Journal
JOURNAL OF COORDINATION CHEMISTRY
Volume 67, Issue 6, Pages 929-942Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/00958972.2014.903328
Keywords
Zinc(II) complexes; NNO Schiff-base ligand; Anticancer activity; DNA and HSA binding
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Funding
- Natural Science Foundation of China [31060121, 21171043]
- Natural Science Foundation of Guangxi [2012GXNSFCB053001]
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Mononuclear and trinuclear zinc(II) complexes (1 and 2) with tridentate NNO Schiff-base ligands (HL1 = N-2-pyridiylmethylidene-4-chloro-2-hydroxy-phenylamine, HL2 = N-2-pyridiylmethylidene-2-hydroxy-5-chloro-phenylamine) have been synthesized and characterized by single-crystal X-ray diffraction and elemental analysis. The binding properties of zinc(II) complexes with calf thymus DNA (CT-DNA) and HSA were investigated by UV-visible, fluorescence, and circular dichroism spectra. The zinc(II) complexes bind significantly to CT-DNA by intercalation and bind to protein HSA through a static quenching mechanism. The in vitro cytotoxicity of the complexes on human tumor cells lines was assessed by 3-(4,5-dimathylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide, Hoechst 33258 staining experiments.
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