Article
Chemistry, Physical
Nimya Ann Mathews, M. R. Prathapachandra Kurup
Summary: In this study, three novel mixed ligand complexes of copper were synthesized and characterized by spectroscopy and X-ray crystallography. The complexes' interaction with CT-DNA, cleavage ability, and cytotoxicity were investigated.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Freeha Hafeez, Ameer Fawad Zahoor, Azhar Rasul, Asim Mansha, Razia Noreen, Zohaib Raza, Kulsoom Ghulam Ali, Ali Irfan, Gamal A. El-Hiti
Summary: Piperazine-based dithiocarbamates were designed and synthesized in this study, and their biological activities were evaluated. The types of substituents on the aryl ring were found to affect the anticancer activity of the compounds, and in silico modeling showed that the most potent compound exhibited similar binding affinity to PQ10 and aligned with the lipophilic site of PDE10A.
Article
Biochemistry & Molecular Biology
Marek Studzinski, Pawel Kozyra, Monika Pitucha, Boguslaw Senczyna, Joanna Matysiak
Summary: This study used chromatographic methods to evaluate the lipophilicity of a series of compounds and their impact on pharmacokinetic processes. The results showed that the lipophilicity of these compounds was within the range of potential drug candidates, but some derivatives had a strong protein binding, which may limit their absorption and distribution in the body.
Review
Biochemistry & Molecular Biology
Fernando Ferreira Leite, Natalia Ferreira de Sousa, Bruno Hanrry Melo de Oliveira, Gabrielly Diniz Duarte, Maria Denise Leite Ferreira, Marcus Tullius Scotti, Jose Maria Barbosa Filho, Luis Cezar Rodrigues, Ricardo Olimpio de Moura, Francisco Jaime Bezerra Mendonca-Junior, Luciana Scotti
Summary: This study investigated the role of natural and synthetic chalcones and their anticancer activity in vitro reported from 2019 to 2023. The analysis found that the presence of polar radicals such as hydroxyl and methoxyl contributed to the anticancer activity of chalcones derivatives. The results hope to aid in the development of effective drugs to inhibit colon adenocarcinoma.
Article
Oncology
Pruthvish Reddy, Sushma Pradeep, S. M. Gopinath, Chandan Dharmashekar, G. Disha, M. R. Sai Chakith, Chandrashekar Srinivasa, Ali A. Shati, Mohammad Y. Alfaifi, Serag Eldin I. Elbehairi, Raghu Ram Achar, Ekaterina Silina, Victor Stupin, Natalia Manturova, Chandan Shivamallu, Shiva Prasad Kollur
Summary: Breast cancer is a major cause of female mortality, and researchers are actively exploring alternative therapies with fewer side effects. This study investigated the antiproliferative effects of Terminalia chebula fruit extract and its phytochemical saccharopine, which showed promising results in inhibiting breast cancer cell growth and binding with EGFR. These findings lay the foundation for future research on isolating saccharopine and evaluating its efficacy.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Catarina Lourenco-Lopes, Maria Fraga-Corral, Anton Soria-Lopez, Bernabe Nunes-Estevez, Marta Barral-Martinez, Aurora Silva, Ningyang Li, Chao Liu, Jesus Simal-Gandara, Miguel A. Prieto
Summary: Brown macroalgae, particularly Undaria pinnatifida, is a potential source of fucoxanthin (Fx), a pigment with various bioactivities. This study optimized the conditions for conventional heat extraction (CHE) to maximize the recovery of Fx from Undaria pinnatifida. The Fx-rich extracts showed strong antioxidant and antimicrobial activities, especially against gram-positive bacteria. In silico analysis supported these findings and revealed potential molecular interactions of Fx. This research demonstrates the efficiency of CHE for extracting high amounts of Fx and highlights its potential applications in different industries.
Article
Biochemistry & Molecular Biology
Vivien Posa, Balint Hajdu, Gabor Toth, Orsolya Domotor, Christian R. Kowol, Bernhard K. Keppler, Gabriella Spengler, Bela Gyurcsik, Eva A. Enyedy
Summary: This study investigates the behavior of five (thio)semicarbazones with different donor sets in aqueous solution, the stability of their copper(II) complexes, and their interaction with DNA and topoisomerase II alpha. The results show that the cytotoxicity of the ligands is not correlated with their solubility, lipophilicity, or permeability, while the most lipophilic and stable copper complexes exhibit the highest cytotoxicity.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Santha Kumari Merugu, V. B. R. Krishnan, K. Ravi Kumar, Siddique Akber Ansari, Irfan Aamer Ansari, Hari Babu Bollikolla
Summary: An efficient method for the synthesis of 1,4-dihydropyridines under mild conditions has been developed. The yields of 1,4-dihydropyridines were good to excellent for numerous substrates, and a wide range of functional groups were tolerated. The anticancer efficacy of the produced compounds was investigated using A549, HT-29, and HepG2 cancer cells. Additionally, in-silico docking studies were conducted to understand the structure-based features of the anticancer mechanism and the molecular interactions of the compounds with the Adenosine A2A receptor, the target of cancer medication.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Biochemistry & Molecular Biology
Eslam B. Elkaeed, Reda G. Yousef, Hazem Elkady, Aisha A. Alsfouk, Dalal Z. Husein, Ibrahim M. Ibrahim, Ahmed M. Metwaly, Ibrahim H. Eissa
Summary: Based on the features of EGFR inhibitors, a new semisynthetic theobromine-derived compound was designed and its interaction with EGFR was confirmed. The compound showed promising anti-tumor activity and selectivity.
Article
Biochemistry & Molecular Biology
Musherah M. Alshammari, Raoudha Soury, Khalaf M. Alenezi, Md. Mushtque, M. Moshahid Alam Rizvi, Ashanul Haque
Summary: A new pyrazole-tethered thiazolidine-2,4-dione derivative was synthesized and its structure was confirmed by spectroscopic techniques. Density functional theory calculations were used to determine the molecular features. In vitro cytotoxicity studies showed higher activity and lower toxicity of the compound against breast cancer cell line.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Rasha Ksirri, Kancharla Bhanukiran, Swapan Maity, Pralay Maiti, Siva Hemalatha
Summary: Cervical cancer is a major threat to women's health worldwide, and Gmelina asiatica leaves may serve as a potential source of anticancer molecules against cervical cancer.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Multidisciplinary
Yuhan Jiang, Wei Yang, Fangfang Wang, Bo Zhou
Summary: In this study, template ligand-based 3D-QSAR studies were performed on a series of benzoxazole derivatives toward different cell lines. CoMFA and CoMSIA techniques were used to generate 3D-QSAR models. The results of this study provide guidance for the design of new anticancer drugs and avoiding time-consuming and costly synthesis and biological evaluations.
Article
Multidisciplinary Sciences
Enas Aljuhani, Meshari M. Aljohani, Amerah Alsoliemy, Reem Shah, Hana M. Abumelha, Fawaz A. Saad, Aisha Hossan, Zehbah A. Al-Ahmed, Ahmed Alharbi, Nashwa M. El-Metwaly
Summary: New pyrazole derivatives were synthesized and used to prepare bioactive agents in the form of Cu(II) complexes, characterized and computationally optimized to show effective inhibition against breast cancer cells both in terms of scoring energy values and interaction stability. In vitro screening demonstrated the superior cytotoxicity of these Cu(II) complexes compared to the reference drug Doxorubicin on the breast cancer cell line.
Article
Chemistry, Multidisciplinary
Ratchanok Pingaew, Prasit Mandi, Veda Prachayasittikul, Anusit Thongnum, Supaluk Prachayasittikul, Somsak Ruchirawat, Virapong Prachayasittikul
Summary: The study found that hydroxyl-containing bisindoles exhibited good anticancer activity against multiple cancer cell lines, with some derivatives also showing antimalarial effects, while non-hydroxyl-containing bisindoles were more suitable as antimalarial agents. Five QSAR models were constructed to guide the design and synthesis of an additional set of 22 compounds. Molecular docking revealed the binding modes between the compounds and target proteins.
Article
Biochemistry & Molecular Biology
Vinodkumar P. P. Sajjan, Lakkappa B. B. Anigol, Prabhuodeyara M. M. Gurubasavaraj, Dhanashree Patil, Parutagouda Shankaragouda Patil, Neelamma B. B. Gummagol, Ching Kheng Quah, Qin Ai Wong, Ismail Celik
Summary: A series of novel hydrazone compounds have been synthesized and characterized. These compounds showed promising cytotoxicity activities against cancer cell lines and further computational analysis suggested their potential as anticancer agents.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Materials Science, Multidisciplinary
Khairunnadhrah Jasri, Ahmed Saud Abdulhameed, Ali H. Jawad, Zeid A. ALOthman, Tarek A. Yousef, O. K. Al Duaij
Summary: Employing agricultural waste to develop activated carbon is a sustainable approach. This study developed a mesoporous activated carbon through microwave radiation-assisted K2CO3 activation of agricultural waste. The optimized conditions resulted in a high removal efficiency (99.6%) of methylene blue. The OPFPKSAC exhibited excellent adsorption capability and demonstrated potential for the removal of toxic pollutants.
DIAMOND AND RELATED MATERIALS
(2023)
Article
Environmental Sciences
Imran Ali, Stoyanova Alyona, Kon'kova Tatiana, Gaydukova Anastasiya, Hassan M. Albishri, Wael Hamad Alshitari
Summary: A sorption-electroflotation method using carbon nanomaterials was developed to remove non-biodegradable and carcinogenic toxic metal ions. Carbon nanotubes (CNTs) and carbon nanoshells (CNSs) were used to remove Ni(II), Co(II), Zn(II), Fe(II), and Cu(II). Surface properties and composition of the nanomaterials were characterized, and different models were applied to analyze the data. The method showed excellent removal efficiency, with the highest percentage removal achieved through simultaneous sorption-electroflotation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Physical
Janejira Ratthiwal, Noelia Lazaro, Antonio Pineda, Roberto Esposito, Zeid A. ALOthman, Prasert Reubroycharoen, Rafael Luque
Summary: In this study, the continuous-flow hydrogenation of furfural with 2-propanol was carried out using transition metal-based catalysts. C-MIL-101(Fe) and C-MIL-125(Ti) were successfully synthesized and compared for their performance in the hydrogenation of furfural. The calcined C-MIL-125(Ti) catalyst exhibited better furfural conversion and selectivity.
CATALYSIS COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Kareem Yusuf, Anusree Natraj, Kelvin Li, Mohamed Ateia, Zeid A. ALOthman, William R. Dichtel
Summary: Two-dimensional polymers in the form of layered covalent organic frameworks (COFs) show promise as adsorbent-based separations due to their tunable properties. High-quality single crystals of two 2D COFs exhibit improved separation characteristics in gas chromatography compared to polycrystalline samples. In this study, inverse pulse gas chromatography was used to characterize the dispersive and specific adsorption properties of single-crystalline and polycrystalline COFs for the separation of linear n-alkanes and polar probes.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Analytical
N. Hareesha, J. G. Manjunatha, T. Girish, Zeid A. ALOthman
Summary: This research presents a low-cost and green electrochemical method for the detection of the ecological toxin catechol. The electro-polymerised methyl orange-activated carbon paste electrode (Poly(MO)ACPE) was used as an electrocatalyst. The Poly(MO)ACPE demonstrated good electrocatalytic activity for the redox reaction of catechol, showing higher peak current response compared to the bare carbon paste electrode (BCPE).
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2023)
Article
Environmental Sciences
N. N. A. Nadhirah Long Tamjid Farki, Ahmed Saud Abdulhameed, S. N. Surip, Zeid A. ALOthman, Ali H. Jawad
Summary: The novelty of this research lies in using microwave-assisted H3PO4 activation to convert mixed biomass wastes from tropical fruit into activated carbon, and testing its effectiveness in adsorbing methylene blue dye. The adsorption key parameters were optimized using response surface methodology with Box Behnken design. The study proposed a tailored adsorption mechanism of methylene blue on the surface of the activated carbon derived from durian seeds and rambutan peels.
INTERNATIONAL JOURNAL OF PHYTOREMEDIATION
(2023)
Review
Biochemistry & Molecular Biology
Cristian D'Ovidio, Marcello Locatelli, Miryam Perrucci, Luigi Ciriolo, Kenneth G. Furton, Isil Gazioglu, Abuzar Kabir, Giuseppe Maria Merone, Ugo de Grazia, Imran Ali, Antonio Maria Catena, Michele Treglia, Luigi T. Marsella, Fabio Savini
Summary: LC-MS/MS plays a crucial role in screening and tracking pharmacotoxicological and forensic cases due to its advanced features. This review paper focuses on its applications in pharmacotoxicology and highlights its importance in the development of pharmacological and forensic research. It discusses therapeutic drug monitoring and clinical approaches as well as the determination of illicit drugs.
Article
Geosciences, Multidisciplinary
Muhammad Shahid, Sana Khalid, Natasha Natasha, Tasveer Zahra Tariq, Zeid A. Alothman, Abdullah A. Al-Kahtani, Muhammad Imran, Behzad Murtaza
Summary: Groundwater contamination by arsenic is a major concern, and this study found that Chishtian tehsil in Bahawalnagar district had arsenic levels exceeding the World Health Organization limit. Arsenic was also found in milk and human hair samples. Risk assessment revealed potential health hazards associated with the high arsenic levels in the groundwater.
PHYSICS AND CHEMISTRY OF THE EARTH
(2023)
Article
Energy & Fuels
Ahmad Hapiz, Laili Azmiati Arni, Tumirah Khadiran, Zeid A. ALOthman, Lee D. Wilson, Ali H. Jawad
Summary: In this study, a recoverable and promising adsorbent for the removal of acid red 88 (AR88 dye) from aqueous media was developed by grafting an aromatic ring aldehyde (salicylaldehyde) onto the biopolymer matrix of magnetic chitosan. Various characterization methods were used to determine the physicochemical properties of the adsorbent. The experimental parameters for the adsorption performance were optimized using a Box-Behnken design. The maximum dye adsorption capacity of the hydrothermally grafted CS-SL/Fe3O4 with AR88 was determined, and the intermolecular interactions contributing to the dye adsorption were identified. This study presents a recoverable and promising magnetic grafted chitosan adsorbent for the removal of anionic dyes from aqueous media and suggests its potential application for removing other water contaminants.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Article
Multidisciplinary Sciences
Ali H. Jawad, Shihab Ezzuldin M. Saber, Ahmed Saud Abdulhameed, Ahlam M. Farhan, Zeid A. ALOthman, Lee D. Wilson
Summary: This research aimed to use natural Iraqi bentonite clay (NIBC) to adsorb the organic dye (methylene blue, MB) from aqueous media. Analytical methods were performed to analyze the physicochemical characteristics of NIBC. The study examined the impacts of adsorbent dosage, pH, and initial concentrations on the removal of MB. Results showed that NIBC had a maximum adsorption capacity of 256 mg/g for MB.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Engineering, Environmental
Najeeb Ullah Khan, Muhammad Shahid, Sana Khalid, Natasha Natasha, Zeid A. Alothman, Abdullah A. Al-Kahtani, Muhammad Imran, Behzad Murtaza
Summary: Groundwater contamination with arsenic is a potential health hazard in several regions of Pakistan. Despite low levels of arsenic in the environment, significant levels were detected in food and human samples.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2023)
Article
Environmental Sciences
Ahmad Hapiz, Ali H. Jawad, Lee D. Wilson, Zeid A. ALothman, Ahmed Saud Abdulhameed, Sameer Algburi
Summary: In this study, bamboo waste was activated using pyrolysis-assisted ZnCl2 to produce mesoporous activated carbon, which showed high removal efficiency for cationic dyes. The adsorption process followed the Freundlich model, and the optimal operational conditions were identified. The study also revealed the adsorption mechanism of the activated carbon and its potential for wastewater treatment applications.
INTERNATIONAL JOURNAL OF PHYTOREMEDIATION
(2023)
Article
Biochemistry & Molecular Biology
Imran Ali, Anastasya Gaydukova, Tatiana Kon'kova, Zeid Abdullah ALOthman, Mika Sillanpaa
Summary: This study investigated the acid leaching process of grinding waste from a heat-resistant nickel alloy. Optimal conditions for acid dissolution were established to maximize the extraction of nickel, the main component of the alloy. These results are significant for industry professionals in metal recovery and environmentalists in waste treatment.
Article
Engineering, Environmental
Mani Govindasamy, Zeid A. ALOthman, Razan A. Alshgari, Rameshkumar Arumugam, Chi-Hsien Huang
Summary: In this study, an enzyme-free electrochemical sensor based on orthorhombic bismuth molybdate nanoparticles decorated graphene oxide composite was developed for detecting hexestrol. Hexestrol is a non-steroidal estrogen with carcinogenic and toxic effects on the human body. The modified sensor showed high selectivity, reproducibility, and stability, and had a wide linear range and low limit of detection, making it suitable for real-time applications.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Laili Azmiati Arni, Ahmad Hapiz, Ahmed Saud Abdulhameed, Tumirah Khadiran, Zeid A. ALOthman, Lee D. Wilson, Ali H. Jawad
Summary: A magnetic chitosan grafted-benzaldehyde (CS-BD/Fe3O4) was synthesized as a promising adsorbent for acid red 88 (AR88) dye removal. The variables influencing AR88 dye adsorption were studied using the Box-Behnken design, and the adsorption profiles were described by the Temkin model and pseudo-first-order kinetics model. The CS-BD/Fe3O4 demonstrated high adsorption capacity (154.1 mg/g) and various mechanisms, such as electrostatic attraction and π-π interaction, were involved in the adsorption process. This research highlights the potential of CS-BD/Fe3O4 as an effective bio-adsorbent for azo dye removal from contaminated wastewater.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)