Article
Nanoscience & Nanotechnology
Lingyun Jin, Saeed Rohani
Summary: In this study, illicium verum extract (IVE) was incorporated into polycaprolacton/collagen nanofibrous scaffolds through electrospinning technique. The resulting membranes were characterized in vitro and their efficacy in spinal cord injury repair was evaluated in a rat model. In vitro studies demonstrated that the IVE-loaded scaffolds exhibited fibrous morphology and protected against cellular death under oxidative stress conditions. In vivo study showed that the developed scaffolds improved locomotor function after 8 weeks of treatment.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Chen Qiu, Yuan Sun, Jinying Li, Jiayi Zhou, Yuchen Xu, Cong Qiu, Kang Yu, Jia Liu, Yuanqing Jiang, Wenyu Cui, Guanghao Wang, He Liu, Weixin Yuan, Tuoying Jiang, Yaohui Kou, Zhen Ge, Zhiying He, Shaomin Zhang, Yong He, Luyang Yu
Summary: A novel cell delivery platform called the hyper expansion scaffold (HES) has been developed to enable high cell loading. The HES facilitates self-promoted and efficient cell absorption through a dual driving force model. In vitro and in vivo experiments have demonstrated that the HES has great potential as a powerful and efficient vehicle for delivering high densities of cells for nerve repair and tissue engineering.
Article
Nanoscience & Nanotechnology
Sisi Mi, Zhuo Chang, Xue Wang, Jiaxin Gao, Yu Liu, Wenjia Liu, Wangxiao He, Zhongquan Qi
Summary: Spinal cord injury (SCI) is a severe injury of the central nervous system, causing functional dysfunction and paralysis in millions of patients. A bioactive scaffold, called a spinal cord assembly (SCA), was created using cell-sheet technology and stem cells. This scaffold released neurotrophic exosomes, promoting neuronal regeneration, axonal extension, angiogenesis, and inhibiting glial scar formation in a SCI rat model.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Neurosciences
Ashraful Islam, Veronica J. Tom
Summary: Spinal cord injury is a devastating event that can permanently disrupt multiple functions, and delivering genetic material using viral vectors has the potential to promote axon regeneration and overcome obstacles. However, various factors should be considered when using viral vector for gene therapy. Gene therapy shows promise in preclinical models for treating spinal cord injury.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Medicine, Research & Experimental
Guangjin Gu, Jie Ren, Bin Zhu, Zhongju Shi, Shiqing Feng, Zhijian Wei
Summary: Spinal cord injury (SCI) is an irreversible disease process with a high disability and mortality rate. Curcumin, as the main active ingredient in turmeric, plays an important role in reducing inflammation and oxidation, protecting neurons, and ultimately reducing spinal cord injury by effectively curbing the process of secondary injury.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Engineering, Biomedical
Yuan-huan Ma, Hui-juan Shi, Qing-shuai Wei, Qing-wen Deng, Jia-hui Sun, Zhou Liu, Bi-qin Lai, Ge Li, Ying Ding, Wan-ting Niu, Yuan-shan Zeng, Xiang Zeng
Summary: The study introduces a mechanically enhanced decellularized spinal cord (DSC) scaffold with a thin poly (lactic-co-glycolic acid) (PLGA) outer shell, showing promise for effective in situ neuroengineering after spinal cord injury (SCI).
Review
Cell Biology
Jia Feng, Yifan Zhang, Zhihan Zhu, Chenyang Gu, Ahmed Waqas, Lukui Chen
Summary: Exosomes, as intracellular mediators, have been implicated in the pathophysiological processes of various diseases, including spinal cord injury. They are considered to potentially play a significant role in the treatment of SCI.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Engineering, Biomedical
Xingzhi Liu, Lulu Zhang, Zhongjuan Xu, Xuan Xiong, Yanzhen Yu, Hanfei Wu, Hong Qiao, Junjie Zhong, Zhe Zhao, Jianwu Dai, Guangli Suo
Summary: This study aims to develop genetically engineered miR21-loaded exosomes that can be stably tethered to a collagen-I scaffold, promoting the sustained release of miR21 and benefiting spinal cord injury repair.
ACTA BIOMATERIALIA
(2022)
Review
Engineering, Biomedical
D. Silva, R. A. Sousa, A. J. Salgado
Summary: Hydrogel delivery systems have the potential to promote regeneration after spinal cord injury by supporting axonal growth and endogenous regeneration, as well as loading and releasing therapeutic agents. Important characteristics to consider when designing hydrogels as delivery systems include rheology, mesh size, swelling, degradation, gelation temperature, and surface charge.
MATERIALS TODAY BIO
(2021)
Review
Biochemistry & Molecular Biology
Bogdan Costachescu, Adelina-Gabriela Niculescu, Marius Gabriel Dabija, Raluca Ioana Teleanu, Alexandru Mihai Grumezescu, Lucian Eva
Summary: This review focuses on the recent advancements in the treatment and repair of spinal cord injuries, including the use of nanocarriers, biomolecules, cell therapies, and biomaterial scaffolds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Dingyang Liu, He Shen, Yeyu Shen, Ge Long, Xinghui He, Yannan Zhao, Zhiquan Yang, Jianwu Dai, Xing Li
Summary: The study indicates that the scaffold loaded with dual cues shows good effects in promoting neuron and endothelial cell migration, as well as axon and vessel regeneration. Long-term therapeutic effects include revascularization, spinal cord axonal regeneration, fibrotic scar reduction, electrophysiological recovery, and motor function improvement.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Polymer Science
Fei Xue, Tianyi Liu, Xin Liu, Kexin Chen, Lijie Duan, Guanghui Gao
Summary: The reduced graphene oxide composite xanthan gum scaffold for spinal cord repair, constructed through freeze-drying technology, possesses high electrical conductivity, soft mechanical properties, and a porous internal structure. It promotes orderly growth of regenerated nerve fibers and inhibits glial scar formation, leading to restoration of locomotor function in spinal cord injury.
EUROPEAN POLYMER JOURNAL
(2022)
Review
Neurosciences
Rakib Uddin Ahmed, Chase A. Knibbe, Felicia Wilkins, Leslie C. Sherwood, Dena R. Howland, Maxwell Boakye
Summary: Animal models are important for spinal cord injury research. Small animal models have advantages in terms of management and cost, but their neurologic and anatomical differences may limit their translation to humans. In contrast, large animal models are more similar to humans and have greater translational value in studying spinal cord injury.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Engineering, Biomedical
Andrew J. Ciciriello, Bapurao Surnar, Giovanni D. Medy, Xiaoyu Su, Shanta Dhar, Courtney M. Dumont
Summary: Drug delivery requires precision in timing, location, and dosage. To address the challenges in achieving therapeutic benefits, researchers have developed the BEACON platform, which utilizes an implantable biomaterial as a target for systemically delivered nanoparticles (NPs). The BEACON system has demonstrated temporal dexterity, decreased off-target accumulation, and retention of NPs in the target biomaterial, showing its broad applicability in improving targeted drug delivery.
ACTA BIOMATERIALIA
(2022)
Review
Chemistry, Multidisciplinary
Yiran Li, Ting Dong, Zhiwei Li, Shilei Ni, Fang Zhou, Olawale A. Alimi, Shaojuan Chen, Bin Duan, Mitchell Kuss, Shaohua Wu
Summary: Spinal cord injury is a devastating neurological condition, and neural tissue engineering combined with electrospinning technique shows great potential for its treatment.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Engineering, Biomedical
Kiran Pawar, Brian J. Cummings, Aline Thomas, Lonnie D. Shea, Ariel Levine, Sam Pfaff, Aileen J. Anderson
Article
Chemistry, Multidisciplinary
Aline M. Thomas, Jaime L. Palma, Lonnie D. Shea
JOURNAL OF CONTROLLED RELEASE
(2015)
Article
Engineering, Biomedical
Aline M. Thomas, Matthew B. Kubilius, Samantha J. Holland, Stephanie K. Seidlits, Ryan M. Boehler, Aileen J. Anderson, Brian J. Cummings, Lonnie D. Shea
Article
Engineering, Biomedical
Aline M. Thomas, Andrew J. Gomez, Jaime L. Palma, Woon Teck Yap, Lonnie D. Shea
Article
Environmental Sciences
Werner Olipitz, Dominika Wiktor-Brown, Joe Shuga, Bo Pang, Jose McFaline, Pallavi Lonkar, Aline Thomas, James T. Mutamba, Joel S. Greenberger, Leona D. Samson, Peter C. Dedon, Jacquelyn C. Yanch, Bevin P. Engelward
ENVIRONMENTAL HEALTH PERSPECTIVES
(2012)
Article
Cell Biology
Aline M. Thomas, Stephanie K. Seidlits, Ashley G. Goodman, Todor V. Kukushliev, Donna M. Hassani, Brian J. Cummings, Aileen J. Anderson, Lonnie D. Shea
INTEGRATIVE BIOLOGY
(2014)
Article
Materials Science, Biomaterials
Aline M. Thomas, Lonnie D. Shea
JOURNAL OF MATERIALS CHEMISTRY B
(2014)
Article
Engineering, Biomedical
Aline M. Thomas, Nicholas M. Beskid, Jennifer L. Blanchfield, Aaron M. Rosado, Andres J. Garcia, Brian D. Evavold, Julia E. Babensee
Summary: The study demonstrated that local delivery of DC10s modulates immune cell recruitment and attenuates disease progression in a preclinical model of MS.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Aline M. Thomas, Frederik Barkhof, Jeff W. M. Bulte
Summary: Imaging technology is an essential component in the management of multiple sclerosis, allowing for the evaluation of therapeutic efficacy. The development of molecular imaging probes has expanded our ability to assess and monitor multiple sclerosis and its treatments at the molecular level. However, despite the demonstrated utility of molecular imaging probes in multiple sclerosis applications, their use remains limited in both preclinical and clinical settings.
Review
Cell & Tissue Engineering
Xue-Song Liang, Zheng-Wu Sun, Aline M. M. Thomas, Shen Li
Summary: This meta-analysis evaluated the effects of mesenchymal stem cells (MSCs) on Huntington disease (HD) and found positive outcomes in morphological changes, motor coordination, muscle strength, neuromuscular electromyography activity, cortex-related motor function, and striatum-related motor function. However, MSC therapy did not have a significant impact on cognition.
STEM CELLS INTERNATIONAL
(2023)
Article
Medicine, Research & Experimental
Shaima Salman, David J. Meyers, Elizabeth E. Wicks, Sophia N. Lee, Emmanuel Datan, Aline M. Thomas, Nicole M. Anders, Yousang Hwang, Yajing Lyu, Yongkang Yang, Walter Jackson, Dominic Dordai, Michelle A. Rudek, Gregg L. Semenza
Summary: A low-molecular-weight compound called 32-134D has been found to effectively inhibit gene expression mediated by HIF-1 and HIF-2 in hepatocellular carcinoma (HCC) cells, and blocks tumor growth. When combined with anti-PD1 therapy in a mouse model, 32-134D increased the rate of tumor eradication from 25% to 67%. This compound alters gene expression related to the tumor immune microenvironment, leading to improved immune response against the tumor.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Cell & Tissue Engineering
Chengyan Chu, Yue Gao, Xiaoyan Lan, Jianwen Lin, Aline M. Thomas, Shen Li
STEM CELL REVIEWS AND REPORTS
(2020)
Article
Polymer Science
Giri Gururajan, Victoria Froude, Stephen Riutta, Aline Thomas, Ian Gao, S. L. Samuels, D. F. Massouda, M. Weinberg, A. A. Ogale
JOURNAL OF APPLIED POLYMER SCIENCE
(2008)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)