Review
Instruments & Instrumentation
Prakash Khadka, Jack Dummer, Philip C. Hill, Rajesh Katare, Shyamal C. Das
Summary: Inhaled drug delivery is a promising method for treating tuberculosis and reducing treatment duration. This review examines the clinical implications of pulmonary drug delivery in TB treatment, as well as the delivery systems and animal studies involving rifampicin. The lack of relevant clinical studies and high-dose animal models for inhaled rifampicin formulations is identified as a research gap.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Lucila Garcia-Contreras, Vasu Sethuraman, Masha Kazantseva, Anthony Hickey
Summary: The study found that the combination of rifampicin liposomes (RLs) and rifampicin microparticles (RMs) with liposomes can enhance the permeation of rifampicin into granulomas. RLs delivered via the pulmonary route showed more significant reduction in lung bacterial burden and spleen weight in TB-infected guinea pigs compared to other treatment groups.
Article
Pharmacology & Pharmacy
Christian Etschmann, Regina Scherliess
Summary: Lung tuberculosis is a deadly infectious disease that affects millions of people worldwide. Despite being treatable, many patients only achieve sub-therapeutic concentrations of antibiotics in the infected lung tissue, leading to an alarming number of multi drug resistant tuberculosis cases each year. In this study, researchers demonstrate the effectiveness of using softpellets, engineered dry powder agglomerates, to deliver high doses of antibiotics directly to the lungs. Furthermore, a new process design called vibro-pelletisation for producing softpellets is introduced.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Jibriil P. Ibrahim, Shadabul Haque, Robert J. Bischof, Andrew K. Whittaker, Michael R. Whittaker, Lisa M. Kaminskas
Summary: Enhancing the delivery of therapeutic agents to the lung lymph can significantly improve the treatment and prevention of lung-related illnesses. However, the access of liposomes, a commonly used carrier, to the lung lymphatics after inhalation is limited. Alternative approaches need to be identified to maximize the delivery of drugs to the lung lymph.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Sowmya Ramachandran, Priyanka Prakash, Noratiqah Mohtar, K. Sudesh Kumar, Thaigarajan Parumasivam
Summary: This review provides an overview of the literature on inhalable nano-formulations for the delivery of anti-TB drugs. Previous studies have shown that inhalable nanoparticles can increase therapeutic efficacy and minimize adverse drug reactions, but none of them have progressed into clinical trials to date. This could be due to the high cost and lack of medical acceptance.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2023)
Review
Dermatology
Catherine Barker, Hesham Alshaikh, Dirk Elston
Summary: Atypical mycobacterial infections are commonly acquired through water exposure and tuberculosis is still highly prevalent worldwide. It is essential to maintain a high level of suspicion for cutaneous tuberculosis and atypical mycobacterial infections in this era of global connection. Improved diagnostic techniques have led to enhanced detection and treatment outcomes.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Medicine, General & Internal
Emily A. Kendall, Hamidah Hussain, Amber Kunkel, Rachel W. Kubiak, Anete Trajman, Richard Menzies, Paul K. Drain
Summary: The study found that using symptom-based screening for TB before initiating TPT can effectively reduce the occurrence of active TB cases, but may lead to an increase in drug resistance. Screening for subclinical TB can eliminate this increase in drug resistance, but if the screening requirement reduces access to TPT interventions, it may decrease the overall impact of TB prevention.
Article
Chemistry, Analytical
Rongchao Mei, Yunqing Wang, Xizhen Zhao, Qi Kang, Dazhong Shen, Lingxin Chen
Summary: Understanding the behavior of photothermal nanomedicines (PTNMs) in vivo is crucial for drug development and evaluation, but remains challenging. A near-infrared light-responsive surface-enhanced Raman scattering strategy can reveal key parameters such as the depth of PTNMs under biological tissue and the drug release ratio in vivo. This study provides a new avenue for studying drug release of PTNMs and reporting depth accurately, promoting the application of PTNMs in vivo.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Jianqing Peng, Qin Wang, Mingyang Guo, Chunyuan Liu, Xuesheng Chen, Ling Tao, Ke Zhang, Xiangchun Shen
Summary: In this study, a CS-coated liposome loaded with OMT was used for the treatment of lethal RSV infection. The CS-coated liposome enhanced the distribution and retention of OMT in lung tissue, effectively alleviating RSV infection. Thus, the CS-coated liposome could be a potential inhalable nanocarrier for preventing pulmonary infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Rami Ayoun Alsoud, Robin J. J. Svensson, Elin M. M. Svensson, Stephen H. H. Gillespie, Martin J. J. Boeree, Andreas H. H. Diacon, Rodney Dawson, Rob E. E. Aarnoutse, Ulrika S. H. Simonsson
Summary: This study aimed to develop a combined quantitative tuberculosis biomarker model for assessing drug efficacy in early bactericidal activity studies. By using CFU and TTP data simultaneously, the model provides an efficient approach to evaluate drug efficacy and describe the relationship between CFU and TTP over time.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Environmental Sciences
Marzie Alizadeh, Padideh Naderi Asrami, Elif Esra Altuner, Fulya Gulbagca, Rima Nour Elhouda Tiri, Aysenur Aygun, Fatih Sen, Somaye Cheraghi, Idris Kaynak
Summary: This study aimed to develop sensors sensitive to antibiotics by synthesizing metallic nanoparticles and evaluate their performance for tuberculosis drugs. The modified electrode showed the highest signal, and characterization techniques were used to determine the morphology of the nanoparticles. The results indicated a positive correlation between the size of the nanoparticles and the current intensity.
Article
Engineering, Biomedical
Pranav Ponkshe, Sheng Feng, Chalet Tan
Summary: Inhalation delivery of liposomal drugs offers advantages for treating pulmonary diseases, with several inhalable liposomes currently in clinical trials for various indications in the lungs. This review discusses the general principles of pulmonary delivery and the clinical development of inhalable liposomal drugs.
BIOMEDICAL MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Federica Rinaldi, Patrizia Nadia Hanieh, Simona Sennato, Federica De Santis, Jacopo Forte, Maurizio Fraziano, Stefano Casciardi, Carlotta Marianecci, Federico Bordi, Maria Carafa
Summary: Treatment of pulmonary infections caused by Mycobacterium abscessus is challenging due to the bacterium's natural resistance to antibiotics. Formulating rifampicin-loaded liposomes for lung delivery can help increase the local concentration of the drug and enhance its biological activity against intracellular mycobacteria. Overall, liposome formulation of rifampicin represents a promising strategy for combating Mycobacterium abscessus infections.
Article
Pharmacology & Pharmacy
Kamila Bohne Japiassu, Francois Fay, Alessandro Marengo, Sebastiao A. Mendanha, Catherine Cailleau, Younes Louaguenouni, Qinglin Wang, Stephanie Denis, Nicolas Tsapis, Thais Leite Nascimento, Eliana Martins Lima, Elias Fattal
Summary: In this study, lipid nanoparticulate platforms loaded with dexamethasone were developed and evaluated. The dexamethasone-loaded liposomes, with sizes below 150 nm, were coated with polyethylene glycol, hyaluronic acid, or a mixture of both to cross the pulmonary mucus layer and target alveolar proinflammatory macrophages expressing CD44. In vitro experiments showed that encapsulated dexamethasone in liposomes, especially in HA-bearing ones, improved anti-inflammatory efficacy compared to the free drug. In vivo data demonstrated that dexamethasone-loaded liposomes exhibited improved consistency in efficacy compared to free dexamethasone.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Monica Joshi, Bala Prabhakar
Summary: Rifampicin-loaded bovine serum albumin nanoparticles were prepared using a desolvation method with EDC as the cross-linking agent, showing a biphasic in vitro release pattern. The formulation demonstrated suitability for pulmonary delivery and the potential for reducing the dose required for tuberculosis treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Medicinal
Mohammed M. Mehanna, Amina Tarek Mneimneh, Khaled Abed El Jalil
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2020)
Review
Pharmacology & Pharmacy
Mohammed M. Mehanna, Amina Tarek Mneimneh
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Pharmacology & Pharmacy
Jana K. Alwattar, Racha Chouaib, Alia Khalil, Mohammed M. Mehanna
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Nanoscience & Nanotechnology
Mohammed M. Mehanna, Amina Tarek Mneimneh, Souraya Domiati, Ahmed N. Allam
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Article
Nanoscience & Nanotechnology
Mohammed M. Mehanna, Rana Sarieddine, Jana K. Alwattar, Racha Chouaib, Hala Gali-Muhtasib
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Article
Nanoscience & Nanotechnology
Salma M. Mohyeldin, Wael M. Sanny, Doaa Ragab, Doaa A. Abdelmonsif, Rania G. Aly, Nazik A. Elgindy
Summary: SUL-LPS were developed to enhance the permeability and oral bioavailability of SUL, resulting in improved antidepressant action. Pharmacodynamic study showed elevated serotonin and dopamine expressions with SUL-LPS compared to free drug.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Pharmacology & Pharmacy
Amina T. Mneimneh, Mohammed M. Mehanna
Summary: Collagen-based scaffolds play a significant role in promoting regeneration, repair, and recovery of spinal cord injuries by providing a suitable environment for tissue repair, axonal regeneration, and vascularization. They are biocompatible, biodegradable, and widely used in pharmaceutical, cosmetic, food industries, and tissue engineering. Functionalized with different ligands and factors, collagen in scaffolds enhances its binding specificity and activity.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Pharmacology & Pharmacy
Mohammed M. Mehanna, Kawthar K. Abla
Summary: The discovery of predisposition and genetic alterations in cancer cells has led to the investigation of exogenous small interference RNA (siRNA) as a therapeutic option for cancer treatment. However, the limitations of siRNA, such as hindered cellular uptake, have spurred the development of various nanocarriers to improve their transportation. The emergence of nanohybrid systems aims to overcome these limitations and synergize the advantages of multiple nanocarriers for targeted cancer therapy.
THERAPEUTIC DELIVERY
(2022)
Review
Pharmacology & Pharmacy
Mohammed M. Mehanna, Kawthar K. Abla
Summary: This article provides a detailed explanation of the concept, stages, factors influencing the freeze-drying process, and the recent innovative technologies proposed to overcome the limitations of traditional freeze-drying. It also highlights the importance of quality by design, critical quality attributes, and the drawbacks of lyophilization.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Kawthar K. Abla, Amina T. Mneimneh, Ahmed N. Allam, Mohammed M. Mehanna
Summary: This study developed and evaluated an oral fast dissolving film containing tadalafil-loaded niosomes for the treatment of benign prostatic hyperplasia (BPH). The optimized niosomes showed high entrapment efficiency and the film had desirable characteristics. The tadalafil-loaded niosomal film demonstrated faster release and enhanced bioavailability compared to the marketed tablet.
Article
Polymer Science
Kawthar K. Abla, Souraya Domiati, Rania El Majzoub, Mohammed M. Mehanna
Summary: This study aimed to design a thermo-responsive intranasal limonene-based microemulsion mucoadhesive nanogel to enhance the efficacy of propranolol, which is the first-line drug for managing migraine attacks. The microemulsion, loaded in the nanogel, exhibited favorable physicochemical characteristics and showed improved nasal permeability compared to the control gel. Histopathological examination confirmed the safety profile of the nanogel. Furthermore, the nanogel significantly increased the brain availability of propranolol, indicating its potential for migraine management.
Review
Pharmacology & Pharmacy
Mohammed M. Mehanna, Amina Tarek Mneimneh
Summary: The drug delivery field has expanded to overcome challenges such as poor drug solubility and absorption. Lipids are promising for delivering poorly water-soluble and lipophilic drugs, and various nanoparticles offer unique benefits as pharmaceutical carriers. The trend in synthesis is towards simple, cost-effective techniques, with self-emulsifying systems gaining superiority over other carriers.
ADVANCED PHARMACEUTICAL BULLETIN
(2021)
Article
Pharmacology & Pharmacy
Mohammed Maher Mehanna
INTERNATIONAL JOURNAL OF PHARMACEUTICAL INVESTIGATION
(2020)
Article
Pharmacology & Pharmacy
Mohammed Maher Mehanna
INTERNATIONAL JOURNAL OF PHARMACEUTICAL INVESTIGATION
(2020)
Article
Pharmacology & Pharmacy
Mohammed M. Mehanna, Kawthar Khalil Abla, Hoda A. Elmaradny
Summary: The study designed and evaluated a novel microemulsion based on D-limonene and Gelucire(R) 44/12, optimized through investigating the impact of microemulsion components and ratios on the isotropic region of the pseudo-ternary phase diagram. The optimized microemulsion displayed good optical transparency and stability.
ADVANCED PHARMACEUTICAL BULLETIN
(2021)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)