Review
Gastroenterology & Hepatology
Elliot S. Coburn, Corey A. Siegel, Michael Winter, Eric D. Shah
Summary: HLH is rare among IBD patients treated with biologics, with most cases having identifiable infection or malignancy at diagnosis and a history of immunomodulator use. Survival rate is 70%, with risk factors possibly including younger age, male gender, Crohn's disease, and treatment induction phase.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Hematology
Amir A. A. Mahmoud, Ali Abdelhay, Alia Khamis, Mariam Mostafa, Ahmed Shehadah, Mohamed Salah Mohamed, Basant Eltaher, Talha Malik
Summary: Hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening immune dysregulation disease. Patients with inflammatory bowel disease (IBD) have an increased risk of developing HLH due to immunosuppressive therapy and viral infections. However, data on the association between IBD and HLH is limited.
ANNALS OF HEMATOLOGY
(2023)
Article
Pediatrics
Katherine F. Sweeny, Yanjia J. Zhang, Bonnie Crume, Colin A. Martz, Melissa M. Blessing, Stacy A. Kahn
Summary: The case describes a 16-year-old boy with MIS-C and severe inflammatory bowel disease. Treatment with a combination of steroids, intravenous immunoglobulin, and infliximab led to symptom resolution over a 3-week period. Emphasizing the need to investigate the impact of COVID-19 and MIS-C on inflammatory disorders.
Review
Cell Biology
Giovanni Cirillo, Flor Negrete-Diaz, Daniela Yucuma, Assunta Virtuoso, Sohaib Ali Korai, Ciro De Luca, Eugenijus Kaniusas, Michele Papa, Fivos Panetsos
Summary: This paper provides a comprehensive overview of the pathogenesis and therapeutic approaches for inflammatory bowel diseases. The interaction between the enteric and central nervous systems and the role of the vagus nerve in autoimmune diseases are highlighted. Neuroprosthetic stimulation of the vagus nerve, particularly transcutaneous stimulation of the auricular branch, has been suggested as a potential therapeutic approach for controlling intestinal inflammation.
Review
Gastroenterology & Hepatology
Ayseguel Aksan, Karima Farrag, Irina Blumenstein, Oliver Schroeder, Axel U. Dignass, Juergen Stein
Summary: Chronic intestinal failure, a rare complication of Crohn's disease, can greatly impact quality of life and treatment options include home-based parenteral nutrition and intravenous infusion. However, 60% of patients may need lifelong reliance on parenteral nutrition, and promising new drugs have brought new dimensions to therapy.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Marilyn Hagan, Bu' Hussain Hayee, Ana Rodriguez-Mateos
Summary: Polyphenols (PPs) may have therapeutic benefits in gastrointestinal (GI) disorders like IBS or IBD, but the evidence base is inconsistent and further research is needed to clarify their effects.
Review
Medicine, General & Internal
Andreea Salcudean, Andreea Georgiana Nan, Cristina Raluca Bodo, Marius Catalin Cosma, Elena Gabriela Strete, Maria Melania Lica
Summary: Inflammatory bowel disease (IBD) is a chronic, immune-mediated condition of the gastrointestinal tract, which significantly reduces quality of life in pediatric populations. Physical symptoms such as abdominal pain and fatigue are accompanied by mental and emotional distress, leading to poor body image and low self-esteem. Diagnosis and treatment of mental health problems in pediatric IBD patients can improve adherence to treatment and reduce long-term morbidity and mortality.
Review
Gastroenterology & Hepatology
Bo Shen
Summary: Endoscopic therapy has become the main treatment for inflammatory bowel diseases and associated complications, such as strictures, fistulas, abscesses, bleeding lesions, and polyps. The development of interventional IBD is supported by a better understanding of the disease process, advancements in endoscopic technology, and the training of next-generation specialists.
GASTROENTEROLOGY REPORT
(2022)
Review
Pharmacology & Pharmacy
Rocio Rivera Rodriguez, Jeremy James Johnson
Summary: Inflammatory Bowel Disease (IBD) is a chronic autoimmune disease characterized by intestinal inflammation. The incidence of IBD is rapidly increasing in newly developed countries, making it a global concern. Two major types of IBD, ulcerative colitis (UC) and Crohn's disease (CD), have different manifestations and locations of inflammation in the digestive tract. Current FDA-approved treatments for IBD are only effective for 50% of patients and come with serious side effects, highlighting the need for safer and more effective therapies. Plant-based diets, such as the Mediterranean diet rich in anti-inflammatory phytochemicals, have shown benefits in preventing and improving symptoms of IBD. Terpenes, a class of phytochemicals abundant in Mediterranean herbs and citrus fruits, have been studied for their potential to modulate inflammatory signaling in IBD. However, there is still conflicting and inconclusive evidence regarding their effectiveness. This review evaluates preclinical studies on terpenes and their impact on basic inflammatory signaling in IBD.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Joseph Sleiman, Asif A. Hitawala, Benjamin Cohen, Katie Falloon, Marian Simonson, Benjamin Click, Urmi Khanna, Anthony P. Fernandez, Florian Rieder
Summary: The study revealed that Sweet syndrome may precede or occur concurrently with inflammatory bowel disease in a significant proportion of cases. Azathioprine-associated Sweet syndrome and IBD-related Sweet syndrome present distinct clinical characteristics and treatment responses.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Public, Environmental & Occupational Health
Wafa Alimam, Atte Nikkila, Jani Raitanen, Kaija-Leena Kolho, Anssi Auvinen
Summary: The purpose of the study was to examine the association between residential mobility and childhood inflammatory bowel disease (IBD) risk. The findings suggest a slightly decreased risk of childhood IBD associated with residential mobility, especially when moving to rural areas and distances less than 50 km.
ANNALS OF EPIDEMIOLOGY
(2023)
Review
Chemistry, Medicinal
Dandan Liu, Varma Saikam, Katie A. Skrada, Didier Merlin, Suri S. Iyer
Summary: Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract, which can be diagnosed through endoscopy and biopsy. However, these methods are expensive and invasive, so alternative noninvasive biomarkers are being explored for disease management and prognosis.
MEDICINAL RESEARCH REVIEWS
(2022)
Review
Gastroenterology & Hepatology
Anna M. Buchner, Yecheskel Schneider, Gary R. Lichtenstein
Summary: Biological therapy targeting tumor necrosis factor-alpha has become crucial in treating patients with inflammatory bowel disease, but high costs limit accessibility. Biosimilars offer the potential to reduce expenditures and increase availability, providing more options for patients.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Dermatology
Khalaf Kridin, Ralf J. Ludwig
Summary: Isotretinoin does not increase the risk of Crohn's disease, but it may be associated with a slight and temporary increase in the risk of ulcerative colitis. However, it can lower the risk of irritable bowel syndrome.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Natalia Mouratidou, Petter Malmborg, Jacob Jaras, Vignir Sigurdsson, Olof Sandstrom, Ulrika L. Fagerberg, Gabriella Broms, Jonas F. Ludvigsson, Ola Olen
Summary: The validity of register-based definitions of childhood-onset inflammatory bowel disease (IBD) in the Swedish National Patient Register (NPR) is high and can be used to identify patients in observational research.
CLINICAL EPIDEMIOLOGY
(2022)
Article
Pediatrics
Nagehan Emiralioglu, Dilber Ademhan Tural, Hayriye Hizarcioglu Gulsen, Yasin Maruf Ergen, Beste Ozsezen, Birce Sunman, Incinur Saltik Temizel, Ebru Yalcin, Deniz Dogru, Ugur Ozcelik, Nural Kiper
Summary: The incidence of CD in CF patients is about 1.4%, with common symptoms being poor weight gain and fatty stools before CD diagnosis. Symptoms usually improve after starting a gluten-free diet._CFTR dysfunction has been suggested to increase susceptibility to CD, and CF patients with persistent gastrointestinal symptoms despite treatment should be screened for CD.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Pediatrics
Asuman Nur Karhan, Saliha Esenboga, Ersin Gumus, Betul Karaatmaca, Deniz Cagdas, Hulya Demir, Inci Nur Saltik Temizel, Hasan Ozen, Aysel Yuce, Ilhan Tezcan
Summary: The nutritional status of patients with primary immunodeficiencies (PID) was evaluated in this study. Malnutrition was found to be common among PID patients, with chronic, acute, and mixed-type malnutrition detected in a significant portion of the patients. Hospitalization history was inversely related to body mass index and weight for age Z-scores, and patients with malnutrition had daily caloric intake below requirements.
PEDIATRICS INTERNATIONAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Buket Acar, Ersin Gumus, Selcen Ozcan-Bulut, Cansu Ozsin-Ozler, Meryem Seda Boyraz, Cagman Tan, Ismail Yaz, Begum Ozbek, Deniz Cagdas, Inci Nur Saltik-Temizel, Hulya Demir, Hasan Ozen, Erdem Karabulut, Ilhan Tezcan, Aysel Yuce, Ezel Berker
Summary: The cytokine profile in gingival crevicular fluid and serum of pediatric inflammatory bowel disease (IBD) patients was evaluated, with 50 IBD patients and 21 healthy children enrolled in the study. Patients with IBD were categorized into subgroups based on disease activity and response to treatment, and the levels of pro- and anti-inflammatory cytokines were measured. Results showed that disease activity might impact gingival inflammation in pediatric patients with IBD due to increased cytokine interactions and severity of inflammation.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Pediatrics
Pinar Simsek Onat, Duygu Demirtas, Hayriye Hizarcioglu Gulsen, Ersin Gumus, Inci Nur Saltik Temizel, Hasan Ozen, Hulya Demir, Erkan Parlak
Summary: A retrospective analysis of 46 pediatric patients who underwent ERCP at Hacettepe University revealed a strong correlation between levels of neurotensin and obesity-related markers. Chronic pancreatitis and acute pancreatitis were the most common indications for ERCP in these patients, with endoscopic sphincterotomy being the most common treatment method.
GUNCEL PEDIATRI-JOURNAL OF CURRENT PEDIATRICS
(2021)
Article
Gastroenterology & Hepatology
Pinar Simsek-Onat, Hayriye Hizarcioglu-Gulsen, Yasin Maruf Ergen, Ersin Gumus, Hasan Ozen, Hulya Demir, Seza Ozen, Inci Nur Saltik-Temizel
Summary: This study found that neutrophil-to-lymphocyte ratio (NLR) values in pediatric inflammatory bowel disease (IBD) were significantly higher during diagnosis and active disease compared to the remission period. NLR can be used as a non-invasive inflammatory biomarker for initial evaluation and follow-up of disease activity in children with IBD.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Transplantation
Hayriye Hizarcioglu-Gulsen, Ersin Gumus, Hulya Demir, Inci N. Saltik-Temizel, Ali Varan, Hilmi Anil Dincer, Ahmet Bulent Dogrul, Hasan Ozen
Summary: Immunosuppressive therapy carries risks for complications, including opportunistic infections and posttransplant lymphoproliferative disease. This case report highlights the development of posttransplant lymphoproliferative disease in a 3.5-year-old boy who was seropositive for Epstein-Barr virus after liver transplant.
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2022)
Article
Pediatrics
Ersin Gumus, Asuman Nur Karhan, Numan Demir, Tutku Soyer, Hasan Ozen, Feridun Cahit Tanyel
Summary: This study assessed the role of intraluminal impedance (MII-pH) in evaluating GERD in children with repaired esophageal atresia (EA). The results showed that the majority of reflux episodes in these patients were non-acidic and could not be detected with standard pH monitoring. Therefore, MII-pH monitoring should be preferred over conventional pH monitoring in the surveillance of EA patients.
GUNCEL PEDIATRI-JOURNAL OF CURRENT PEDIATRICS
(2022)
Article
Medicine, General & Internal
Zeynelabidin Ozturk, Hulya Demir, Asuman Nur Karhan, Inci Nur Saltik Temizel, Hasan Ozen
Summary: This study analyzed 158 children who received 179 episodes of individualized parenteral nutrition. The most common indications were hematological malignancies, gastrointestinal surgery, and hematopoietic stem cell transplantation. The most common metabolic complications included electrolyte imbalances and elevated liver enzymes. Central venous catheters were more efficient for providing targeted energy. Maintaining blood glucose, lipids, and electrolyte levels within the normal range is crucial for individualized parenteral nutrition.
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Editorial Material
Pediatrics
Demet Baltu, Eda Didem Kurt Sukur, Ersin Gumus, Tugba Tastemel Ozturk, Yasin Maruf Ergen, Duygu Demirtas, Bora Gulhan, Fatih Ozaltin, Diclehan Orhan, Hasan Ozen, Ali Duzova
PEDIATRIC NEPHROLOGY
(2023)
Editorial Material
Pediatrics
Demet Baltu, Eda Didem Kurt Sukur, Ersin Gumus, Tugba Tastemel Ozturk, Yasin Maruf Ergen, Duygu Demirtas, Bora Gulhan, Fatih Ozaltin, Diclehan Orhan, Hasan Ozen, Ali Duzova
PEDIATRIC NEPHROLOGY
(2023)
Review
Pediatrics
Merve Guvenoglu, Pelin Ozlem Simsek-Kiper, Can Kosukcu, Ekim Z. Taskiran, Inci Nur Saltik-Temizel, Safak Gucer, Eda Utine, Koray Boduroglu
Summary: Congenital diarrheal disorders are rare intestinal diseases that occur in infants and have a genetic basis. This study reports a case of a 17-month-old male infant with congenital diarrhea, and molecular autopsy and histopathological examination revealed that the patient had intestinal epithelial tufting enteropathy.
PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION
(2022)
Article
Pediatrics
Gulnar Agakisiyeva, Damla Yildirim, Hayriye Hizarcioglu-Gulsen, Ersin Gumus, Asuman N. Karhan, Erdem Karabulut, Hasan Ozen, Hulya Demir, Inci N. Saltik-Temizel
Summary: Dietary habits may be a risk factor for functional constipation, especially during rapid growth period. Higher carbohydrate and lower fat intake may be associated with an increased risk of functional constipation. Longer duration of breastfeeding and more frequent use of squatting toilet may be related to a lower risk of functional constipation.
MINERVA PEDIATRICS
(2022)
Article
Pediatrics
Asuman Nur Karhan, Hayriye Hizarcioglu-Gulsen, Ersin Gumus, Zuhal Akcoren, Hulya Demir, Inci Nur Saltik-Temizel, Diclehan Orhan, Hasan Ozen
Summary: This study identified the etiologies of hepatic steatosis in children through a retrospective review of liver biopsies. The most common diagnoses were inborn errors of metabolism and nonalcoholic fatty liver disease/steatohepatitis. Patients with inborn errors of metabolism had higher rates of consanguineous marriage and positive family history compared to those with NAFLD/NASH, along with common clinical and biochemical findings.
PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION
(2021)
