4.6 Article

A chronic care model significantly decreases costs and healthcare utilisation in patients with inflammatory bowel disease

Journal

JOURNAL OF CROHNS & COLITIS
Volume 6, Issue 3, Pages 302-310

Publisher

ELSEVIER SCIENCE BV
DOI: 10.1016/j.crohns.2011.08.019

Keywords

Inpatient healthcare utilisation; Chronic care model; Extended roles IBD nurse; Dedicated IBD clinic

Funding

  1. Schering-Plough
  2. Abbott
  3. Ferring
  4. Orphan
  5. Fresenius Kabi
  6. RAH

Ask authors/readers for more resources

Introduction: Inflammatory bowel disease (IBD) is a chronic condition, yet the model of care is often reactive. We sought to examine whether a formal IBD service (IBDS) reduced inpatient healthcare utilisation or lowered costs for inpatient care. Material and methods: With protocols, routine nurse phone follow-up a help-line, more proactive care was delivered, with many symptoms and concerns dealt with prior to routine presentation. Over two five month periods before (2007/8) and after (2009/10) introducing a formal IBDS two discrete cohorts of admitted IBD patients were identified at a single centre. Each patient was assigned five contemporaneously admitted, age and gender matched controls. Inpatient healthcare utilisation was compared between patients and controls and disease-specific factors amongst the two IBD cohorts. Results: The initial audit captured 102 admitted IBD patients (510 controls, median age 44 years, 57% female); the second audit 95 patients (475 controls, median age 46 years, 45.3% female). In 2009/10, the number of admissions was lower in IBD patients than in controls (mean 1.53+1-1.03 vs. 2.54+/-2.35; p<0.0001). This contrasts with the first audit, where IBD patients had more admissions than controls. Following IBDS introduction, the mean total cost of inpatient care was lower for IBD patients than controls (US$12,857.48 (US$15,236.79) vs. US$ 30,467.78 (US$ 53,760.20), p=0.005). In addition, patients known to a specialist gastroenterologist (GE) and the IBD Service tended to have the lowest mean number of admissions (GE and IBDS 1.14 (+1-0.36) vs. no GE/IBDS 1.64 (+1-1.25)). Conclusions: Healthcare utilisation and disease burden in IBD decreased significantly since introducing an IBDS. These data suggest that proactive management improved outcomes. Contact with a gastroenterologist and IBDS seemed to give best results. Crown Copyright (C) 2011 Published by Elsevier B.V. on behalf of European Crohn's and Colitis Organisation. All rights reserved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Gastroenterology & Hepatology

Proactive Metabolite Testing in Patients on Thiopurine May Yield Long-Term Clinical Benefits in Inflammatory Bowel Disease

Alex Barnes, Soong-Yuan J. Ooi, Kate D. Lynch, Nina Parthasarathy, Maria Bishara, Michael Gounder, Rachel Grafton, Peta Leach, Peter Bampton, Alexandra Sechi, Watson Ng, Susan Connor, Daniel van Langenberg, Reme Mountifield, Jane M. Andrews

Summary: This study aimed to evaluate the long-term outcomes of patients on thiopurines following therapeutic drug monitoring (TDM) for the treatment of inflammatory bowel disease (IBD). The findings showed that TDM resulted in a change in management for the majority of patients and led to an increase in the number of patients in remission. Proactive TDM allowed for the identification and management of inappropriate dosing and was associated with higher levels of clinical remission.

DIGESTIVE DISEASES AND SCIENCES (2023)

Article Gastroenterology & Hepatology

Alterations to the duodenal microbiota are linked to gastric emptying and symptoms in functional dyspepsia

Erin R. Shanahan, Seungha Kang, Heidi Staudacher, Ayesha Shah, Anh Do, Grace Burns, Veronique S. Chachay, Natasha A. Koloski, Simon Keely, Marjorie M. Walker, Nicholas J. Talley, Mark Morrison, Gerald J. Holtmann

Summary: This study indicates a link between duodenal microbiota, gastric emptying, and FD symptoms, and this link is largely independent of long-term dietary intake.
Review Gastroenterology & Hepatology

Asia-Pacific guidelines for managing functional dyspepsia overlapping with other gastrointestinal symptoms

Kok-Ann Gwee, Yeong Yeh Lee, Hidekazu Suzuki, Uday Chand Ghoshal, Gerald Holtmann, Tao Bai, Giovanni Barbara, Min-hu Chen, Andrew Seng Boon Chua, Peter R. Gibson, Xiaohua Hou, Jinsong Liu, Atsushi Nakajima, Nitesh Pratap, Sanjeev Sachdeva, Kewin Tien Ho Siah, Alex Yu Sen Soh, Kentaro Sugano, Jan Tack, Victoria Ping Yi Tan, Xudong Tang, Marjorie Walker, Deng-Chyang Wu, Ying-Lian Xiao, Khairil Khuzaini Zulkifli, Clarissa Toh

Summary: Contemporary systems categorize patients into sub-classes based on symptoms to enable targeted treatment, but overlapping symptom categories negatively impact outcomes, lacking guidance on management. An APAGE working group developed clinical practice guidelines for management of patients with functional dyspepsia (FD) who have overlaps with other functional gastrointestinal disorders. They identified putative pathophysiology and provided a management algorithm for primary and secondary care clinicians.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2023)

Article Gastroenterology & Hepatology

Diabetes mellitus is an independent risk factor for a greater frequency of early satiation and diarrhea at one and three years: Two prospective longitudinal population-based studies

Natasha A. Koloski, Michael Jones, Marjorie M. Walker, Michael Horowitz, Gerald Holtmann, Nicholas J. Talley

Summary: Diabetes is an independent risk factor for an increased frequency of gastrointestinal symptoms, adjusting for lifestyle and psychological factors.

NEUROGASTROENTEROLOGY AND MOTILITY (2023)

Letter Gastroenterology & Hepatology

Letter to the Editor: Insurance should cover vancomycin for primary sclerosing cholangitis

Ahmad H. Ali, Cynthia W. Buness, Ryan Fischer, Gerald J. Holtmann, Ayesha Shah, Peter Lewindon, Shamita Shah, Amol S. Ragnekar, Amy E. Taylor, Aparna Goel, Kenneth L. Cox, Leina Alrabadi, Steve Wadsworth, Sakil S. Kulkarni, Keith D. Lindor

HEPATOLOGY (2023)

Article Gastroenterology & Hepatology

Dose intensification strategy influences infliximab pharmacokinetics but not clinical response after the same number of doses

Ashish Srinivasan, Peter De Cruz, Melissa Sam, Catherine Toong, Daniel R. van Langenberg

Summary: This study compared two different strategies, repeat infliximab induction and shorter dose interval, for addressing secondary loss of response in patients with inflammatory bowel disease. The study found that both strategies had similar clinical response rates, but they resulted in distinct pharmacokinetic profiles.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2023)

Review Gastroenterology & Hepatology

Placebo effects in functional dyspepsia: Causes and implications for clinical trials

Michael P. Jones, Gerald Holtmann

Summary: Placebo responses provide insights into mechanisms beyond the intervention and affect the potential efficacy of new interventions in clinical trials. This mini-review discusses the systematic review and meta-analysis conducted by Bosman and colleagues on placebo response in functional dyspepsia clinical trials. It also explores potential mechanisms of placebo response in the context of brain-gut interaction disorders and extra-gastrointestinal disorders.

NEUROGASTROENTEROLOGY AND MOTILITY (2023)

Article Immunology

Type 2 and type 17 effector cells are increased in the duodenal mucosa but not peripheral blood of patients with functional dyspepsia

Grace L. Burns, Jessica K. Bruce, Kyra Minahan, Andrea Mathe, Thomas Fairlie, Raquel Cameron, Crystal Naudin, Prema M. Nair, Michael D. E. Potter, Mudar Zand Irani, Steven Bollipo, Robert Foster, Lay T. T. Gan, Ayesha Shah, Natasha A. Koloski, Paul S. Foster, Jay C. Horvat, Martin Veysey, Gerald Holtmann, Nick Powell, Marjorie M. Walker, Nicholas J. Talley, Simon Keely

Summary: This study found that patients with functional dyspepsia have increased Th2 and Th17 lymphocyte populations in the duodenal mucosa, and these cells are of effector and memory phenotype, indicating that the microinflammation in functional dyspepsia may be antigen-driven.

FRONTIERS IN IMMUNOLOGY (2023)

Review Gastroenterology & Hepatology

Unravelling the controversy with small intestinal bacterial overgrowth

Ayesha Shah, Uday C. Ghoshal, Gerald J. Holtmann

Summary: The aim of this review is to summarize the current and emergent approaches to characterize the small intestinal microbiota and discuss the treatment options for management of small intestinal bacterial overgrowth (SIBO). This review captures the growing body of evidence for the role of SIBO, a type of small intestinal dysbiosis in the pathophysiology various gastrointestinal and extraintestinal disorders. Although recurrence is common, targeted modulation of the gut microbiome as a therapeutic option for management of SIBO is associated with improvement in symptoms and quality of life.

CURRENT OPINION IN GASTROENTEROLOGY (2023)

Review Gastroenterology & Hepatology

Upper GI endoscopy in subjects with positive fecal occult blood test undergoing colonoscopy: systematic review and meta-analysis

Ayesha Shah, Ali Eqbal, Naomi Moy, Natasha Koloski, Helmut Messmann, Bradley J. Kendall, Prateek Sharma, Uwe Dulleck, Michael P. Jones, Gerald J. Holtmann

Summary: This study aimed to determine the prevalence of upper gastrointestinal (UGI) lesions in subjects with a positive fecal occult blood test (FOBT+). The results showed that the prevalence of UGI cancers in FOBT+ subjects was 0.8%, and the prevalence of UGI clinically significant lesions (CSLs) was 30.4%. Anemia was associated with UGI cancers and UGI CSLs, while gastrointestinal symptoms were not associated with UGI CSLs.

GASTROINTESTINAL ENDOSCOPY (2023)

Review Gastroenterology & Hepatology

Evaluation of small intestinal bacterial overgrowth

Uday C. Ghoshal, Ujjala Ghoshal, Ayesha Shah, Gerald Holtmann

Summary: There is a significant interest in gut microbiota dysbiosis, specifically small intestinal bacterial overgrowth (SIBO), however, the current diagnostic methods for SIBO are not satisfactory. This review discusses the different invasive and noninvasive tests for diagnosing SIBO, their methodology, interpretation, sensitivity, specificity, and limitations. It also presents potential methods for diagnosis of SIBO that may be useful in clinical practice in the future.

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY (2023)

Review Gastroenterology & Hepatology

Small Intestinal Bacterial Overgrowth Complicating Gastrointestinal Manifestations of Systemic Sclerosis: A Systematic Review and Meta-analysis

Ayesha Shah, Veenaa Pakeerathan, Michael P. Jones, Purna C. Kashyap, Kate Virgo, Thomas Fairlie, Mark Morrison, Uday C. Ghoshal, Gerald J. Holtmann

Summary: This systematic review and meta-analysis investigated the prevalence of small intestinal bacterial overgrowth (SIBO) in systemic sclerosis (SSc), as well as the risk factors and the effects on gastrointestinal symptoms. The study found that SIBO prevalence in SSc patients is 39.9%, with a 10-fold increased prevalence compared to controls. It also suggested that antimicrobial therapy should be considered for SSc patients with SIBO and diarrhea.

JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY (2023)

Article Gastroenterology & Hepatology

Development and Validation of a Patient-Reported Experience Measure for Gastrointestinal Endoscopy The Comprehensive Endoscopy Satisfaction Tool (CEST)

Marguerite J. Kutyla, Jessica J. McMaster, Adam Haig, Natasha Koloski, Luke Hourigan, Vera Meeusen, Ayesha Shah, Nicholas J. Talley, Michael P. Jones, Gerald J. Holtmann

Summary: This study aimed to develop and validate a patient-reported experience measure for GI endoscopy. The Comprehensive Endoscopy Satisfaction Tool captures relevant domains that influence the patient's experience and identifies factors that shape satisfaction. The tool was tested in a large number of patients and found to be valid and responsive.

JOURNAL OF CLINICAL GASTROENTEROLOGY (2023)

Article Gastroenterology & Hepatology

Clinical trial: Combination allopurinol-thiopurine versus standard thiopurine in patients with IBD escalating to immunomodulators (the DECIDER study)

Abhinav Vasudevan, Danny Con, Peter De Cruz, Miles P. Sparrow, Antony B. Friedman, Mayur Garg, Soleiman Kashkooli, Peter R. Gibson, Daniel R. van Langenberg

Summary: This study compared the use of thiopurine-allopurinol combination therapy with standard thiopurine therapy in IBD. The results showed that the thiopurine-allopurinol group had better outcomes in the primary efficacy assessment, fewer adverse events, and less frequent thiopurine dose adjustments.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2023)

Article Gastroenterology & Hepatology

Utility of panenteric capsule endoscopy for the detection of small-bowel Crohn's disease in patients with a normal magnetic resonance enterography: A prospective observational pilot study

Anuj Bohra, Diana Lewis, Jonathan P. Segal, Abhinav Vasudevan, Daniel R. Van Langenberg, Olga Niewiadomski

Summary: This study examines the diagnostic utility of panenteric Crohn's capsule endoscopy in detecting active small-bowel Crohn's disease when imaging is normal but there is a high clinical suspicion. The results show that Crohn's CE is an effective diagnostic test that can improve quality of life and guide treatment.

JGH OPEN (2023)

No Data Available