Article
Infectious Diseases
Zhenjie Zhang, Dongle Su, Xinan Meng, Ruobing Liang, Weijian Wang, Na Li, Yaqiong Guo, Aizhen Guo, Shujing Li, Zengyuan Zhao, Lihua Xiao, Yaoyu Feng
Summary: The study showed a significantly higher infection rate of Cryptosporidium parvum during the outbreak, particularly associated with watery diarrhea in neonatal calves at a large cattle farm in Hebei Province, China. The subtype identified in the C. parvum isolates was IIdA20G1, highlighting the importance of monitoring and controlling the spread of this pathogen in China.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Parasitology
Filipe L. M. Mendonca, Julia G. Carvalho, Rafael J. Silva, Luana C. A. Ferreira, Daiane M. Cerqueira, Horst Rogge, Joao P. Andrade, Layanne D. Ferreira, Markus V. V. Araujo, Tiago F. Moreira, Antonio U. Carvalho, Elias J. Facury
Summary: Isoquinoline alkaloids supplementation in calves experimentally inoculated with Cryptosporidium parvum showed decreased intensity and duration of symptoms, reduced requirement for supportive therapy, and prevented mortality among animals.
VETERINARY PARASITOLOGY
(2021)
Article
Parasitology
Ngalla E. Jillani, Atunga Nyachieo, Daniel C. Chai, James Nyabuga Nyariki
Summary: This study successfully developed and validated an infant baboon infection model of cryptosporidiosis, finding that 2x10(4) oocysts were an effective minimum quantifiable experimental infection dose, which could contribute to further research on the treatment and prevention of cryptosporidiosis.
PARASITES & VECTORS
(2021)
Article
Immunology
Xiaoyi Liu, Jing Wang, Jun Liu, Xuming Li, Yuanlin Guan, Suyun Qian, Xinlei Jia
Summary: This study highlights the importance of recognizing the potential severity of Cryptosporidium infection, even among individuals with normal immune systems. The use of mNGS testing can detect infections that conventional methods fail to find, and can assist in timely diagnosis and treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
P. Y. Iroh Tam, S. L. M. Arnold, L. K. Barrett, C. R. Chen, T. M. Conrad, E. Douglas, M. A. Gordon, D. Hebert, M. Henrion, D. Hermann, B. Hollingsworth, E. Houpt, K. C. Jere, R. Lindblad, M. S. Love, L. Makhaza, C. W. McNamara, W. Nedi, J. Nyirenda, D. J. Operario, J. Phulusa, G. Quinnan, L. A. Sawyer, H. Thole, N. Toto, A. Winter, W. C. Van Voorhis
Summary: The study evaluated the efficacy, pharmacokinetics, and safety of clofazimine in HIV patients with cryptosporidiosis. Results showed that clofazimine did not significantly reduce Cryptosporidium shedding, but led to more adverse effects in severely immunocompromised HIV patients. This suggests limitations in the safety and efficacy of clofazimine for treating cryptosporidiosis in this patient population.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Parasitology
Firas Alali, Ibrahim Abbas, Marwa Jawad, Nawal Hijjawi
Summary: Cryptosporidium, a parasitic organism, is a significant cause of diarrheal disease in humans and animals globally. There is a high prevalence of cryptosporidiosis in both humans and animals in Iraq, with reports indicating confusing results and a need for further epidemiological and molecular studies to accurately assess the situation.
Article
Medicine, General & Internal
Mariam Danish Iqbal, Tahir Naeem, Umar Khurshid, Fatima Hameed
Summary: The study aimed to investigate the frequency of Cryptosporidium infection among children with persistent diarrhea, with a result of 28% infection rate. It highlights the importance of hygiene education, accurate diagnosis, and treatment for Cryptosporidiosis, as well as the need for further research on this pathogen.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Microbiology
Jiayuan Su, Yiting Shen, Na Li, Yu Li, Ziding Zhang, Lihua Xiao, Yaqiong Guo, Yaoyu Feng
Summary: This study investigated the expression and function of CpCDPK1 and CpCDPK9 in Cryptosporidium parvum infection. The results suggest that these two proteins may have different roles in the infection process.
Article
Engineering, Environmental
Asli Onursal, Bulent Icgen
Summary: This study investigated the removal capacities of different types of wastewater treatment plants (WWTPs) for Giardia intestinalis and Cryptosporidium parvum. The results showed that G. intestinalis had lower removal capacities compared to C. parvum in all types of WWTPs tested. Therefore, it is necessary to monitor the discharge of G. intestinalis in WWTPs to reduce potential risks to public health.
WATER ENVIRONMENT RESEARCH
(2023)
Article
Microbiology
Yongli Wang, Minghui Gao, Xiaoying Li, Wenshuai Zhu, Mengchun Zhao, Jiayue Li, Xiaomeng Liu, Letian Cao, Songrui Li, Sumei Zhang, Longxian Zhang, Shuhua Fan
Summary: Adaptive immune responses and T lymphocytes play important roles in parasite-induced protection, but the role of CD8(+) T lymphocytes in resolving C. parvum infection is unclear. Our study identified an immunodominant CD8(+) T-cell response induced by the glycoprotein-derived epitope Gp40/15-SVF9 in C57BL/6 mice. Crystal structure analyses showed similarities between the interaction of H-2K(b)-SVF9 peptide and a dominant epitope presented by HLA-A*0201, which can be recognized by human TCRs. Additionally, we found multiple conformations of the SVF9 peptide, potentially recognized by TCRs.
Article
Microbiology
Fanfan Shu, Yu Li, Wenlun Chu, Xuehua Chen, Ziding Zhang, Yaqiong Guo, Yaoyu Feng, Lihua Xiao, Na Li
Summary: Calcium-dependent protein kinases (CDPKs) play important roles in Cryptosporidium spp., triggering various biological processes. This study characterized CpCDPK2A and its expression pattern in different stages of Cryptosporidium. Although the specific role of CpCDPK2A remains unclear, it has the potential to be a drug target for treating cryptosporidiosis.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Veterinary Sciences
Magdalena Grabbe, Ivan Conejeros, Zahady D. Velasquez, Seyed Sajjad Hasheminasab, Faustin Kamena, Axel Wehrend, Ulrich Gaertner, Anja Taubert, Carlos Rodrigo Hermosilla
Summary: In this study, it was shown for the first time that neonate bovine PMN are capable of forming NETs against C. parvum-sporozoites and oocysts, regardless of their stage. The research also found that C. parvum strongly induces suicidal neonatal NETosis in a P2X1-dependent manner, suggesting its anti-cryptosporidial effects through various mechanisms.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Immunology
Denise Ann Dayao, Justyna Jaskiewcz, Sangun Lee, Bruno Cesar Oliveira, Abhineet Sheoran, Giovanni Widmer, Saul Tzipori
Summary: Cryptosporidiosis has been identified as a major cause of morbidity and mortality in children with diarrhea in low-income countries. One of the main challenges in developing vaccines to control this disease is the lack of well-characterized immunocompetent rodent models. In this study, two mouse models were optimized and compared for vaccine evaluation, providing valuable references for future research.
INFECTION AND IMMUNITY
(2022)
Article
Infectious Diseases
Estelle Menu, Emilie Mosnier, Arnaud Cotrel, Loic Favennec, Romy Razakandrainibe, Stephane Valot, Denis Blanchet, Frederic Dalle, Damien Costa, Melanie Gaillet, Magalie Demar, Franck de Laval
Summary: Cryptosporidiosis outbreaks were poorly documented in South America. In a remote forest area along the Surinam-French Guiana border, 51 cases of cryptosporidiosis were reported in 2018, primarily affecting children and soldiers. The main source of infection was found to be contaminated tap water. Implementing alternative water supply or treatment is crucial for the affected population.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Biotechnology & Applied Microbiology
Alyaa Farid, Silvia Aiad, Gehan Safwat
Summary: Cryptosporidiosis is an intestinal infection caused by the protozoan parasite Cryptosporidium spp. This study aimed to produce antibodies for the diagnosis of cryptosporidiosis and investigate their protective effects in infected calves and mice. The results showed that the produced antibodies had high sensitivity in detecting the disease and significantly reduced oocyst shedding and inflammatory cytokine production.
Letter
Obstetrics & Gynecology
Johnny S. Younis, Ido Izhaki, Scott M. Nelson
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Review
Obstetrics & Gynecology
Johnny S. Younis, Nora Shapso, Yval Ben-Sira, Scott M. Nelson, Ido Izhaki
Summary: Endometriotic cystectomies have a significant impact on serum anti-Mullerian hormone levels but not on antral follicle counts. The detrimental effects on anti-Mullerian hormone levels can be detected at early, intermediate, and late postoperative time points. Anti-Mullerian hormone levels may provide a more accurate assessment of the risk of iatrogenic depletion of the ovarian reserve in women with endometrioma.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Plant Sciences
Beny Trabelcy, Ido Izhaki, Yoram Gerchman
Summary: The nutritious pulp of fleshy fruits facilitates seed dispersal, but the low nitrogen content in fruit pulp potentially stimulates seed digestion, causing a conflict of interest between plants and fruit consumers.
JOURNAL OF ECOLOGY
(2022)
Letter
Obstetrics & Gynecology
Johnny S. Younis, Ido Izhaki, Scott M. Nelson
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Review
Obstetrics & Gynecology
Manal Massalha, Ido Izhaki, Rula Iskander, Raed Salim
Summary: This study examined the effect of inhaled nitrous oxide on the success rate and pain score for women undergoing external cephalic version (ECV). The meta-analysis of 26 records found that the use of nitrous oxide did not increase the success rate of ECV or affect pain scores.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Review
Obstetrics & Gynecology
Hedi Benyamini Raischer, Manal Massalha, Rula Iskander, Ido Izhaki, Raed Salim
Summary: This study compared the use of knotless barbed sutures (KBSs) and conventional smooth sutures for uterine incision closure in cesarean section. The use of KBSs was found to be associated with decreased closure time and less frequent need for additional hemostatic sutures. Other perioperative outcomes were not affected, but the risk of postoperative ileus was reduced.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2022)
Article
Multidisciplinary Sciences
Oshrat Ben-Hamo, Ido Izhaki, Rachel Ben-Shlomo, Baruch Rinkevich
Summary: Through studying a population of Botryllus schlosseri, researchers discovered three co-existing novel life-history strategies that are achieved through colonial fission. These strategies originate from a stable environment and exhibit high within-strategy variation in traits. Six traits showed significant differences among the strategies.
SCIENTIFIC REPORTS
(2022)
Article
Ornithology
Yosef Kiat, Ido Izhaki
Summary: Split moult is an adaptive strategy to cope with time constraints, mainly occurring among long-distance migrants and species wintering in northern or temperate zones. The conclusions of previous studies may be flawed, as split moult is not initiated during the birds' first winter. Although there is decoupling between primary and secondary feathers, there is no difference in moult sequence, which is a common mechanism among many passerines.
Article
Remote Sensing
Dor Keshet, Anna Brook, Dan Malkinson, Ido Izhaki, Motti Charter
Summary: This study found that using drones can better monitor rodent activity in fields. By calculating burrow numbers and biomass, farmers can utilize precision agriculture methods to control rodents efficiently and reduce pesticide use.
Article
Biodiversity Conservation
Roy Talbi, Yoni Gavish, Ido Izhaki, Avi Bar-Massada
Summary: In this study, the researchers explored the benefits and adverse effects of cattle egrets on agriculture and adjacent ecosystems. They found that the expansion of cattle egrets in Mediterranean agroecosystems was facilitated by cattle grazing and human activities. While cattle egrets function as pest control agents in croplands, they also act as harmful predators in natural habitats.
BIOLOGICAL CONSERVATION
(2023)
Article
Ornithology
Ron Haran, David Troupin, Ido Izhaki
Summary: CapsuleDead Sea Sparrows transferred their breeding colony to a new, less arid zone within a nature reserve due to changes in their historical breeding colony location. Using GIS layers, we found that factors affecting their nest site preference included distance from human activity, proximity to historic springs, and areas affected by fire. The birds gradually moved to the new areas exposed by the retreating Dead Sea, highlighting the importance of understanding natural and anthropogenic influences in managing breeding sites and planning for their protection.
Article
Multidisciplinary Sciences
Beny Trabelcy, Nimrod Shteindel, Maya Lalzar, Ido Izhaki, Yoram Gerchman
Summary: The researchers have found that specific bacteria capable of consuming plants' secondary metabolites can change the interactions between plants and frugivores, benefiting both parties. While plants produce fleshy fruits to attract fruit-eating animals for seed dispersal, digestion of seeds by animals reduces plant fitness. The plant Ochradenus baccatus uses the myrosinase-glucosinolates system to protect its seeds, and the study shows that digestion of O. baccatus fruits is hindered in naive birds, but unaffected in experienced birds. Pantoea bacteria, found in the guts of experienced birds as well as the fruits, thrive on the hydrolysis products of glucosinolates and protect both naive birds and plant seedlings from their effects.
NATURE COMMUNICATIONS
(2023)
Review
Nutrition & Dietetics
Enav Yefet, Liron Bar, Ido Izhaki, Rula Iskander, Manal Massalha, Johnny S. S. Younis, Zohar Nachum
Summary: This systematic review and meta-analysis of randomized controlled trials aimed to evaluate the effects of probiotic supplements on glycemic control and metabolic parameters in women with gestational diabetes mellitus (GDM). The results showed that compared to placebo, women receiving probiotic supplements had significantly lower fasting serum glucose, insulin, homeostatic model assessment for insulin resistance (HOMA-IR), triglycerides, total cholesterol, and VLDL levels. The use of probiotic supplements containing Lactobacillus acidophilus also led to decreased neonatal birth weight.
Article
Multidisciplinary Sciences
Oshrat Ben-Hamo, Ido Izhaki, Rachel Ben-Shlomo, Baruch Rinkevich
Summary: By studying the life cycle of Botryllus schlosseri, it was found that different life history strategies lead to different aging processes, forming a novel aging phenomenon called Orshina rhythm, which includes important components such as reproduction, lifespan, death, rejuvenation, and fission events.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Oncology
Johnny S. Younis, Ido Izhaki
FRONTIERS IN ONCOLOGY
(2023)
