Article
Chemistry, Inorganic & Nuclear
J. A. Eremina, E. Lider, N. Kuratieva, D. G. Samsonenko, L. S. Klyushova, D. G. Sheven, R. E. Trifonov, V. A. Ostrovskii
Summary: A series of mixed-ligand copper(II) complexes have been synthesized and characterized by various methods. The structures, cytotoxic effects on cell lines, and stability of the complexes were investigated. Additionally, the interaction of the complexes with DNA was also studied.
INORGANICA CHIMICA ACTA
(2021)
Article
Chemistry, Medicinal
Salah S. Massoud, Febee R. Louka, Nahed M. H. Salem, Roland C. Fischer, Ana Torvisco, Franz A. Mautner, Jan Vanco, Jan Belza, Zdenek Dvorak, Zdenek Travnicek
Summary: In this study, six copper complexes were synthesized and characterized. The complexes exhibited significant antiproliferative activity against human cancer cells, with the sixth complex showing the highest cytotoxicity compared to the reference drug cisplatin. Complex seven was able to induce apoptosis in A2780 cells, while complexes four and six showed considerable induction of autophagy and a potential cuproptosis effect.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Mathias L. L. Skavenborg, Mads Sondrup Moller, Susanne Mossin, T. David Waite, Christine J. J. McKenzie
Summary: Heteroleptic copper complexes of an asymmetrical pincer ligand containing a central anionic sulfonamide donor have been prepared and shown to catalyze the electro-reduction of O2 to H2O2. The addition of a weak organic acid increases the reaction rate and the coulombic efficiency of H2O2 production was determined to be 48% by iodometric titration.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Suwitra Charoensuk, Jing Tan, Mohini Sain, Hathaikarn Manuspiya
Summary: This report presents a significant leap in designing electronic structures that display reversible dual-phase photoluminescence properties from single-crystal hybrid ligand frameworks. The three-dimensional Cu(C3N2H4)(4)Cl-2 complex frameworks show potential for luminescence Cu-based sensors to detect heavy metal ion species using emission intensity.
Article
Chemistry, Inorganic & Nuclear
Dai-Hong Cai, Bai-Hua Chen, Qi-Yan Liu, Xue-Yi Le, Liang He
Summary: Copper complexes show potential as anticancer agents, with three new Cu(II) complexes exhibiting good antiproliferative activity against various cancer cells and DNA oxidative cleavage. The complexes also display strong binding affinity with DNA and human serum albumin. Through inducing DNA damage and ROS-mediated mitochondrial dysfunction, the Cu(II) complexes lead to cancer cell apoptosis.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Physical
Julia A. Eremina, Ksenia S. Smirnova, Lyubov S. Klyushova, Alexey S. Berezin, Elizaveta Lider
Summary: In this study, four new mixed-ligand copper(II) complexes were synthesized and characterized. Two crystal structures of the complexes with 5-benzyltetrazole were established for the first time. The complexes were screened for cytotoxic activity against three cancer cell lines, with [Cu(phen)(L)(2)] and [Cu(dmphen)(L)(2)] showing the highest cytotoxicity.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Inorganic & Nuclear
Tania Zhivkova, Daniela C. Culita, Abedulkadir Abudalleh, Lora Dyakova, Teodora Mocanu, Augustin M. Madalan, Milena Georgieva, George Miloshev, Anamaria Hanganu, Gabriela Marinescu, Radostina Alexandrova
Summary: In this study, two families of homo- and heterometallic complexes were synthesized and their cytotoxic and genotoxic effects on different types of cells were investigated. The results showed that these compounds could significantly inhibit the growth and proliferation of cells within a certain concentration range, with the complexes containing Au(I) exhibiting higher cytotoxic and genotoxic activity. Some of the complexes also showed more pronounced cytotoxic potential than commercially available antitumor agents.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Yating Chen, Zhilin Ke, Lingyu Yuan, Meixiang Liang, Shuhua Zhang
Summary: We synthesized and analyzed nine unique copper(II) hydrazylpyridine salicylaldehyde and 1,10-phenanthroline complexes. It was found that these complexes exhibited higher anticancer activity and lower cytotoxicity towards normal cells compared to other substances. Specifically, Cugdupt1 and Cugdupt8 induced cell death through ATP depletion and activation of mitophagy pathways.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
William Meza-Morales, Yair Alvarez-Ricardo, Marco A. Obregon-Mendoza, Antonino Arenaza-Corona, Maria Teres Ramirez-Apan, Ruben A. Toscano, Juan Carlos Poveda-Jaramillo, Raul G. Enriquez
Summary: Four different geometries of the same metal complexes, including square pyramidal, octahedral, trigonal-pyramidal, and trigonal-bipyramidal, were reported in this study. Improving crystallinity involved suppressing the phenolic interactions by etherification and esterification. The complexes were fully characterized and their cytotoxic activities were evaluated.
Article
Chemistry, Inorganic & Nuclear
Ekaterina A. Ermakova, Julia A. Golubeva, Ksenia S. Smirnova, Lyubov S. Klyushova, Ilia V. Eltsov, Alexander A. Zubenko, Leonid N. Fetisov, Alexandra E. Svyatogorova, Elizaveta V. Lider
Summary: In this study, five new mixed-ligand zinc(II) complexes were synthesized using 1H-tetrazole-5-acetic acid as a bifunctional ligand in the presence of secondary ligands. The complexes were characterized by elemental analysis, IR spectroscopy, and powder X-ray diffraction. Thermogravimetric analysis showed that all complexes exhibited thermal stability up to 250 degrees C. Among them, complex 2 showed the highest cytotoxicity against HepG-2 and MCF-7 cells.
Article
Chemistry, Inorganic & Nuclear
Daniel Obitz, Reece G. Miller, Nils Metzler-Nolte
Summary: The synthesis of bioconjugates of ruthenium(ii) dipyridophenazine complexes with two different cell penetrating peptides (CPPs) was described, with characterization done by various methods. The bioconjugates show similar low vitro cytotoxicity to the parent metal complexes.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Multidisciplinary
Kakoli Malakar, Balasubramaniam Selvakumaran, Mariappan Murali, Pitchan Arul Prakash, Somasundaram Sangeetha, Winaki P. Sohtun, Mohamed Sultan Mohamed Jaabir, Marappan Velusamy
Summary: Eight novel mixed-ligand copper(ii) complexes were characterized and found to exhibit excellent activity and cytotoxicity in cancer treatment.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Salman Khursheed, Hifzur R. Siddique, Sartaj Tabassum, Farukh Arjmand
Summary: In this study, a series of complexes were synthesized to investigate the effect of metal ions in analogous ligand scaffolds on DNA binding and cytotoxic response. The copper(II) complex showed the highest anticancer activity among the complexes tested.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Jin Wang, Zhi-Meng Zhang, Ming-Xue Li
Summary: The synthesis of four metal complexes and their antimicrobial and cytotoxic activities were investigated in this study. The results showed that the antibacterial activity of cadmium (II) and antimony (III) complexes was enhanced compared to their ligands, with Cd2 and Sb2 demonstrating effective antibacterial activity and Cd2 showing the most effective antiproliferative activity against HepG2 cells.
INORGANICA CHIMICA ACTA
(2022)
Article
Chemistry, Inorganic & Nuclear
Vasily A. Ilichev, Liubov Silantyeva, Anton F. Rogozhin, Artem N. Yablonskiy, Boris A. Andreev, Roman Rumyantsev, Georgy K. Fukin, Mikhail N. Bochkarev
Summary: A new mixed Eu(II)-Cu(I) iodide compound exhibits intense double-peaked photoluminescence upon UV light excitation, with significant changes in relative intensity of peaks with temperature variation, making it a promising luminescent thermometer. Time-resolved PL studies revealed the presence of two luminescent centers excited by electron capture, showing significant changes in peak intensity ratio and relative sensitivity within a specific temperature range.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Multidisciplinary
Jin'an Zhao, Kun Peng, Yan Guo, Jin Zhang, Shufang Chen, Jiyong Hu
NEW JOURNAL OF CHEMISTRY
(2015)
Article
Chemistry, Inorganic & Nuclear
Jin'an Zhao, Yan Guo, Kun Peng, Jin Zhang, Chuangcheng Zhang, Liangliang Hu, Shufang Chen, Jiyong Hu
Article
Chemistry, Multidisciplinary
Jin-An Zhao, Shu-Fang Chen, Dan-Dan Zhao, Yan Guo, Kun Peng, Ji-Yong Hu
CHINESE CHEMICAL LETTERS
(2013)
Article
Chemistry, Inorganic & Nuclear
Jin'an Zhao, Dandan Zhao, Yan Guo, Kun Peng, Xinling Li, Shufang Chen, Jiyong Hu
INORGANICA CHIMICA ACTA
(2014)
Article
Chemistry, Inorganic & Nuclear
Jin'an Zhao, Dandan Zhao, Yan Guo, Kun Peng, Shufang Chen, Jiyong Hu
SYNTHESIS AND REACTIVITY IN INORGANIC METAL-ORGANIC AND NANO-METAL CHEMISTRY
(2014)
Article
Chemistry, Inorganic & Nuclear
Jin'an Zhao, Dandan Zhao, Kun Peng, Yan Guo, Shufang Chen, Jiyong Hu
TRANSITION METAL CHEMISTRY
(2013)
Article
Chemistry, Inorganic & Nuclear
Kun Peng, Viviane Mawamba, Ellina Schulz, Mario Loehr, Carsten Hagemann, Ulrich Schatzschneider
INORGANIC CHEMISTRY
(2019)
Article
Chemistry, Inorganic & Nuclear
Kun Peng, Richard Einsele, Peter Irmler, Rainer F. Winter, Ulrich Schatzschneider
Article
Chemistry, Inorganic & Nuclear
Kun Peng, Dominik Moreth, Ulrich Schatzschneider
Summary: The study demonstrates that internal alkynes react faster than terminal alkynes in the catalyst-free iClick reaction, with rate constants of 7.7 x 10(-3) and 5.6 x 10(-3) M-1 s(-1) for the reaction with methyl propiolate for Pd(II) and Pt(II) azido complexes, respectively. Pseudo-first-order rate constants were obtained through IR spectroscopy monitoring the disappearance of azido vibration, showing a general reactivity trend of Pd > Pt and CF3,COOEt > COOCH3,COOCH3 >> H,COOCH3.
Review
Chemistry, Inorganic & Nuclear
Kun Peng, Bing-Bing Liang, Wenting Liu, Zong-Wan Mao
Summary: Research on platinum coordination complexes as anticancer drugs has been conducted for over half a century with the inspiration from the success of cisplatin in cancer chemotherapy. Despite the emergence of numerous promising platinum complexes, most have failed to enter clinical applications. Strategies have been proposed in recent decades to address the complicated reasons for the abandonment of platinum antitumor candidates from experiment to clinic. With advancements in targeted therapy and immunotherapy, anticancer platinum drugs are facing new opportunities and challenges.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Junshuai Zhang, Jiyong Hu, Kun Peng, Wei Song, Shuangcheng Zhi, Endian Yang, Jin'an Zhao, Hongwei Hou
CHEMICAL COMMUNICATIONS
(2019)
Article
Chemistry, Multidisciplinary
Kun Peng, Alexandra Friedrich, Ulrich Schatzschneider
CHEMICAL COMMUNICATIONS
(2019)