Article
Pharmacology & Pharmacy
Hui Li, Yao Zhang, Hong Shu, Wenhao Lv, Chunhong Su, Fang Nie
Summary: This article reviews recent developments in the application of UTMD-mediated gene and drug delivery in the diagnosis and treatment of tumors, including the concept, mechanism of action, clinical application status, and advantages of UTMD. Furthermore, future perspectives in this field are also discussed.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Pharmacology & Pharmacy
Rachel Chapla, Katherine T. Huynh, Carolyn E. Schutt
Summary: Targeted delivery of therapeutics is crucial for reducing systemic toxicity and optimizing therapeutic efficacy. Ultrasound-controlled targeting is an externally-stimulated drug delivery strategy, using ultrasound waves to stimulate gas-filled microbubbles and deliver attached cargo to surrounding cells. The attachment of nanocarrier particles to microbubbles greatly enhances drug delivery capabilities.
Article
Biochemistry & Molecular Biology
Martynas Maciulevicius, Diana Navickaite, Sonam Chopra, Baltramiejus Jakstys, Saulius Satkauskas
Summary: Research has shown that different calcium concentrations affect cell membrane permeability and cell viability during sonoporation, with ultrasound-microbubble cavitation playing a significant role. The study also indicates that inertial cavitation activities are directly involved in calcium delivery via sonoporation, leading to rapid cell death.
Article
Chemistry, Multidisciplinary
Ines Beekers, Simone A. G. Langeveld, Bram Meijlink, Antonius F. W. van der Steen, Nico de Jong, Martin D. Verweij, Klazina Kooiman
Summary: This study investigated the interaction between microbubbles and endothelial cells during drug delivery. It found that targeted microbubbles were internalized by the cells, leading to changes in microbubble oscillation and resulting membrane perforation. The study provides important insights into the mechanisms of microbubble-mediated drug delivery.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Multidisciplinary Sciences
Reina Kobayashi, Jun Narita, Natsumi Nakaoka, Marie Pierre Krafft, Daisuke Koyama
Summary: Microbubbles show potential applications in drug and gene delivery. Drug release can be triggered by ultrasound and desorption of molecules from the microbubble shell can be observed. The relationship between vibrational characteristics and molecular desorption suggests the possibility of controlling desorption using ultrasound.
SCIENTIFIC REPORTS
(2023)
Article
Acoustics
Spiros Kotopoulis, Christina Lam, Ragnhild Haugse, Sofie Snipstad, Elisa Murvold, Taeraneh Jouleh, Sigrid Berg, Rune Hansen, Mihaela Popa, Emmet Mc Cormack, Odd Helge Gilja, Albert Poortinga
Summary: The aim of this study was to develop high load-capacity antibubbles that can be visualized using diagnostic ultrasound and the encapsulated drug can be released and delivered using clinically translatable ultrasound. The antibubbles were developed by optimising a silica nanoparticle stabilised double emulsion template. The results showed that the developed antibubbles can be visualized using diagnostic ultrasound and have a long half-life, indicating their potential as a viable concept for ultrasound guided drug delivery.
ULTRASONICS SONOCHEMISTRY
(2022)
Article
Acoustics
Caixia Jia, Jianmin Shi, Yao Yao, Tao Han, Alfred C. H. Yu, Peng Qin
Summary: During the recovery of sonoporated cells, localized blebs undergo nucleation, expansion, pausing and retraction on a time scale of tens of seconds to minutes, which are specifically involved in reversibly sonoporated cells. The blebs spatially correlate with the membrane perforation site and temporally lag the resealing of perforated membrane. The diameter and lifetime of the blebs positively correlate with the degree of sonoporation, and intracellular calcium transients might be an upstream signal for triggering blebbing nucleation.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Engineering, Chemical
Martin P. Walsh, Rohan Tikekar, Nitin Nitin, Steven Wrenn
Summary: This study investigates the effectiveness of high-frequency ultrasound-induced microbubble cavitation on bacterial inactivation using liposomal bilayers as a model for bacterial cell membranes. The addition of a positive charge on micmbubbles increased their proximity to liposomes, but dampened microbubble's oscillation. Microstreaming from stable cavitation at 3.3 MHz led to approximately 19% mixing of phospholipids, while inertial cavitation at 1.0 MHz increased this mixing to 50%.
JOURNAL OF FOOD ENGINEERING
(2021)
Review
Oncology
Senbo Liu, Yan Zhang, Yang Liu, Wenkang Wang, Shuochen Gao, Weitang Yuan, Zhenqiang Sun, Lin Liu, Chengzeng Wang
Summary: Cancer immunotherapy has made promising progress, but its therapeutic efficacy needs to be improved. Ultrasound-targeted microbubble destruction is an emerging technology that can remodel the tumor microenvironment and enhance the effectiveness of immunotherapy.
BRITISH JOURNAL OF CANCER
(2023)
Article
Pharmacology & Pharmacy
Martynas Maciulevicius, Mindaugas Tamosiunas, Diana Navickaite, Saulius Satkauskas, Mindaugas S. Venslauskas
Summary: In this study, the efficiency of delivering the anticancer drug doxorubicin into cells using cell sonoporation was investigated. The results showed that inertial cavitation is an efficient technique for the release and intracellular transfer of doxorubicin. Cell death caused by doxorubicin was related to intranuclear and extranuclear mechanisms as revealed by cell confocal imaging. The rate of forward scattering was found to have a high and significant correlation with doxorubicin delivery efficiency and cell viability.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Sofie Snipstad, Sigurd Hanstad, Astrid Bjorkoy, Yrr Morch, Catharina de Lange Davies
Summary: Therapeutic agents benefit from encapsulation in nanoparticles for improved pharmacokinetics and biodistribution, while microbubbles in combination with ultrasound enhance delivery of nanoparticles to cells by mechanisms such as sonoporation and sonoprinting. The proximity between cells, nanoparticles, and microbubbles plays a crucial role in uptake efficiency.
Article
Multidisciplinary Sciences
Louis Lo, Oro Uchenunu, Roberto J. Botelho, Costin N. Antonescu, Raffi Karshafian
Summary: Ultrasound-stimulated microbubble (USMB) treatment is a promising strategy for cancer therapy, promoting drug delivery and impairing cell viability. However, it has heterogeneous effects on cell viability, allowing some cells to survive and/or proliferate through adaptive mechanisms.
Review
Pharmacology & Pharmacy
Arvin Honari, Shashank R. Sirsi
Summary: Despite recent advancements in ultrasound-mediated drug delivery, no platform utilizing ultrasound contrast agents has received FDA approval. The sonoporation effect has promising applications in clinical settings, but there are safety concerns. Clinical trials are being conducted to evaluate sonoporation's efficacy in treating tumors.
Review
Chemistry, Multidisciplinary
Zihao Wen, Chen Liu, Zihao Teng, Quanyi Jin, Zhihuan Liao, Xuan Zhu, Shuaidong Huo
Summary: Ultrasound has been used to enhance drug delivery efficiency by improving cell membrane permeability. The cavitation effect generated by ultrasound can facilitate the delivery of various cargoes, especially nanocarriers. Understanding the biophysical mechanism of ultrasound-cell membrane interaction is significant for the scientific community in drug delivery and nanomedicine.
Article
Engineering, Biomedical
Martynas Maciulevicius, Kumar Anubhav Tiwari, Diana Navickaite, Sonam Chopra, Saulius Satkauskas, Renaldas Raisutis
Summary: In this study, analysis of microbubble (MB) cavitation signals in the acoustic field was conducted to optimize the current cavitation dosimetry model through signal processing. The study identified the optimal frequency range associated with the highest values of differential inertial cavitation dose (ICD) to be 1.5-1.8 MHz, showing clear distinctions from other frequency ranges in MB dynamics tracking and sonoporation optimization.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2021)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)