Article
Biochemistry & Molecular Biology
Randolph Stone, Emily C. Saathoff, David A. Larson, John T. Wall, Nathan A. Wienandt, Skuli Magnusson, Hilmar Kjartansson, Shanmugasundaram Natesan, Robert J. Christy
Summary: This preclinical trial evaluated the use of omega-3-rich acellular fish skin graft (FSG) or fetal bovine dermis (FBD) in treating deep partial thickness burns. The results showed that FSG was more effective in stimulating granulated tissue formation than FBD, and it accelerated re-epithelialization and wound healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jaechul Yoon, Dogeon Yoon, Hyeongjin Lee, JiUn Lee, SeoYul Jo, Dohern Kym, Haejun Yim, Jun Hur, Wook Chun, GeunHyung Kim, Yong Suk Cho
Summary: This study compared the wound healing ability of acellular fish skin graft with bovine collagen skin graft. It found that the acellular fish skin graft had faster healing compared to the bovine collagen skin graft, possibly due to the synergistic effect of its unique biophysical structure and bioactive components.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Dermatology
Lei Chen, Jing Yang, De-yun Wang, Jun-mei Jiang, Bao-de Zhang, Zun-jiang Zhao, Xu-Lin Chen, Da-lun Lv
Summary: To evaluate the efficacy of one-step acellular dermis combined with autologous split thickness skin grafting in the treatment of burn or trauma wounds by a multicenter controlled study. In patients with extensive burns, it is even difficult to repair the wounds due to the shortage of autologous skin. The traditional skin grafting method has disadvantages such as large damage to the donor site, insufficient skin source, and unsatisfactory appearance, wear resistance, and elasticity of the wound tissue after skin grafting.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Surgery
Ivan R. Almeida, Adriana C. Gonqalves, Fernanda B. Correa, Julio C. D. Castro, Elaine C. O. Guirro, Jayme A. Farina Jr, Pedro S. Coltro
Summary: The aim of this study was to compare clinical and biomechanical features of scars resulting from the treatment of burn contractures using different acellular dermal matrices. The results suggest that there is no significant difference in the quality of the scar when using acellular dermal matrices compared to only split-thickness skin graft.
Article
Cell Biology
Lizhe Zhuang, Rahul M. Visalakshan, Pritinder Kaur
Summary: Skin ageing is a complex process influenced by various factors, with a decline in the number and function of pericytes potentially playing a significant role in impaired skin regeneration.
Article
Surgery
Tao Ma, Lianji Xu, Yanming Chen, Junyi Zhang, Xinming Han, Libin Jiang
Summary: This study prospectively examined the combination of a pedicled temporal rotation flap with an acellular human dermal graft for intermediate-sized lower eyelid defect reconstruction. The technique achieved 100% flap survival at 6 months, with satisfactory functionality and cosmetic results. The combination proved to be ideal for reconstructing intermediate-sized full-thickness lower eyelid defects.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2022)
Reprint
Materials Science, Multidisciplinary
Andrei Pissarenko, Marc A. Meyers
Summary: Skin, as the primary protective barrier of the body, regulates body temperature and stores water and lipids for healthy metabolism. Research on the mechanical behavior and deformation mechanisms of skin has led to the development of experimental techniques and models for various applications.
PROGRESS IN MATERIALS SCIENCE
(2021)
Review
Pharmacology & Pharmacy
Javier Salazar, Thais Carmona, Flavia C. Zacconi, Diego Venegas-Yazigi, Claudio Cabello-Verrugio, Won Il Choi, Cristian Vilos
Summary: Skin plays a preventive role in protecting the body's internal organs from damage caused by microorganisms and external environmental assaults. The dermis, representing the main section of the skin, contributes critically to skin physiology due to its diverse cellularity, vasculature, and release of molecular mediators. The complex structure of the skin limits substance transport, leading to the study of different nanoparticles for skin illness treatment and dermo-cosmetic applications. This study provides a detailed morphological description of the dermis, analyzes its role in regulating skin homeostasis and its alterations in pathophysiological conditions, and highlights its potential as a therapeutic target. Additionally, the use of nanoparticles for skin illness treatments, focusing on dermis release, and the promotion of metal-organic frameworks as an integrative strategy for skin treatments are described.
Article
Dermatology
Yuichiro Segawa, Hisayuki Tono, Hiromu Chiba, Yota Sato, Yoshihide Asano
Summary: Local skin flap and full-thickness skin graft are commonly used for nasal reconstruction, but both have their drawbacks. The modified dermis graft technique offers a simple and effective solution, avoiding the creation of new scars and providing superior aesthetic and functional outcomes.
JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
Je Yeon Byeon, Yong Seon Hwang, Hwan Jun Choi, Jun Hyuk Kim, Da Woon Lee
Summary: Micronized acellular dermal matrix (ADM) treatment has shown positive results in treating diabetic foot ulcers (DFU) that have invaded ligaments or bones, with a low recurrence rate. Close follow-up of weight bearing areas allows for early identification and treatment of recurrence.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Biology
Marius Kroger, Jorg Scheffel, Evgeny A. Shirshin, Johannes Schleusener, Martina C. Meinke, Jurgen Lademann, Marcus Maurer, Maxim E. Darvin
Summary: This study demonstrates a noninvasive method (TPE-FLIM) that can visualize macrophages in human dermis. The method shows high sensitivity and specificity, making it valuable for studying the role of macrophages in health and disease.
Article
Medicine, General & Internal
Youn Hwan Kim, Hyung Sup Shim, Jihye Lee, Sang Wha Kim
Summary: The study compared the wound size reduction rate between patients receiving paste-type ADM and standard wound care over a 12-week period, showing significantly greater reduction rates in the ADM group, with most wounds achieving healing successfully.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Fuhuan Chen, Jiake Chai, Jingyu Zhao, Jiang Wu, Baoguo Chen
Summary: This study investigated the impact of exogenous hyaluronic acid on acellular dermal matrix paired with thin skin autograft. The results showed that the combination of hyaluronic acid and thin skin autograft had better biomechanical qualities and therapeutic effects compared to acellular dermal matrix alone, approaching the reconstructive result of self-thick skin autograft in all indexes.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Yanqi Li, Siyu An, Chengliang Deng, Shune Xiao
Summary: Human acellular amniotic membrane (HAAM) has emerged as a promising tool in regenerative medicine with low immunogenicity and good anti-infective and anti-scarring results. This review provides a comprehensive overview of HAAM, including its preparation, sterilization, preclinical research, and clinical applications. The review also discusses the potential of HAAM as a skin dressing and cell delivery system and the need for further research into its regenerative mechanisms.
Article
Virology
Nydia C. De la Cruz, Maureen Moeckel, Lisa Wirtz, Katharina Sunaoglu, Wolfram Malter, Max Zinser, Dagmar Knebel-Moersdorf
Summary: This study found that intact skin samples only allowed viral access from the edges, while HSV-1 efficiently invaded the basal layer of the epidermis and gained access to suprabasal layers. The expression of receptors nectin-1 and HVEM correlated with the susceptibility of all epidermal layers to HSV-1 infection. Interestingly, mechanical wounding did not facilitate HSV-1 entry via the skin surface, indicating that successful invasion of HSV-1 depends on reaching its receptors, which was not achieved by skin lesions under ex vivo conditions.
JOURNAL OF VIROLOGY
(2021)