Article
Microbiology
Cedric Lood, Charlotte Peeters, Quentin Lamy-Besnier, Jeroen Wagemans, Daniel De Vos, Marijke Proesmans, Jean-Paul Pirnay, Fedoua Echahidi, Denis Pierard, Matthieu Thimmesch, Anca Boeras, Katrien Lagrou, Evelien De Canck, Elke De Wachter, Vera van Noort, Rob Lavigne, Peter Vandamme
Summary: The study found that Burkholderia multivorans, a pathogenic bacterium within the Burkholderia cepacia complex, primarily spreads among cystic fibrosis patients through environmental sources with rare cases of patient-to-patient transmission. Genomic analysis of an endemic strain infecting multiple patients revealed significant genomic diversity between patients, suggesting the presence of a microdiverse reservoir for this strain with active diversification. Additionally, the study identified specific genomic adaptations across multiple patients, indicating that the genomic background of a strain may dictate its route of adaptation within the cystic fibrosis lung.
Article
Infectious Diseases
Niyas Khalid Ottu Para, Sreya Vemuri, Georgey Koshy, Dima Ibrahim, Seema Oomen, Sudhakar V. Reddappa, Mohammad Shoaib Nadaf, Raja Muhammad Irfan, Nicholas Wyon, Mohammed Zeki Ahmed, Supriya Sundaram
Summary: This article reports a case of cepacia syndrome in an immunocompetent man without cystic fibrosis. The case provides detailed information on the disease presentation, investigations, and management strategy employed.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Wen Zen, Ye Qiu, Mengxin Tang, Hui Zhang, Mianluan Pan, Shudan Tang, Jianquan Zhang
Summary: High titers of neutralizing anti-interferon-gamma autoantibodies can lead to severe immunodeficiency. This report presents a rare case of disseminated Talaromyces marneffei and Burkholderia cepacia infection, resulting in the patient's death from disseminated intravascular coagulation.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Infectious Diseases
Yan Jia, Ya Liu, Yi Liu, Kaitai Yang, Yanfeng Liu
Summary: This study investigated the clinical characteristics and prognosis of Burkholderia cepacia (BC) infection in hematopoietic stem cell transplantation (HSCT) patients. The results showed that BC infection increased the risk of death in patients, especially when combined with respiratory failure. Procalcitonin and septic shock were identified as independent risk factors for death.
BMC INFECTIOUS DISEASES
(2022)
Article
Immunology
Philippe Perot, Jacques Fourgeaud, Claire Rouzaud, Beatrice Regnault, Nicolas Da Rocha, Helene Fontaine, Jerome Le Pavec, Samuel Dolidon, Margaux Garzaro, Delphine Chretien, Guillaume Morcrette, Thierry Jo Molina, Agnes Ferroni, Marianne Leruez-Ville, Olivier Lortholary, Anne Jamet, Marc Eloit
Summary: In March 2022, a 61-year-old woman in France who had received a heart-lung transplant was diagnosed with chronic hepatitis characterized by increased liver enzymes. Metagenomic next-generation sequencing revealed the presence of an unknown circovirus, named human circovirus 1 (HCirV-1), in a liver biopsy sample. The viral genome was undetectable in blood samples from 2017-2019, but became detectable in September 2020 and reached high titers in January 2022, concurrent with liver damage indicated by elevated liver enzyme levels and high viral copies in the liver and blood.
EMERGING INFECTIOUS DISEASES
(2023)
Review
Infectious Diseases
Lorena van den Bogaart, Oriol Manuel
Summary: Lung transplant recipients are at higher risk of developing infectious diseases caused by multi-drug resistant pathogens. These difficult-to-treat infections pose a therapeutic challenge and may be a contraindication to lung transplantation. Despite the availability of new antibiotic options, limited data on their efficacy and safety in the transplant population and the lack of clinical evidence for selecting the most appropriate antibiotic therapy are major concerns. In this review, we summarize the best evidence available for the choice of antibiotic and duration of therapy for MDR/XDR P. aeruginosa, Burkholderia cepacia complex, Mycobacterium abscessus complex, and Nocardia spp. infections in lung transplant candidates and recipients.
Article
Ophthalmology
Amit Kumar Deb, Pratima Chavan, Subashini Kaliaperumal, Sujatha Sistla, Haritha Madigubba, Sandip Sarkar, Aswathi Neena
Summary: This study reports a rare outbreak of cluster endophthalmitis caused by gram-negative, opportunistic bacilli, Burkholderia cepacia complex (Bcc). The clinical presentations, surveillance reports, and final visual outcomes vary among the patients. Extensive surveillance in the operating room is essential in identifying the potential source of infection, but in some cases, the source may not be identifiable.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
David J. Hall, Jefree J. Schulte, Erik E. Lewis, Swaroop R. Bommareddi, Charles T. Rohrer, Samir Sultan, James D. Maloney, Malcolm M. DeCamp, Daniel P. McCarthy
Summary: This article reports a case of lung transplantation for post-COVID-19 pulmonary fibrosis. The patient recovered rapidly after the surgery and has done well in follow-up.
ANNALS OF THORACIC SURGERY
(2022)
Article
Immunology
Edgard de Freitas Vianna, Nicoli Izzy Miotto Menezes, Mila Muraro de Almeida, Fla'via Alvim Dutra de Freitas, Cassiana da Costa Ferreira Leite, Monica Cassia Firmida, Davi Ribeiro Iglesias de Medeiros, Robson Souza Leao, Rodolpho Mattos Albano, Elizabeth Andrade Marques
Summary: The genome analysis of Burkholderia cenocepacia complex III revealed high virulence and antimicrobial resistance, with a predominance of genes related to invasion mechanisms and flagellar biosynthesis. Additionally, the isolate exhibited bacterial dissemination mechanisms with invasive determinants.
Article
Medicine, General & Internal
Jesper Romhild Davidsen, Christian B. Laursen, Mikkel Hojlund, Thomas Kromann Lund, Klaus Nielsen Jeschke, Martin Iversen, Anna Kalhauge, Elisabeth Bendstrup, Jorn Carlsen, Michael Perch, Daniel Pilsgaard Henriksen, Hans Henrik Lawaetz Schultz
Summary: This study found that pleural thickening identified by lung ultrasound may serve as a potential surrogate marker to distinguish restrictive allograft syndrome (RAS) from bronchiolitis obliterans syndrome (BOS) in chronic lung allograft dysfunction (CLAD) patients after lung transplant. This discovery provides a new method for clinical diagnosis of CLAD patients post lung transplant.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Respiratory System
Rianald Fischer, Carsten Schwarz, Rebecca Weiser, Eshwar Mahenthiralingam, Knut Smerud, Nils Meland, Hugo Flaten, Philip Rye
Summary: This study evaluated the safety and efficacy of inhaled OligoG as a therapy for CF patients with Bcc infection. The results showed a decrease in bacterial colony-forming units after OligoG treatment, although the difference was not statistically significant. There was no significant improvement in lung function parameters, but some quality of life scores showed relative improvement. The study suggests the potential of OligoG for the treatment of Bcc infection.
JOURNAL OF CYSTIC FIBROSIS
(2022)
Article
Cardiac & Cardiovascular Systems
Jose Luis Campo-Canaveral De La Cruz, Ben Dunne, Philippe Lemaitre, Mindaugas Rackauskas, Jiri Pozniak, Yui Watanabe, Andrea Mariscal, Jonathan Yeung, Kazuhiro Yasufuku, Andrew Pierre, Marc de Perrot, Thomas K. Waddell, Marcelo Cypel, Shaf Keshavjee, Laura Donahoe
Summary: LLTx from deceased donors is used to address donor-recipient size mismatch for small recipients. While LLTx patients often have longer ICU stays and higher mortality rates than LTx patients, recent advancements have led to comparable survival rates between the two procedures.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Respiratory System
C. Olcese, R. Casciaro, D. Pirlo, C. Debbia, E. Castagnola, F. Cresta, C. Castellani
Summary: In this case, a CF patient was co-infected with COVID-19 and Bc, and was treated with antibiotics, dexamethasone, remdesivir, and heparin, leading to gradual improvement and discharge. The reciprocal role of SARS-CoV-2 and Bc, as well as the impact of individual therapies on the outcome, remain unclear.
JOURNAL OF CYSTIC FIBROSIS
(2021)
Review
Infectious Diseases
Maria Teresa Rosanova, Pedro Serrano-Aguilar, Leticia Rodriguez-Rodriguez, Roberto Lede
Summary: This systematic review examines the mortality rate associated with Burkholderia cepacia bacteremia in children. The findings suggest that although the available evidence is scarce and of low quality, the clinical course of this condition does not always lead to high mortality rates.
REVISTA CHILENA DE INFECTOLOGIA
(2022)
Article
Surgery
Naofumi Miyahara, Alberto Benazzo, Felicitas Oberndorfer, Akinori Iwasaki, Viktoria Laszlo, Balasz Dome, Mir Ali Hoda, Peter Jaksch, Walter Klepetko, Konrad Hoetzenecker
Summary: miR-21 expression was higher in restrictive allograft syndrome (RAS) than in bronchiolitis obliterans syndrome (BOS) specimens, with a significant increase in serum concentration over time in RAS patients. Vimentin, NICD, and p-SMAD 2/3 were positive in a higher proportion of BOS patients compared to RAS cases.
TRANSPLANT INTERNATIONAL
(2022)