Article
Medicine, General & Internal
Lisa Takahashi, Tomoaki Ishigami, Hirofumi Tomiyama, Yuko Kato, Hiroyuki Kikuchi, Koichiro Tasaki, Jun Yamashita, Shigeru Inoue, Masataka Taguri, Toshitaka Nagao, Taishiro Chikamori, Yoshihiro Ishikawa, Utako Yokoyama
Summary: Research has shown that myosin-11 may serve as a biomarker for detecting spatial expansion of atherosclerotic regions, with circulating levels associated with the presence of multiple atherosclerotic areas. Additionally, myosin-11 is predominantly expressed in the medial layer of human atherosclerotic lesions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Physiology
Joseph Foon Yoong Hoh
Summary: The kinetics of myosin control the speed and power of muscle contraction. Mammalian skeletal muscles express twelve kinetically different myosin heavy chain (MyHC) genes, providing a wide range of muscle speeds to meet various functional demands. This review provides an overview of the historical and current views on how cell lineage, neural impulse patterns, and thyroid hormone influence MyHC gene expression in limb muscles during development and adult life, and the molecular mechanisms involved.
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2023)
Article
Anatomy & Morphology
Vika Smerdu
Summary: In order to verify the co-expression of the "novel" MyHC-15, -2x, and -2b isoforms with other known isoforms in human intrafusal fibres, a set of antibodies were used to demonstrate the expression of nine isoforms in different regions of intrafusal fibres in two upper limb muscles. The expression pattern of isoforms differs along the length, across different muscle spindles and muscles, and may depend on the antibodies used.
JOURNAL OF ANATOMY
(2023)
Article
Clinical Neurology
C. A. Sewrya, L. Feng, D. Chambers, E. Matthews, R. Phadke
Summary: The study found that embryonic myosin heavy chains are down-regulated at or soon after birth, while fetal myosin heavy chains are down-regulated at 4-6 months. The co-expression of embryonic and fetal myosin heavy chains in dystrophic muscle may suggest delays in maturation or underlying abnormalities. Embryonic myosin heavy chains are a useful marker for regeneration, but other factors like denervation and stress must also be considered.
NEUROMUSCULAR DISORDERS
(2021)
Article
Cell Biology
Michaeljohn Kalakoutis, Ross D. D. Pollock, Norman R. R. Lazarus, R. Andrew Atkinson, Marc George, Onur Berber, Roger C. C. Woledge, Julien Ochala, Stephen D. R. Harridge
Summary: The specific force (SF) of human aging in single muscle fibers is inconsistent in different studies, which may result from variations in the health status/physical activity levels and methodological differences. This study compared SF in fibers from older hip fracture patients, healthy master cyclists, and healthy nontrained young adults using two different activating solutions. The results showed that the activating solution significantly affected the force and revealed a difference in sensitivity in muscle fibers of hip fracture patients.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Physiology
Joseph F. Y. Hoh
Summary: This review examines the kinetic properties and distribution of MyHC in extraocular muscles, as well as their regulation and function. Different MyHC are regulated by different mechanisms in neurogenic and myogenic processes and express differently during development. Lastly, the combination of different MyHC and speeds play a role in accomplishing eye movement tasks.
Review
Biochemistry & Molecular Biology
Gabryela Kuhnen, Tiago Guedes Russomanno, Marta Murgia, Nicolas J. Pillon, Martin Schoenfelder, Henning Wackerhage
Summary: Adult skeletal muscle fibres can be classified into different types based on the expression of specific genes. The proportions of these muscle fibre types can be altered through gene gain or loss-of-function. In particular, transcriptional regulators play a significant role in regulating the expression of muscle fibre-specific genes. After exercise, the expression of certain genes increases or decreases, suggesting their involvement in muscle fibre adaptation. DNA sequence variants of muscle fibre genes may contribute to the variation in muscle fibre type proportions in the human population.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Romain Nicot, Gwenael Raoul, Alexandre R. Vieira, Joel Ferri, James J. Sciote
Summary: This study explored the association between genetic polymorphisms in ACTN3 and bruxism, and found that ACTN3 genotypes influence self-reported bruxism in patients with dentofacial deformity through specific masseter muscle fiber characteristics.
Article
Cell Biology
Travis Ruan, Dylan Harney, Yen Chin Koay, Lipin Loo, Mark Larance, Leslie Caron
Summary: Skeletal muscle weakness is associated with negative health outcomes. Current research lacks adequate cellular models, but this study developed a scalable monolayer system to differentiate human embryonic stem cells into mature skeletal muscle cells within 26 days. The combination treatment of testosterone, follistatin, and a cocktail of myokines further enhanced muscle cell differentiation and fusion. This cellular model provides a powerful tool for studying muscle development and drug discovery.
Article
Sport Sciences
Gaspard Fournier, Clara Bernard, Maxime Cievet-Bonfils, Raymond Kenney, Maxime Pingon, Elliot Sappey-Marinier, Benedicte Chazaud, Julien Gondin, Elvire Servien
Summary: This study aimed to compare the composition of the semitendinosus muscle between men and women. The results showed that men had a lower proportion of SDH-positive muscle fibers and a higher percentage of fast muscle fibers. There were also differences in the distribution and cross-sectional area of MyHC isoforms. These sex differences may have functional consequences.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2022)
Article
Biochemistry & Molecular Biology
Hao Guan, Ikuo Yonemitsu, Yuhei Ikeda, Takashi Ono
Summary: This study aimed to investigate the effects of functional mandibular lateral shift (FMLS) on masticatory muscles in growing rats and whether these effects can be reversed. FMLS was shown to lead to changes in muscle mass, fiber size, fiber type, and gene expression in the masticatory muscles. However, these changes were found to revert to normal conditions after a recovery period. Therefore, early orthodontic treatment for FMLS is recommended to prevent asymmetric alterations in masticatory muscles.
Article
Dentistry, Oral Surgery & Medicine
E. Tentolouri, G. S. Antonarakis, I Georgiakaki, S. Kiliaridis
Summary: The study found that the impact of different treatment methods on the treatment outcome of Class II division 1 malocclusion patients varies. In functional appliance treatment, masticatory muscle thickness has a certain influence on treatment outcomes, while there is no significant correlation in fixed appliance treatment.
EUROPEAN JOURNAL OF PAEDIATRIC DENTISTRY
(2021)
Article
Biochemistry & Molecular Biology
Keisuke Hitachi, Yuri Kiyofuji, Hisateru Yamaguchi, Masashi Nakatani, Masafumi Inui, Kunihiro Tsuchida
Summary: This study investigated the effects of the loss of MyHC-IIb and MyHC-IIx on skeletal muscle function using a mouse model. The results showed that the simultaneous loss of IIb and IIx led to severe muscle hypoplasia after 2 weeks of age in mice. Increased expression of other MyHCs was observed in 3-week-old mice, but it was not sufficient to compensate for the loss of IIb and IIx. Aberrant sarcomere structure and altered expression of sarcomere components were also observed. These findings contribute to the understanding of molecular mechanisms underlying skeletal muscle wasting disorders caused by the loss of skeletal muscle MyHCs.
Article
Dentistry, Oral Surgery & Medicine
Chiaki Nakamura, Iwao Sato, Yoko Ueda, Shinichi Kawata, Kenta Nagahori, Takuya Omotehara, Tomiko Yakura, Yutaro Natsuyama, Zhong-Lian Li, Masahiro Itoh
Summary: The study investigates the relationship between learning and memory deficits, hippocampal pathologic changes, and reduced masseter muscle (MM) function caused by toothlessness and soft diet feeding in senescence-accelerated mouse prone 8 (SAMP8) strain. The results show that CGRP and VEGF-A are involved in MM formation in aging SAMP8 mice. Additionally, MyHC isoform expression also changes under different chewing conditions.
JOURNAL OF ORAL REHABILITATION
(2023)
Article
Physiology
Alexander Sonne, Anna Katarina Antonovic, Elise Melhedegaard, Fariha Akter, Jesper L. Andersen, Heinz Jungbluth, Nanna Witting, John Vissing, Edmar Zanoteli, Arianna Fornili, Julien Ochala
Summary: This study aimed to investigate whether mutations in the RYR1 gene, which is related to muscle disorders, affect the regulation of myosin. The results showed that these mutations may have negative consequences on the structure and function of myosin, contributing to the phenotype of congenital myopathy.
Letter
Dentistry, Oral Surgery & Medicine
Romain Nicot, Matthias Schlund, Gwenael Raoul
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2019)
Article
Dentistry, Oral Surgery & Medicine
Romain Nicot, Matthias Schlund, Camille Sentucq, Gwenael Raoul
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2019)
Article
Dentistry, Oral Surgery & Medicine
Fanny Bruguiere, James J. Sciote, Thomas Roland-Billecart, Gwenael Raoul, Francois Machuron, Joel Ferri, Romain Nicot
JOURNAL OF ORAL REHABILITATION
(2019)
Article
Dentistry, Oral Surgery & Medicine
M. Schlund, A. Depeyre, G. Raoul, R. Nicot
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2019)
Article
Dentistry, Oral Surgery & Medicine
Romain Nicot, Charles Druelle, Matthias Schlund, Thomas Roland-Billecart, Raoul Gwenael, Joel Ferri, Didier Gosset
DENTAL TRAUMATOLOGY
(2019)
Article
Dentistry, Oral Surgery & Medicine
L. Marti-Flich, M. Schlund, G. Raoul, J-M Maes, J. Ferri, T. Wojcik, R. Nicot
JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY
(2020)
Article
Dentistry, Oral Surgery & Medicine
C. Druelle, M. Schlund, J-C Lutz, M. Constant, G. Raoul, R. Nicot
JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY
(2020)
Review
Dentistry, Oral Surgery & Medicine
R. Nicot, G. Raoul, J. Ferri, M. Schlund
JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY
(2020)
Article
Dentistry, Oral Surgery & Medicine
T. Roland-Billecart, G. Raoul, M. Kyheng, J. J. Sciote, J. Ferri, R. Nicot
Summary: A study of 183 orthognathic surgery patients found no significant difference in TMJ health after BSSO between different types of osteosynthesis. The hybrid fixation technique offers advantages and does not impact postoperative TMD compared to miniplate fixation.
JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY
(2021)
Letter
Dentistry, Oral Surgery & Medicine
M. Schlund, G. Raoul, L. Marti-Flich, R. Nicot
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2020)
Article
Multidisciplinary Sciences
Romain Nicot, Kay Chung, Alexandre R. Vieira, Gwenael Raoul, Joel Ferri, James J. Sciote
Article
Dentistry, Oral Surgery & Medicine
A. Laventure, G. Raoul, R. Nicot, J. Ferri, L. Lauwers
Summary: After autogenic bone grafting, patients with oligodontia had an average horizontal bone graft increase of 4.60 mm and an average sinus lift increase of 9.95 mm. The average number of implants placed per patient was 9, with 5 of them placed on grafted sites. The overall implant survival rate was 100%, leading to significant improvements in patient quality of life through implant-supported fixed dentures.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2021)
Review
Dentistry, Oral Surgery & Medicine
Romain Nicot, Florent Barry, Henry Chijcheapaza-Flores, Maria Jose Garcia-Fernandez, Gwenael Raoul, Nicolas Blanchemain, Feng Chai
Summary: The study aimed to develop minimally invasive therapies for temporomandibular joint osteoarthritis (TMJOA) and evaluate pain models in rats. Among the 59 reviewed papers, 18 long-term TMJOA-related pain models were identified, induced by injection of toxic substances or physical methods.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Allan Bokobza, Ludovic Lauwers, Gwenael Raoul, Romain Nicot, Joel Ferri
Summary: This study evaluated an advanced technique for restoring atrophic premaxilla, repositioning implants through segmental osteotomy for anatomically and physiologically optimal occlusal function. Results show successful functional and aesthetic outcomes in a small group of patients, but further validation with a larger sample size is needed.
JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Florent Barry, Matthias Schlund, Gwenael Raoul, Luc Myon, Joel Ferri, Romain Nicot
Summary: Pedicle ossification after maxillofacial reconstruction with bony free flap is a rare and misunderstood complication. It is usually asymptomatic but may result in severe clinical symptoms. This study proposes a classification for pedicle ossification based on radiological features and vascular calcification progression and describes a case of metachronous ossification.
JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY
(2022)