bone abnormal remodeling, showing potential applications for early OA treatment.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Na Ren, Na Liang, Mengwei Dong, Zhichao Feng, Ling Meng, Chunhui Sun, Aizhu Wang, Xin Yu, Wenhan Wang, Juan Xie, Chao Liu, Hong Liu
Summary: In this study, researchers directed the differentiation of mesenchymal stem cells (MSCs) towards osteoblast lineage by using nanoscale zeolitic imidazolate framework-8 (ZIF-8) nanoparticles. They encapsulated the ZIF-8 nanoparticles with stem cell membranes (SCMs) to improve biocompatibility and targeted ability towards MSCs. The internalized SCM/ZIF-8 nanoparticles demonstrated excellent biocompatibility and increased osteogenic potentials of MSCs. Furthermore, the activated cyclic adenosine 3,5-monophosphate (cAMP)-PKA-CREB signaling pathway was found to dominate in accelerating osteogenic differentiation. In vivo experiments showed that SCM/ZIF-8 nanoparticles greatly promoted the formation of new bone tissue.
Article
Engineering, Biomedical
Maedeh Rahimnejad, Cindy Charbonneau, Zinan He, Sophie Lerouge
Summary: The rising incidence of bone disorders has created a demand for minimally invasive therapies. Injectable bioactive fillers can be used to fill irregular cavities in non-load bearing sites, and thermosensitive chitosan hydrogels provide an interesting option as in-situ injectable biomaterials. However, they lack osteoconductivity.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Biochemistry & Molecular Biology
Mohammad Mohammadalipour, Tayebeh Behzad, Saeed Karbasi, Mojtaba Babaei Khorzoghi, Zahra Mohammadalipour
Summary: This study prepared a novel electrospun nanocomposite structure (PLC) by adding lignin and cellulose nanofiber to PHB, which showed more symmetrical fibers, higher surface roughness, better hydrophilicity, smaller crystal size, and more reasonable biodegradability compared to PHB. These changes led to the improvement of mechanical properties, cell behavior, bioactivity, and osteogenesis promotion, suggesting that PLC could enhance biological responses compared to PHB.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Mary Anne S. Melo, Lei Chenga, Ke Zhanga, Michael D. Weir, Lidiany K. A. Rodrigues, Hockin H. K. Xu
Article
Dentistry, Oral Surgery & Medicine
Fang Li, Michael D. Weir, Jihua Chen, Hockin H. K. Xu
Article
Dentistry, Oral Surgery & Medicine
Fang Li, Michael D. Weir, Ashraf F. Fouad, Hockin H. K. Xu
Article
Dentistry, Oral Surgery & Medicine
Bashayer H. Baras, Jirun Sun, Mary Anne S. Melo, Franklin R. Tay, Thomas W. Oates, Ke Zhang, Michael D. Weir, Hockin H. K. Xu
Article
Dentistry, Oral Surgery & Medicine
Hong Chen, Yunhao Tang, Michael D. Weir, Jianghong Gao, Satoshi Imazato, Thomas W. Oates, Lei Lei, Suping Wang, Tao Hu, Hockin H. K. Xu
Article
Dentistry, Oral Surgery & Medicine
Wen Zhou, Xian Peng, Xuedong Zhou, Michael D. Weir, Mary Anne S. Melo, Franklin R. Tay, Satoshi Imazato, Thomas W. Oates, Lei Cheng, Hockin H. K. Xu
Article
Dentistry, Oral Surgery & Medicine
Xiuzhi Fei, Yuncong Li, Michael D. Weir, Bashayer H. Baras, Haohao Wang, Suping Wang, Jirun Sun, Mary A. S. Melo, Jianping Ruan, Hockin H. K. Xu
Article
Cell & Tissue Engineering
Gengtao Qiu, Mingguang Huang, Jin Liu, Ping Wang, Abraham Schneider, Ke Ren, Thomas W. Oates, Michael D. Weir, Hockin H. K. Xu, Liang Zhao
Summary: The novel CPCC + DOX scaffold demonstrated excellent mechanical properties and strong antibacterial activity, while also supporting proliferation and osteogenic differentiation of hPDLSCs. This scaffold has the potential to enhance bone regeneration and combat bone infections in dental, craniofacial, and orthopedic applications.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Heba Mitwalli, Rashed AlSahafi, Ebtehal G. Albeshir, Quan Dai, Jirun Sun, Thomas W. Oates, Mary Anne S. Melo, Hockin H. K. Xu, Michael D. Weir
Summary: The study developed a new bioactive nanocomposite with antibacterial and remineralizing properties by incorporating DMAHDM and nCaF2. The composites demonstrated good mechanical properties, potent antibacterial activity against biofilms, and high F and Ca ion releases, showing potential for preventing caries.
JOURNAL OF DENTISTRY
(2021)
Article
Engineering, Biomedical
Christopher J. Panebianco, Sanjna Rao, Warren W. Hom, James H. Meyers, Tiffany Y. Lim, Damien M. Laudier, Andrew C. Hecht, Michael D. Weir, Jennifer R. Weiser, James C. Iatridis
Summary: This study developed an injectable composite biomaterial using degradable oxidized alginate microbeads for delivering annulus fibrosus cells to injured intervertebral discs. The composite material achieved a balance between biomechanical and biological demands, providing promising results for cell delivery and repair.
Article
Dentistry, Oral Surgery & Medicine
Rashed AlSahafi, Heba Mitwalli, Abdullah Alhussein, Mary Anne S. Melo, Frederico Martinho, Christopher D. Lynch, Thomas W. Oates, Hockin H. K. Xu, Michael D. Weir
Summary: This study investigated the efficacy of a novel resin cement containing DMAHDM and NACP in inhibiting saliva microcosm biofilm. The results showed that the cement exhibited strong antibacterial action and continuous ion release, indicating its potential for remineralization.
JOURNAL OF DENTISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Hanan Filemban, Ghalia Bhadila, Xiaohong Wang, Mary Ann S. Melo, Thomas W. Oates, Gary D. Hack, Christopher D. Lynch, Michael D. Weir, Jirun Sun, Hockin H. K. Xu
Summary: This study developed a bioactive low-shrinkage-stress composite with antibacterial and remineralizing properties. After thermal cycling, the composite demonstrated good mechanical properties and maintained its strong antibacterial activity. This material shows great potential in inhibiting recurrent caries and increasing restoration longevity.
JOURNAL OF DENTISTRY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Wen Zhou, Hong Chen, Michael D. Weir, Thomas W. Oates, Xuedong Zhou, Suping Wang, Lei Cheng, Hockin H. K. Xu
Summary: This review provides an overview of cutting-edge research on the development of new bioactive restorations to inhibit secondary caries in enamel and dentin under biofilms. Novel bioactive materials are categorized based on their remineralization and antibacterial biofunctions. However, there is still a need for new intelligent and pH-responsive materials, and the evaluation should be performed using more clinically relevant biofilm-based secondary caries models.
JOURNAL OF DENTISTRY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Ghalia Y. Bhadila, Bashayer H. Baras, Abdulrahman A. Balhaddad, Mary Ann Williams, Thomas W. Oates, Michael D. Weir, Hockin H. K. Xu
Summary: This study reviewed different recurrent caries models used to evaluate restorative materials and compared their methodology and parameters. Specific recommendations for future investigations were also provided.
JOURNAL OF DENTISTRY
(2023)
Article
Engineering, Biomedical
Michael D. Weir, Papatya Kaner, Alexander Marin, Alexander K. Andrianov
Summary: The study used novel polyphosphazenes to modify tooth surfaces, improving the stability of the bonded interface between composite restorations and teeth. Results showed significant and stable adsorption of polyphosphazenes onto teeth, potentially leading to a more stable bonded interface.
REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE
(2021)
