Letter
Medicine, General & Internal
Edoardo G. Giannini, Tommaso Testa, Federica Grillo, Luca Mastracci, Serena Arrigo, Piero Cai, Sabrina Paolino, Martina Burlando, Livia Pisciotta, Elena Formisano, Giuseppe Cittadini, Francesco Copello, Sabrina Tuo, Giorgia Bodini
Summary: The establishment of an interdisciplinary IBD center is associated with improved healthcare utilization, including a decrease in hospitalizations per patient/year, a decrease in length of hospitalization, and an increase in patients on biologics.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Gastroenterology & Hepatology
Rebecca K. Grant, William M. Brindle, Ian D. R. Arnott
Summary: The impact of a dedicated inflammatory bowel disease flare clinic was assessed. Attenders had more changes to maintenance medications made and less steroid use than inflammatory bowel disease patients reviewed at the Acute Receiving Unit. This model of care may potentially reduce hospital admissions.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Health Care Sciences & Services
Carlos Escobar, Beatriz Palacios, Unai Aranda, Margarita Capel, Antoni Sicras, Aram Sicras, Antonio Hormigo, Roberto Alcazar, Nicolas Manito, Manuel Botana
Summary: Between 2015 and 2019, the costs of patients with chronic kidney disease (CKD) in Spain were high, with cardiovascular hospitalizations being the key determinant. Medication costs accounted for only a small proportion of total CKD costs. Costs associated with cardiovascular hospitalizations, cardiovascular and diabetic medications, as well as hospitalization and mortality rates, all decreased over the study period.
BMC HEALTH SERVICES RESEARCH
(2021)
Article
Medicine, General & Internal
Chao Yang, Jianyan Long, Ying Shi, Zhiye Zhou, Jinwei Wang, Ming-Hui Zhao, Haibo Wang, Luxia Zhang, Josef Coresh
Summary: This study evaluated the healthcare resource utilization for chronic kidney disease (CKD) and other major non-communicable chronic diseases (NCDs) in China. The presence of diagnosed CKD alongside each major NCD was associated with longer hospital stays and higher in-hospital mortality rates. CKD is a major public health burden in China.
Article
Multidisciplinary Sciences
Rashidul Alam Mahumud, Jeff Gow, Md Parvez Mosharaf, Satyajit Kundu, Md. Ashfikur Rahman, Natisha A. Dukhi, Md A. Shahajalal, Sabuj Kanti A. Mistry
Summary: This study examined healthcare utilization among Bangladesh patients with chronic diseases from a gender perspective. It was found that patients with chronic heart disease were more likely to use healthcare services. Additionally, male patients had higher utilization rates compared to female patients.
Article
Medicine, General & Internal
Anais Lacasse, Hermine Lore Nguena Nguefack, G. Page, Manon Choiniere, Oumar Malle Samb, Joel Katz, Nancy Menard, Bilkis Vissandjee, Meriem Zerriouh, TorSaDE Cohort Working
Summary: This study aimed to assess sex and gender differences in healthcare utilisation among workers living with chronic pain. The study found three distinct trajectories of healthcare utilisation among the study population. It also found that, independent of other sociodemographic characteristics and severity of health condition, females were more likely to belong to the trajectory of heavy healthcare utilisation.
Article
Medicine, General & Internal
Anais Lacasse, Hermine Lore Nguena Nguefack, G. Page, Manon Choiniere, Oumar Malle Samb, Joel Katz, Nancy Menard, Bilkis Vissandjee, Meriem Zerriouh, TorSaDE Cohort Working
Summary: The objective of this study was to assess sex and gender differences in healthcare utilisation trajectories among workers living with chronic pain. The study found three distinct healthcare utilisation trajectories in the study population, and sex had an impact on the trajectory and stability of healthcare contacts over time. The results underline the importance of assessing sex-based disparities in help-seeking behaviours, access to healthcare and resource utilisation among persons living with chronic pain.
Article
Cardiac & Cardiovascular Systems
F. R. Piersma, J. Neefs, W. R. Berger, N. W. E. van den Berg, R. Wesselink, S. P. J. Krul, J. R. de Groot
Summary: After initial cardiac assessment in the nurse-led outpatient clinic, approximately half of the newly referred AF patients were referred back to their GP, indicating that this strategy may help reduce the burden of AF patients on secondary or tertiary cardiology outpatient clinics.
NETHERLANDS HEART JOURNAL
(2022)
Article
Medicine, General & Internal
Grace C. Lovett, Phil Ha, Andrew T. Roberts, Sally Bell, Danny Liew, Stephen Pianko, William Sievert, Suong T. T. Le
Summary: The economic burden and healthcare utilization costs associated with decompensated chronic liver disease (CLD) in Australia were evaluated in this study. The findings showed that hospital admission and readmission for decompensated CLD were common, with a high 1-year mortality rate and significant costs.
INTERNAL MEDICINE JOURNAL
(2023)
Article
Medicine, General & Internal
Anne Hoy Seemann Vestergaard, Christian Fynbo Christiansen, Mette Asbjoern Neergaard, Jan Brink Valentin, Soren Paaske Johnsen
Summary: This study investigated healthcare resource utilization before death for patients with COPD, heart failure, and cancer, finding similar illness trajectories for all three patient populations. The findings suggest the need to reassess efforts in achieving equal access to palliative care interventions for patients with different terminal illnesses.
Article
Respiratory System
David Singer, Benjamin Chastek, Andrew Sargent, Jonathan C. Johnson, Sharash Shetty, Craig Conoscenti, Elana J. Bernstein
Summary: This study aimed to assess the relationship between the rate of decline in lung function and an increase in hospitalization among patients with chronic fibrosing ILD. The results showed that a decline in FVC% ≥ 10% was associated with an increased odds of inpatient hospitalization.
BMC PULMONARY MEDICINE
(2023)
Article
Medicine, General & Internal
Magdalini Patseadou, Catherine Chamay Weber, Dagmar M. Haller
Summary: This publication describes a protocol concerning a large cohort of unaccompanied asylum-seeking minors settled in Switzerland from 2015 to 2016. The aim is to assess their health status and examine their trajectories of healthcare services utilization over a 3-year period.
Article
Cardiac & Cardiovascular Systems
Imran Satia, Alexandra J. Mayhew, Nazmul Sohel, Om Kurmi, Kieran J. Killian, Paul M. O'Byrne, Parminder Raina
Summary: This study found that chronic cough is associated with a greater burden on social participation, healthcare use, and personal care. Productive chronic cough in males is associated with limited social participation activities, emergency department visits, and hospitalization. Females with productive chronic cough experience reduced frequency of social participation activities and more emergency department visits. Dry chronic cough in females is associated with limited social participation activities and increased emergency department visits.
RESPIRATORY MEDICINE
(2023)
Article
Respiratory System
Nawar Diar Bakerly, Dominy Browning, Isabelle Boucot, Jodie Crawford, Sheila McCorkindale, Norman Stein, John P. New
Summary: The study suggests that initiating fluticasone furoate/vilanterol in patients with chronic obstructive pulmonary disease may be a more cost-effective alternative to current therapies.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2021)
Article
Health Care Sciences & Services
David Chua, Donata Sackey, Meryl Jones, Michelle Smith, Lauren Ball, Tracey Johnson
Summary: This study evaluated the acceptability, utilisation, and perceived benefits of the Mater CALD Health Coordinator Service (M-CHooSe) for patients from culturally and linguistically diverse backgrounds. The results showed that patients were accepting of referrals to M-CHooSe and both healthcare professionals and patients reported benefits from the service, highlighting its potential to improve healthcare equity, accessibility, and system efficiency.
AUSTRALIAN JOURNAL OF PRIMARY HEALTH
(2023)
Article
Gastroenterology & Hepatology
Alex Barnes, Soong-Yuan J. Ooi, Kate D. Lynch, Nina Parthasarathy, Maria Bishara, Michael Gounder, Rachel Grafton, Peta Leach, Peter Bampton, Alexandra Sechi, Watson Ng, Susan Connor, Daniel van Langenberg, Reme Mountifield, Jane M. Andrews
Summary: This study aimed to evaluate the long-term outcomes of patients on thiopurines following therapeutic drug monitoring (TDM) for the treatment of inflammatory bowel disease (IBD). The findings showed that TDM resulted in a change in management for the majority of patients and led to an increase in the number of patients in remission. Proactive TDM allowed for the identification and management of inappropriate dosing and was associated with higher levels of clinical remission.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Erin R. Shanahan, Seungha Kang, Heidi Staudacher, Ayesha Shah, Anh Do, Grace Burns, Veronique S. Chachay, Natasha A. Koloski, Simon Keely, Marjorie M. Walker, Nicholas J. Talley, Mark Morrison, Gerald J. Holtmann
Summary: This study indicates a link between duodenal microbiota, gastric emptying, and FD symptoms, and this link is largely independent of long-term dietary intake.
Review
Gastroenterology & Hepatology
Kok-Ann Gwee, Yeong Yeh Lee, Hidekazu Suzuki, Uday Chand Ghoshal, Gerald Holtmann, Tao Bai, Giovanni Barbara, Min-hu Chen, Andrew Seng Boon Chua, Peter R. Gibson, Xiaohua Hou, Jinsong Liu, Atsushi Nakajima, Nitesh Pratap, Sanjeev Sachdeva, Kewin Tien Ho Siah, Alex Yu Sen Soh, Kentaro Sugano, Jan Tack, Victoria Ping Yi Tan, Xudong Tang, Marjorie Walker, Deng-Chyang Wu, Ying-Lian Xiao, Khairil Khuzaini Zulkifli, Clarissa Toh
Summary: Contemporary systems categorize patients into sub-classes based on symptoms to enable targeted treatment, but overlapping symptom categories negatively impact outcomes, lacking guidance on management. An APAGE working group developed clinical practice guidelines for management of patients with functional dyspepsia (FD) who have overlaps with other functional gastrointestinal disorders. They identified putative pathophysiology and provided a management algorithm for primary and secondary care clinicians.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Natasha A. Koloski, Michael Jones, Marjorie M. Walker, Michael Horowitz, Gerald Holtmann, Nicholas J. Talley
Summary: Diabetes is an independent risk factor for an increased frequency of gastrointestinal symptoms, adjusting for lifestyle and psychological factors.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Letter
Gastroenterology & Hepatology
Ahmad H. Ali, Cynthia W. Buness, Ryan Fischer, Gerald J. Holtmann, Ayesha Shah, Peter Lewindon, Shamita Shah, Amol S. Ragnekar, Amy E. Taylor, Aparna Goel, Kenneth L. Cox, Leina Alrabadi, Steve Wadsworth, Sakil S. Kulkarni, Keith D. Lindor
Article
Gastroenterology & Hepatology
Ashish Srinivasan, Peter De Cruz, Melissa Sam, Catherine Toong, Daniel R. van Langenberg
Summary: This study compared two different strategies, repeat infliximab induction and shorter dose interval, for addressing secondary loss of response in patients with inflammatory bowel disease. The study found that both strategies had similar clinical response rates, but they resulted in distinct pharmacokinetic profiles.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Michael P. Jones, Gerald Holtmann
Summary: Placebo responses provide insights into mechanisms beyond the intervention and affect the potential efficacy of new interventions in clinical trials. This mini-review discusses the systematic review and meta-analysis conducted by Bosman and colleagues on placebo response in functional dyspepsia clinical trials. It also explores potential mechanisms of placebo response in the context of brain-gut interaction disorders and extra-gastrointestinal disorders.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Immunology
Grace L. Burns, Jessica K. Bruce, Kyra Minahan, Andrea Mathe, Thomas Fairlie, Raquel Cameron, Crystal Naudin, Prema M. Nair, Michael D. E. Potter, Mudar Zand Irani, Steven Bollipo, Robert Foster, Lay T. T. Gan, Ayesha Shah, Natasha A. Koloski, Paul S. Foster, Jay C. Horvat, Martin Veysey, Gerald Holtmann, Nick Powell, Marjorie M. Walker, Nicholas J. Talley, Simon Keely
Summary: This study found that patients with functional dyspepsia have increased Th2 and Th17 lymphocyte populations in the duodenal mucosa, and these cells are of effector and memory phenotype, indicating that the microinflammation in functional dyspepsia may be antigen-driven.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Gastroenterology & Hepatology
Ayesha Shah, Uday C. Ghoshal, Gerald J. Holtmann
Summary: The aim of this review is to summarize the current and emergent approaches to characterize the small intestinal microbiota and discuss the treatment options for management of small intestinal bacterial overgrowth (SIBO). This review captures the growing body of evidence for the role of SIBO, a type of small intestinal dysbiosis in the pathophysiology various gastrointestinal and extraintestinal disorders. Although recurrence is common, targeted modulation of the gut microbiome as a therapeutic option for management of SIBO is associated with improvement in symptoms and quality of life.
CURRENT OPINION IN GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Ayesha Shah, Ali Eqbal, Naomi Moy, Natasha Koloski, Helmut Messmann, Bradley J. Kendall, Prateek Sharma, Uwe Dulleck, Michael P. Jones, Gerald J. Holtmann
Summary: This study aimed to determine the prevalence of upper gastrointestinal (UGI) lesions in subjects with a positive fecal occult blood test (FOBT+). The results showed that the prevalence of UGI cancers in FOBT+ subjects was 0.8%, and the prevalence of UGI clinically significant lesions (CSLs) was 30.4%. Anemia was associated with UGI cancers and UGI CSLs, while gastrointestinal symptoms were not associated with UGI CSLs.
GASTROINTESTINAL ENDOSCOPY
(2023)
Review
Gastroenterology & Hepatology
Uday C. Ghoshal, Ujjala Ghoshal, Ayesha Shah, Gerald Holtmann
Summary: There is a significant interest in gut microbiota dysbiosis, specifically small intestinal bacterial overgrowth (SIBO), however, the current diagnostic methods for SIBO are not satisfactory. This review discusses the different invasive and noninvasive tests for diagnosing SIBO, their methodology, interpretation, sensitivity, specificity, and limitations. It also presents potential methods for diagnosis of SIBO that may be useful in clinical practice in the future.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Ayesha Shah, Veenaa Pakeerathan, Michael P. Jones, Purna C. Kashyap, Kate Virgo, Thomas Fairlie, Mark Morrison, Uday C. Ghoshal, Gerald J. Holtmann
Summary: This systematic review and meta-analysis investigated the prevalence of small intestinal bacterial overgrowth (SIBO) in systemic sclerosis (SSc), as well as the risk factors and the effects on gastrointestinal symptoms. The study found that SIBO prevalence in SSc patients is 39.9%, with a 10-fold increased prevalence compared to controls. It also suggested that antimicrobial therapy should be considered for SSc patients with SIBO and diarrhea.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Marguerite J. Kutyla, Jessica J. McMaster, Adam Haig, Natasha Koloski, Luke Hourigan, Vera Meeusen, Ayesha Shah, Nicholas J. Talley, Michael P. Jones, Gerald J. Holtmann
Summary: This study aimed to develop and validate a patient-reported experience measure for GI endoscopy. The Comprehensive Endoscopy Satisfaction Tool captures relevant domains that influence the patient's experience and identifies factors that shape satisfaction. The tool was tested in a large number of patients and found to be valid and responsive.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Abhinav Vasudevan, Danny Con, Peter De Cruz, Miles P. Sparrow, Antony B. Friedman, Mayur Garg, Soleiman Kashkooli, Peter R. Gibson, Daniel R. van Langenberg
Summary: This study compared the use of thiopurine-allopurinol combination therapy with standard thiopurine therapy in IBD. The results showed that the thiopurine-allopurinol group had better outcomes in the primary efficacy assessment, fewer adverse events, and less frequent thiopurine dose adjustments.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Anuj Bohra, Diana Lewis, Jonathan P. Segal, Abhinav Vasudevan, Daniel R. Van Langenberg, Olga Niewiadomski
Summary: This study examines the diagnostic utility of panenteric Crohn's capsule endoscopy in detecting active small-bowel Crohn's disease when imaging is normal but there is a high clinical suspicion. The results show that Crohn's CE is an effective diagnostic test that can improve quality of life and guide treatment.