Article
Biochemistry & Molecular Biology
Jung-Hwan Kim, Eui Hwa Jang, Ji-Yeon Ryu, Jiyong Lee, Jae Ho Kim, Wonhyoung Ryu, Young-Nam Youn
Summary: We investigated the effectiveness of a sirolimus-embedded silk microneedle wrap as an external vascular device for drug delivery, inhibition of neointimal hyperplasia, and vascular remodeling. In a vein graft model using dogs, the sirolimus-embedded silk MN wrap successfully delivered the drug to the intimal layer and prevented vein graft dilatation. It also inhibited neointimal hyperplasia, resulting in decreased collagen density in the intima layer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Allan John R. Barcena, Joy Vanessa D. Perez, Olivia Liu, Amy Mu, Francisco M. Heralde, Steven Y. Huang, Marites P. Melancon
Summary: Arteriovenous fistula (AVF) is the preferred vascular access for chronic hemodialysis, but its high failure rates limit its use. Neointimal hyperplasia (NIH) is a predominant cause of AVF failure, and systemic therapies have not shown clear benefits. Localized therapeutic approaches can improve AVF maturation rates by providing structural and functional support, as well as by delivering higher doses of drugs without systemic adverse effects.
Article
Materials Science, Multidisciplinary
Carleigh Klusman, Benjamin Martin, Joy Vanessa D. Perez, Allan John R. Barcena, Marvin R. Bernardino, Erin Marie D. San Valentin, Jossana A. Damasco, Huckie C. Del Mundo, Karem A. Court, Biana Godin, Gino Martin Canlas, Natalie Fowlkes, Richard Bouchard, Jizhong Cheng, Steven Y. Huang, Marites P. Melancon
Summary: Arteriovenous fistulas (AVFs) are important for hemodialysis patients, but can lead to complications when they fail to mature. The most common cause of non-maturation is neointimal hyperplasia (NIH). To address this issue, researchers developed a perivascular wrap containing polycaprolactone (PCL), rosuvastatin (ROSU), and gold nanoparticles (AUNPs). Their study showed that ROSU-loaded wraps reduced NIH and AuNP-loaded wraps improved device visualization. These results suggest that the wraps can promote AVF maturation and suppress NIH while enhancing imaging quality.
ADVANCED FIBER MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
JiYong Lee, Eui Hwa Jang, Jae Ho Kim, SeungHyun Park, Yosup Kang, Sanghyun Park, KangJu Lee, Jung-Hwan Kim, Young-Nam Youn, WonHyoung Ryu
Summary: This study introduces a novel silk microneedle wrap that can effectively inhibit intimal hyperplasia. By directly injecting anti-proliferation drugs at anastomosis sites while ensuring sufficient vascular exchanges, the silk microneedle wrap demonstrated positive outcomes in inhibiting neointimal formation.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
Leo Bogdanov, Daria Shishkova, Rinat Mukhamadiyarov, Elena Velikanova, Anna Tsepokina, Alexander Terekhov, Vladislav Koshelev, Anastasia Kanonykina, Amin Shabaev, Alexey Frolov, Nikita Zagorodnikov, Anton Kutikhin
Summary: This study investigated the relationship between vasa vasorum (VV), myeloperoxidase-positive (MPO+) clusters, and intimal hyperplasia (IH) in vascular pathology. Using rat models and a clinical scenario, the study found a strong correlation between the quantities of VV and MPO+ clusters, and demonstrated that MPO+ cluster density was significantly associated with IH. Additionally, the study showed that the quantity and density of VV correlated with IH in bypass grafts for coronary artery bypass graft surgery. These findings highlight the pathophysiological importance of excessive VV in vascular injury and exposure to cardiovascular risk factors, and propose an explanatory mechanism for the higher long-term patency of arterial grafts in coronary artery bypass graft surgery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Judith Heiss, Katja Grun, Laura Tempel, Mattia Matasci, Andrea Schrepper, Michael Schwarzer, Reinhard Bauer, Martin Forster, Alexander Berndt, Christian Jung, P. Christian Schulze, Dario Neri, Marcus Franz
Summary: This study compared two formats of immunocytokines and identified potential target cells of IL9. The results showed that targeted delivery of IL9 could have beneficial effects in a mouse model of pulmonary hypertension (PH). Furthermore, IL9 treatment increased the number of regulatory T cells (Tregs) and reduced lung tissue damage in PH mice.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Chemistry, Multidisciplinary
Tuomas O. Lilius, Kristian Nygaard Mortensen, Claire Deville, Terhi J. Lohela, Frederik Filip Staeger, Bjorn Sigurdsson, Elisabetta M. Fiordaliso, Marko Rosenholm, Chris Kamphuis, Freek J. Beekman, Andreas I. Jensen, Maiken Nedergaard
Summary: Nanoparticles hold promise for treating CNS disorders, but the BBB remains a barrier. Intra-cisterna magna administration of gold nanoparticles combined with hypertonic saline significantly increases their uptake in deep brain regions. Visualization by MRI shows that AuNPs enter the CNS through periarterial spaces and are cleared from the brain within 24 hours.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Physical
Salar Khaledian, Danial Kahrizi, Sajad Moradi, Fleming Martinez
Summary: This study successfully designed lipid nanocarriers for loading poorly water-soluble anticancer drugs, which demonstrated sustained release patterns and suitable cytotoxicity against acute myeloid leukemia cells through chitosan/tragacanth encapsulated natural lipid SLNs.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Biochemistry & Molecular Biology
John Aaron Howell, Nicholas Gaouette, Mariper Lopez, Stephen P. Burke, Eddie Perkins, Gene L. L. Bidwell III
Summary: In this study, a new protein inhibitor called SynB1-ELP-p50i, which inhibits the NF-κB inflammatory pathway, has been developed. It successfully reduces inflammation-induced tissue damage following ischemic stroke in rat models, leading to a decrease in infarct volume and an improvement in survival rate. These findings demonstrate the potential of ELP-delivered biologics as a therapy for ischemic stroke and other central nervous system disorders, and highlight the importance of targeting inflammation in stroke treatment.
Article
Biochemistry & Molecular Biology
John Aaron Howell, Nicholas Gaouette, Mariper Lopez, Stephen P. Burke, Eddie Perkins, Gene L. Bidwell
Summary: This study demonstrates the potential of SynB1-ELP-p50i as a therapeutic strategy for ischemic stroke, as it effectively reduces inflammatory cytokine production, decreases infarct volume, improves survival, and has no toxic effects. These findings highlight the importance of targeting inflammation in the treatment of ischemic stroke and other CNS disorders.
Review
Pharmacology & Pharmacy
Christopher D. Conrady, Steven Yeh
Summary: Uveitis is a group of inflammatory disorders of the eye that require medical and surgical management, with challenges in drug delivery due to absorption barriers. New drugs and drug delivery platforms are being developed to reduce intraocular inflammation and its complications.
Article
Nanoscience & Nanotechnology
Megan Kimicata, Bhushan Mahadik, John P. Fisher
Summary: This study introduces an innovative interlayer drug delivery system for small-diameter vascular grafts used in coronary artery bypass surgeries, which allows for precise temporal and spatial control of sustained heparin release. The method supports endothelial cell function and promotes an antithrombotic environment by controlling the release of heparin within a gelatin methacrylate interlayer.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Yansong Dong, Yalan Tu, Ye Liu, Maolin Jiang, Emil Bulatov, Youyong Yuan, Jun Wang
Summary: Anticancer nanomedicines can effectively aggregate around tumor blood vessels to create drug reservoirs for targeted drug delivery, improving therapeutic efficiency for cancer treatment.
Article
Chemistry, Multidisciplinary
Rawan Charbaji, Mrityunjoy Kar, Loryn E. Theune, Julian Bergueiro, Anne Eichhorst, Lucila Navarro, Patrick Graff, Friederike Stumpff, Marcelo Calderon, Sarah Hedtrich
Summary: This report describes the synthesis of novel disulfide-containing dendritic polyglycerol (dPG)-based nanogels and their preclinical testing for efficient transmucosal drug delivery. Absorption studies show that these nanogels efficiently overcome mucosal barriers and deliver anti-inflammatory biomacromolecules into epithelial tissues, resulting in local anti-inflammatory effects. The study also highlights the importance of a multifaceted approach for the preclinical testing of mucosal drug-delivery systems.
Review
Biochemistry & Molecular Biology
Jessie Clare, Justin Ganly, Christina A. Bursill, Huseyin Sumer, Peter Kingshott, Judy B. de Haan
Summary: This review focuses on the mechanisms of inflammation and redox stress in the context of stent design and discusses whether targeted mechanistic approaches can lead to improved outcomes for patients.
Article
Cell & Tissue Engineering
Jeremie D. Oliver, Shihai Jia, Leslie R. Halpern, Emily M. Graham, Emma C. Turner, John S. Colombo, David W. Grainger, Rena N. D'Souza
Summary: Clefts of the lip and/or palate are common orofacial birth defects, with challenges in correcting severe cleft defects through surgery alone. Advances in tissue engineering offer new avenues to stimulate bone formation at the site of surgical correction for palatal clefts, potentially improving treatment outcomes.
TISSUE ENGINEERING PART B-REVIEWS
(2021)
Article
Obstetrics & Gynecology
Goro Kuramoto, Ibrahim A. Hammad, Brett D. Einerson, Amanda A. Allshouse, Michelle Debbink, David W. Grainger, Robert M. Silver, Teruo Okano
Summary: This study demonstrates the feasibility of transplanting human umbilical cord mesenchymal stem cell sheets in a rat model and highlights the potential benefits of reducing uterine fibrosis and scarring. The use of stem cell sheets significantly reduces fibroblast infiltration and uterine scar tissue formation during healing.
AMERICAN JOURNAL OF PERINATOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Kyungsook Kim, Sophia Bou-Ghannam, Sumako Kameishi, Masatoshi Oka, David W. Grainger, Teruo Okano
Summary: The evolution of drug discovery in the early 20th century saw a shift from focusing on symptom control to pursuing radical cures, with cell therapy emerging as a promising new treatment targeting specific tissues and dynamic signaling environments. Cell delivery methods play a crucial role in realizing the therapeutic potential of cell therapy, especially in the context of mesenchymal stem cell (MSC) engraftment and bioactive function. Cell sheet technology is presented as a breakthrough in cell therapy, showcasing therapeutic success in tissue regeneration and discussing its anticipated clinical impacts.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
James M. Anderson, David W. Grainger
Summary: Sung Wan Kim's initial efforts as an independent investigator were focused on improving the understanding of early events in blood/material interactions, leading to the development of blood compatible materials. His studies were supported by NIH grants for over 40 years and contributed to the fields of biomaterials and non-thrombogenic biomaterial research.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Cell Biology
Hallie Thorp, Kyungsook Kim, Makoto Kondo, Travis Maak, David W. Grainger, Teruo Okano
Summary: Current treatments for articular cartilage defects do not reliably regenerate native hyaline cartilage or halt cartilage degeneration. Novel tissue engineering approaches focus on allogeneic mesenchymal stem cells to develop three-dimensional constructs for direct replacement of hyaline cartilage, aiming to improve treatment outcomes. Among emerging technologies, cell sheet tissue engineering offers promising capabilities for in vitro differentiation and effective transplantation based on controlled cellular interactions.
Article
Cell & Tissue Engineering
Hallie Thorp, Kyungsook Kim, Sophia Bou-Ghannam, Makoto Kondo, Travis Maak, David W. Grainger, Teruo Okano
Summary: The study investigated the effects of cell sheet multilayering technique on the fabrication of MSC-derived hyaline-like cartilage 3D layered constructs, demonstrating its potential to increase construct thickness and cellular interactions, while also identifying a thickness threshold that hinders chondrogenesis rate and extent.
REGENERATIVE THERAPY
(2021)
Article
Cell & Tissue Engineering
Makoto Kondo, Sumako Kameishi, Kyungsook Kim, Nicolas F. Metzler, Travis G. Maak, Douglas T. Hutchinson, Angela A. Wang, Miki Maehara, Masato Sato, David W. Grainger, Teruo Okano
Summary: This study demonstrates the preclinical safety and efficacy of scaffold-free, human juvenile cartilage-derived-chondrocyte (JCC) sheets. JCCs show stable and high growth potential in vitro, supporting the possibility of scale-up to mass production for commercialization. The engineered JCC sheets show stable hyaline cartilage formation, indicating a promising strategy for clinical cartilage repair.
NPJ REGENERATIVE MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Ulrich Dirnagl, Georg N. Duda, David W. Grainger, Petra Reinke, Ronenn Roubenoff
Summary: Biomedical research accuracy and relevance are costly problems, with issues in data quality, reporting, methodology, and reproducibility. Preclinical models and clinical data are deficient, leading to inefficient translation from basic research to clinical solutions, resulting in wasted resources and limited new clinical solutions for diseases.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Computer Science, Information Systems
Alan H. Morris, Christopher Horvat, Brian Stagg, David W. Grainger, Michael Lanspa, James Orme, Terry P. Clemmer, Lindell K. Weaver, Frank O. Thomas, Colin K. Grissom, Ellie Hirshberg, Thomas D. East, Carrie Jane Wallace, Michael P. Young, Dean F. Sittig, Mary Suchyta, James E. Pearl, Antinio Pesenti, Michela Bombino, Eduardo Beck, Katherine A. Sward, Charlene Weir, Shobha Phansalkar, Gordon R. Bernard, B. Taylor Thompson, Roy Brower, Jonathon Truwit, Jay Steingrub, R. Duncan Hiten, Douglas F. Willson, Jerry J. Zimmerman, Vinay Nadkarni, Adrienne G. Randolph, Martha A. Q. Curley, Christopher J. L. Newth, Jacques Lacroix, Michael S. D. Agus, Kang Hoe Lee, Bennett P. DeBoisblanc, Frederick Alan Moore, R. Scott Evans, Dean K. Sorenson, Anthony Wong, Michael Boland, Willard H. Dere, Alan Crandall, Julio Facelli, Stanley M. Huff, Peter J. Haug, Ulrike Pielmeier, Stephen E. Rees, Dan S. Karbing, Steen Andreassen, Eddy Fan, Roberta M. Goldring, Kenneth Berger, Beno W. Oppenheimer, E. Wesley Ely, Brian W. Pickering, David A. Schoenfeld, Irena Tocino, Russell S. Gonnering, Peter J. Pronovost, Lucy A. Savitz, Didier Dreyfuss, Arthur S. Slutsky, James D. Crapo, Michael R. Pinsky, Brent James, Donald M. Berwick
Summary: Delivering the best care in various clinical settings is a challenging problem. Evidence-based guidelines currently address only a fraction of the care provided by clinicians, especially in underserved areas. The use of validated clinical decision support systems (eActions) could help overcome cognitive limitations in advanced healthcare environments.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2022)
Article
Cell Biology
Sophia Bou-Ghannam, Kyungsook Kim, Makoto Kondo, David W. Grainger, Teruo Okano
Summary: Cell sheet technology is a scaffold-free 3D cell delivery platform that can sustain cell engraftment, survival, and reparative function. Recent evidence shows that cell sheets stimulate mesenchymal stem cells (MSC) to produce paracrine factors. This study introduces a centrifugation strategy to enhance MSC paracrine factor production by stacking and centrifuging cell sheets, resulting in a 3D MSC-delivery platform with boosted therapeutic factor production capacity.
Article
Cell & Tissue Engineering
Masatoshi Oka, Sumako Kameishi, Yun-Kyoung Cho, Sun U. U. Song, David W. W. Grainger, Teruo Okano
Summary: Chronic kidney disease (CKD) is the irreversible loss of nephron function, leading to toxins build-up, inflammation, and fibrosis. Mesenchymal stem/stromal cell (MSC) transplantation is a promising strategy to treat CKD, but concerns remain about kidney decapsulation. In this study, clinically relevant human clonal BMSC (cBMSC) sheets were transplanted onto intact renal capsule, effectively suppressing tubular epithelial cell injury and renal fibrosis in a rat model of ischemia-reperfusion injury (IRI).
TISSUE ENGINEERING PART C-METHODS
(2023)
Article
Cell Biology
Celia M. Dunn, Sumako Kameishi, Yun-Kyoung Cho, Sun U. Song, David W. Grainger, Teruo Okano
Summary: Mesenchymal stromal cells (MSCs) have diverse immunomodulatory functions and hold promise as a treatment for immune-related diseases. In this study, IFN-γ priming and thermoresponsive cultureware were combined to produce transplantable scaffold-free immunosuppressive cell sheets. The use of human clinical-grade single-cell-derived clonal bone marrow-derived MSCs further enhances the clinical relevance of this approach. The results show that MSC sheets produced with IFN-γ priming upregulate expression of immunosuppressive factors and exhibit increased ability to inhibit T-cell proliferation.
Article
Biophysics
Lara J. Gamble, David Radford, David W. Grainger, David G. Castner
Summary: This study characterized the properties of self-assembled monolayers (SAMs) of perfluoroalkanethiols on gold surfaces using XPS, NEXAFS, and ToF-SIMS techniques. It was found that SAMs with longer carbon chains exhibited higher ordering on gold surfaces, while SAMs with shorter carbon chains showed lower ordering.
Editorial Material
Cell Biology
Georg N. Duda, David W. Grainger, Robert E. Guldberg, Gady Goldsobel, Glenn D. Prestwich, Brenna Rauw, Hans-Dieter Volk
Summary: Translational impact assessment is crucial in determining the potential of biomedical research discoveries to be transformed into practical, beneficial products for human health. However, measuring translational success is challenging as it goes beyond commercial achievements and may vary from case to case. Prioritizing societal impact is essential in a globalized society.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Pranothi Mulinti, Dorina Diekjurgen, Kristen Kurtzeborn, Narayanaganesh Balasubramanian, Shane J. Stafslien, David W. Grainger, Amanda E. Brooks
Summary: In this study, a small basic peptide known for its antimicrobial properties was genetically linked to a mechanically robust silk-like peptide. The fusion protein showed both heparin-binding and antimicrobial capabilities, creating a designer silk-like protein with improved hemocompatibility and antimicrobial properties.
BIOENGINEERING-BASEL
(2022)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)