Article
Clinical Neurology
Lawrence R. Robinson
Summary: This article reviews the epidemiology, classification, localization, prognosis, and mechanisms of recovery of traumatic peripheral nerve injuries (PNIs). Electrodiagnostic assessments are critical in treating patients with PNIs, as they aid in localizing the injury and determining the extent of axon loss. Mechanisms of recovery may include recovery from conduction block, muscle fiber hypertrophy, distal axonal sprouting, and axon regrowth. Early surgical intervention is recommended for patients with complete or severe nerve injuries.
Article
Clinical Neurology
Stewart Yeoh, Wesley S. Warner, Ilyas Eli, Mark A. Mahan
Summary: The study compared different types of nerve injuries in mice and found that closed traction injuries resulted in more severe and long-term neurological deficits compared to other types of injuries. This suggests that stretch injuries present unique pathology and functional deficits, providing an opportunity to study the pathophysiology of clinical injury mechanisms. Further validation in large animal models will be needed for comparison with human injuries.
JOURNAL OF NEUROSURGERY
(2021)
Article
Engineering, Biomedical
Qi Quan, Lei Hong, Yu Wang, Rui Li, Xin Yin, Xiaoqing Cheng, Guangbo Liu, He Tang, Haoye Meng, Shuyun Liu, Quanyi Guo, Biqin Lai, Qing Zhao, Min Wei, Jiang Peng, Peifu Tang
Summary: Hypoxia in damaged tissues may play a key role in stimulating macrophages, promoting endothelial-to-mesenchymal transition, and driving the migration of endothelial cells to the injured region to form regenerative bridge tissue. The final nerve defect repair outcomes were similar with autografts after intervention by this material, challenging the view that hypoxia is exclusively involved in peripheral nerve regeneration.
Article
Biophysics
Tanmay Majmudar, Sriram Balasubramanian, Rachel Magee, Bernard Gonik, Anita Singh
Summary: Characterizing the viscoelastic behavior of neonatal peripheral nerves is crucial for understanding stretch-related peripheral nerve injuries. This study investigated the viscoelastic stress relaxation response of neonatal piglet brachial plexus and tibial nerves at different strain levels and testing durations. The biomechanical data revealed that there were no significant differences in stress relaxation between two strain levels after 90 seconds, but stress reduction was slightly higher at 10% strain compared to 20% after 300 seconds. Additionally, nerves tested for 300 seconds showed significantly higher stress reduction compared to 90 seconds for both strain levels and nerve types.
JOURNAL OF BIOMECHANICS
(2021)
Review
Biochemistry & Molecular Biology
Elena Stocco, Silvia Barbon, Aron Emmi, Cesare Tiengo, Veronica Macchi, Raffaele De Caro, Andrea Porzionato
Summary: In peripheral nerve injuries with substance loss, graft positioning is required. The available options include autografts, allografts, and hollow nerve conduits. However, none of the current alternatives fully satisfy the anatomical and functional nerve regeneration requirements, and future research should focus on wall and/or inner lumen organization/functionalization. This review aims to describe common alternatives for severe peripheral nerve injury recovery, highlighting future conduits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Hu Yang, Yanzhao Dong, Zewei Wang, Jingtian Lai, Chenjun Yao, Haiying Zhou, Ahmad Alhaskawi, Sohaib Hasan Abdullah Ezzi, Vishnu Goutham Kota, Mohamed Hasan Abdulla Hasan Abdulla, Hui Lu
Summary: Traumatic neuromas are hyperplastic, reparative nerve reactions following trauma or surgery, manifesting as nodular masses. Common symptoms include painful hypersensitivity and neuralgic pain caused by trigger points, significantly impacting patients' quality of life.
FRONTIERS IN NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Martin Aman, Maximilian Mayrhofer-Schmid, Daniel Schwarz, Martin Bendszus, Simeon C. Daeschler, Tess Klemm, Ulrich Kneser, Leila Harhaus, Arne H. Boecker
Summary: This study investigates the potential of an acellular collagen-elastin matrix wrapped around a peripheral nerve after induction of scar tissue formation. The results show that the application of a collagen-elastin matrix around the nerve can reduce scar tissue formation, promote nerve regeneration, and improve functional recovery.
Article
Cell Biology
Yu-Mei Feng, Jian Shao, Min Cai, Yi-Yue Zhou, Yi Yao, Jia-Xi Qian, Zi-Han Ding, Mao-Rong Jiang, Deng-Bing Yao
Summary: Our previous studies have shown that lncRNA H19 is upregulated in injured rat sciatic nerve during Wallerian degeneration and affects neural repair and regeneration. In this study, we disrupted or overexpressed lncRNA H19 in rats and found that its overexpression inhibited axon growth but enhanced myelination. Gait and pain analysis revealed that lncRNA H19 overexpression delayed functional recovery, while interfering with its expression improved recovery.
NEURAL REGENERATION RESEARCH
(2023)
Article
Neurosciences
Andrei V. Chernov, Veronica I. Shubayev
Summary: Sexual dimorphism is a powerful yet understudied factor that influences the timing and efficiency of gene regulation in axonal injury and repair processes in the peripheral nervous system. By studying the degenerating nerve stumps of different sexes, we have identified common and distinct biological processes, enriching our knowledge of transcriptional regulation in peripheral nerve injury and repair.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Environmental Sciences
Wolfgang Grisold, Valentina Alda Carozzi
Summary: Toxic neuropathies are caused by various substances through different mechanisms, with a wide range of toxic agents that can affect the nervous system in different ways. Clinically, the most common type is cumulative toxicities, presenting as axonal symmetric neuropathies.
Article
Otorhinolaryngology
Kayva L. L. Crawford, Yu-Jin Lee, Marisa Hom, Eben L. L. Rosenthal, Ryan K. K. Orosco, Quyen T. T. Nguyen
Summary: We demonstrate the efficacy of ALM-488 in labeling degenerated facial nerves using quantitative image analysis and qualitative survey data in a murine facial nerve transection model.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Review
Biochemistry & Molecular Biology
Tariq Malik, Ahmed Malik, Alaa Abd-Elsayed
Summary: Work-related injuries are common and costly, especially when nerve damage is involved. Preventing work-related nerve dysfunction is challenging due to its multifactorial nature. Currently, there are no evidence-based guidelines for clinicians to evaluate work-related nerve dysfunction, making effective management difficult. Further research is needed to better understand the pathophysiology of chronic nerve injury and identify new targets for pharmacological interventions.
Article
Radiology, Nuclear Medicine & Medical Imaging
Kanav Goyal, Purnima Aggarwal, Monica Gupta
Summary: This study compared the CSA of the sural and tibial nerves in diabetic peripheral neuropathy patients, finding that the CSA of the tibial nerve had higher sensitivity in the DPN group for screening purposes. Ultrasound can be used as the initial diagnostic tool for detecting DPN, especially in cases where nerve conduction studies are negative.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jonathan T. Reeder, Zhaoqian Xie, Quansan Yang, Min-Ho Seo, Ying Yan, Yujun Deng, Katherine R. Jinkins, Siddharth R. Krishnan, Claire Liu, Shannon McKay, Emily Patnaude, Alexandra Johnson, Zichen Zhao, Moon Joo Kim, Yameng Xu, Ivy Huang, Raudel Avila, Christopher Felicelli, Emily Ray, Xu Guo, Wilson Z. Ray, Yonggang Huang, Matthew R. MacEwan, John A. Rogers
Summary: The study introduces an implantable microfluidic device that provides targeted and minimally invasive cooling power with real-time temperature feedback control in living tissues, allowing for the elimination of pain signals at arbitrary depths.
Article
Radiology, Nuclear Medicine & Medical Imaging
Peng Loon Cheah, Thiagu Krisnan, Jeannie Hsiu Ding Wong, Faizatul Izza Rozalli, Farhana Fadzli, Kartini Rahmat, Nortina Shahrizaila, Li Kuo Tan, Ouzreiah Nawawi, Norlisah Ramli
Summary: This study investigated the utility of DTI in determining the microstructural integrity of nerves in CMT patients. Significant differences in DTI parameters were found between CMT and controls, with correlations between DTI parameters, muscle atrophy grade, and CMTNS. FA and RD were shown to be able to discriminate CMT from controls with high sensitivity and specificity.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Surgery
Ajani G. Nugent, Zubin Panthaki, Seth Thaller
JOURNAL OF CRANIOFACIAL SURGERY
(2015)
Article
Surgery
Dragana Ajdic, Yasmina Zoghbi, David Gerth, Zubin J. Panthaki, Seth Thaller
AESTHETIC SURGERY JOURNAL
(2016)
Review
Oncology
Rachita Sood, Jeena M. Easow, Geoffrey Konopka, Zubin J. Panthaki
Article
Critical Care Medicine
Ali M. Soltani, Matthew J. Best, Cameron S. Francis, Bassan J. Allan, Morad Askari, Zubin J. Panthaki
JOURNAL OF BURN CARE & RESEARCH
(2014)
Editorial Material
Surgery
Zubin Jal Panthaki
JOURNAL OF CRANIOFACIAL SURGERY
(2014)
Meeting Abstract
Oncology
C. Takita, I. M. Reis, D. Yakoub, Z. Panthaki, C. Boneti, W. M. Kassira, M. Moller, S. Samuels, L. M. Freedman, A. Ahamad, S. B. Kesmodel, E. Avisar
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2018)
Meeting Abstract
Surgery
Erin M. Wolfe, Sydney A. Mathis, Steven Ovadia, Taylor Wiener, Daisy Gonzalez, Prakash Mathew, Damien D. Pearse, Christopher J. Salgado, Zubin J. Panthaki
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2019)
Editorial Material
Surgery
Mahmood J. Al Bayati, Mario J. Samaha, Georges J. Samaha, Mutaz B. Habal, Seth R. Thaller, Zubin J. Panthaki
JOURNAL OF CRANIOFACIAL SURGERY
(2021)
Article
Surgery
Zubin J. Panthaki
JOURNAL OF CRANIOFACIAL SURGERY
(2021)
Book Review
Surgery
Zubin J. Panthaki, Seth R. Thaller
JOURNAL OF CRANIOFACIAL SURGERY
(2021)
Review
Surgery
Erin M. Wolfe, Sydney A. Mathis, Steven A. Ovadia, Zubin J. Panthaki
Summary: Collagen and human amniotic membrane (hAM) are biomaterials approved by the FDA for peripheral nerve repair. They both have shown to reduce scarring and fibrosis of injured nerves. However, the comparative advantages and disadvantages of these materials have not been definitively determined. This systematic review evaluates the literature on the roles of hAM and collagen nerve wraps and conduits in peripheral nerve regeneration in preclinical models. The majority of studies reported positive outcomes, indicating the potential of both materials in enhancing peripheral nerve regeneration. However, relatively few studies reported significant findings, except for studies evaluating hAM wraps.
JOURNAL OF RECONSTRUCTIVE MICROSURGERY
(2023)
Editorial Material
Surgery
Sinan Kallo Jabori, Shivani Pandya, Anabel Epstein, Lee Weber, Zubin Panthaki, Devinder Singh, Seth R. Thaller
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Medicine, General & Internal
Emily R. Finkelstein, Federico Perez-Quirante, Zubin Panthaki
Summary: A 43-year-old male with acute myeloid leukemia and Fournier's gangrene underwent multiple debridements resulting in complete effacement of the scrotum. Reconstruction using bilateral gracilis muscle rotational flaps and split-thickness skin grafting achieved a pleasing aesthetic result. Healthcare providers may consider this method for similar cases in the future.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Surgery
Amanda F. Spielman, Ammara Ghumman, Zubin Panthaki, Anne-Sophie Lessard
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2020)
Letter
Oncology
Yasmina Zoghbi, Emily A. Borsting, Jimmy H. Chim, Zubin J. Panthaki
