Article
Instruments & Instrumentation
Inbar Shreiber-Livne, Liron Sulimani, Anna Shapira, Shiri Procaccia, David Meiri, Alejandro Sosnik
Summary: This study investigates the encapsulation of non-psychoactive CBD in nanoparticles to improve its oral performance. The CBD-loaded nanoparticles exhibit high encapsulation efficiency and release the drug more efficiently under intestine-like conditions. Oral pharmacokinetics in rats demonstrate a significant increase in drug concentration and faster absorption compared to free CBD suspension. The study highlights the potential of this nanotechnology strategy to enhance the oral bioavailability of CBD.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Polymer Science
Victoria J. Barber, Meredith A. Borden, Jill W. Alty, Ly D. Tran, Hilmar Koerner, Luke A. Baldwin, Erik J. Alexanian, Frank A. Leibfarth
Summary: There is an increasing demand for degradable polymers in sustainable plastics and medical implants. To improve their usability, it is necessary to have a better understanding of degradation factors and develop new tools for modulation. In this study, poly(caprolactone) was modified through C-H xanthylation, resulting in changes in material properties and slower degradation. The interplay between molecular and materials characteristics was found to impact the degradation rate.
Article
Pharmacology & Pharmacy
Ekta Singh, Riyaz Ali M. Osmani, Rinti Banerjee, Amr Selim Abu Lila, Afrasim Moin, Khaled Almansour, Hany H. Arab, Hadil Faris Alotaibi, El-Sayed Khafagy
Summary: This study developed leflunomide-loaded nanoparticles as a local drug delivery system for the treatment of rheumatoid arthritis. The nanoparticles showed sustained drug release in simulated synovial fluid and demonstrated efficacy in reducing inflammation and immune responses without notable toxicity in animal models. These findings suggest that intra-articularly administered leflunomide nanoparticles could be a potential alternative to systemic drugs for the treatment of rheumatoid arthritis.
Article
Pharmacology & Pharmacy
Natalia Toncheva-Moncheva, Erik Dimitrov, Georgi Grancharov, Denitsa Momekova, Petar Petrov, Stanislav Rangelov
Summary: This study developed novel block copolymer nanocarriers for enhancing the solubility of CBD in water and achieving high encapsulation efficiency and controlled drug release. The block copolymers were synthesized and CBD was loaded into micellar carriers. The CBD-loaded micelles showed higher encapsulation efficiency and slower drug release compared to the non-modified copolymer. The micellar CBD demonstrated pronounced antitumor activity against HL-60 and HUT-78 cell lines.
Article
Pharmacology & Pharmacy
Cansu Ulker Turan, Yuksel Guvenilir
Summary: In recent years, there has been increasing attention on the use of biocompatible electrospun nanofibers for drug delivery applications, as they offer advantages such as high surface area and controlled drug release, while mimicking the extracellular matrix. In this study, tetracycline hydrochloride-loaded nanofibrous membranes were fabricated using a combination of synthetic polymers and natural proteins/polysaccharides to create a novel controlled drug delivery system. Various characterization techniques were used to examine the drug incorporation and release behavior, and the system showed promising drug release and antibacterial activity, making it a potential candidate for wound dressing applications in the treatment of skin infections.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Ruben Varela-Fernandez, Maria Isabel Lema-Gesto, Miguel Gonzalez-Barcia, Francisco Javier Otero-Espinar
Summary: The study achieved controlled and prolonged release of idebenone by designing and developing PCL implants, providing a new strategy for treating LHON. Through in vitro evaluation, it was found that PCL implants not only have high stability but also long-lasting drug release capability.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Polymer Science
Ramasamy Anbarasan, Appachi Murugesan, Balakrishnan Meenarathi
Summary: Ring opening polymerization (ROP) of epsilon-caprolactone (CL) was conducted at 160 degrees C using an initiator (dye) and a catalyst (MnO2) under nitrogen atmosphere. The synthesized fluorescent poly(epsilon-caprolactone) (PCL) with dye end capping showed hydrophobicity and suitability for ultrasound accelerated drug release.
IRANIAN POLYMER JOURNAL
(2022)
Article
Multidisciplinary Sciences
Priya Patel, Mihir Raval, Aneka Manvar, Vishal Airao, Vaibhav Bhatt, Pranav Shah
Summary: This study aimed to develop SB-loaded PCL/Pluronic F68 nanoparticles for the treatment of lung cancer. The nanoparticles demonstrated long circulation and successful lung tumor-targeting potential, and effectively inhibited tumor growth. Moreover, the nanoparticles significantly improved SB bioavailability.
Review
Polymer Science
Siti Hajar Ahmad Shariff, Wan Khartini Wan Abdul Khodir, Shafida Abd Hamid, Muhammad Salahuddin Haris, Mohamad Wafiuddin Ismail
Summary: The use of nanoparticles in drug delivery systems for cancer treatment, particularly PCL-PEG-based micelles as potential drug carriers, has gained significant attention. While studies have shown the efficacy of PCL-PEG micelles for breast cancer therapy, further research is needed to evaluate their effectiveness for other specific cancer types.
Article
Instruments & Instrumentation
Ana Isabel Fraguas-Sanchez, Dolores Hernan, Consuelo Montejo, Justin L. Poklis, Aron H. Lichtman, Ana Isabel Torres-Suarez
Summary: This study evaluates the pharmacokinetics and release characteristics of CBD formulated in polymer microparticles for subcutaneous administration. Comparing the release of CBD from two microparticle formulations in vitro and in vivo, it was found that they had similar dissolution profiles in vitro but significant differences in blood and brain pharmacokinetics. Extended release of CBD was achieved after a single subcutaneous administration.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Polymer Science
Karolis Norinkevicius, Jeppe Madsen, Line Elmstrom Christiansen, Sebastian Meier, Andreas Horner, Radoslaw Gorecki, Torsten Hoybye Bak Regueira, Anders Egede Daugaard
Summary: The synthesis of block copolymers based on polyethylene glycol (PEG) and polycaprolactone (PCL) was reported. PEG-b-PCL diblock copolymers were prepared using enzymatic and tin-mediated ring-opening polymerization. Well-defined PEG-b-PCL-b-PEG triblock copolymers were synthesized through the coupling of PEG-b-PCL diblock copolymers. The aggregation behavior of diblock and triblock copolymers was studied using a direct hydration technique. The inclusion of amine-functional diblock copolymer favored cylindrical micelle formation.
Article
Polymer Science
Julia Radwan-Praglowska, Lukasz Janus, Marek Piatkowski, Aleksandra Sierakowska, Ernest Szajna, Dalibor Matysek, Dariusz Bogdal
Summary: Epilepsy is a common neurological disease that can have a significant negative impact on quality of life, especially when symptoms are drug-resistant. Cannabidiol, derived from Cannabis Sativa, offers new hope for epilepsy treatment, with potential benefits in increasing bioactivity through transdermal delivery.
Article
Polymer Science
Wanda Celentano, Stefania Ordanini, Riccardo Bruni, Luca Marocco, Pietro Medaglia, Andrea Rossi, Stefano Buzzaccaro, Francesco Cellesi
Summary: Well-defined amphiphilic PCL-PEG copolymers with complex molecular architectures were synthesized using ROP and ATRP. These copolymers were used to produce self-assembled nanoparticles for drug encapsulation, with the ability to tune self-assembly, particle size, and drug loading by designing specific macromolecular architectures.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Polymer Science
Pierre P. D. Kondiah, Thankhoe A. Rants'o, Sipho Mdanda, Lauwrence M. Mohlomi, Yahya E. Choonara
Summary: This study aimed to create a thermo-responsive nano-hydrogel delivery system for the treatment of psoriasis vulgaris. The results showed that the synthesized drug-delivery system was less toxic to keratinocyte cells compared to the current treatment and had potential value for transdermal drug delivery.
Article
Polymer Science
Yuandou Wang, Shuxin Wang, Wenju Hu, Feng Su, Fusheng Liu, Suming Li
Summary: Amphiphilic block copolymers were synthesized and photo-crosslinked hydrogels were prepared. The hydrogels exhibited high swelling and excellent biocompatibility. Drug loading efficiency and release rate were dependent on the hydrogel properties. Hydrogels with higher drug concentration and shorter hydrophobic block length showed higher anti-cancer activity. Therefore, these hydrogels have great potential for long-term local cancer therapy.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Article
Pharmacology & Pharmacy
Antonio Inserra, Giada Giorgini, Sebastien Lacroix, Antonella Bertazzo, Jocelyn Choo, Athanasios Markopolous, Emily Grant, Armita Abolghasemi, Danilo De Gregorio, Nicolas Flamand, Geraint Rogers, Stefano Comai, Cristoforo Silvestri, Gabriella Gobbi, Vincenzo Di Marzo
Summary: This study found that repeated administration of lysergic acid diethylamide (LSD) induces prosocial effects in mice and affects the composition of the hippocampal endocannabinoidome and gut microbiota.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ester Pagano, Barbara Romano, Donatella Cicia, Fabio A. Iannotti, Tommaso Venneri, Giuseppe Lucariello, Maria Francesca Nani, Fabio Cattaneo, Paola De Cicco, Maria D'Armiento, Marcello De Luca, Ruggiero Lionetti, Stefania Lama, Paola Stiuso, Pietro Zoppoli, Geppino Falco, Silvia Marchiano, Stefano Fiorucci, Raffaele Capasso, Vincenzo Di Marzo, Francesca Borrelli, Angelo A. Izzo
Summary: TRPM8 is overexpressed in colorectal cancer and its high expression is associated with lower survival rate of patients and hyperactivation of related signaling pathways. TRPM8 may serve as a prognostic marker and potential drug target for colorectal cancer.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Obstetrics & Gynecology
Camille Dugas, Laurence Laberee, Julie Perron, Gabrielle St-Arnaud, Veronique Richard, Veronique Perreault, Nadine Leblanc, Isabelle Marc, Vincenzo Di Marzo, Alain Doyen, Alain Veilleux, Julie Robitaille
Summary: This study compared the macronutrient and energy content of human milk between women with and without GDM. The results showed that protein, lactose, and energy content were similar between the two groups, but the concentration of TG was higher in women with GDM. Maternal age and fasting glucose level were associated with the composition of human milk, and TG in human milk was associated with infant growth in children without GDM.
BREASTFEEDING MEDICINE
(2023)
Article
Medicine, Research & Experimental
Hilal Kalkan, Ester Pagano, Debora Paris, Elisabetta Panza, Mariarosaria Cuozzo, Claudia Moriello, Fabiana Piscitelli, Armita Abolghasemi, Elisabetta Gazzerro, Cristoforo Silvestri, Raffaele Capasso, Andrea Motta, Roberto Russo, Vincenzo Di Marzo, Fabio Arturo Iannotti
Summary: This study found that there are changes in the gut microbiota composition, short-chain fatty acids (SCFAs) levels, and related metabolites in the mdx mouse model of Duchenne muscular dystrophy (DMD) compared to healthy controls. Supplementation with sodium butyrate (NaB) in mdx mice showed similar benefits as deflazacort (DFZ) in terms of muscle strength, autophagy, and inflammation. In LPS-stimulated C2C12 myoblasts, NaB reduced inflammation, promoted autophagy, and prevented dysregulation of microRNAs targeting the endocannabinoid CB1 receptor gene through the activation of GPR109A and PPAR gamma receptors. This suggests a potential disease-modifying approach for DMD and other muscular dystrophies.
EMBO MOLECULAR MEDICINE
(2023)
Article
Chemistry, Medicinal
Francesca Intranuovo, Leonardo Brunetti, Pietro DelRe, Giuseppe Felice Mangiatordi, Angela Stefanachi, Antonio Laghezza, Mauro Niso, Francesco Leonetti, Fulvio Loiodice, Alessia Ligresti, Magdalena Kostrzewa, Jose Brea, Maria Isabel Loza, Eddy Sotelo, Michele Saviano, Nicola Antonio Colabufo, Chiara Riganti, Carmen Abate, Marialessandra Contino
Summary: CB2R, a receptor in the endocannabinoid system, is overexpressed in inflammatory pathologies and its activation has anti-inflammatory effects. FAAH is an enzyme responsible for breaking down endocannabinoids, and inhibiting FAAH while activating CB2R may have synergistic anti-inflammatory effects. Through chemical analysis, a small library of adamantyl-benzamides was designed as potential dual agents to activate CB2R and inhibit FAAH. The new compounds showed promising anti-inflammatory effects by reducing pro-inflammatory cytokines and increasing anti-inflammatory cytokines.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Alexandre Perez-Lopez, Ana Isabel Torres-Suarez, Cristina Martin-Sabroso, Juan Aparicio-Blanco
Summary: The blood-brain barrier (BBB) poses challenges for drug delivery to the central nervous system, resulting in unmet medical needs for brain diseases. Research on the three-dimensional structure of the BBB provides insights into its pathology and aids in the development of novel brain disease therapies. Various 3D models, including hydrogel, spheroid, organoid-based static models, and microfluidic-based BBB-on-a-chip models, have been developed to mimic the human neurovascular unit. This review discusses the development and application of these BBB models for permeability testing of nanomedicines, as well as their advantages and disadvantages, and the validation of their results with in vivo preclinical data.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Martina Di Bartolomeo, Tibor Stark, Serena Di Martino, Fabio Arturo Iannotti, Jana Ruda-Kucerova, Giovanni Luca Romano, Martin Kuchar, Samuele Laudani, Petr Palivec, Fabiana Piscitelli, Carsten T. Wotjak, Claudio Bucolo, Filippo Drago, Vincenzo Di Marzo, Claudio D'Addario, Vincenzo Micale
Summary: Adolescent exposure to cannabinoids, such as THC, may increase the risk of psychosis in individuals exposed to perinatal insult. In this study, the researchers examined the effects of peripubertal THC exposure on rats that were also exposed to prenatal methylazoxymethanol acetate (MAM) or perinatal THC (pTHC). They found that the rats exposed to MAM or pTHC exhibited adult phenotypes relevant to schizophrenia, including social withdrawal and cognitive impairment. The researchers also observed changes in gene expression and DNA methylation, suggesting potential molecular mechanisms underlying these effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
M. Cristina Beneitez Garcia, Rocio Giron Moreno, Ines Colmena Crespo, Rosalia M. Diez-Orejas, M. Isabel Martin Fontelles, Carlos Goicoechea Garcia, Eva M. Sanchez-Robles, M. Esther Gil-Alegre
Summary: The misuse of opioids not only poses a public health emergency but also has significant social and economic implications. The main therapy involves the use of opioid antagonists. This study evaluates the anti-opioid properties of naloxone loaded-poly(lactic-co-glycolic) acid microparticles (NX-MP) both in vitro and in vivo. The results demonstrate the efficacy of NX-MP in antagonizing morphine effects and suggest its potential as a non-addictive alternative to naltrexone.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Cell Biology
Federica Maccarinelli, Daniela Coltrini, Silvia Mussi, Mattia Bugatti, Marta Turati, Paola Chiodelli, Arianna Giacomini, Floriana De Cillis, Nadia Cattane, Annamaria Cattaneo, Alessia Ligresti, Michela Asperti, Maura Poli, William Vermi, Marco Presta, Roberto Ronca
Summary: Prostate cancer often relapses as castration-resistant prostate cancer (CRPC) and is a leading cause of male death. A recently described form of cell death called ferroptosis requires abundant cytosolic labile iron, and its induction can be enhanced by inhibiting glutathione peroxidase-4 with RSL3. This study demonstrates that iron supplementation significantly increases the effectiveness of RSL3 in triggering lipid peroxidation and cancer cell death in prostate cancer. Additionally, the combination of RSL3 with the anti-androgen drug enzalutamide shows superior inhibition of prostate cancer and prevents the development of CRPC.
CELL DEATH DISCOVERY
(2023)
Article
Biochemistry & Molecular Biology
Analia Young Hwa Cho, Hery Chung, Javier Romero-Parra, Poulami Kumar, Marco Allara, Alessia Ligresti, Carlos Gallardo-Garrido, Hernan Pessoa-Mahana, Mario Faundez, Carlos David Pessoa-Mahana
Summary: The endocannabinoid system (ECS) is a broad-spectrum modulator of homeostasis in mammals, offering therapeutic opportunities for various pathologies. In this study, a new library of compounds targeting the CB2 receptor was synthesized by combining natural product motifs with a benzo[d]imidazole scaffold. SAR analysis revealed the importance of bulky aliphatic or aromatic natural product motifs in receptor recognition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Hayatte-Dounia Mir, Giada Giorgini, Vincenzo Di Marzo
Summary: This review article focuses on the expanded endocannabinoid system (eCBome) and the gut microbiome, which are increasingly attracting attention as sources of chemical signals regulating food intake, energy metabolism, and body weight. The article describes the mechanisms through which these two systems, in interactions with other signaling systems, intervene in eating disorders, based on studies in experimental models or patients. Furthermore, the article discusses the possibility of the involvement of the eCBome-gut microbiome axis in eating disorders, considering the emerging multi-faceted cross-talk mechanisms between these complex systems.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Cell Biology
Hilal Kalkan, Elisabetta Panza, Ester Pagano, Giuseppe Ercolano, Claudia Moriello, Fabiana Piscitelli, Monika Sztretye, Raffaele Capasso, Vincenzo Di Marzo, Fabio Arturo Iannotti
Summary: In this study, the researchers investigated the role of the endocannabinoid system in simvastatin-induced muscle toxicity. They found that the expression of endocannabinoids and specific miRNAs targeting the endocannabinoid CB1 gene increased in myoblasts exposed to simvastatin. Moreover, they discovered that the dysregulation of the CB1 receptor and its downstream signaling pathways contributed to statin-induced myopathy.
CELL DEATH & DISEASE
(2023)
Article
Instruments & Instrumentation
Ana Isabel Fraguas-Sanchez, Dolores Hernan, Consuelo Montejo, Justin L. Poklis, Aron H. Lichtman, Ana Isabel Torres-Suarez
Summary: This study evaluates the pharmacokinetics and release characteristics of CBD formulated in polymer microparticles for subcutaneous administration. Comparing the release of CBD from two microparticle formulations in vitro and in vivo, it was found that they had similar dissolution profiles in vitro but significant differences in blood and brain pharmacokinetics. Extended release of CBD was achieved after a single subcutaneous administration.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Microbiology
Thomas Deschenes, Fred Wilfried Elom Tohoundjona, Pier-Luc Plante, Vincenzo Di Marzo, Frederic Raymond
Summary: This study compared the performance of machine learning approaches according to different types of data representations derived from shotgun metagenomics. Gene-based approaches provided similar or improved classification performances compared to taxonomic and functional profiles. Feature selection based on biological function also improved classification performance for some pathologies. This study proposes new approaches to represent microbiome data for machine learning.
Article
Pharmacology & Pharmacy
Tangui Barre, Vincenzo Di Marzo, Fabienne Marcellin, Patrizia Burra, Patrizia Carrieri
Summary: Obesity and nonalcoholic fatty liver disease (NAFLD) are global epidemics. The endocannabinoid system is seen as a key target for treating NAFLD. Although clinical trials are lacking, research suggests potential benefits of phytocannabinoids in treating liver steatosis. Cannabis plant should be considered a major prospect for NAFLD treatment. Overcoming scientific and non-scientific barriers is necessary for further research.
CANNABIS AND CANNABINOID RESEARCH
(2023)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)
