Review
Cell Biology
Ze Liu, Qi Liu, Hongbin Guo, Jieyu Liang, Yi Zhang
Summary: Distraction osteogenesis (DO) is a bone regeneration technology that promotes new bone formation through continuous and stable traction force. However, the long consolidation course of DO can lead to complications. Current treatment strategies include gene, growth factor, stem-cell, physical, and pharmacological therapies, with physical and pharmacological therapies being considered safe and effective. Recent research provides evidence for the effectiveness of physical and pharmacological therapies in promoting bone healing during DO.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Tie Liu, Wen Fang, Gang Wu, Yining Li, Janak L. Pathak, Yuelian Liu
Summary: This study investigated the bone defect healing potential of biomimetically fabricated low dose BMP2-doped CaP (BMP2.BioCaP) grafts in sheep humerus/femoral defects. The results showed that BMP2.BioCaP grafts had strong bone regenerative potential, comparable to autologous bone graft and more effective than DBB grafts, while exhibiting lower immunogenicity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Mei Fu, Jun Li, Mingchong Liu, Chensong Yang, Qidong Wang, Hongrui Wang, Bingdi Chen, Qingge Fu, Guixin Sun
Summary: We designed a nanocomposite hydrogel with osteoimmunomodulatory and osteoinductive activities to promote osteogenesis of bone marrow stem cells. The hydrogel exhibited desirable mechanical strength, stability, porosity, and biocompatibility. In addition, the combination of sericin and nanohydroxyapatite showed synergistic effects on bone regeneration, enhancing osteogenic differentiation in rat BMSCs.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Boqing Zhang, Xingyu Gui, Ping Song, Xiujuan Xu, Likun Guo, Yanlong Han, Li Wang, Changchun Zhou, Yujiang Fan, Xingdong Zhang
Summary: Three-dimensional printing technologies have opened up new possibilities for manufacturing bioceramics with complex shapes. In this study, a large-scale hydroxyapatite porous bioceramic was fabricated using digital light projection (DLP) printing, demonstrating the potential to regulate material bioactivity and promote bone regeneration.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Biochemistry & Molecular Biology
Ileana Ielo, Giovanna Calabrese, Giovanna De Luca, Sabrina Conoci
Summary: This review summarizes recent advances in HA-based biocomposites for bone regeneration, including the commonly used inorganic matrices, polymers, and crosslinkers. Research shows that HA composites are generally biocompatible, although results from clinical studies on humans sometimes remain controversial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Qian Zhang, Xingyuan Qu, Chen Liang, Hongyan Li, Siyu Du, Chang Wang, Yuandong Xie, Yi Zheng, Lei Wang
Summary: This study investigated the regulatory effect of N-isopropylacrylamide-modified polyethyleneimine (PEN)-delivered oligodeoxynucleotide (ODN) MT01 on bone regeneration in vitro and in vivo. The results showed that PEN efficiently delivered MT01 and promoted bone regeneration without cytotoxicity to cells.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Georgia-Ioanna Kontogianni, Catarina Coelho, Remy Gauthier, Sonia Fiorilli, Paulo Quadros, Chiara Vitale-Brovarone, Maria Chatzinikolaidou
Summary: Nanohydroxyapatite (nanoHA) is a highly biocompatible and osteoconductive material for bone regeneration. By enriching nanoHA with strontium ions, enhanced mechanical properties and biological activity can be achieved. In this study, nanoHA and nanoHA with different substitution degrees of calcium with strontium ions (Sr-nanoHA_50 and Sr-nanoHA_100) were evaluated for their cytotoxicity and osteogenic potential. All three nanoHA-based materials showed cytocompatibility, needle-shaped nanocrystals, and enhanced osteogenic activity. Gene expression analysis demonstrated significant upregulation of osteocalcin, osteonectin, and osteopontin in all three compositions compared to the control. These findings indicate the great potential of the produced compounds for bone regeneration.
Article
Biotechnology & Applied Microbiology
Shahrokh Hatefi, Milad Sh Etemadi, Javad Alizargar, Venous Behdadipour, Khaled Abou-El-Hossein
Summary: The application of Distraction Osteogenesis (DO) techniques in reconstruction surgeries is advantageous with fewer side effects. However, the development of automatic devices for controlled continuous force still requires further research. A two-axis continuous distractor is proposed for mandibular reconstruction, meeting the current requirements.
BIOENGINEERING-BASEL
(2022)
Review
Agriculture, Dairy & Animal Science
Mario Garcia-Gonzalez, Fernando Munoz, Antonio Gonzalez-Cantalapiedra, Monica Lopez-Pena, Nikola Saulacic
Summary: Periosteal distraction osteogenesis (PDO) is a promising new technique for bone regeneration that has shown better results in animal models such as rabbits and rats compared to minipigs. The quality of studies has improved since the implementation of ARRIVE guidelines in 2010, but there is still room for enhancing transparency, comparability, and reproducibility in future research.
Review
Biotechnology & Applied Microbiology
Albert Thomas Anastasio, Ariana Paniagua, Carrie Diamond, Harrison R. Ferlauto, Joseph S. Fernandez-Moure
Summary: Achieving bone fracture union post-trauma is a major challenge for orthopedic surgeons, with various risk factors including environmental and patient-specific factors. Nitric oxide plays a crucial role in fracture healing, and there are new delivery mechanisms to enhance bone healing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Physical
Olga Cvijanovic Peloza, Ana Terezija Jerbic Radetic, Mirjana Baricic, Luka Bukovac, Sanja Zoricic Cvek
Summary: Autologous dentin is commonly used in guided bone regeneration due to its similarity to native bone. The xenogeneic bone biomaterial Cerabone(R) is biocompatible but not easily resorbed. This study aimed to track the healing of critical-sized bone defects after implanting bovine devitalized dentin, rat dentin, and xenogeneic bone biomaterial, and to monitor the systemic response in rats. The results showed successful bridging of the bone defect in all three groups, with rat dentin being the most optimal biomaterial for bone regeneration.
Article
Biotechnology & Applied Microbiology
Xin Huang, Donghua Huang, Ting Zhu, Xiaohua Yu, Kaicheng Xu, Hengyuan Li, Hao Qu, Zhiyuan Zhou, Kui Cheng, Wenjian Wen, Zhaoming Ye
Summary: This study comprehensively explored the interactions between osteoinductive and osteo-immunomodulatory properties of metal ions, especially zinc ions (Zn2+), during bone healing process. It was found that Zn2+ significantly enhanced osteogenic differentiation of periosteum-derived progenitor cells through induction of M2 polarization via the PI3K/Akt/mTOR pathway. The favorable immunomodulatory effect of Zn2+ further improved the osteogenic differentiation of progenitor cells in vitro, and in vivo experiments confirmed the scaffolds' spontaneous osteogenesis and pro-healing osteoimmunomodulation.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Physiology
Kai Liu, Sulong Wang, Ainizier Yalikun, Peng Ren, Aihemaitijiang Yusufu
Summary: This study observed the effect of the accordion technique (AT) during the distraction phase on chondrogenesis and bone regeneration. It was found that low amplitude AT can enhance chondrogenesis and bone regeneration by activating the angiogenesis factor pathway and upregulating the expression of osteogenic-related biomarkers.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Patricia Garcia-Garcia, Ricardo Reyes, Daniel Garcia-Sanchez, Flor Maria Perez-Campo, Jose Carlos Rodriguez-Rey, Carmen Evora, Patricia Diaz-Rodriguez, Araceli Delgado
Summary: This study successfully enhanced the bone density in osteoporotic mice by using aptamer-functionalized nanoparticles carrying SFRP1 silencing GapmeR, without causing any toxic effects.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Cell Biology
Feng Wang, Wenbo Wang, Lingchi Kong, Li Shi, Mengwei Wang, Yimin Chai, Jia Xu, Qinglin Kang
Summary: This study found that ADM2 accelerates bone regeneration by enhancing the osteogenic differentiation and pro-angiogenic potential of BMSCs, possibly through the NF-κB/β-catenin and AKT/β-catenin pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)