Article
Orthopedics
Itaru Kawashima, Masaki Matsushita, Kenichi Mishima, Yasunari Kamiya, Yusuke Osawa, Bisei Ohkawara, Kinji Ohno, Hiroshi Kitoh, Shiro Imagama
Summary: This study aimed to evaluate the impact of FGFR3 signaling on bone regeneration and bone mineralization during menopause using a transgenic mouse model. The results showed that upregulated FGFR3 decreased newly regenerated bone and bone mineral density in OVX mice. Therefore, FGFR3 signaling may be a potential therapeutic target for postmenopausal osteoporosis.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Biotechnology & Applied Microbiology
Shuo Wu, Lijie Zhang, Ruidan Zhang, Kang Yang, Qin Wei, Qiyu Jia, Jian Guo, Chuang Ma
Summary: Injecting bone marrow mesenchymal stem cells and recombinant rat platelet-derived growth factor BB (rrPDGF-BB) into the distraction area can promote the formation and differentiation of new bone tissue, thereby promoting bone regeneration and healing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Xinkun Shen, Kai Fang, Kendrick Hii Ru Yie, Zixin Zhou, Yiding Shen, Shuyi Wu, Yue Zhu, Zhennan Deng, Pingping Ma, Jianfeng Ma, Jinsong Liu
Summary: This study investigates the osteoinduction capabilities of a series of strontium-doped titanium implants under normal and osteoporotic conditions. The results indicate that high proportion strontium-doped coatings are more favorable for implant restorations in osteoporosis patients.
BIOACTIVE MATERIALS
(2022)
Article
Cell Biology
Sina Vakili, Fatemeh Zal, Zohreh Mostafavi-pour, Amir Savardashtaki, Farhad Koohpeyma
Summary: The study demonstrated that quercetin and vitamin E could prevent osteoporosis by regulating the total number of bone cells, possibly through modulating autophagy and apoptosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Jingwei Liu, Xueying Chang, Daming Dong
Summary: This study investigates the role of miR-181a-5p in osteogenic differentiation and bone formation, and reveals its mechanism through the modulation of the Runx1/AIF-1 axis.
ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Marissa Chatterjee, Fernanda Faot, Cassia Correa, Jente Kerckhofs, Katleen Vandamme
Summary: The study revealed that ovariectomy-induced osteoporosis only affects specific jaw bone regions, which can be prevented by bisphosphonate treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Nazar M. Kostyshyn, Izabela Swietlicka, Ewa Tomaszewska, Piotr Dobrowolski, Siemowit Muszynski
Summary: The aim of our study was to evaluate the effect of whole body vibration (WBV) treatment as a non-pharmacological method for early osteopenia in ovariectomized female rats. The results indicated that widespread vibration therapy can result in deterioration of trabecular bone histomorphometry.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Yimin Liang, Wei Li, Xiang Li, Jun Nan
Summary: Schisandrin B (SchB) shows anti-osteoporotic activity in an experimental rat model of estrogen deficiency. SchB treatment significantly improves bone metabolism, reduces calcium excretion, and inhibits osteoclastogenesis. Furthermore, SchB treatment upregulates the expression of phospho-PI3K, phospho-Akt, and beta-catenin, thereby improving osteoporosis-induced bone degeneration.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Sima Mousavi, Sina Vakili, Fatemeh Zal, Amir Savardashtaki, Morteza Jafarinia, Soudabeh Sabetian, Damoun Razmjoue, Ali Veisi, Omid Azadbakht, Mohamad Sabaghan, Hamid Behrouj
Summary: The study investigates the combined effects of quercetin and alendronate on osteoporosis markers, autophagy, and apoptosis in ovariectomized rats. The results show that quercetin enhances the anti-osteoporotic effects of alendronate, possibly through the regulation of autophagy and apoptosis mechanisms. The combination of quercetin and alendronate could be a useful therapeutic strategy in the treatment of osteoporosis in postmenopausal women.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Physiology
Kai Liu, Sulong Wang, Ainizier Yalikun, Peng Ren, Aihemaitijiang Yusufu
Summary: This study observed the effect of the accordion technique (AT) during the distraction phase on chondrogenesis and bone regeneration. It was found that low amplitude AT can enhance chondrogenesis and bone regeneration by activating the angiogenesis factor pathway and upregulating the expression of osteogenic-related biomarkers.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Kyosuke Sakaida, Kazuhiro Omori, Masaaki Nakayama, Hiroki Mandai, Saki Nakagawa, Hidefumi Sako, Chiaki Kamei, Satoshi Yamamoto, Hiroya Kobayashi, Satoki Ishii, Mitsuaki Ono, Soichiro Ibaragi, Keisuke Yamashiro, Tadashi Yamamoto, Seiji Suga, Shogo Takashiba
Summary: The study found that the fungal secondary metabolite (+)-terrein has potential therapeutic application against osteoporosis by improving bone density and suppressing osteoclastogenesis through RANKL signal transduction inhibition.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sung-Ju Lee, Hyun Yang, Seong Cheol Kim, Dong Ryun Gu, Jin Ah Ryuk, Seon-A Jang, Hyunil Ha
Summary: Radix Asteris, a traditional Chinese medicine, has been historically used to treat respiratory conditions. This research reveals its potential in managing osteoporosis by inhibiting osteoclast differentiation and protecting against bone degradation. The study also identifies specific constituents in Radix Asteris that regulate bone and fat metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Dong Ryun Gu, Hyun Yang, Seong Cheol Kim, Youn-Hwan Hwang, Hyunil Ha
Summary: Angelica dahurica radix has traditional use in China and Korea for treating headaches, cold-damp pain, and skin diseases. This study found that the water extract of Angelica dahurica radix effectively inhibits osteoclast differentiation and alleviates bone loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Orthopedics
Tao Zhang, Weidong Jiang, Fengchun Liao, Peiqi Zhu, Lina Guo, Zhenchen Zhao, Yan Liu, Xuanping Huang, Nuo Zhou
Summary: This study aimed to investigate whether exosomes derived from distraction osteogenesis (DO) and bone fracture (BF) serum could stimulate osteogenic differentiation and identify the relevant genes involved. The results showed that exosomes accelerated osteogenesis in DO, possibly through co-expression of MSTRG.532277.1 and FBXL14, providing new therapeutic targets for bone regeneration.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Review
Cell Biology
Xiaoli Hou, Faming Tian
Summary: This review explores the role and molecular mechanism of the STAT3 signaling pathway in osteoporosis, particularly its regulation by bone-related cytokines. It also examines the cellular interactions among immune cells, hematopoietic cells, and osteoblastic/osteoclastic cells.
CELL COMMUNICATION AND SIGNALING
(2022)