Article
Gastroenterology & Hepatology
Simon Kurt, Benedicte Caron, Celia Gouynou, Patrick Netter, Carolynne J. Vaizey, StevenD. Wexner, Silvio Danese, Cedric Baumann, Laurent Peyrin-Biroulet
Summary: This study aimed to describe the prevalence of FI in patients with IBD using an available scoring system and identify associated risk factors. The results showed that approximately one fifth of IBD patients in this real-world cohort reported FI. Increased age, diarrhea, stool consistency according to the Bristol stool chart, and abdominal pain were associated with FI.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Gastroenterology & Hepatology
Vivek C. Goodoory, Cho E. Ng, Christopher J. Black, Alexander C. Ford
Summary: This study compared the characteristics of individuals with irritable bowel syndrome (IBS) reporting faecal incontinence (FI) with those who do not report FI. The results showed that individuals with FI were older, more likely to have IBS-D, had lower education levels and incomes, reported more urgency and more severe IBS and psychological symptoms, had lower quality of life scores, and higher healthcare costs.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Nursing
Parichat Thapwong, Christine Norton, Emma Rowland, Noora Farah, Wladyslawa Czuber-Dochan
Summary: This review examines the impact of Inflammatory Bowel Disease (IBD) on family members. It found that IBD negatively affects family members' well-being in various aspects, and they employ both adaptive and maladaptive coping strategies. Family members also expressed the need for better information, support groups, and access to counseling services.
JOURNAL OF CLINICAL NURSING
(2023)
Article
Gastroenterology & Hepatology
Arnau Vich Vila, Shixian Hu, Sergio Andreu-Sanchez, Valerie Collij, Bernadien H. Jansen, Hannah E. Augustijn, Laura A. Bolte, Renate A. A. A. Ruigrok, Galeb Abu-Ali, Cosmas Giallourakis, Jessica Schneider, John Parkinson, Amal Al-Garawi, Alexandra Zhernakova, Ranko Gacesa, Jingyuan Fu, Rinse K. Weersma
Summary: By analyzing the metabolites in fecal samples of patients with inflammatory bowel disease (IBD) and non-IBD controls, along with fecal metagenomics, host genetics, and clinical characteristics, we aimed to reveal metabolic alterations in IBD. The study identified over 300 molecules that were differentially abundant in the feces of patients with IBD, and a specific ratio between a sphingolipid and L-urobilin could distinguish between IBD and non-IBD samples. Additionally, strong associations were found between gut microbiota and fecal metabolome, paving the way for future interventions targeting intestinal inflammation.
Review
Biochemistry & Molecular Biology
Tyler Atagozli, David E. Elliott, Mirac Nedim Ince
Summary: Helminths are multicellular invertebrates that live in the gut of vertebrate animals, including humans. They can cause pathology and require treatment, but can also have commensal or symbiotic relationships with their hosts. Epidemiological data suggests that helminth exposure may provide protection against immune disorders, such as allergies and autoimmune illnesses.
Article
Immunology
Huldani Huldani, Ria Margiana, Fawad Ahmad, Maria Jade Catalan Opulencia, Mohammad Javed Ansari, Dmitry Olegovich Bokov, Nargiza N. Abdullaeva, Homayoon Siahmansouri
Summary: Inflammatory bowel disease (IBD) is caused by various pathophysiologic pathways and immune-pathologic etiologies. Mesenchymal Stem Cells (MSCs) have been suggested as a potential treatment for IBD due to their immune regulatory functions. Clinical trials using MSCs from bone marrow, umbilical cord, and adipose tissue have shown promising results in terms of safety. However, further research is needed to obtain more reliable results and more support from laboratory evidence.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Mohammad Reza Hatamnejad, Marzieh Shirvani, Mohamad Amin Pourhoseingholi, Hedieh Balaii, Shabnam Shahrokh, Hamid Asadzadeh Aghdaei, Amirhosein Koolaeian, Makan Cheraghpour
Summary: This study evaluates the psychometric properties of the Persian version of the Inflammatory bowel disease-fatigue (IBD-F) questionnaire. The questionnaire was translated and validated through face, content, and construct validity. The Persian version of the IBD-F questionnaire was found to be valid and reliable, providing a suitable scale to measure fatigue severity, frequency, and impact on daily activities.
Article
Pharmacology & Pharmacy
Chao Liu, Yuhong Jiang, Ganglei Liu, Zhushu Guo, Qianqian Jin, Dongju Long, Weihan Zhou, Ke Qian, Hua Zhao, Kuijie Liu
Summary: This study found that PPARGC1A was downregulated in DSS-induced colitis and DSS-stimulated colonic epithelial cells, and PDT treatment could upregulate PPARGC1A expression. Knockdown of PPARGC1A could attenuate the therapeutic effects of PDT on DSS-induced colitis and DSS-stimulated colonic epithelial cells.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Aleksandra Kubas, Ewa Malecka-Wojciesko
Summary: Vaccination against COVID-19 is considered safe and effective for patients with IBD, although further research is needed to understand its safety in special populations. The willingness to receive the vaccine among IBD patients is conflicting, with concerns about effectiveness and safety being the most common reasons for hesitancy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Pauline Wils, Benedicte Caron, Ferdinando D'Amico, Silvio Danese, Laurent Peyrin-Biroulet
Summary: This review provides a comprehensive overview of the multifactorial etiology implicated in the chronic abdominal pain of IBD patients and highlights the necessity of pharmacological and non-pharmacological approaches for treatment. Integrating psychological support in care models of IBD can reduce disease burden and healthcare costs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Jasmijn Z. Jagt, Charlotte M. Verburgt, Ralph de Vries, Nanne K. H. de Boer, Marc A. Benninga, Wouter J. de Jonge, Johan E. van Limbergen, Tim G. J. de Meij
Summary: This systematic review provides evidence for distinct faecal metabolomic profiles in paediatric IBD, but results varied across studies possibly due to differences in study design and applied analytical techniques. Faecal metabolomics could provide more insight into host-microbial interactions in IBD, but further studies with standardized methodologies and reporting are needed.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Public, Environmental & Occupational Health
Kristina Aluzaite, Kay Greveson, Shomron Ben-Horin, Rupert Leong, Ola Haj, Michael Schultz
Summary: The study investigated challenges faced by patients with inflammatory bowel disease (IBD) during travel, their information-seeking behavior and associated factors. A significant percentage of participants sought medical advice or were hospitalized overseas, with common barriers including concerns about toilet facilities, cleanliness, and access to medical care. Although a majority sought travel advice, some did not obtain travel insurance coverage for their IBD, which was associated with lack of advice or difficulty in obtaining insurance. Participants traveling for work were more likely to face medical issues overseas and not obtain proper travel insurance.
JOURNAL OF TRAVEL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Andrea Kulyk, Leigh Anne Shafer, Lesley A. Graff, James Stone, Kelcie Witges, Laura E. Targownik, Charles N. Bernstein
Summary: This study aimed to assess the association between different symptoms and disease activity in inflammatory bowel disease (IBD). The results showed that fatigue was the most common symptom, while urgency was strongly associated with disease activity. Different symptoms have different impacts on subjective and objective measurements of IBD.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Keeley M. Fairbrass, David J. Gracie, Alexander C. Ford
Summary: Psychological co-morbidity is more common in patients with inflammatory bowel disease (IBD) and has a cumulative effect on disease behavior, leading to worse disease progression in patients with increasing psychological burden.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Medicine, General & Internal
Mira Mekhael, Helle O. Kristensen, Helene Mathilde Larsen, Therese Juul, Anton Emmanuel, Klaus Krogh, Peter Christensen
Summary: This systematic review evaluated the effects of transanal irrigation (TAI) in patients with neurogenic bowel dysfunction, low anterior resection syndrome, fecal incontinence, and chronic constipation. The results showed improvements in bowel function with TAI, but high discontinuation rates and common side effects were observed. There were no consistent predictive factors for a successful outcome. Limited evidence suggests that TAI may improve bowel function and potentially quality of life.
JOURNAL OF CLINICAL MEDICINE
(2021)
