Article
Immunology
Tariq Azamgarhi, Ashik Shah, Simon Warren
Summary: The study demonstrated that implementing the findings of the OVIVA trial into clinical practice, with follow-up by an established OPAT service for patients on oral antibiotics, is safe and effective. Two-thirds of patients were switched to suitable oral antibiotic regimens, leading to reductions in hospital length of stay and antibiotic costs.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Materials Science, Ceramics
Marta Miola, Anuj Bellare, Roberto Gerbaldo, Francesco Laviano, Enrica Verne
Summary: A novel bone cement formulation was designed using Fe3O4-Ag nanostructures and optimized mixing methods to treat bone tumors and associated complications. The Fe3O4-Ag nanostructures demonstrated good antimicrobial effects and significant influence on mechanical properties and bacteria adhesion.
CERAMICS INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Meng-Wei Chang, Cheng-Ta Wu, Shih-Hsiang Yen, Timothy L. Tan, Po-Chun Lin, Feng-Chih Kuo
Summary: This study aimed to investigate whether a spacer made from commercial ALBC or plain bone cement with additional antibiotics could affect the spacer exchange rate before reimplantation. The results showed that the spacer exchange rate was lower in the commercial ALBC group compared to the plain bone cement group. However, the use of commercial ALBC was not associated with a lower reinfection rate after reimplantation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Infectious Diseases
Konstantinos Anagnostakos, Ismail Sahan
Summary: The optimal impregnation of antibiotic-loaded bone cement in the treatment of periprosthetic hip and knee joint infection remains unknown, and there is uncertainty about the association of suboptimal impregnation with infection persistence. The study retrospectively evaluated 93 patients and found that regardless of the type of antibiotic impregnation used, reinfection or persistence of infection was observed in the majority of cases when the organism was susceptible to the locally inserted antibiotics or not tested. Further studies on the investigation of the optimal impregnation of antibiotic-loaded bone cement are needed.
Review
Biochemistry & Molecular Biology
Sebastian Philipp von Hertzberg-Boelch, Martin Luedemann, Maximilian Rudert, Andre F. Steinert
Summary: This literature review explores the use of antibiotic loaded polymethylmethacrylate bone cements in arthroplasty. It outlines the clinically relevant differences that need to be considered when using antibiotic loaded bone cements for long-term implant fixation or as spacers for treating periprosthetic joint infections. In vitro findings on antibiotic elution and material properties are summarized and their clinical applications are discussed.
Article
Orthopedics
Jiezhi Dai, Yu Zhou, Shasha Mei, Hua Chen
Summary: This retrospective study investigated the effect of antibiotic bone cement on patients with infected diabetic foot ulcer (DFU). The results showed that compared with the control group, the PMMA group had a higher complete wound healing rate, fewer frequencies of debridement procedures, and a shorter healing duration. The application of antibiotic bone cement is an effective solution for infected DFU treatment.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Orthopedics
Haotian Hua, Lei Zhang, Zairan Guo, Wenlong Zhong, Jiangfei Chen, Shilin Wang, Jiangang Guo, Xinwei Wang
Summary: Antibiotic artificial bone implantation and external fixation is an effective method for the treatment of infection after intramedullary nail fixation, which can control the infection and promote fracture healing.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Medicine, General & Internal
Lei Shi, Zhen Tang, Pengfei Tao, Xiaokang Li, Shuo Guo, Xinghui Wei, Xiaodi Yu, Wenwen Liu, Zheng Guo
Summary: This study observed the anti-infective effect of distal femoral tumor prosthesis coated with antibiotic cement and evaluated its potential prospect in clinic. The results showed a significant reduction in infection rate and lower rates of local recurrence and distant metastasis in the anti-infection group compared to the control group. The antibiotic cement-coated technique is a simple and effective method for controlling periprosthetic infection after tumor prosthesis reconstruction.
Article
Medicine, General & Internal
Hassan Serrier, Laure Huot, Sophie Brosset, Cecile Batailler, Tristan Ferry
Summary: The study aims to evaluate the cost-effectiveness of using Cerament-G compared to standard of care in the treatment of chronic long bone osteomyelitis. The study is a prospective, multicenter, randomized, single blind study conducted in 14 French Reference Centers for Complex Osteoarticular infections. The results will support the recommendation for the use of Cerament-G and its reimbursement through the French Health Insurance scheme.
FRONTIERS IN MEDICINE
(2023)
Article
Mathematics, Interdisciplinary Applications
Bahatdin Dasbasi
Summary: A model using fractional-order differential equations is proposed to examine the dynamics of susceptible and resistant bacteria, adaptive immunity cells, and innate cells in an infected individual receiving multiple antibiotics and antivirulence drug therapy. The model's existence, uniqueness, non-negativity, and boundedness of solutions are discussed. Reproduction numbers are developed to assess the model, and the existence and stability of equilibrium points are shown. Numerical simulations using parameter values for Mycobacterium Tuberculosis (Mtb) and Pseudomonas Aeruginosa (Pa) are conducted to demonstrate the model's applicability to real-world examples, and the effects of antivirulence drug therapy in addition to antibiotic therapy are investigated. The role of antivirulence drug therapy in eliminating infectious bacteria is discussed based on the simulation results obtained from the recommended treatment processes for these bacteria. Sensitivity analysis of the reproduction numbers is performed based on the values used in the simulations.
CHAOS SOLITONS & FRACTALS
(2023)
Article
Infectious Diseases
Debora C. Coraca-Huber, Stephan J. M. Steixner, Stevo Najman, Sanja Stojanovic, Ronja Finze, Denis Rimashevskiy, Dina Saginova, Mike Barbeck, Reinhard Schnettler
Summary: This study evaluated the efficacy of specially prepared human bone allografts as antibiotic carriers. The results showed that these allografts successfully loaded antibiotics and released high concentrations of antibiotics in vitro and in vivo. The susceptibility tests demonstrated strong antibacterial activity of the allografts against specific bacterial strains.
Article
Orthopedics
Haotian Hua, Lei Zhang, Zairan Guo, Wenlong Zhong, Jiangfei Chen, Jiangang Guo, Yang Zhang, Peijian Tong, Xinwei Wang
Summary: This study retrospectively analyzed the clinical data of using antibiotic artificial bone (calcium phosphate) in the treatment of infection after internal fixation of tibial plateau fractures. The results showed that this method can effectively control the infection and promote functional recovery.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Pharmacology & Pharmacy
Nasser H. Alotaibi, Muhammad Usman Munir, Nabil K. Alruwaili, Khalid Saad Alharbi, Ayesha Ihsan, Alanood S. Almurshedi, Ikram Ullah Khan, Syed Nasir Abbas Bukhari, Mubashar Rehman, Naveed Ahmad
Summary: The increasing bacterial resistance poses a great challenge in bone infection treatment. This study presents the use of citrate-functionalized mesoporous hydroxyapatite nanocarriers (Ctr-mpHANCs) as drug carriers and treatment options for bone infections caused by bacteria.
Article
Infectious Diseases
Benedikt Paul Blersch, Michael Barthels, Philipp Schuster, Bernd Fink
Summary: The aim of this study was to verify the hypothesis that the use of dual-antibiotic-impregnated cement in knee revision arthroplasty leads to a lower rate of periprosthetic joint infections. The results showed that the use of dual-antibiotic-impregnated cement significantly reduces the incidence of periprosthetic infections after aseptic knee prosthesis replacement.
Article
Pharmacology & Pharmacy
M. Zegre, J. Barros, I. A. C. Ribeiro, C. Santos, L. A. Caetano, L. Goncalves, F. J. Monteiro, M. P. Ferraz, A. Bettencourt
Summary: In this study, the co-delivery of two antimicrobials using poly(D,L-lactic acid) (PDLLA) scaffolds was investigated in a polymicrobial biofilm model. The PDLLA scaffolds showed a sponge-like appearance and were capable of supporting cell proliferation and drug release. The loaded scaffolds demonstrated activity against Staphylococcus aureus and Candida albicans biofilms. Thus, the study revealed the potential of these scaffolds as a next-generation co-delivery system for antimicrobial therapy in bone infections.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Willem-Jan Metsemakers, Noam Emanuel, Or Cohen, Malka Reichart, Inga Potapova, Tanja Schmid, David Segal, Martijn Riool, Paulus H. S. Kwakman, Leonie de Boer, Anna de Breij, Peter H. Nibbering, R. Geoff Richards, Sebastian A. J. Zaat, T. Fintan Moriarty
JOURNAL OF CONTROLLED RELEASE
(2015)
Article
Chemistry, Multidisciplinary
A. de Breij, M. Riool, P. H. S. Kwakman, L. de Boer, R. A. Cordfunke, J. W. Drijfhout, O. Cohen, N. Emanuel, S. A. J. Zaat, P. H. Nibbering, T. F. Moriarty
JOURNAL OF CONTROLLED RELEASE
(2016)
Article
Medicine, Research & Experimental
Elena Khazanov, Noam Emmanuel, Abdel Kareem Azab, Yechezkel Barenholz, Eylon Yavin, Abraham Rubinstein
MOLECULAR PHARMACEUTICS
(2010)
Article
Pathology
Yuval Ramot, Shlomo Nedvetzki, Sefi Rosenfeld, Noam Emanuel, Abraham Nyska
TOXICOLOGIC PATHOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Erez Kachel, Yaron Moshkovitz, Leonid Sternik, Gideon Sahar, Liza Grosman-Rimon, Olga Belotserkovsky, Malka Reichart, Yafit Stark, Noam Emanuel
JOURNAL OF CARDIAC SURGERY
(2020)
Article
Pathology
Yuval Ramot, Shlomo Nedvetzki, Sefi Rosenfeld, Serge D. Rousselle, Abraham Nyska, Noam Emanuel
TOXICOLOGIC PATHOLOGY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Noam Emanuel, Eli E. Machtei, Malka Reichart, Lior Shapira
QUINTESSENCE INTERNATIONAL
(2020)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)
