Article
Engineering, Biomedical
Lucy Geddes, Efrosyni Themistou, James F. Burrows, Fraser J. Buchanan, Louise Carson
Summary: This study aimed to develop an in vitro protocol for assessing the long-term cytotoxicity of bioresorbable polymers. Results showed that PDLLGA samples exhibited increasing cytotoxicity at later degradation stages, while PLLGA samples demonstrated significantly less cytotoxic behavior. Additionally, a new dynamic flow culture methodology was developed and validated to test the cytotoxicity of these degradable materials, along with profiling of inflammatory cytokines released by cells in response to degraded PDLLGA and PLLGA.
ACTA BIOMATERIALIA
(2021)
Article
Polymer Science
Jidong Dai, Min Liang, Zhigang Zhang, Katrien Bernaerts, Tianzhu Zhang
Summary: By crosslinking nucleation to prepare crystalline 4arm-PLGA, the degradation rate of PLGA can be effectively controlled, promoting cell growth and potentially having ideal performance in tissue engineering.
Article
Polymer Science
M. Margarida Cardoso, Ines N. Peca, Telma Lopes, Rui Gardner, A. Bicho
Summary: DWNPs were produced with PLGA and PLLA containing doxorubicin as a model drug. Optical and fluorescence microscopy were used to examine the inner morphology and drug distribution of the double-walled microparticles. The study showed that the double-walled nanoparticles exhibited sustained drug release and the PLLA layer acted as a rate control barrier.
Article
Biochemistry & Molecular Biology
Gianni Pecorini, Simona Braccini, Gianluca Parrini, Federica Chiellini, Dario Puppi
Summary: Polyhydroxyalkanoates are biopolyesters that can be used as unique scaffolding polymer candidates for tissue engineering due to their biocompatibility, biodegradability, environmental sustainability, processing versatility, and mechanical properties. This study explored the fabrication of tissue engineering scaffolds using a solution-extrusion additive manufacturing technique, called Computer-Aided Wet-Spinning (CAWS), by blending poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and poly(D,L-lactide-co-glycolide) (PLGA). The results showed that the blend composition influenced the morphological, physicochemical, and biological properties of the scaffolds, with increasing PLGA content leading to larger pore size, enhanced wettability, and improved thermal stability. In vitro experiments demonstrated the suitability of the scaffolds for cell colonization and differentiation towards an osteoblastic phenotype, particularly with scaffolds richer in PLGA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Lidong Feng, Xinchao Bian, Gao Li, Xuesi Chen
Summary: The study shows that the compatibility between PLLA and PLDLA-m decreases as the L-lactate unit content in PLDLA-m decreases, impacting the crystallization and compatibility of the blends.
Article
Polymer Science
Suyang Dai, Ni Jiang, Zhenbo Ning, Zhihua Gan
Summary: The length of the PDLA block was found to have a significant impact on the degradation behavior of PLLA/4-DL-D blend films.
POLYMER INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Yue Zhang, Anthony Henry Harker, C. J. Luo, Maryam Parhizkar, Mohan Edirisinghe
Summary: This study presents a single-step coaxial electrospray technique for co-encapsulation of two drugs treating type 2 diabetes into biodegradable poly (D,L-lactide-co-glicolide) nanoparticles. The formulated nanoparticles exhibit prolonged and regulated drug release profiles, and demonstrate good cytocompatibility. The findings suggest that this hybrid nanoparticle-based drug delivery system is promising for effectively co-encapsulating multiple drugs and achieving controlled release for the treatment of type 2 diabetes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Anton Iemtsev, Fatima Hassouna, Martin Klajmon, Alex Mathers, Michal Fulem
Summary: This study evaluates the compatibility between biodegradable polyesters and active pharmaceutical ingredients (APIs) and investigates the physical stability of drug carriers using phase diagrams. The results show varying levels of compatibility between different ratios of PLGA and model APIs, with only the IND-PLGA75 formulation remaining stable after storage.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Polymer Science
Xiaohua Chang, Dengwen Hu, Liangren Chen, Yaping Wang, Yutian Zhu
Summary: Thermoresponsive block copolymer micelles have potential in biological applications, with studies showing that changes in hydrophobic/hydrophilic block ratio, micelle concentration and addition of salt can alter the cloud point. Increasing the amount of PLGA hydrophobic block significantly decreases the cloud point, while higher micelle concentration and salt addition also lower the cloud point.
Article
Chemistry, Physical
Jaeik Song, Min-Suk Kook, Byung-Hoon Kim, Young-IL Jeong, Kyung-Jin Oh
Summary: ROS-sensitive nanoparticles were developed for CIP delivery to inhibit UTI, showing potential antibacterial activity in vitro without significant cytotoxicity to cells. Free CIP and CIP-incorporated nanoparticles demonstrated dose-dependent inhibitory effects against bacterial growth, with sustained release properties observed in the nanoparticles. Free CIP and CIP-incorporated nanoparticles showed superior antibacterial activity in a dialysis membrane model compared to free CIP.
Article
Polymer Science
Shih-Jyun Shen, Ying-Chao Chou, Shih-Chieh Hsu, Yu-Ting Lin, Chia-Jung Lu, Shih-Jung Liu
Summary: In this study, drug-loaded microparticles were successfully prepared using electrospraying technique, and their release behavior was investigated. The results showed that the drugs were sustainably released at the target region in vivo and maintained low concentrations in the blood. This technique has the potential for postoperative pain control.
Article
Chemistry, Physical
Bong-Seop Lee
Summary: In a polymer-based drug delivery system, the polymer material entwines the drug and transports it to the desired target. Poly(lactide-co-glycolide) (PLGA) is a widely utilized controlled-release system for drugs with short half-lives, low stability, easy decomposition, and non-toxic side effects. Supercritical fluid (SCF) technology can be employed to prepare or micronize drug-loaded particles without the need for additional purification or cleaning procedures. The liquid-liquid phase transition behavior of PLGA in several supercritical fluids, including dimethyl ether (DME), CO2, chlorodifluoromethane (HCFC-22), and trifluoromethane (HFC-23), has been investigated. The phase behavior of PLGA is primarily controlled by the lactide-to-glycolide ratio in the copolymer backbone.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Biochemistry & Molecular Biology
Monika Smiga-Matuszowicz, Jakub Wlodarczyk, Malgorzata Skorupa, Dominika Czerwinska-Glowka, Kaja Folta, Malgorzata Pastusiak, Malgorzata Adamiec-Organisciok, Magdalena Skonieczna, Roman Turczyn, Michal Sobota, Katarzyna Krukiewicz
Summary: This paper introduces a scaffold material made of PLGA/PISEB fibers and confirms its biocompatibility towards HUVEC. During a 12-week hydrolytic degradation process, the PLGA/PISEB fibers swell and disintegrate, resulting in the formation of highly developed structures resembling seaweeds. The change in the scaffold structure is expected to have a positive effect on blood vessel regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Polymer Science
Airong Xu, Fen Wang, Luwei Zhang, Xingmin Xu, Zhihong Xiao, Rukuan Liu
Summary: A simple and feasible preparation approach was presented in this study to fabricate biodegradable and biocompatible composite films, addressing the issue of environmental pollution caused by polymer materials based on fossil resources being difficult to degrade. The composite films displayed good mechanical properties, re-usability, and thermal stability.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Engineering, Biomedical
Yang Zhou, Yuecheng Cui, Li-Qun Wang
Summary: A dual-sensitive hydrogel was developed by introducing a photocrosslinkable group into triblock copolymers, allowing for excellent shear thinning properties and rapid elastic recovery properties. Through a two-step crosslinking strategy, tissue-like constructs with high shape fidelity can be printed using the dual-sensitive inks.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2021)
Article
Chemistry, Physical
Johan Larsson, Adrian Sanchez-Fernandez, Anna E. Leung, Ralf Schweins, Baohu Wu, Tommy Nylander, Stefan Ulvenlund, Marie Wahlgren
Summary: The anomeric configuration of n-hexadecyl-D-maltopyranoside affects the micelle morphology and rheological behavior, with beta-C(16)G(2) forming worm-like micelles and alpha-C(16)G(2) forming cylindrical micelles. Mixing these surfactants can lead to systems with intermediate rheological properties. The results demonstrate the potential for tailored development of sustainable excipients through geometric variations while maintaining the chemical composition of the system.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Physical
Johan Larsson, Anna E. Leung, Christian Lang, Baohu Wu, Marie Wahlgren, Tommy Nylander, Stefan Ulvenlund, Adrian Sanchez-Fernandez
Summary: The self-assembly of long-tail surfactants can form nanoscale structures that alter the rheology of the system, but this process is affected by the high Krafft temperature. A novel sugar-based surfactant with an unsaturated C16-tail was synthesized, showing the ability to form a stable micellar solution over a wide temperature range, creating a non-Newtonian, viscoelastic fluid. These findings have implications for the development of sustainable formulated products with remarkable thermal resilience.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Pharmacology & Pharmacy
A. Ali, L. Skedung, S. Burleigh, E. Lavant, L. Ringstad, C. D. Anderson, M. Wahlgren, J. Engblom
Summary: This study focused on exploring the impact of different excipients on the sensorial and physical properties of topical products, revealing that variations in emollients, thickeners, and surfactant composition result in differences in sensory and rheological properties. Furthermore, significant differences were observed in afterfeel perception between surfactant-based creams and Pickering creams, with starch particles on the skin leading to higher tactile friction and lower perception of residue coating, stickiness, greasiness, and slipperiness.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Physical
Johan Larsson, Ashley P. Williams, Marie Wahlgren, Lionel Porcar, Stefan Ulvenlund, Tommy Nylander, Rico F. Tabor, Adrian Sanchez-Fernandez
Summary: Recent studies have demonstrated that the rheological properties of systems formed by the self-assembly of long tail sugar-based surfactants into worm-like micelles can be tuned by subtle modifications of the surfactant monomer's molecular characteristics. The anomeric configuration of the surfactant was found to induce significant changes in nanostructure and rheology, with shear-thinning behavior relating to the re-arrangement of worm-like micelles. These findings provide a detailed mechanism by which sugar-based surfactants control the rheology of the fluid, offering potential for future studies in this area.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Medicine, Research & Experimental
Johanna Hjalte, Shakhawath Hossain, Andreas Hugerth, Helen Sjogren, Marie Wahlgren, Per Larsson, Dan Lundberg
Summary: Understanding peptide aggregation propensity is crucial for pharmaceutical development. Methods like H-1 NMR and AA-MD simulations were used to investigate peptide aggregation dynamics and pathways. Results show that both techniques can provide insights into intermolecular interactions and aggregation behavior of peptides.
MOLECULAR PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
A. Ali, L. Ringstad, L. Skedung, P. Falkman, M. Wahlgren, J. Engblom
Summary: Tactile perception was investigated through ex vivo friction measurements using a ForceBoard (TM), providing objective assessments and cost and time savings compared to subjective human panel. The study aimed to compare excised skin and VitroSkin (R) as model substrates for tactile friction measurements and to investigate the effects of different substrates on the results. The results showed that the difference in tactile friction between the two substrates was small on untreated surfaces, but varied over time due to the difference in surface structure. The study also found differences between surfactant-based creams and Pickering creams, indicating that the latter is greasier. It was shown that Pickering emulsions had consistently high tactile friction even with high amounts of oil, suggesting a non-greasy formulation.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Lingping Zhang, Marie Wahlgren, Bjorn Bergenstahl
Summary: This study proposes a new application for an oil-based drug delivery system, focusing on controlled release in the small intestine. Surfactants were added to the oil formulation to better understand the lipolysis mechanism. The results show that viscosity and thermodynamic activity have limited retardation, while gel-forming retarders have a strong effect. Degradable interfacial surfactants do not have the same effect as altering the interfacial composition.
Article
Chemistry, Multidisciplinary
Adrian Sanchez-Fernandez, Johan Larsson, Anna E. Leung, Peter Holmqvist, Orsolya Czakkel, Tommy Nylander, Stefan Ulvenlund, Marie Wahlgren
Summary: The molecular structure of sugar-based surfactants has a strong impact on their self-assembled structure and dynamics. By manipulating the monomer structure, the behavior of the surfactants, including their dynamics and rheological properties, can be controlled.
Article
Chemistry, Multidisciplinary
Shuai Bai Palmkron, Linnea Gustavsson, Marie Wahlgren, Bjorn Bergensthal, Anna Millqvist Fureby
Summary: This study investigates the issue of inhomogeneity in freeze drying, particularly in terms of water content and structure. The results show that the heat transfer in freeze drying is mainly conducted through rectified vapor and radiation. The use of vial holders reduces sample deviation but has limited impact on temperature increase.
PHARMACEUTICAL RESEARCH
(2022)
Article
Chemistry, Physical
Shuai Bai Palmkron, Bjorn Bergenstahl, Sebastian Hakansson, Marie Wahlgren, Anna Millqvist Fureby, Emanuel Larsson
Summary: The structure of a freeze-dried material is crucial for preserving and protecting biologics. This study compares X-ray microtomography (μCT) with scanning electron microscopy (SEM) as methods for characterizing the structure of freeze-dried materials. The results show that there are minor differences in structure between different drying protocols.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Chemistry, Physical
Catalina Fuentes, Jaeyeong Choi, Marie Wahlgren, Lars Nilsson
Summary: Starch modified with octenyl succinic anhydride (OSA) is useful for its emulsifying capacity and anionic properties. The functionality of the modified starch depends on the amount and distribution of OSA grafted to the starch backbone. Electrical asymmetrical flow field-flow fractionation (EAF4) can determine the charge properties and size/molar mass distribution of starch.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Chemistry, Physical
Zandra Gidlof, Betty Lomstein Pedersen, Lars Nilsson, Anita Teleman, Marie Wahlgren, Anna Millqvist-Fureby
Summary: A waxy barley starch-PEG aqueous two-phase system (ATPS) phase diagram was used to investigate the relationship between phase behavior, starch crystallization, and microsphere formation. It was found that the position in the phase diagram influenced the rate of microsphere formation and particle size. However, the properties of dried and redispersed microspheres did not significantly differ. The study identified a robust production space for microsphere production.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Pharmacology & Pharmacy
Amanda Vastberg, Hans Bolinsson, Mats Leeman, Lars Nilsson, Tommy Nylander, Kushal Sejwal, Ida-Maria Sintorn, Kristina Lidayova, Helen Sjogren, Marie Wahlgren, Ulla Elofsson
Summary: Three orthogonal techniques, including DLS, AF4, and MiniTEM, were used to study the thermally induced aggregation of Somatropin at pH 5.8 and 7.0. The results indicated that weaker electrostatic stabilization was the main reason for faster initial aggregation at pH 5.8. AF4 and MiniTEM further revealed the aggregation pathway, showing that smaller elongated aggregates were formed initially, possibly initiated by partly unfolded species, and then assembled into larger aggregates with more complex structures during longer heating.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Medicinal
Claudia Sabate Martinez, Leanne Amery, Giorgia De Paoli, Ulla Elofsson, Anna Millqvist Fureby, Stanley Kwok, Carmen Lopez-Cabezas, Marika Rosenberger, Christian Schoenau, Marie Wahlgren, Mattias Paulsson
Summary: This study conducted a failure mode and effects analysis on the supply process of protein drugs using the Gemba Walk method and the Double Diamond design method. Potential risks related to factors such as temperature, shock, vibration, and lack of awareness among porters and healthcare professionals were identified. Measures such as validated and protocol-based compounding in cleanroom and training and validated transports were suggested to ensure the quality of the drugs.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Adrian Sanchez-Fernandez, Sylvain Prevost, Marie Wahlgren
Summary: This study demonstrates the potential of deep eutectic solvents as a medium for the storage and preservation of proteins in a concentrated regime, without the need for additional excipients, while maintaining stability and activity.
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)