Article
Engineering, Environmental
Kai Ge, Raphael Paus, Vera Penner, Gabriele Sadowski, Yuanhui Ji
Summary: This study determined the solubility of naproxen and indomethacin under different conditions and proposed a micellar solubilization model and pH-dependent solubility model to describe the solubility of APIs in biorelevant media. The strategy provided theoretical guidance for API formulation development.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Medicinal
Kensuke Yoshie, Kazuhiko Ishihara
Summary: Solid dispersions are an effective method for solubilizing water-insoluble drugs, and the use of amphiphilic MPC copolymers as carriers can significantly improve dissolution and supersaturation maintenance. Furthermore, these copolymers enhance cell membrane permeability and oral absorbability.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Chemistry, Applied
Klavdiya A. Naumova, Olga V. Dement'eva, Ivan N. Senchikhin, Victor M. Rudoy
Summary: By using miramistin micelles as a template, mesoporous silica nanocontainers (MSNs) with a high drug encapsulation capacity can be synthesized, and the drug release rate varies depending on the temperatures of solubilizing curcumin and synthesizing MSNs, with a higher rate in acidic medium.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Article
Chemistry, Organic
Kohei Sato, Shoko Tanaka, Junzhen Wang, Kenya Ishikawa, Shugo Tsuda, Tetsuo Narumi, Taku Yoshiya, Nobuyuki Mase
Summary: The novel late-stage solubilization of peptides using hydrazides involves attaching a solubilizing tag through selective N-alkylation at a hydrazide moiety. The tag, which can tolerate ligation and desulfurization conditions, can be detached through a Cu-mediated selective oxidative hydrolysis of the N-alkyl hydrazide. This method was validated through the synthesis of HIV-1 protease.
Review
Pharmacology & Pharmacy
Uddeshya Sharma, Kamal Saroha
Summary: Hydrotropic solubilization is a technique that improves the solubility of poorly soluble drugs by adding a hydrotrope. It offers advantages such as cost-effectiveness, eco-friendliness, and the absence of chemical modification or organic solvents.
INTERNATIONAL JOURNAL OF TOXICOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jonas Schlauersbach, Simon Hanio, Bettina Lenz, Sahithya P. B. Vemulapalli, Christian Griesinger, Ann-Christin Poeppler, Cornelius Harlacher, Bruno Galli, Lorenz Meinel
Summary: Pharmaceutical polymers can impact the solubilization of poorly water-soluble drugs into bile colloids, affecting the flux of certain drugs while not impacting others. Understanding this interplay between drug substance, polymer, and bile colloid may lead to more efficient bile-solubilization formulations through rational polymer selection.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
Adam Juhasz, Laszlo Seres, Norbert Varga, Ditta Ungor, Marek Wojnicki, Edit Csapo
Summary: This study quantitatively investigated the thermodynamic parameters of mixed surfactants, revealing that some mixed micelles have critical micelle concentration lower than predicted by the ideal mixing model, and they exhibit higher solubilization ability for poorly water-soluble model drugs.
Article
Chemistry, Multidisciplinary
Julian David Friedl, Marcel Walther, Pia Katharina Vestweber, Jana Wachter, Patrick Knoll, Arne Matteo Joergensen, Andreas Bernkop-Schnuerch, Maike Windbergs
Summary: To date, buccal administration of lipophilic drugs remains challenging due to poor solubility and limited penetration. In this study, researchers developed mucoadhesive electrospun SEDDS patches to overcome these limitations. The patches showed high encapsulation efficiency, improved drug penetration, and enhanced therapeutic effects, making them a promising approach for oromucosal delivery of lipophilic drugs.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Chemistry, Multidisciplinary
Soyeon Jeong, Jiae Ryu, Qiang Yang, J. Y. Zhu, Chang Geun Yoo
Summary: Hydrotropic solvents enhance the efficiency of lignocellulosic biomass deconstruction by reducing recalcitrance, fractionating target components, and preserving/modifying biomass components. These solvents have a unique amphiphilic structure that effectively separates lignin from cellulose-rich fraction with minimal modification and maximum recovery, aligning with the biorefinery strategy. They act as catalysts in biomass fractionation/degradation and solvents for the dissolution of target components, such as lignin. Furthermore, these solvents have great potential in eco-friendly manufacturing in plant biomass utilization due to their aqueous processing nature.
Article
Chemistry, Physical
Zahra Ansarinik, Hamzeh Kiyani, Mehdi Yoosefian
Summary: Polymer-based drug delivery systems have great potential for delivering poorly water-soluble anticancer drugs through self-assembled nanocarriers. This study investigated the assembly mechanism of abemaciclib drug encapsulated by PEG-PLA copolymer micelles using molecular dynamics simulations. The results showed that hydrophobic and hydrophilic interactions played a crucial role in the drug encapsulation process, and hydrogen bonding and electrostatic interactions also contributed to the aggregation of PEG-PLA copolymer chains.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Medicine, Research & Experimental
Kifayat Ullah Khan, Muhammad Usman Minhas, Syed Faisal Badshah, Muhammad Suhail, Aousaf Ahmad, Shakeel Ijaz
Summary: Poor solubility and bioavailability are significant challenges in the pharmaceutical industry. Various strategies, including the use of nanomatrices, have been explored for improving drug solubility. This review article provides an overview of commonly used drug delivery systems and techniques and discusses their mechanisms of action.
Article
Chemistry, Physical
Asma El Aoud, Emmanuelle Reboul, Aurelien Dupont, Cristelle Meriadec, Franck Artzner, Sebastien Marze
Summary: This study investigated structural transitions in intestinal assemblies containing bile components, dietary fat, and fat-soluble vitamins. Results showed that increasing dietary lipid concentration led to a transition from core-shell micelles to unilamellar vesicles, while increasing fat-soluble vitamin concentration induced various structural transitions in the assemblies. SAXS data was used to propose ideal molecular organizations for the assemblies with and without alpha-tocopherol.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Medicinal
Aleksei Kabedev, Shakhawath Hossain, Madlen Hubert, Per Larsson, Christel A. A. Bergstrom
Summary: Simulations suggest that bile micelles in intestinal fluid may facilitate danazol incorporation into cellular membranes through two different mechanisms. Experimental support for the elevator hypothesis was found, as the micelles themselves solubilized within the membrane.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Chemistry, Physical
Dening Chang, Chenglin Du, Jinyu Liu, Wanqing Sun, Yuxuan Su, Dejin Zang, Teng Liu
Summary: In recent years, the structure-property relationship of block copolymers in administrable drug delivery has been a topic of interest. This study investigated the self-assembling behavior of four block copolymers with different hydrophobic modification groups and found that the enhancement of hydrophobicity led to the formation of smaller micelles or vesicles and improved solubilization and release capacities for hydrophobic drugs. The findings highlight the potential application of hydrophobic modification in sustained release drug carriers.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Polymer Science
Chie Kojima, Tomoka Hirose, Risa Katayama, Akikazu Matsumoto
Summary: 2-Methacryloyloxyethyl phosphorylcholine (MPC) polymers have been used as coating agents and drug delivery carriers in medical devices. In this study, amphiphilic MPC polymers were used, and their self-assembling properties and PTX solubilization were examined. The results suggest that the hydrophobicity and self-assembling properties of amphiphilic MPC polymers play a crucial role in PTX solubilization and drug action, which need to be controlled by the polymer sequence and composition of the hydrophobic monomer.
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)