Journal
JOURNAL OF CRITICAL CARE
Volume 27, Issue 2, Pages 108-118Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.jcrc.2011.06.001
Keywords
Endothelium; pH; Intracellular; Acidosis; Regulation
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Funding
- Progetto di Rilevante Interesse Nazionale Ministero Italiano Universita e Ricerca
- Foundation Jerome Leyeune (Paris, France)
- Regione Campania
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The endothelium represents the largest functional organ in the human body playing an active role in vasoregulation, coagulation, inflammation, and microvascular permeability. Endothelium contributes to maintain vascular integrity, intravascular volume, and tissue oxygenation promoting inflammatory network response for local defense and repair. Acid-basis homeostasis is an important physiologic parameter that controls cell function, and changes in pH can influence vascular tone by regulating endothelium and vascular smooth muscle cells. This review presents a current perspective of the effects of intracellular acidosis on the function and the basic regulatory mechanisms of endothelial cells. (C) 2012 Published by Elsevier Inc.
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