Article
Otorhinolaryngology
Mac Kenzie Reece, Hannah Walker, Isabella Benintendi, Stacey Ward, Ashley Thatcher, R. Michael Johnson, Sameep P. Kadakia
Summary: The clinical use of Integra(TM) has expanded to include scalp reconstruction since its FDA approval in 1996. In this study, the authors aim to describe their protocol for delaying scalp reconstruction with skin grafting following dermal regeneration using Integra(TM), and the results have been predictable and reproducible.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Review
Dentistry, Oral Surgery & Medicine
G. Romano, J. Bouaoud, A. Moya-Plana, N. Benmoussa, J. -F. Honart, N. Leymarie
Summary: The study compared the use of Integra dermal regeneration template in scalp reconstruction after tumor resection by analyzing literature and a series of 20 patients. Results showed that in large scalp full thickness defects after cancer resection, DRT appears to be a suitable reconstruction option for patients with comorbidities and aggressive tumors. This technique allows immediate coverage of the calvarium with short operative time and prevents healing delay, while maintaining oncologic follow-up and facilitating the diagnosis of cancer recurrences.
JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY
(2021)
Review
Medicine, General & Internal
Philippe Taupin, Ankur Gandhi, Sunil Saini
Summary: Integra Dermal Regeneration Template is a bilayer membrane made of cross-linked type I collagen and glycosaminoglycans, with a semi-permeable silicone sheet cover. It guides wound repair towards a regenerative pathway through stages such as imbibition, fibroblast migration, neovascularization, and remodeling/maturation. Its application has expanded from burn treatment to reconstructive surgery.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Otorhinolaryngology
Jacob C. Maus, Kshipra Hemal, Mija Khan, Bennett W. Calder, Malcolm W. Marks, Anthony J. Defranzo, Ivo Alexander Pestana
Summary: The use of dermal regeneration template and staged skin grafting is a reliable option for post-cancer scalp reconstruction in poor flap candidates, while radiotherapy is associated with adverse outcomes. Negative pressure wound therapy simplifies postoperative wound care regimens and may accelerate healing, providing better results compared to other methods.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Clinical Neurology
Madelyn Stroder, Jeffrey S. Litt, N. Scott Litofsky
Summary: Reconstructive salvage of complex cranial and scalp defects takes time and a multidisciplinary approach. Patient age and duration of reconstruction treatment may impact outcomes, with judicious choice of materials and techniques being critical to success.
WORLD NEUROSURGERY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Alfonso Mogedas-Vegara, Eugenia Agut-Busquet, Mireia Yebenes Marsal, Jesus Luelmo Aguilar, Oscar Escuder de la Torre
Summary: The study retrospectively analyzed the experience of using Integra in scalp reconstruction surgery for elderly patients with oncologic scalp defects. The results showed a high success rate and low incidence of complications, making it suitable for patients with comorbidities.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2021)
Article
Urology & Nephrology
Marco Falcone, Mirko Preto, Davide Ciclamini, Federica Peretti, Anna Scarabosio, Gideon Blecher, Lorenzo Cirigliano, Ilaria Ferro, Natalia Plamadeala, Martina Scavone, Massimiliano Timpano, Paolo Gontero
Summary: The combination of acellular dermal matrix with split thickness skin grafts shows significant advantages in terms of operative, functional and cosmetic outcomes for phalloplasty, including shorter healing time, improved graft take, shorter operative time, reduced hospital stay, and higher satisfaction with cosmesis.
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2023)
Article
Surgery
Sammy Othman, Sameer Shakir, Said C. Azoury, Tess Lukowiak, Thuzar M. Shin, Joseph F. Sobanko, Christopher J. Miller, Jeremy R. Etzkorn, John P. Fischer, Stephen J. Kovach
Summary: This study evaluated different methods for scalp defect reconstruction. The results showed that local tissue rearrangement may be more reliable for smaller defects, while Bilayer Wound Matrix may have comparable efficacy to free flap reconstruction for larger defects and may be more cost-effective.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Clinical Neurology
Andrea Scotti, Elisa Benanti, Federica Augelli, Franz Wilhelm Baruffaldi Preis
Summary: Aplasia cutis congenita is a rare congenital abnormality characterized by the absence of a portion of skin at birth. Treatment options vary, and the use of Integra(R) Dermal regeneration template can be effective in treating this condition.
PEDIATRIC NEUROSURGERY
(2021)
Review
Otorhinolaryngology
Shivam Patel, Kasra Ziai, Jessyka G. Lighthall, Scott G. Walen
Summary: Acellular dermal matrices (ADMs) are composed of a basement membrane and acellular dermal layer of collagen, providing a platform for mucosal epithelization and neovascularization. They support adequate wound healing and soft tissue repairs, reducing the need for autologous tissue grafts and minimizing donor site morbidity. The literature on ADMs in head and neck reconstruction for cosmetic and reconstructive purposes is rapidly evolving.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2022)
Article
Genetics & Heredity
Fedele Lembo, Domenico Parisi, Liberato Roberto Cecchino, Francesco Ciancio, Alessandro Innocenti, Aurelio Portincasa
Summary: The study presented the experience in microsurgical treatment of pseudosyndactylies in recessive dystrophic epidermolysis bullosa (RDEB) patients, comparing traditional dressing with vaseline gauze with an innovative glove protocol using Integra((R)) dermal regeneration template. The new protocol showed significant advantages in reducing hospital stay time, healing time, dressing pain and increasing recurrence-free interval, providing consistent and successful long-term results for the patients.
ORPHANET JOURNAL OF RARE DISEASES
(2021)
Article
Surgery
Toshifumi Akazawa, Mitsuru Sekido
Summary: In this study, the authors successfully treated refractory lateral malleolar ulcers using PAT grafts and Integra template. The patients achieved good dermal regeneration and reported improved quality of life without recurrence. This minimally invasive method is particularly suitable for elderly patients and reduces postoperative pain.
INDIAN JOURNAL OF SURGERY
(2023)
Article
Medicine, General & Internal
Marzia Petrocelli, Giulia Togo, Silvia Ricci, Flavia Zeneli, Sebastiano Cutrupi, Annamaria Baietti, Paola Bonavolonta, Luigi Califano, Luigi Angelo Vaira, Alfonso Scarpa, Arianna Di Stadio, Giovanni Salzano
Summary: Although scalp avulsion is rare, it poses challenges in terms of management and esthetic restoration due to involvement of neurovascular structures and scar retraction. Various algorithms and techniques are available for extensive scalp defect reconstruction, depending on the type of defect. In this study, we describe six cases of total scalp avulsion that underwent immediate combined reconstruction with split-thickness skin graft (STSG) and Integra(R) matrix.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Muhammad Harirah, Kyle Sanniec, Tyler Yates, Omar Harirah, James F. Thornton
Summary: Scalp reconstruction has evolved with time, presenting challenges particularly in cases of scalp cancers with large defects. More than 10 years of consecutive scalp reconstructions by the senior author provided data and recommendations for surgeons. Most defects were repaired using adjacent tissue transfer or Integra dermal regeneration templates, with some complications observed but scalp reconstruction was deemed safe for outpatient settings, even in elderly patients.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Review
Dermatology
Gustavo E. Prezzavento, Rodrigo N. Juarez Calvi, Juan A. Rodriguez, Philippe Taupin
Summary: Objective: This study aimed to evaluate the use of Integra Dermal Regeneration Template (IDRT) in the reconstruction of skin tumor defects. The results showed that IDRT is a valid option for reconstructing oncologic surgical defects of the skin in different anatomical locations. Patients reported satisfaction with the results and no cases of infection were encountered.
JOURNAL OF WOUND CARE
(2022)