Article
Dermatology
K. Wolk, T. -C. Brembach, D. Simaite, E. Bartnik, S. Cucinotta, A. Pokrywka, M. L. Irmer, J. Triebus, E. Witte-Haendel, G. Salinas, T. Leeuw, H. -D. Volk, K. Ghoreschi, R. Sabat
Summary: The expression of G-CSF is high in HS skin, especially in inflamed nodules and abscesses. IL-1 and IL-17 induce G-CSF production, and G-CSF blood levels correlate with the severity of HS.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Review
Dermatology
J. Karim Ead, David G. Armstrong
Summary: GM-CSF is a glycoprotein with immunomodulatory properties derived from both hemopoietic and nonhemopoietic sources. In patients with diabetic foot ulcers, GM-CSF activation is impaired, leading to impaired inflammatory response. Correcting macrophage immune dysfunction with exogenous GM-CSF may help restore immune balance and promote wound healing.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Shao-Yu Tang, Yi-Chin Lee, Chien-Wei Tseng, Po-Hsun Huang, Ko-Lin Kuo, Der-Cherng Tarng
Summary: This study found that G-CSF can improve angiogenic function in patients with peripheral arterial disease (PAD) associated with chronic kidney disease (CKD) through a hypoxia/IL-10 signaling cascade.
Article
Medicine, General & Internal
Slawomir Lewicki, Monika Lesniak, Agnieszka Sobolewska-Ruta, Aneta Lewicka, Marta Grodzik, Eugeniusz K. Machaj, Marek Saracyn, Jacek Z. Kubiak, Zygmunt Pojda
Summary: Encapsulation of cytokines in liposomes is an efficient method to deliver cytokines to cells at working concentrations without affecting cell morphology or proliferation. This method has great potential and important applications in tissue regeneration and other fields.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Virology
Sarah Stonedahl, J. Smith Leser, Penny Clarke, Huntington Potter, Timothy D. D. Boyd, Kenneth L. L. Tyler
Summary: West Nile virus (WNV) is the main cause of epidemic arboviral encephalitis in the United States. Depleting microglia in WNV-infected mice enhances viral replication and tissue injury, while augmenting microglial activation through GM-CSF administration reduces viral titers and apoptotic activity and increases survival. Stimulation of microglial activation may be a viable therapeutic approach for WNV neuroinvasive disease.
JOURNAL OF VIROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Atsushi Takamatsu, Kotaro Yoshida, Fumihito Toshima, Kazuto Kozaka, Naho Yamamoto, Yoshimichi Sai, Toshifumi Gabata
Summary: This study aims to clarify the incidence and clinicoradiologic characteristics of pegfilgrastim-induced aortitis. The results of the study found that the incidence of pegfilgrastim-induced aortitis may be higher than previously reported and may be more common in patients with esophageal cancer and those who received specific anticancer drugs. Furthermore, CT findings indicated that pegfilgrastim-induced aortitis is often characterized by involvement of the aortic arch and proximal branches.
Article
Oncology
Chong Wei, Yan Zhang, Wei Wang, Wei Zhang
Summary: Substituting PEG-rhG-CSF for short-acting rhG-CSF in the DA-EPOCH regimen significantly reduces the incidence of febrile neutropenia and related hospitalization, while simplifying management for both patients and healthcare providers.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Neurosciences
Lillian J. Brady, Kirsty R. Erickson, Kelsey E. Lucerne, Aya Osman, Drew D. Kiraly, Erin S. Calipari
Summary: Cocaine use disorder is associated with alterations in immune function and changes in peripheral cytokine expression, impacting responses to drug-related cues and highlighting the critical interaction between the brain and immune system. Upregulation of granulocyte colony-stimulating factor (G-CSF) by cocaine enhances the drug's effects on dopamine terminals through a release-based mechanism, indicating a potential role of immune factors in altering drug responses.
PSYCHOPHARMACOLOGY
(2021)
Article
Oncology
Takeo Fujii, Hasan Rehman, Su Yun Chung, Janice Shen, James Newman, Vernon Wu, Adam Hines, Elham Azimi-Nekoo, Fatima Fayyaz, Meeyoung Lee, George Raptis, Mikala Egeblad, Xinhua Zhu
Summary: The study found that G-CSF use was not associated with an increased risk of brain metastasis in patients with de novo Stage IV breast cancer. However, pulmonary embolism/deep venous thrombosis may be related to brain metastasis. Further research is needed to determine if DVT/PE with or without elevated NETs levels in the blood can predict the development of brain metastasis in these patients.
Article
Immunology
An-ran Xi, Yi-jun Luo, Jin-Tao Guan, Wei-Jie Wang, Zheng-Hao Xu
Summary: This study analyzed the efficacy and safety of granulocyte-macrophage colony-stimulating factor (GM-CSF) antibodies in COVID-19 patients. The results showed that GM-CSF antibody treatment can reduce the incidence of invasive mechanical ventilation and have slight but not significant effects on mortality and ventilation improvement. Sensitivity analysis revealed statistically significant results for mortality and ventilation improvement rate when one study was excluded. Furthermore, GM-CSF antibodies did not increase the risks of secondary infection and adverse events.
INFLAMMOPHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Guang-Yin Shen, Jeong-Hun Shin, Yi-Sun Song, Hyun-Woo Joo, In-Hwa Park, Jin-Hee Seong, Na-Kyoung Shin, A-Hyeon Lee, Young Jong Cho, Yonggu Lee, Young-Hyo Lim, Hyuck Kim, Kyung-Soo Kim
Summary: The study showed that G-CSF can reduce cardiomyocyte apoptosis in diabetic cardiomyopathy by increasing autophagy levels. The anti-apoptotic effect of G-CSF was found to be abrogated by autophagy inhibitors, indicating the significance of autophagy up-regulation in mediating the protective effects of G-CSF.
DIABETES & METABOLISM JOURNAL
(2021)
Article
Oncology
Vincenzo Adamo, Lorenzo Antonuzzo, Marco Danova, Michelino De Laurentiis, Paolo Marchetti, Carmine Pinto, Giovanni Rosti
Summary: This study aims to improve adherence to guideline recommendations for the prevention of febrile neutropenia and to enhance patient care.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Medicine, General & Internal
Yosuke Dotsu, Hiroyuki Yamaguchi, Minoru Fukuda, Takayuki Suyama, Noritaka Honda, Yasuhiro Umeyama, Hirokazu Taniguchi, Hiroshi Gyotoku, Shinnosuke Takemoto, Ryuta Tagawa, Ryosuke Ogata, Hiromi Tomono, Midori Shimada, Hiroaki Senju, Katsumi Nakatomi, Seiji Nagashima, Hiroshi Soda, Hiroaki Ikeda, Kazuto Ashizawa, Hiroshi Mukae
Summary: This study examined the real-world incidence of febrile neutropenia among patients with thoracic malignancies treated with single-agent amrubicin chemotherapy, and found that the incidence rate was 30%. It suggests that prophylactic G-CSF should be administered during practical use of this chemotherapy regimen for patients who have already undergone chemotherapy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yulia Michailov, Ali AbuMadighem, Eitan Lunenfeld, Joseph Kapelushnik, Mahmoud Huleihel
Summary: The study indicates that AML and CYT treatment have a significant negative impact on male fertility, but GCSF injection can improve this damage, restore spermatogenesis and fertility, showing potential value in preserving/restoring fertility in leukemia patients undergoing chemotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Allergy
Sharon Van Nevel, Jozefien Declercq, Gabriele Holtappels, Bart N. Lambrecht, Claus Bachert
Summary: This study aimed to identify underlying molecular pathways of type 2-low chronic rhinosinusitis (CRS) and improve personalized treatments. The results showed that G-CSF is an important cytokine regulating neutrophils in type 2-low CRS and has potential in the diagnosis and therapy of the disease.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Dapeng Hu, Chong Wang, Annette M. O'Connor
Article
Veterinary Sciences
Samantha A. Naberhaus, Adam C. Krull, Bailey L. Arruda, Paulo Arruda, Orhan Sahin, Kent J. Schwartz, Eric R. Burrough, Drew R. Magstadt, Franco Matias Ferreyra, Igor R. H. Gatto, Henrique Meiroz de Souza Almeida, Chong Wang, Amanda J. Kreuder
FRONTIERS IN VETERINARY SCIENCE
(2020)
Article
Immunology
Shollie M. Falkenberg, Rohana P. Dassanayake, Mitchell Palmer, Simone Silveira, James A. Roth, Eric Gauger, Troy J. Kaiser, Christian Guidarini, John D. Neill, Julia F. Ridpath
Article
Microbiology
Wannarat Yim-Im, Haiyan Huang, Jie Park, Chong Wang, Gabriela Calzada, Phillip Gauger, Karen Harmon, Rodger Main, Jianqiang Zhang
Summary: The ZMAC cell line is more advantageous for isolating PRRSV from lung and serum samples compared to the MARC-145 cell line. However, not all PRRSV isolates obtained from ZMAC cells are able to grow in MARC-145 cells. This report provides important guidelines to improve PRRSV isolation from clinical samples for further characterization and/or production of autogenous vaccines.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Veterinary Sciences
Dapeng Hu, Ting-Yu Cheng, Paul Morris, Jeffrey Zimmerman, Chong Wang
Summary: In this study, five spatially balanced sampling methods were compared to simple random sampling based on a livestock disease transmission model. The results showed that four of the five spatially balanced sampling methods performed better in terms of detecting at least one infected farms, requiring testing fewer farms than simple random sampling for any given probability of detection.
PREVENTIVE VETERINARY MEDICINE
(2021)
Article
Veterinary Sciences
Ting-Yu Cheng, Alexandra Henao-Diaz, Korakrit Poonsuk, Alexandra Buckley, Albert van Geelen, Kelly Lager, Karen Harmon, Phillip Gauger, Chong Wang, Aruna Ambagala, Jeffrey Zimmerman, Luis Gimenez-Lirola
Summary: The study demonstrated the feasibility of using oral fluid for PRV diagnosis and surveillance, showing similar performance of PRV gB PCR on oral fluid and nasal swab specimens. Quantitative analysis using PCR indicated successful detection of PRV gB DNA in oral fluid samples.
PREVENTIVE VETERINARY MEDICINE
(2021)
Article
Health Care Sciences & Services
Min Zhang, Chong Wang, Annette M. O'Connor
Summary: This research developed a method to quantify the correlation in antimicrobial resistance across populations and detected an unnoticed trend of susceptible bacteria. The application of this method revealed positive correlation in antibiotic resistance of susceptible bacteria across different populations, providing insights for potential clinical interventions.
BMC MEDICAL RESEARCH METHODOLOGY
(2021)
Article
Multidisciplinary Sciences
Min Zhang, Chong Wang, Annette O'Connor
Summary: Multidrug resistance poses a significant threat to public health and treatment of bacterial infections. A Bayesian framework using a Gaussian mixture model is proposed to proactively identify multidrug resistant bacteria by estimating resistance levels for antibiotics, showing signs of joint resistance to specific drug combinations. This model provides a timely tool for early detection of MDR and potential clinical intervention.
Article
Veterinary Sciences
Edison S. Magalhaes, Jeffrey J. Zimmerman, Pete Thomas, Cesar A. A. Moura, Giovani Trevisan, Derald J. Holtkamp, Chong Wang, Christopher Rademacher, Gustavo S. Silva, Daniel C. L. Linhares
Summary: This study developed an automated framework to analyze the risk factors for swine wean-to-finish mortality by integrating data from multiple sources. The results showed that sow farm health and productivity were closely linked to subsequent mortality during the wean-to-finish phase.
PREVENTIVE VETERINARY MEDICINE
(2022)
Article
Virology
Michael Welch, Jie Park, Karen Harmon, Jianqiang Zhang, Pablo Pineyro, Luis Gimenez-Lirola, Min Zhang, Chong Wang, Abby Patterson, Phillip C. Gauger
Summary: The experimental challenge studies evaluated the pathogenesis of a porcine parainfluenza virus type 1 isolate in pigs. Results indicate that despite PPIV-1 infection and replication in challenged swine, significant clinical respiratory disease was not observed.
Article
Medicine, General & Internal
Dapeng Hu, Chong Wang, Annette M. O'Connor
Summary: This paper presents a method for testing the homogeneity assumption of between-study variance in network meta-analysis, with validation through simulation and application in a study of antibiotic treatments for BRD. The results show that non-homogeneous between-study variance can influence the estimation of relative effect sizes and confidence intervals in NMA.
SYSTEMATIC REVIEWS
(2021)
Article
Cell Biology
Sanjana Mahadev Bhat, Nyzil Massey, Denusha Shrestha, Locke A. Karriker, Tomislav Jelesijevic, Chong Wang, Chandrashekhar Charavaryamath
Summary: Exposure to organic dust in agriculture can cause respiratory symptoms and loss of lung function. Mitochondrial dysfunction induced by organic dust may be related to the secretion of HMGB1. Neutralization of HMGB1 secreted by organic dust exposure can rescue mitochondrial dysfunction in human bronchial epithelial cells.
CELL AND TISSUE RESEARCH
(2022)
Article
Agriculture, Dairy & Animal Science
Justin Brown, Korakrit Poonsuk, Ting-Yu Cheng, Chris Rademacher, Erin Kalkwarf, Liying Tian, Lauren A. McKeen, Chong Wang, Luis Gimenez-Lirola, David Baum, Locke A. Karriker
Summary: Antibodies can be transmitted from a sow to her piglets through milk, and their levels can be monitored in the sow's serum to determine if they can provide protection for the piglets. This study compared two diagnostic assays for the detection of antibodies for a specific virus in pigs, and found moderate agreement between the assays. The high-throughput neutralization assay showed advantages over the fluorescent focus neutralization assay in terms of specificity and result discrimination.
Article
Agriculture, Dairy & Animal Science
Edison S. S. Magalhaes, Danyang Zhang, Chong Wang, Pete Thomas, Cesar A. A. Moura, Derald J. J. Holtkamp, Giovani Trevisan, Christopher Rademacher, Gustavo S. S. Silva, Daniel C. L. Linhares
Summary: In this study, a data-wrangling pipeline was built to integrate diverse and dispersed data streams collected from a swine production company, creating a master table that was used to predict the nursery mortality of groups of pigs. The Support Vector Machine model demonstrated the best overall prediction results, showing high accuracy in forecasting nursery mortality.
Article
Microbiology
Gaurav Rawal, Jianqiang Zhang, Patrick G. Halbur, Phillip C. Gauger, Chong Wang, Tanja Opriessnig
Summary: The pathogenicity of currently circulating PRCV variant isolates was compared to traditional PRCV isolates, and it was found that the variant isolates are more transmissible and pathogenic. Additionally, it was observed that infection with the variant isolates did not impact influenza A virus infection. These findings raise concerns about the evolution of PRCV towards more highly pathogenic and transmissible strains and emphasize the importance of monitoring such viruses.