Review
Dermatology
Loren E. Hernandez, Noreen Mohsin, Marita Yaghi, Fabio Stefano Frech, Isabella Dreyfuss, Keyvan Nouri
Summary: Merkel cell carcinoma is a rare neuroendocrine carcinoma that primarily occurs in sun-exposed areas of elderly individuals. Recent research has shown that the Merkel cell polyomavirus and immunologic factors play important roles in its pathogenesis. Immunotherapy appears to hold promise as a treatment modality for Merkel cell carcinoma.
DERMATOLOGIC THERAPY
(2022)
Review
Oncology
Adnan Fojnica, Kenana Ljuca, Saghir Akhtar, Zoran Gatalica, Semir Vranic
Summary: Merkel cell carcinoma is a rare and aggressive type of skin cancer. Biomarkers for predicting treatment response in MCC are limited. Immune checkpoint inhibitors present a promising treatment option.
Review
Medicine, Research & Experimental
James A. DeCaprio
Summary: Merkel cell carcinoma (MCC) has two distinct etiologies, with one caused by viral DNA integration and the other by UV damage. Despite different causes, both forms of MCC have similar presentation, prognosis, and response to therapy. Oncogenic transcriptional programs, cell proliferation rates, and neuroendocrine differentiation programs play important roles in both types of MCC.
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 16, 2021
(2021)
Article
Oncology
Konstantin Drexler, Barbara Schwertner, Silke Haerteis, Thiha Aung, Mark Berneburg, Edward K. Geissler, Maria E. Mycielska, Sebastian Haferkamp
Summary: Merkel cell carcinoma is a rare but highly aggressive skin cancer. In this study, researchers found that the plasma membrane citrate transporter (pmCiC) is upregulated in Merkel cell carcinoma cell lines. Cancer cells import extracellular citrate via pmCiC to support their metabolism, which is critical for proliferation and metastasis. Inhibition of pmCiC can decrease the growth rate of Merkel cell carcinoma cell lines, suggesting that targeting pmCiC may be a potential anti-cancer therapy.
Review
Oncology
Aimin Yang, Wilson Adrian Wijaya, Lei Yang, Yinhai He, Ying Cen, Junjie Chen
Summary: Recent studies have found a significant correlation between MCPyV positivity and overall survival (OS) and progression-free survival (PFS) in MCC patients. However, the predictive and clinicopathological value of MCPyV positivity still needs further investigation.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Steffi Silling, Alexander Kreuter, Thilo Gambichler, Thomas Meyer, Eggert Stockfleth, Ulrike Wieland
Summary: Merkel cell polyomavirus (MCPyV) is a common virus on human skin, leading to the development of a rare but aggressive Merkel cell carcinoma (MCC) in older individuals, especially those with fair skin, male sex, and immunosuppression. The incidence of MCC, caused by MCPyV or UV damage, is increasing globally, with risk factors including male sex, older age, fair skin, intense UV exposure, and immunosuppression. Early diagnosis and prompt treatment are crucial for reducing MCC morbidity and mortality.
Review
Oncology
Mehran Behruj Yusuf, Grant McKenzie, Abbas Rattani, Paul Tennant, Jeffrey Bumpous, Donald Miller, Neal Dunlap
Summary: Merkel cell carcinoma (MCC) of the head and neck presents unique challenges in management compared to MCC in other anatomical locations. Immunotherapy has revolutionized the prognosis for MCC patients, but resistance to treatment remains a significant issue. Understanding the oncogenesis and different therapeutic options is crucial for improving outcomes in MCC patients.
Article
Medicine, General & Internal
Ameeta Lubina Nayak, Arthur Travis Pickett, Megan Delisle, Brittany Dingley, Ranjeeta Mallick, Trevor Hamilton, Heather Stuart, Martha Talbot, Gregory Mckinnon, Evan Jost, Eva Thiboutot, Valerie Francescutti, Sal Samman, Alexandra Easson, Angela Schellenberg, Shaila Merchant, Julie La, Kaitlin Vanderbeck, Frances Wright, David Berger-Richardson, Pamela Hebbard, Olivia Hershorn, Rami Younan, Erica Patocskai, Samuel Rodriguez-Qizilbash, Ari Meguerditichian, Vanina Tchuente, Suzanne Kazandjian, Alex Mathieson, Farisa Hossain, Jessika Hetu, Martin Corsten, Angelina Tohme, Carolyn Nessim, Stephanie Johnson-Obaseki
Summary: This study, the largest Canadian evaluation of survival outcomes for head and neck MCC, found that disease staging and treatment modalities are associated with survival. Multimodal treatment is associated with higher survival rates across all stages of the disease.
Review
Pathology
Nehal I. Rizk, Heba M. Midan, Gouda Kamel Helal, Ahmed I. Abulsoud, Shereen Saeid Elshaer, Ahmed A. El-Husseiny, Doaa Fathi, Nourhan M. Abdelmaksoud, Sherif S. Abdel Mageed, Mohammed S. Elballal, Mohamed Bakr Zaki, Mai A. Abd-Elmawla, Tohada M. AL-Noshokaty, Mahmoud A. Elrebehy, Walaa A. El-Dakroury, Logyna A. Abulsoud, Ahmed S. Doghish
Summary: Merkel cell carcinoma (MCC) is a rare invasive form of skin cancer characterized by nodules on the face, head, or neck. It has a high mortality rate and lacks a universal molecular signature for its pathogenesis. Variations in microRNA expression have been associated with MCC and studying their potential role beyond survival in MCC is important.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Biochemistry & Molecular Biology
Elena Dellambra, Maria Luigia Carbone, Francesca Ricci, Francesco Ricci, Francesca Romana Di Pietro, Gaia Moretta, Sofia Verkoskaia, Elisa Feudi, Cristina M. Failla, Damiano Abeni, Luca Fania
Summary: Merkel cell carcinoma (MCC) is a rare and highly aggressive neuroendocrine carcinoma of the skin, with increasing incidence worldwide. Treatment of advanced MCC tumors with immune checkpoint inhibitors has shown effective results, highlighting the importance of immunotherapy in managing this disease.
Article
Oncology
S. P. D'Angelo, S. Bhatia, A. S. Brohl, O. Hamid, J. M. Mehnert, P. Terheyden, K. C. Shih, I Brownell, C. Lebbe, K. D. Lewis, G. P. Linette, M. Milella, H. Xiong, G. Guezel, P. T. Nghiem
Summary: Avelumab monotherapy demonstrated significant long-term overall survival in patients with metastatic Merkel cell carcinoma whose disease had progressed after chemotherapy, supporting its role as a standard of care for these patients.
Article
Oncology
Annie J. Wang, Brendan McCann, William C. L. Soon, Paolo B. De Ieso, Mathias Bressel, Andrew Hui, Margaret Chua, David L. Kok
Summary: MCC is a rare and aggressive skin malignancy, with Australia having the highest reported incidence in the world. This retrospective audit of MCC patients at PMCC from 1980 to 2018 showed a high rate of locoregional recurrence and no significant change over the past four decades.
Review
Dermatology
Loren E. Hernandez, Noreen Mohsin, Nicole Levin, Isabella Dreyfuss, Fabio Frech, Keyvan Nouri
Summary: Basal cell carcinoma (BCC) is the most common malignancy worldwide, with low mortality but significant morbidity due to its potential for local destruction. Staying up to date with the latest pathogenesis and treatment updates is important for dermatologists. This article provides a comprehensive review of BCC's pathogenesis, available treatments, and ongoing clinical trials.
DERMATOLOGIC THERAPY
(2022)
Article
Dermatology
Madison Weber, Minh Binh Nguyen, Meng Yen Li, Pooja Flora, Masahiro Shuda, Elena Ezhkova
Summary: The regeneration of Merkel cells in adult skin and their origin from progenitor cells have been debated topics. Understanding Merkel cell regeneration is crucial for the study of Merkel cell carcinoma, a rare skin cancer, and its association with Merkel cell progenitors and polyomavirus. This study identified SOX9+ cells as postnatal Merkel cell progenitors and showed that they can be reprogrammed to express neuroendocrine markers by Merkel cell polyomavirus T antigens.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Inmaculada Ribera-Cortada, Jose Guerrero-Pineda, Isabel Trias, Luis Veloza, Adriana Garcia, Lorena Marimon, Sherley Diaz-Mercedes, Jose Ramon Alamo, Maria Teresa Rodrigo-Calvo, Naiara Vega, Ricardo Lopez del Campo, Rafael Parra-Medina, Tarek Ajami, Antonio Martinez, Oscar Reig, Maria J. Ribal, Juan Manuel Corral-Molina, Pedro Jares, Jaume Ordi, Natalia Rakislova
Summary: Penile squamous cell carcinoma (PSCC) is a rare and aggressive tumor with dual pathogenesis. The understanding of its molecular landscape is limited, hindering the development of targeted treatment. Current studies on genetic alterations in PSCC have shown inconsistency in methodologies and limited case numbers, leading to different findings. Identified mutations and copy number alterations involve several genes and pathways. However, their relevance, role in signaling pathways, and association with HPV status remain unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Dermatology
Jessica Asinari, Alfredo Zucchi, Giuseppe Pedrazzi, Claudio Feliciani, Mohamad Goldust, Torello Lotti, Francesca Satolli
DERMATOLOGIC THERAPY
(2020)
Article
Dermatology
Eleonora Rodighiero, Mariabeatrice Bertolani, Roberta Saleri, Giuseppe Pedrazzi, Torello Lotti, Claudio Feliciani, Francesca Satolli
DERMATOLOGIC THERAPY
(2020)
Review
Dermatology
Francesca Satolli, Marco Gandolfi, Miriam Rovesti, Alfredo Zucchi, Manuguerra Roberta, Ignazio Stanganelli, Mariabeatrice De Felici Del Giudice, Lotti Torello, Claudio Feliciani
DERMATOLOGIC THERAPY
(2020)
Letter
Dermatology
Miriam Rovesti, Elena Pierobon, Cristina Vaschieri, Giovanni Genovese, Angelo Valerio Marzano, Torello Lotti, Francesca Satolli, Claudio Feliciani
DERMATOLOGIC THERAPY
(2020)
Review
Dermatology
Ghasem Rahmatpour Rokni, Dipali Rathod, Mohammad Tabarestani, Ali Mirabi, Abhijeet Jha, Valerio de Vita, Hamed Mashhadi Kholerdi, Claudio Feliciani, Mohammad Jafferany, Uwe Wollina, Torello Lotti, Mohamad Goldust
DERMATOLOGIC THERAPY
(2020)
Letter
Dermatology
Vito Di Lernia, Mohamad Goldust, Claudio Feliciani
DERMATOLOGIC THERAPY
(2020)
Editorial Material
Dermatology
S. Di Nuzzo, M. Bertolani, M. B. de Felici del Giudice, D. Casanova, R. Manuguerra, C. Feliciani
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2021)
Article
Dermatology
Maria Beatrice Bertolani, Eleonora Rodighiero, Marco Gandolfi, Torello Lotti, Giuseppe Pedrazzi, Mario Puviani, Massimo Milani, Claudio Feliciani, Francesca Satolli
Summary: Retinoids and antibiotics are commonly used as topical treatments for mild to moderate acne, with irritant contact dermatitis being a common side effect. Short contact therapy (SCT) may improve local tolerability, and a gel containing tretinoin, clindamycin, and glycolic acid has shown to be effective in acne treatment. The SCT approach could potentially improve skin tolerability and adherence to treatment.
DERMATOLOGIC THERAPY
(2021)
Article
Dermatology
Miriam Rovesti, Alfredo Zucchi, Claudio Feliciani, Francesca Satolli
Summary: A case of lentigo maligna melanoma of the scalp in an elderly patient was treated with surgery and subsequent application of 5% and 3.75% Imiquimod, leading to complete regression of the lesion. 3.75% Imiquimod, already used for actinic keratosis, could be a useful and less side effect treatment option.
ANAIS BRASILEIROS DE DERMATOLOGIA
(2021)
Article
Dermatology
Elena Pierobon, Chiara Cortelazzi, Michele Maria Dominici, Claudio Feliciani, Sergio Di Nuzzo
Summary: Soft tissues perineurioma is a rare benign nerve sheath tumor that usually affects the acral sites of young people. Complete surgical excision and reconstructive surgery may be challenging, but can lead to full functional recovery. We report a case of successful radical surgical excision with autologous full-thickness skin graft resulting in complete functional recovery.
DERMATOLOGY REPORTS
(2022)
Article
Dermatology
Elena Pierobon, Lerica Germi, Andrea Sechi, Giampaolo Trevisan, Elena Pezzolo, Claudio Feliciani, Luigi Naldi
Summary: Dermatoses affecting palms can be challenging to diagnose and treat. This article highlights the importance of a thorough analysis of patient history and clinical features, using an iconic case of a bricklayer with chronic palm desquamation attributed to a specific adverse effect of ranolazine intake.
DERMATOLOGY REPORTS
(2022)
Article
Dermatology
L. Borradori, N. Van Beek, C. Feliciani, B. Tedbirt, E. Antiga, R. Bergman, B. C. Boeckle, M. Caproni, F. Caux, N. S. Chandran, G. Cianchini, M. Daneshpazhooh, D. De, D. Didona, G. M. Di Zenzo, M. Dmochowski, K. Drenovska, J. Ehrchen, M. Goebeler, R. Groves, C. Guenther, B. Horvath, M. Hertl, S. Hofmann, D. Ioannides, B. Itzlinger-Monshi, J. Jedlickova, C. Kowalewski, K. Kridin, Y. L. Lim, B. Marinovic, A. Marzano, J. -M. Mascaro, J. M. Meijer, D. Murrell, K. Patsatsi, C. Pincelli, C. Prost, K. Rappersberger, M. Sardy, J. Setterfield, M. Shahid, E. Sprecher, K. Tasanen, S. Uzun, S. Vassileva, K. Vestergaard, A. Vorobyev, I. Vujic, G. Wang, K. Wozniak, S. Yayli, G. Zambruno, D. Zillikens, E. Schmidt, P. Joly
Summary: The background provides detailed information about bullous pemphigoid (BP) and its impact on patients. The objective of the study is to update the guidelines for managing this disease. The results suggest that treatment should be tailored based on the severity of BP and patients' comorbidities. High-potency topical corticosteroids are recommended as the main treatment, while the use of doxycycline and dapsone is controversial. B-cell-depleting therapy and intravenous immunoglobulins can be considered in treatment-resistant cases. The final version of the guideline received consent from several patient organizations.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Pediatrics
Maria Beatrice De Felici Del Giudice, Carolina Calanca, Chiara Sassetti, Carlo Caffarelli, Claudio Feliciani, Susanna Esposito
Summary: We report a case of a 12-year-old boy with severe pemphigus vulgaris resistant to conventional therapies and an urticarial reaction to rituximab. This case highlights the importance of considering pemphigus vulgaris in children and the use of rituximab as a treatment option.
Article
Dermatology
Mariabeatrice Bertolani, Eleonora Rodighiero, Roberta Saleri, Giuseppe Pedrazzi, Simona Bertoli, Alessandro Leone, Claudio Feliciani, Torello Lotti, Francesca Satolli
Summary: The study aimed to assess the association between the Mediterranean diet and IGF-1 in acne patients and examine the impact of systemic treatment on IGF-1 serum levels. The findings suggest that the Mediterranean diet may have a protective role in the pathogenesis of acne.
DERMATOLOGY REPORTS
(2022)
Article
Nutrition & Dietetics
Marcella Malavolti, Carlotta Malagoli, Catherine M. Crespi, Furio Brighenti, Claudia Agnoli, Sabina Sieri, Vittorio Krogh, Chiara Fiorentini, Francesca Farnetani, Caterina Longo, Cinzia Ricci, Giuseppe Albertini, Anna Lanzoni, Leonardo Veneziano, Annarosa Virgili, Calogero Pagliarello, Claudio Feliciani, Pier Alessandro Fanti, Emi Dika, Giovanni Pellacani, Marco Vinceti
BRITISH JOURNAL OF NUTRITION
(2017)
