Review
Endocrinology & Metabolism
Fang Zhang, Xiaohui Pan, Xinyue Zhang, Nanwei Tong
Summary: TZDs have a positive impact on fat remodeling and improve insulin sensitivity, suggesting a potentially valuable approach in cardiometabolic risk management.
Article
Biochemistry & Molecular Biology
Robert Hauffe, Michaela Rath, Wilson Agyapong, Wenke Jonas, Heike Vogel, Tim J. Schulz, Maria Schwarz, Anna P. Kipp, Matthias Bluher, Andre Kleinridders
Summary: The intake of high-fat diets leads to obesity, oxidative stress, inflammation, and insulin resistance. The trace element selenium can protect against the development of diet-induced insulin resistance. However, selenium might not be able to attenuate insulin resistance in the presence of obesity.
Article
Nutrition & Dietetics
Maria Luisa Ojeda, Fatima Nogales, Olimpia Carreras, Eloisa Pajuelo, Maria Del Carmen Gallego-Lopez, Ines Romero-Herrera, Belen Begines, Jorge Moreno-Fernandez, Javier Diaz-Castro, Ana Alcudia
Summary: This study investigates the effects of low-dose selenite and Se nanoparticles on adipose tissue deposition and insulin secretion in adolescent rats. The results show that low selenite supplementation promotes adipogenesis, while Se nanoparticle administration prevents fat depots and inflammation.
Article
Endocrinology & Metabolism
Irving L. M. H. Aye, Fredrick J. Rosario, Anita Kramer, Oddrun Kristiansen, Trond M. Michelsen, Theresa L. Powell, Thomas Jansson
Summary: Obesity in pregnancy is associated with adipose tissue inflammation, endoplasmic reticulum stress, insulin resistance, increased adiponectin ubiquitination, and decreased total abundance of adiponectin.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Nutrition & Dietetics
Eva Hassler, Gunter Almer, Gernot Reishofer, Hannes Deutschmann, Wilfried Renner, Markus Herrmann, Stefan Leber, Alexander Staszewski, Felix Gunzer, Harald Mangge
Summary: This study investigates the association between osteocalcin levels and the distribution of subcutaneous and intermuscular adipose tissue of the mid-thigh, as well as the impact of different training methods on osteocalcin levels. The results show a negative correlation between osteocalcin and the distribution of adipose tissue, as well as muscle area, in the mid-thigh. Additionally, osteocalcin is negatively related to serum insulin. These findings provide further insights into the role of osteocalcin in glucose metabolism.
Article
Agriculture, Dairy & Animal Science
Yusheng Liang, Fabiana F. Cardoso, Claudia Parys, Felipe C. Cardoso, Juan J. Loor
Summary: Branched-chain amino acids can activate mTOR and insulin signaling in subcutaneous adipose tissue, leading to increased amino acid transport into tissues and reduced BCAA metabolism. Increasing BCAA supply may help improve the function of subcutaneous adipose tissue.
Article
Nutrition & Dietetics
Allah Nawaz, Yasuhiro Nishida, Akiko Takikawa, Shiho Fujisaka, Tomonobu Kado, Aminuddin Aminuddin, Muhammad Bilal, Ishtiaq Jeelani, Muhammad Rahil Aslam, Ayumi Nishimura, Takahide Kuwano, Yoshiyuki Watanabe, Yoshiko Igarashi, Keisuke Okabe, Saeed Ahmed, Azhar Manzoor, Isao Usui, Kunimasa Yagi, Takashi Nakagawa, Kazuyuki Tobe
Summary: Astaxanthin has beneficial effects on adipose tissue in obese mice, reducing oxidative stress and macrophage infiltration, maintaining healthy AT function, and preventing pathological remodeling of AT.
Article
Agriculture, Dairy & Animal Science
Miguel Chirivi, C. Javier Rendon, Madison N. Myers, Crystal M. Prom, Sambit Roy, Aritro Sen, Adam L. Lock, G. Andres Contreras
Summary: The exposure to endotoxin can enhance lipolysis and reduce insulin sensitivity in adipose tissue, leading to decreased sensitivity of adipocytes to the antilipolytic action of insulin.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Adam Prabata, Koji Ikeda, Elda Putri Rahardini, Ken-Ichi Hirata, Noriaki Emoto
Summary: The study demonstrates that GPNMB negatively regulates macrophage inflammatory capacities and ameliorates WAT inflammation in obesity, making it a promising therapeutic target for metabolic disorders associated with obesity.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Daniel Castellano-Castillo, Bruno Ramos-Molina, Wilfredo Oliva-Olivera, Luis Ocana-Wilhelmi, Maria Isabel Queipo-Ortuno, Fernando Cardona
Summary: This study aimed to analyze the changes in H3K4me3 histone mark in human adipose tissue under obesity and insulin resistance conditions. The results showed that H3K4me3 enrichment in gene promoters was closely related to higher mRNA levels, and differentially enriched H3K4me3 could regulate genes in adipose tissue, affecting its function during obesity and insulin resistance.
Article
Nutrition & Dietetics
Xin Shu, Jiaqi Wu, Tao Zhang, Xiaoyu Ma, Zuoqin Du, Jin Xu, Jingcan You, Liqun Wang, Ni Chen, Mao Luo, Jianbo Wu
Summary: The study suggests that PCSK9 expression in adipose tissue may mediate statin-induced adipocyte insulin resistance. PCSK9 deficiency could protect against statin-induced impairments in insulin signaling.
Article
Biochemistry & Molecular Biology
Klaudia Berk, Karolina Konstantynowicz-Nowicka, Tomasz Charytoniuk, Ewa Harasim-Symbor, Adrian Chabowski
Summary: Available data suggests that cannabidiol (CBD) can improve symptoms of insulin resistance by modulating sphingolipid concentrations. CBD reduces ceramide content in adipose tissues, enhancing insulin sensitivity. Therefore, CBD may be considered as a potential therapeutic strategy for treating insulin resistance and metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Penghua Fang, Ran Ge, Yuqing She, Juan Zhao, Jing Yan, Xizhong Yu, Yu Jin, Wenbin Shang, Zhenwen Zhang
Summary: Obesity is associated with insulin resistance and T2DM, while physical exercise can improve this condition by increasing the expression of spexin in adipose tissue. Combining spexin with exercise training is an effective therapeutic strategy for age-associated diseases.
AGEING RESEARCH REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Ignacio Colon-Mesa, Neira Sainz, Patricia Corrales, Maria Collantes, Philipp Kaldis, Jose Alfredo Martinez, Gema Medina-Gomez, Maria Jesus Moreno-Aliaga, Xavier Escote
Summary: The aim of this study was to investigate the effect of p27 deletion on the activity of brown adipose tissue and the susceptibility to develop obesity and glucose homeostasis disturbances in mice. The results showed that p27 knockout mice were more prone to obesity and insulin resistance. The study suggested that p27 may play a role in brown adipose tissue activation and the development of obesity and insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Huqun Li, Chongshu Wang, Jiefang Zhao, Cuilian Guo
Summary: JNK plays a role in olanzapine-induced insulin resistance by promoting IRS1Ser307 phosphorylation and inflammation in eWAT, indicating its potential as a drug target for this condition.
BIOMEDICINE & PHARMACOTHERAPY
(2021)