Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Takeshi Matsumoto, Takashi Komori, Yuta Yoshino, Tadaaki Ioroi, Tsukasa Kitahashi, Hiromu Kitahara, Kohei Ono, Tamami Higuchi, Masayo Sakabe, Hiroshi Kori, Masahiro Kano, Ritsuko Hori, Yukio Kato, Shinji Hagiwara
Summary: The study characterized the stability, tumor targeting, and payload release of liposome-encapsulated gemcitabine, FF-10832, in mouse models of pancreatic cancer. Results showed that FF-10832 had superior pharmacokinetic properties and better antitumor activity and tolerability compared to unencapsulated gemcitabine. This suggests that FF-10832 is a promising candidate for the treatment of pancreatic cancer.
PHARMACEUTICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Huan Tang, Zheng Zhang, Ming Zhu, Yizhuo Xie, Zhe Lv, Rui Liu, Yujia Shen, Jin Pei
Summary: The study developed estrone-modified GEM-loaded PEGylated liposomes (ES-SSL-GEM) to improve the targeting ability and therapeutic effect for lung cancer treatment. The results showed that ES-SSL-GEM had a uniform particle size, good stability, and slow release behavior. It significantly inhibited A549 cell proliferation and suppressed tumor growth, indicating its potential application in lung cancer treatment.
Article
Nanoscience & Nanotechnology
Kang He, Taiwei Wang, Junyu Chen, Xuemiao Huang, Zeyu Wang, Zhaoyun Yang, Kai Wang, Weixin Zhao, Jian Jiang, Lijing Zhao
Summary: In this study, a RA-loaded PEGylated liposome drug delivery system was devised to effectively inhibit the progression of prostate cancer. The LRA exhibited stable physicochemical properties and a diameter of 173.5±15.3 nm. It inhibited the growth of prostate cancer cells through the regulation of tumor-related proteins expression, induction of apoptosis, and modulation of cell cycle-related proteins.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Multidisciplinary Sciences
Daniel R. Principe, Alexandre F. Aissa, Sandeep Kumar, Thao N. D. Pham, Patrick W. Underwood, Rakesh Nair, Rong Ke, Basabi Rana, Jose G. Trevino, Hidayatullah G. Munshi, Elizaveta Benevolenskaya, Ajay Rana
Summary: There is currently no effective treatment for pancreatic ductal adenocarcinoma (PDAC). In this study, researchers identified a subset of gemcitabine-resistant tumor cells enriched for calcium/calmodulin signaling. Inhibition of calcium-dependent calmodulin activation led to the loss of drug-resistant phenotypes, and calcium chelation or depletion impaired ERK activation and restored therapeutic responses to gemcitabine. Calcium channel blockers also enhanced therapeutic responses to gemcitabine.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Polymer Science
Ning Li, Zhenyu Duan, Lili Wang, Chunhua Guo, Hu Zhang, Zhongwei Gu, Qiyong Gong, Kui Luo
Summary: An amphiphilic peptide dendrimer conjugated with gemcitabine has been developed as a nano-prodrug for breast cancer therapy, showing self-assembled behavior and effective release of the drug. In vivo studies confirm the therapeutic efficacy of the drug against breast cancer, indicating potential applications for gemcitabine and other anticancer agents.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Wenjing Tang, Zui Zhang, Cheng Li, Yuxiu Chu, Jun Qian, Tianlei Ying, Weiyue Lu, Changyou Zhan
Summary: A facile PEG-scFv-based separation method combined with HPLC was developed to quantify free and liposomal doxorubicin in plasma, showing higher accuracy and sensitivity compared to traditional SPE methods. This approach is suitable for quality assessment and pharmacokinetics evaluation of PEGylated liposomal drugs and other PEGylated nanocarriers.
Article
Multidisciplinary Sciences
Yang Liu, Xuebo Quan, Jie Li, Jiawei Huo, Xing Li, Zhongpu Zhao, Shumu Li, Jing Wan, Jiao Li, Shuai Liu, Tao Wang, Xing Zhang, Bo Guan, Rui Wen, Zhenwen Zhao, Chunru Wang, Chunli Bai
Summary: A novel drug delivery system, Lp-IO, was developed to induce lipid peroxidation and ferroptosis in cancer cells. Lp-IO integrated ultrasmall iron oxide nanoparticles, MRI tracing, and pH/ROS-sensitive drug delivery for combination cancer therapies. It achieved synergistic antineoplastic effects and reduced chemotherapeutic toxicity by delivering doxorubicin.
NATIONAL SCIENCE REVIEW
(2023)
Article
Pharmacology & Pharmacy
Mohsen Ghaferi, Aun Raza, Maedeh Koohi, Warda Zahra, Azim Akbarzadeh, Hasan Ebrahimi Shahmabadi, Seyed Ebrahim Alavi
Summary: This study evaluated the therapeutic efficacy of doxorubicin and carboplatin loaded into PEG-modified liposome nanoparticles for glioblastoma treatment. The results showed that PEG-Lip-DOX/CB exhibited controlled release of the drugs and significantly increased their cytotoxicity against cancer cells. In vivo experiments also demonstrated that PEGylated liposomes improved therapeutic effects and reduced side effects compared to non-PEGylated liposomes.
Review
Cell Biology
Alica K. Beutel, Christopher J. Halbrook
Summary: Pancreatic ductal adenocarcinoma (PDA) is a leading cause of cancer-related deaths worldwide and its treatment is challenging due to a lack of durable responses to standard-of-care chemotherapies. Gemcitabine, a cornerstone in PDA treatment, faces resistance mechanisms that have not yet been overcome in patient care.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Xiaoke Tan, Xin Zhu, Duanjie Xu, Yanmei Shi, Zhenzhen Wang, Mingzhuo Cao, Kai Hu, Lingzhou Zhao, Junwei Zhao, Mingsan Miao, Huahui Zeng, Xiangxiang Wu
Summary: A novel platform for anti-tumor drug delivery was developed by incorporating an amphiphilic stachydrine-octadecane conjugate onto the liposome surfaces, enabling mitochondria-targeted therapy in pancreatic cancer. The developed liposomes showed stable properties and reduced toxicity while exhibiting significant efficacy in inhibiting tumor growth and reducing tumor size.
FRONTIERS IN CHEMISTRY
(2022)
Article
Engineering, Environmental
Xiao Fu, Xiaoxuan Zhang, Danqing Huang, Liang Mao, Yudong Qiu, Yuanjin Zhao
Summary: Inspired by the structures of octopus tentacles, researchers have developed a novel adhesive microneedle patch with gemcitabine encapsulation for the treatment of pancreatic cancer. The patch, made of gelatin methacryloyl, demonstrates good biocompatibility, flexibility, and drug loading efficiency. It can adhere to the irregular surfaces of tumors and efficiently release gemcitabine to penetrate tumor tissues, showing promising anti-tumor efficacy in vitro and in a mouse model.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Multidisciplinary Sciences
Chen Chen, Binfeng Wu, Mingge Wang, Jinghua Chen, Zhaohui Huang, Jin-Song Shi
Summary: Our findings suggest that GABRP may serve as a downstream target of CD44s to diminish gemcitabine resistance in pancreatic cancer, and both CD44s and GABRP molecules have the potential to become prognostic biomarkers for PDAC patients with gemcitabine resistance.
Article
Pharmacology & Pharmacy
Tianli Zhang, Mengmeng Liu, Qing Liu, Gary Guishan Xiao
Summary: Wogonin can enhance the sensitivity of pancreatic cancer cells to gemcitabine chemotherapy, possibly by promoting apoptosis through inhibiting the Akt signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jingjing Yao, Min Huang, Qinghong Shen, Ming Ding, Shaofang Yu, Yajuan Guo, Yuefang Lin, Yaqiu Zheng, Wenbo Chen, Wenxin Yan, Zhongqiu Liu, Dawei Wang, Ming Hu, Linlin Lu
Summary: Pancreatic cancer has a low overall survival rate and is often resistant to the first-line drug, Gemcitabine. This study found that c-Myc and PD-L1 were highly expressed in pancreatic tumors and dFdC-resistant cells. Moreover, the combination of dFdC and c-Myc inhibitors enhanced drug sensitivity, while overexpression of c-Myc reduced sensitivity. Additionally, ARTS was shown to reverse dFdC resistance in vitro and suppress pancreatic cancer in vivo.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)