Article
Public, Environmental & Occupational Health
Astrid Ytrehus Jorgensen, Lisa Aarhus, Bo Engdahl, Bernt Bratsberg, Vegard Fykse Skirbekk, Ingrid Sivesind Mehlum
Summary: This long-term study based on the Norwegian population shows a link between hearing loss and an increased risk of receiving disability pension, especially among younger adults and workers with lower education levels. The association between hearing loss and sick leave is weaker.
Article
Economics
Olivier Marie, Judit Vall Castello
Summary: We examine the impact of a significant reduction in paid sick leave benefits in Spain on work absences. Our findings reveal a decrease in the frequency of absences, but an increase in the duration of each absence. Overall, the policy has led to a reduction in the number of days lost to sick leave. However, there has been an increase in both relapses and work-related accidents, suggesting that some individuals returned to work prematurely. The displacement towards other unaffected benefit schemes has offset nearly 40% of the estimated absence reductions resulting from the cut in sick leave benefits.
JOURNAL OF LABOR ECONOMICS
(2023)
Article
Multidisciplinary Sciences
Nina Elisabeth Klevanger, Lene Aasdahl, Marit By Rise
Summary: This study aims to explore supervisors' experiences with attending to employees' sick leave and return to work process. The findings suggest that supervisors value their presence at the workplace and the need to obtain information, whilst considering individual and environmental influences on return-to-work and allocating responsibility. However, supervisors find obtaining information and managing responsibility challenging, indicating a possible disproportionate knowledge and responsibility in the return-to-work process.
Article
Public, Environmental & Occupational Health
Adrian Salinas Fredricson, Carina Kruger Weiner, Johanna Adami, Annika Rosen, Bodil Lund, Britt Hedenberg-Magnusson, Lars Fredriksson, Pia Svedberg, Aron Naimi-Akbar
Summary: This study investigated the use of social insurance benefits by TMD patients before and after their first diagnosis or surgical event. The results showed that TMD patients rely more on social benefits compared to the general population, and this reliance continues even after surgical treatment. Patients who undergo multiple surgical interventions have a higher level of dependence.
Article
Genetics & Heredity
Carl Michael Baravelli, Aasne Karine Aarsand, Sverre Sandberg, Mette Christophersen Tollanes
Summary: A nationwide study found that individuals with porphyria cutanea tarda (PCT) have an increased risk of long-term sick leave and disability pension. These findings highlight the significant morbidity associated with PCT and the need for long-term follow-up and monitoring.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Review
Pharmacology & Pharmacy
V Leso, P. Gervetti, M. C. Macrini, F. Russo, I. Iavicoli
Summary: This review explores potential factors related to work disability in patients with inflammatory bowel diseases, aiming to provide guidance for successful clinical and occupational management. Factors such as disease activity and severity, surgical treatment, comorbidities, and demographic characteristics have been suggested to predict work disability, but further research is needed to confirm their roles. A multidisciplinary approach may be necessary to improve patients' well-being and manage risks in the workplace.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Anastasia Katsoula, Georgios Axiaris, Afroditi Mpitouli, Maria Palatianou, Angeliki Christidou, Nikolaos Dimitriadis, Andreas Nakos, Ploutarchos Pastras, Panagiotis Kourkoulis, Pantelis Karatzas, Miltiadis Moutzoukis, Charalampos Zlatinoudis, Athanasios Philippidis, Anastasia Kourikou, Georgios Kokkotis, Antonios Gklavas, Angeliki Machaira, Aikaterini Mantaka, Persefoni Talimtzi, Evaggelia Anagnostopoulou, Ioannis E. Koutroubakis, Ioannis Papaconstantinou, Georgios Bamias, Spilios Manolakopoulos, Nicoletta Mathou, Konstantina Paraskeva, Andreas Protopappas, Eftychia Tsironi, Konstantinos H. H. Katsanos, Dimitrios K. K. Christodoulou, Georgios Papatheodoridis, Georgios Michalopoulos, Georgios Theocharis, Christos Triantos, Ioannis Pachiadakis, Konstantinos Soufleris, Nikolaos Viazis, Gerassimos J. Mantzaris, Georgios Tribonias, Maria Tzouvala, Angeliki Theodoropoulou, Konstantinos Karmiris, Evanthia Zampeli, Spyridon Michopoulos, Anna-Bettina Haidich, Olga Giouleme
Summary: The aim of this study was to validate the content of IBD-Disk in a Greek cohort of IBD patients. The results showed good correlation and consistency between the scores of IBD-Disk and IBD-DI at baseline and follow-up. Female gender and extraintestinal manifestations were significantly associated with a higher IBD-Disk total score. Therefore, the Greek version of IBD-Disk was proven to be a reliable and valid tool for assessing IBD-related disability.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Renata de Sa Brito Froes, Andre da Luz Moreira, Antonio Jose de V. Carneiro, Jessica P. L. Moreira, Ronir R. Luiz, Adriana Maria Hilu de Barros Moreira, Camila Cesar Monnerat, Heitor Siffert Pereira de Souza, Ana Teresa Pugas Carvalho
Summary: In Rio de Janeiro, one-sixth of Crohn's disease patients are affected by work disability, with risk factors mainly related to disease duration and complications. As this disability impacts young patients after a relatively short period of illness, the socioeconomic burden of CD is expected to increase in the future due to the rising prevalence.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Multidisciplinary Sciences
Emma Jelliffe, Paul Pangburn, Stefan Pichler, Nicolas R. Ziebarth
Summary: The study reveals that during the COVID-19 pandemic, more than half of US employees were unaware of the new emergency sick leave options provided by the federal government, resulting in around 8 million employees using sick leave while 15 million employees were unable to access paid sick leave, with women being 69% more likely to face unaddressed sick leave needs.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Public, Environmental & Occupational Health
Adrian Singapore Salinas Fredricson, Carina Kruger Weiner, Johanna Adami, Annika Rosen, Bodil Lund, Britt Hedenberg-Magnusson, Lars Fredriksson, Pia Svedberg, Aron Naimi-Akbar
Summary: This study investigates the impact of musculoskeletal diseases (MSD) and mental and behavioural disorders (MBD) comorbidity on sick leave (SL) and disability pension (DP) among temporomandibular disorder (TMD) patients. The results show that TMD patients are more dependent on SL and DP benefits compared to the general population, and this difference remains even after considering the influence of MSD and MBD comorbidity.
Article
Development Studies
Thomas Leoni
Summary: The article investigates graded sick leave benefits in Sweden, Finland and Germany, finding both commonalities and differences in institutional background, benefit design and governance. The design and governance variations of the models lead to significant differences in their diffusion, while all schemes face a common set of obstacles and challenges related to stakeholder roles, employer involvement and assessment of residual work ability.
SOCIAL POLICY & ADMINISTRATION
(2021)
Review
Gastroenterology & Hepatology
Mirabella Zhao, Lorant Gonczi, Peter L. Lakatos, Johan Burisch
Summary: New data shows that the incidence and prevalence of inflammatory bowel diseases (IBD) are on the rise worldwide, with approximately 0.2% of the European population currently suffering from IBD. Medical therapy and disease management have significantly advanced, emphasizing close monitoring of disease progression and a treat-to-target approach to prevent early bowel damage and disability. The surgical rate in Europe has decreased over time, with high health economic burden associated with IBD in the region.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Public, Environmental & Occupational Health
Astrid de Wind, Birgit H. P. M. Donker-Cools, Lyanne Jansen, Clare H. H. Luymes, Sylvia J. J. van der Burg-Vermeulen, Shirley Oomens, Johannes R. R. Anema, Frederieke G. G. Schaafsma
Summary: This study achieved multidisciplinary consensus among twelve occupational health experts on an ICF-based instrument for the assessment of work capacity and guidance in return to work. The study resulted in 20 core items, including personal functioning, social functioning, and physical functioning. The use of this ICF-based instrument is expected to facilitate interdisciplinary and intradisciplinary communication and contribute to appropriate and sustainable employability.
Article
Public, Environmental & Occupational Health
Jennifer L. Pomeranz, Diana Silver, Sarah A. Lieff, Jose A. Pagan
Summary: Paid sick leave is associated with lower mortality risks and increased use of health services. However, the U.S. lacks a national law and not all employers offer paid leave, especially to low-wage workers. States have enacted paid sick-leave laws or preemption laws, leading to regulatory gaps in certain states. This creates substantial inequities nationally. A national paid sick-leave law should be enacted by the federal government.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2022)
Review
Cell Biology
Giovanni Cirillo, Flor Negrete-Diaz, Daniela Yucuma, Assunta Virtuoso, Sohaib Ali Korai, Ciro De Luca, Eugenijus Kaniusas, Michele Papa, Fivos Panetsos
Summary: This paper provides a comprehensive overview of the pathogenesis and therapeutic approaches for inflammatory bowel diseases. The interaction between the enteric and central nervous systems and the role of the vagus nerve in autoimmune diseases are highlighted. Neuroprosthetic stimulation of the vagus nerve, particularly transcutaneous stimulation of the auricular branch, has been suggested as a potential therapeutic approach for controlling intestinal inflammation.
Article
Gastroenterology & Hepatology
Anders Forss, Mark Clements, Par Myrelid, Hans Strid, Charlotte Soderman, Agnieszka Wagner, David Andersson, Fredrik Hjelm, Ola Olen, Jonas Halfvarson, Jonas F. Ludvigsson
Summary: This study demonstrates the long-term clinical effectiveness of ustekinumab in patients with active Crohn's disease, as well as its improvement in Health-related Quality of Life (HRQoL) measures.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Oncology
Wenjie Ma, Marjorie M. Walker, Marcus Thuresson, Bjorn Roelstraete, Filip Skoldberg, Ola Olen, Lisa L. Strate, Andrew T. Chan, Jonas F. Ludvigsson
Summary: This study found that patients with diverticular disease who have colorectal histopathology have a 33% increased risk of overall incident cancer, with specific increases in colon, liver, pancreatic, and lung cancers.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Gastroenterology & Hepatology
Jie Chen, Yajing Zhou, Yuhao Sun, Shuai Yuan, Rahul Kalla, Jing Sun, Jianhui Zhao, Lijuan Wang, Xuejie Chen, Xuan Zhou, Siqi Dai, Yu Zhang, Gwo-tzer Ho, Dajing Xia, Qian Cao, Zhanju Liu, Susanna C. Larsson, Xiaoyan Wang, Kefeng Ding, Jonas Halfvarson, Xue Li, Evropi Theodoratou, Jack Satsangi
Summary: This study identified 14 proteins associated with the risk of ulcerative colitis (UC) through the analysis of serum proteomic profiling data. Further analysis using Mendelian randomisation confirmed the causal relationship between two chemokines and the increased risk of UC. Additionally, a new protein associated with UC risk was identified. Reverse Mendelian randomisation analysis did not find any influence of genetic predisposition to UC on these three inflammation proteins.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Rheumatology
Sofia Exarchou, Johan K. Wallman, Daniela Di Giuseppe, Eva Klingberg, Valgerdur Sigurdardottir, Sara Wedren, Ulf Lindstrom, Carl Turesson, Lennart T. H. Jacobsson, Johan Askling
Summary: This study aimed to estimate the prevalence of clinically diagnosed Psoriatic Arthritis (PsA) in Sweden in 2017 and assess the use of disease-modifying antirheumatic drugs (DMARDs) among PsA patients in contact with specialized rheumatology care. The prevalence of PsA in Sweden was approximately 0.35% among adults aged 18 to 79 years in 2017, and nearly three-fourths of PsA patients in recent contact with specialized rheumatology care received DMARD therapy in 2017.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Hilde Berner Hammer, Sigve Lans Pedersen, Maria K. K. Jonsson, Linda Mathsson-Alm, Isabel Gehring, Joe Sexton, Espen A. A. Haavardsholm, Johan Askling
Summary: This study compared two different laboratory methods for assessing calprotectin in plasma samples from patients with early or established rheumatoid arthritis (RA). The results showed high correlations between the two methods and similar correlations with clinical examinations. The study supports the robustness of calprotectin analyses and suggests its inclusion in assessments offered by clinical routine laboratories.
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
(2023)
Article
Medicine, General & Internal
Jiangwei Sun, Fang Fang, Ola Olen, Mingyang F. Song, Jonas Halfvarson, Bjorn Roelstraete, Hamed Khalili, Jonas Ludvigsson
Summary: In this study, individuals who underwent endoscopic biopsy with normal mucosa were followed up for a median of 10 years. The study found that these individuals had an elevated risk of inflammatory bowel disease (IBD) for at least 30 years. These findings imply the presence of a substantial symptomatic period before the diagnosis of IBD and emphasize the importance of considering the long-term risk of IBD in patients with symptoms but normal mucosa on gastrointestinal investigation.
Article
Gastroenterology & Hepatology
Aiva Lundberg Bave, Ola Olen, Jonas Soederling, Jonas F. Ludvigsson, Annika Bergquist, Caroline Nordenvall
Summary: Colectomy in UC patients was not associated with a decreased risk of subsequent PSC. The observed differences in the risk of PSC development over calendar periods are likely due to changes in PSC-diagnosis and UC-treatment.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Correction
Public, Environmental & Occupational Health
J. F. Ludvigsson, P. Appelros, J. Askling
CLINICAL EPIDEMIOLOGY
(2023)
Article
Rheumatology
Ulf Lindstrom, Daniela di Giuseppe, Sofia Exarchou, Gerd-Marie Alenius, Tor Olofsson, Eva Klingberg, Lennart Jacobsson, Johan Askling, Johan K. Wallman
Summary: This study aimed to compare the treatment outcomes of patients with newly diagnosed psoriatic arthritis (PsA) and rheumatoid arthritis (RA) using methotrexate (MTX) monotherapy. The results showed that PsA patients were less likely to continue the use of MTX compared to RA patients, and the effectiveness of MTX was also lower in PsA.
Article
Gastroenterology & Hepatology
David Bergman, Bjorn Roelstraete, Jiangwei Sun, Fahim Ebrahimi, Johan Askling, Jonas F. Ludvigsson
Summary: A study found that there is an association between microscopic colitis (MC) and rheumatoid arthritis (RA), with MC patients being nearly twice as likely to develop RA compared to the general population. This study is important as it highlights the need for expedited evaluation for RA in MC patients presenting with joint symptoms and/or arthralgia, thus preventing delay in RA diagnosis.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Kyle Staller, Ola Olen, Jonas Soderling, Bjorn Roelstraete, Hans Tornblom, Braden Kuo, Long H. Nguyen, Jonas F. Ludvigsson
Summary: The study found that previous use of antibiotics was associated with an increased risk of developing irritable bowel syndrome (IBS), particularly among those with multiple antibiotic dispensations.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Jiangwei Sun, Bjorn Roelstraete, Emma Svennberg, Jonas Halfvarson, Johan Sundstrom, Anders Forss, Ola Olen, Jonas F. Ludvigsson
Summary: This study found that patients with inflammatory bowel disease (IBD) have an increased risk of developing arrhythmias. This increased risk persists even 25 years after the diagnosis of IBD.
Article
Gastroenterology & Hepatology
Archana Shubhakar, Bas C. Jansen, Alex T. Adams, Karli R. Reiding, Nicholas T. Ventham, Rahul Kalla, Daniel Bergemalm, Paulina A. Urbanowicz, Richard A. Gardner, Manfred IBD BIOM Consortium, Manfred Wuhrer, Jonas Halfvarson, Jack Satsangi, Daryl L. Fernandes, Daniel I. R. Spencer
Summary: This study investigated a composite serum N-glycomic biomarker to predict future disease course in newly diagnosed IBD patients. The biomarker showed a predictive capacity for treatment escalation in both the discovery and replication cohorts of patients.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Amiko M. Uchida, John J. Garber, Ashley Pyne, Kathryn Peterson, Bjorn Roelstraete, Ola Olen, Jonas Halfvarson, Jonas F. Ludvigsson
Summary: In this nationwide cohort study, EoE was found to be associated with a 3.5-fold increased risk of later IBD diagnosis, possibly due to genetic or early environmental risk factors.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Soran Rabin Bozorg, Jonas Soderling, Karl Marild, John J. Garber, Amiko M. Uchida, Martin Neovius, Jonas F. Ludvigsson, Asa H. Everhov