Article
Polymer Science
Henry Chijcheapaza-Flores, Nicolas Tabary, Feng Chai, Mickael Maton, Jean-Noel Staelens, Frederic Cazaux, Christel Neut, Bernard Martel, Nicolas Blanchemain, Maria Jose Garcia-Fernandez
Summary: This study aims to combine the properties of hydrogels based on chitosan (CHT) and the polymer of beta cyclodextrin (PCD) for local delivery of cinnamaldehyde (CN) in diabetic foot ulcers. The results demonstrated the successful development of a cytocompatible (ISO 10993-5) injectable hydrogel with antibacterial and antibiofilm activity. Furthermore, a partial active molecule release and an increase in hydrogel elasticity were observed in the presence of CN.
Article
Food Science & Technology
Lei Sun, Gil Rogiers, Chris W. Michiels
Summary: This study investigated the antimicrobial mechanisms of trans-cinnamaldehyde (t-CIN) in Listeria monocytogenes, revealing that the YvcK protein plays a crucial role in diverting substrates to UDP-GlcNAc biosynthesis, and t-CIN interferes with this pathway, leading to a peptidoglycan synthesis defect. Complementation with wild-type yvcK gene restored tolerance to t-CIN, and evolutionary experiments identified suppression mutations related to UDP-GlcNAc biosynthesis that partially reversed t-CIN sensitivity. Feeding N-acetylglucosamine or increasing UDP-GlcNAc synthetic enzymes restored t-CIN tolerance in the yvcK mutant.
Article
Pharmacology & Pharmacy
Afreen Jailani, Shanthini Kalimuthu, Vidhyashree Rajasekar, Sumanta Ghosh, Pierre-Yves Collart-Dutilleul, Naveen Fatima, Hyun Koo, Adline Princy Solomon, Frederic Cuisinier, Prasanna Neelakantan
Summary: In this study, a novel platform using porous silicon microparticles loaded with natural compound trans-cinnamaldehyde (TC) was developed to inhibit biofilm formation of dental caries pathogens. The results showed that pSi-TC significantly inhibited biofilm formation, reduced adhesion to the substrate, and hindered acid production. This study highlights the potential of using pSi-TC as a dental caries-preventive material.
Article
Chemistry, Applied
Seyed Fakhreddin Hosseini, Jaber Ghaderi, M. Carmen Gomez-Guillen
Summary: Biofunctional quadripartite films were developed by incorporating trans-Cinnamaldehyde into chitosan/poly(vinyl alcohol)/fish gelatin matrices. The addition of CIN increased tensile strength, reduced elongation-at-break, enhanced hydrophobicity, decreased water solubility and absorption. The films also showed antimicrobial activity, DPPH radical scavenging activity, and promising potential as inner functional packaging for food products.
FOOD HYDROCOLLOIDS
(2021)
Article
Food Science & Technology
Alejandro Aragon-Gutierrez, Raquel Heras-Mozos, Miriam Gallur, Daniel Lopez, Rafael Gavara, Pilar Hernandez-Munoz
Summary: This study successfully prepared novel active films based on EVOH and CIN, with CIN lowering the glass transition temperature of EVOH and resulting in films with antifungal and radical scavenging activity.
Article
Biochemistry & Molecular Biology
Serena Berberolli, Mar Collado-Gonzalez, Yadira Gonzalez-Espinosa, Gurmeet Kaur, Priyanka Sahariah, Francisco M. Goycoolea
Summary: trans-Cinnamaldehyde-loaded oil-in-water nanocapsules coated with different types of chitosan were prepared. The nanocapsules showed similar hydrodynamic diameter and positive zeta-potential. N,N,N-trimethyl chitosan-coated nanocapsules exhibited the highest trans-cinnamaldehyde association efficiency and total payload release. N-(6-(N,N,N-trimethylammoniumyl)hexanoyl)chitosan chloride-coated nanocapsules were the only formulations stable in phosphate buffer saline after incubation. Further research should focus on the stability and biological performance of the developed nanocapsules in culture media.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Mingxin Hu, Shanthini Kalimuthu, Chengfei Zhang, Islam A. A. Ali, Prasanna Neelakantan
Summary: Enterococcus faecalis is a common opportunistic pathogen with high antibiotic tolerance and biofilm-forming ability. Combining trans-cinnamaldehyde with an FDA-approved biosurfactant significantly reduces bacterial viability and biomass of E. faecalis biofilms. This study highlights the potential of the newly developed TC-ASL complex as an anti-biofilm strategy.
Article
Food Science & Technology
Tareq M. Osaili, Fayeza Hasan, Dinesh Kumar Dhanasekaran, Reyad S. Obaid, Anas A. Al-Nabulsi, Mutamed Ayyash, Layal Karam, Ioannis N. Savvaidis, Richard Holley
Summary: The study evaluated the antimicrobial effect of active essential oil components on Listeria monocytogenes, Salmonella spp., and Escherichia coli O157:H7 in chicken tawook during storage. Results showed that the marinade significantly reduced L. monocytogenes and Salmonella spp. numbers at 10°C, while the addition of essential oils did not affect the pathogen populations.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2021)
Article
Infectious Diseases
Zorana Kovacevic, Marko Samardzija, Olga Horvat, Dragana Tomanic, Miodrag Radinovic, Katarina Bijelic, Annamaria Galfi Vukomanovic, Nebojsa Kladar
Summary: The main objective of this study was to quantify antimicrobial use (AMU) on three dairy farms in Serbia and investigate the association between AMU and the emergence of antimicrobial resistance (AMR) in mastitis-associated pathogens. The results confirmed a relationship between the use of common antibiotics in mastitis treatment and AMR of isolated mastitis-associated pathogens, highlighting the importance of this aspect in combating global antimicrobial resistance.
Article
Infectious Diseases
Islam A. A. Ali, Jukka P. Matinlinna, Celine M. Levesque, Prasanna Neelakantan
Summary: This study comprehensively investigated the inhibitory effect of trans-cinnamaldehyde (TC) on Enterococcus faecalis biofilm formation, proteolytic and hemolytic activities. The results showed that sub-inhibitory concentrations of TC could reduce biofilm formation, exopolysaccharides, proteolytic and hemolytic activities in E. faecalis. Mechanistic studies revealed significant downregulation of virulence regulators in E. faecalis. This highlights the potential of TC to inhibit E. faecalis biofilm formation and virulence.
Article
Chemistry, Physical
Dennis To, Anant Kakar, Gergely Kali, Richard Wibel, Patrick Knoll, Florentine Marx, Andreas Bernkop-Schnuerch
Summary: The study demonstrates the improved biofilm eradication of aminoglycosides by incorporating imine derivatives into self-emulsifying drug delivery systems (SEDDS). The iminated aminoglycosides successfully formed nanoemulsions with antimicrobial efficacy while maintaining their antimicrobial potency. Compared to native aminoglycosides, the combination of iminated aminoglycosides with SEDDS exhibited superior anti-biofilm properties.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Chi-Hui Cheng, Yao-Yuan Tu, Jui-Che Lin
Summary: This study successfully improved the mechanical characteristics and antimicrobial capability of chitosan hydrogel by introducing a novel chemical crosslinker and a natural antibacterial agent. The results indicate that the chitosan hydrogel with the highest crosslinked degree, grafted with cinnamaldehyde and incorporated with silver nanoparticles, holds great promise for further clinical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Changzeng Wei, Chenyue Fan, Dongchao Xie, Shitong Zhou, Haihua Zhang, Qizhen Du, Peng Jin
Summary: The aim of this study was to enhance the stability and antimicrobial effects of cinnamaldehyde (CA) by developing ethosomal nanoparticles (CALG-ENPs). The fabricated CALG-ENPs had a mean size of 103.5 nm and a CA loading of 32.62 mg/g ethosome. The CALG-ENPs exhibited good dispersion stability under low pH conditions (>4) at 4 degrees Celsius for 25 days. The sustained-release properties of the nanoparticles were observed at 20 and 37 degrees Celsius, with significantly higher retaining amounts of CA compared to free CA.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jing Tian, Xiao-Li Shan, Si-Ning Wang, Hui-Hua Chen, Pei Zhao, Dong-Dong Qian, Ming Xu, Wei Guo, Chen Zhang, Rong Lu
Summary: This study found that TCA can alleviate cardiac hypertrophy, and its mechanism of action may be related to the reduction of tubulin detyrosination.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Plant Sciences
David Lopez-Gonzalez, Yolanda Ferradas, Fabrizio Araniti, Elisa Grana, Jose M. Hermida-Ramon, Maria Victoria Gonzalez, Marta Teijeira, Manuel Rey, Manuel J. Reigosa, Adela M. Sanchez-Moreiras
Summary: This study investigated the phytotoxic effects of trans-cinnamaldehyde on Arabidopsis thaliana seedlings. The compound inhibited root growth and induced the formation of adventitious roots. It also caused alterations to the mitochondria, hormonal mismatch, and oxidative stress in the treated seedlings.
FRONTIERS IN PLANT SCIENCE
(2023)