Article
Polymer Science
WeiCong Zhang, Ying Wang, Juan Guo, Chao Huang, Yong Hu
Summary: New pH-sensitive polysaccharide supramolecular hydrogel microparticles (HMPs) were constructed based on carboxymethyl beta-cyclodextrin/chitosan inclusion complex (CM-beta-CD/CS) and EDTA-chitosan (EDCS) in aqueous solution, showing highlighted pH-dependent release characteristics for potential protein drug delivery applications.
Article
Materials Science, Multidisciplinary
Weijie Xu, Xin Gao, Huaping Tan, Shengke Li, Tianle Zhou, Jianliang Li, Yong Chen
Summary: This study aims to develop a polysaccharide-based hydrogel dressing with self-healing ability and sustained antibacterial function for wound healing. The dressing shows good elasticity and sustained release performance, and it also supports the survival and proliferation of stem cells.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Polymer Science
Muhammad Umar Aslam Khan, Zahida Yaqoob, Mohamed Nainar Mohamed Ansari, Saiful Izwan Abd Razak, Mohsin Ali Raza, Amna Sajjad, Sajjad Haider, Fauzi Mh Busra
Summary: Composite hydrogels of CS/PVA and GO/CS/PVA were successfully synthesized and analyzed using various techniques, showing good swelling and drug release properties. The study also revealed better antibacterial and cell viability behaviors of the composite materials, indicating their potential as biomaterials in biomedical applications.
Article
Chemistry, Physical
Niloufar Khosravi, Leila Youseftabar-Miri, Faten Divsar, Sara Hallajian, Kaynaz Hafezi
Summary: A biocompatible and biodegradable hydrogel nanocomposite was synthesized for controlled and sustained release of gabapentin. The hydrogel composite exhibited high drug encapsulation and loading efficiency, and the drug release followed the Higuchi kinetics model and Fick-ian diffusion mechanism. The chitosan-based hydrogel showed excellent biocompatibility and thermosensitive properties, making it a promising drug carrier.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Polymer Science
Sasan Dan, Maryam Kalantari, Ata Kamyabi, Madjid Soltani
Summary: In this research, chitosan-itaconic acid graft copolymer hydrogel was successfully synthesized with optimized reaction conditions. The structure, morphology, thermal stability, swelling behavior, antibacterial properties, and drug-loading capabilities of the hydrogel were studied and characterized, with successful loading of ciprofloxacin as a model drug.
Article
Chemistry, Inorganic & Nuclear
Chen Li, Fayong Li, Ke Wang, Qing Wang, Hailu Liu, Xiaoyan Sun, Dong Xie
Summary: In this study, a functionalized carboxymethyl chitosan-graphene oxide-gelatin composite hydrogel with excellent swelling property, high biocompatibility, and drug delivery efficiency was prepared by ionic crosslinking. The composite hydrogel exhibited porous structures with randomly distributed but regularly arranged pores in the cross section. The thermal stability and swelling ratio of the composite hydrogel were improved, leading to improved drug delivery efficiency and prolonged drug administration.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Cassiele T. Cesco, Artur J. M. Valente, Alexandre T. Paulino
Summary: Chitosan/DNA blend hydrogel and chitosan/pectin blend hydrogel were synthesized for releasing methylene blue, and characterized by various techniques. The study revealed that the methylene blue loading had different impacts on the hydrogels, with higher release rates observed in simulated gastric fluid. The release kinetics of methylene blue in the hydrogels followed a pseudo-second-order mechanism.
Article
Polymer Science
Pan Wu, Yaru Fang, Kezhou Chen, Mi Wu, Wenchang Zhang, Shiyu Wang, Dongwen Liu, Junqing Gao, Huaiguo Li, Jianhua Lv, Yan Zhao
Summary: Double network (DN) hydrogels were formed by covalent crosslinking and physical crosslinking using sodium methacrylate alginate (MASA) and carboxymethyl chitosan (CMCS). The addition of poly(ethylene glycol) diacrylate (PEGDA) as a crosslinker significantly improved the compressive strength and light transmittance of the hydrogels. The drug release behavior of the DN hydrogels was pH sensitive and correlated with the content of PEGDA.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Fei Liu, Wenyu Li, Hongting Liu, Teng Yuan, Yu Yang, Wen Zhou, Yang Hu, Zhuohong Yang
Summary: The study introduces a 3D printed double-network hydrogel scaffold with improved mechanical properties and long-lasting antibacterial ability, allowing for adjustable drug release behavior for potential tissue regeneration applications.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Chemistry, Physical
Bahar Kanci Bozoglan, Osman Duman, Sibel Tunc
Summary: New OXI-loaded hydrogels with high antifungal activity were developed for onychomycosis treatment. The release of OXI from the hydrogels can be controlled by adjusting the amount of MMT in the hydrogel matrix.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Biochemistry & Molecular Biology
Muhammad Umar Aslam Khan, Sajjad Haider, Mohsin Ali Raza, Saqlain A. Shah, Saiful Izwan Abd Razak, Mohammad Rafiq Abdul Kadir, Fazli Subhan, Adnan Haider
Summary: The research explored the potential of composite hydrogels based on ARX, CS, and rGO for wound dressing in skin wound healing, demonstrating their excellent antibacterial properties and controlled drug release capabilities. The hydrogels showed pH sensitivity and maximum drug release at pH 7.4 and 37 degrees C, making them promising biomaterials for treating and caring for skin wounds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biophysics
Mohammad Akrami-Hasan-Kohal, Mahnaz Eskandari, Atefeh Solouk
Summary: The study developed a sustained release formulation using dexamethasone sodium phosphate-loaded chitosan nanoparticles embedded in silk fibroin hydrogel. The scanning electron microscopy showed the prepared drug delivery system had a properly interconnected porous structure, indicating potential for drug delivery applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Materials Science, Ceramics
Nga H. N. Do, Thinh H. Pham, Phung K. Le, Anh C. Ha
Summary: In this study, thermo-sensitive hydrogels made from chitosan and beta-glycerophosphate (GP) were used to post-load diclofenac sodium (DS) for temperature-controlled-release at inflammatory sites. The hydrogels showed sol-gel and swelling behaviors in response to temperature changes. The developed chitosan hydrogels had specific surface area, pore size, and pore volume within certain ranges. The hydrogels exhibited adaptive swelling to temperature changes and showed significantly improved DS loading capacity compared to previous studies.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mostafa Saeedi, Mohammad Reza Moghbeli, Omid Vahidi
Summary: In this study, chitosan was crosslinked using glycyrrhizic acid as a new crosslinking agent, and the obtained hydrogels showed biocompatibility for controlled release of gallic acid in transdermal therapy. The crosslinking of chitosan with glycyrrhizic acid formed a covalent amide linkage, resulting in the formation of a crosslinked hydrogel network structure.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Xiaoyan Hong, Hao Ding, Jiao Li, Yuanyuan Xue, Luyi Sun, Fuchuan Ding
Summary: A new semi-interpenetrating network hydrogel P(AM-co-AA)/CS with excellent mechanical properties and anti-fatigue characteristics was synthesized, which can be used to manufacture pressure sensors and drug-controlled release carriers.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Article
Biotechnology & Applied Microbiology
Yongsheng Gao, Douglas Vogus, Zongmin Zhao, Wei He, Vinu Krishnan, Jayoung Kim, Yujie Shi, Apoorva Sarode, Anvay Ukidve, Samir Mitragotri
Summary: Antiproliferative chemotherapeutic agents show promise for treating inflammatory arthritis, but face limitations in clinical application due to high systemic toxicity and low joint bioavailability. A new intra-articular drug delivery system combining hyaluronic acid hydrogels and drug nanocrystals offers a potential solution for localized and sustained delivery of camptothecin, with positive results shown in rat models of collagen-induced arthritis.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Chemistry, Physical
Zonglin Liu, Baoqiang Li, Yujie Feng, Dechang Jia, Caicai Li, Qingfeng Sun, Yu Zhou
Summary: In this study, a hybrid material Ni(PO3)(2)/CNTs was designed with excellent HER performance and stability as a non-noble metal electrocatalyst. The pi-pi interaction between NiPc and CNTs, as well as the inlaid structure, effectively prevented corrosion and aggregation of nanoparticles, leading to remarkable HER performance.
APPLIED SURFACE SCIENCE
(2022)
Article
Multidisciplinary Sciences
Jayoung Kim, Yongsheng Gao, Zongmin Zhao, Danika Rodrigues, Eden E. L. Tanner, Kelly Ibsen, Pradip K. Sasmal, Rajasekhar Jaladi, Shanavas Alikunju, Samir Mitragotri
Summary: In this study, a deep eutectic-based formulation was developed to achieve sustained release of apomorphine. The formulation formed a microemulsion upon subcutaneous injection, entrapping apomorphine and significantly slowing its release. This formulation could potentially convert the current three-injections-a-day therapy into an every-other-day therapy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
Shuang Li, Jingwen Xu, Rui Li, Yongkang Wang, Maoyi Zhang, Jie Li, Shizhen Yin, Guodong Liu, Lijuan Zhang, Baoqiang Li, Qi Gu, Yewang Su
Summary: We present a stretchable electronic facial mask (SEFM) as a platform for facial healthcare, capable of integrating various sensors and actuators. A specific SEFM for sonophoresis is developed to enhance the delivery effect of a drug mask. Various approaches, including the design of a joined silicone layer and the single-side soft pressing (SSSP) technique, are employed to overcome technical challenges and can be extended to the design and fabrication of other stretchable electronics. The mechanical, thermal, electrical, and ultrasonic characteristics of the SEFM are validated through finite element analysis and experiments. Results from animal and human facial experiments demonstrate the SEFM's ability to accelerate drug delivery and increase skin moisture content.
Article
Chemistry, Physical
Zonglin Liu, Baoqiang Li, Yujie Feng, Dechang Jia, Caicai Li, Yu Zhou
Summary: This study successfully improves the activity and stability of carbon-supported ruthenium-based catalysts through the design of a special structure for the carbon carrier. The coexistence of sp(2) and sp(3) carbon nuclei in N-doped carbon dots effectively modulates the electronic structure of the active center Ru, improving the reactivity of the reaction intermediates and achieving excellent catalytic activity.
Article
Chemistry, Physical
Jiaxin Dong, Baoqiang Li, Jin Xiao, Guanxiong Liu, Vladimir Baulin, Yujie Feng, Dechang Jia, Aslan Yu Tsivadze, Yu Zhou
Summary: Carbon dots (CDs) have wide applications in metal ion recognition and detection, promising in environmental monitoring and biomedical science. However, due to the presence of multiple functional groups with different affinities, the prediction of recognized metal ions is limited. In this study, CDs with different chelating ligands were synthesized, and specific recognition of Fe3+ and Cu2+ was achieved. Exponential type functions were established to predict the specific recognition of metal ions. This study proposes a new strategy for specific recognition of heavy metal ions using tailor-made CDs with chelating ligands.
Article
Biochemistry & Molecular Biology
Muqiao Han, Qi Han, Shanwei Wu, Hu Xiao, Lei Zhang, Yibo Lin, Fangang Meng, Shanshan Zhao
Summary: This study investigated the effects of NaOCl dose and solution pH on the properties of PVDF ultrafiltration membranes. The results showed that membrane pores increased with exposure time prolonging, and more pores were observed at pH 8 aging condition. Different chemical groups were formed under different pH conditions. The hydrophilicity and pure water permeability of the membranes had slight changes during NaOCl aging process. The antifouling properties of some membranes were slightly improved, while others showed severer flux decline with humic acid filtration.
Article
Materials Science, Composites
Guanxiong Liu, Baoqiang Li, Zonglin Liu, Jiaxin Dong, Xuefeng Kang, Yujie Feng, Dechang Jia, Yu Zhou
Summary: Carbon dots/hydroxyapatite filler combines the ROS scavenging ability of carbon dots (CDs) and the mechanical property improvement ability of hydroxyapatite. CDs have optical fluorescence, regulate ROS, and have the ability to bind calcium ions. ROS-HA, synthesized by chelating CDs and hydroxyapatite, showed high scavenging rates for hydroxyl and superoxide radicals. It greatly improved the adhesion performance of hydrogel-based composites and has potential applications in wound dressing.
COMPOSITES COMMUNICATIONS
(2023)
Review
Chemistry, Multidisciplinary
Kolade Adebowale, Rick Liao, Vineeth Chandran Suja, Neha Kapate, Andrew Lu, Yongsheng Gao, Samir Mitragotri
Summary: Cell therapies have shown promise in treating previously incurable diseases, and the engineering of cell surfaces with various materials has emerged as a valuable tool to enhance their therapeutic performance. This review summarizes recent advances in decorating cell surfaces with nanoparticles, microparticles, and polymeric coatings, and highlights the benefits of surface modifications in protecting carrier cells, enhancing cell trafficking, and delivering therapeutic agents. While these technologies are still in the proof-of-concept stage, their promising efficacy from preclinical studies provides a strong foundation for future clinical translation, revolutionizing the field of cell therapies.
ADVANCED MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Yongsheng Gao, Mayumi Ikeda-Imafuku, Zongmin Zhao, Maithili Joshi, Samir Mitragotri
Summary: HAPPI is a polymer peptide-based hemostatic agent that selectively binds to activated platelets and injury sites, providing effective treatment for various lethal traumatic bleeding conditions.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Correction
Nanoscience & Nanotechnology
Guanxiong Liu, Baoqiang Li, Jie Li, Jiaxin Dong, Yujie Feng, Dechang Jia, Aslan Yu Tsivadze, Yu Zhou
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Guanxiong Liu, Baoqiang Li, Jie Li, Jiaxin Dong, Vladimir Baulin, Yujie Feng, Dechang Jia, Yuri V. Petrov, Aslan Yu Tsivadze, Yu Zhou
Summary: EGTA-derived carbon dots (EGTA-CDs) exhibit bone-targeting ability with a synthetic yield of 87.6%. EGTA-CDs show superior calcium ion affinity and better bone affinity compared to other derived carbon dots, indicating their potential as novel bone-targeting drugs.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Chemical
Yongliang Wang, Yaxin Xu, Yunfei Wang, Baoqiang Li, Chunfeng Wang, Zhidong Han, Ling Weng
Summary: In this study, layered chitosan hydrogel and layered magnetic chitosan hydrogel were successfully constructed by improving the reaction-diffusion process. These tailored hydrogels possessed ordered layered structures and enhanced mechanical properties, especially toughness. The yield strength of magnetic chitosan hydrogel was significantly improved with the addition of magnetite nanoparticles.
Review
Biotechnology & Applied Microbiology
Yongsheng Gao, Maithili Joshi, Zongmin Zhao, Samir Mitragotri
Summary: PEGylation, the covalent attachment of polyethylene glycol (PEG) to therapeutic agents, is an established drug delivery approach that improves the pharmacokinetics and pharmacodynamics of drugs. PEGylation improves solubility, circulation time, and reduces immunogenicity of drugs with minimal undesirable properties. PEGylation has been successfully applied to various therapeutic modalities and has resulted in numerous PEGylated drugs currently in clinical use.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Dong Chen, Chaoqun Wang, Hongjun Yu, Guanxiong Liu, Baolin Qian, Bangliang Chen, Zhongyu Li, Yongzhi Zhou, Shangha Pan, Baoqiang Li, Yong Ma
Summary: In this study, chitosan-derived nitrogen-doped carbon dots (CNDs) with reactive oxygen species (ROS) scavenging capabilities were synthesized and applied in the prevention of hepatic ischemia-reperfusion injury (HIRI). CNDs showed scavenging ability against ROS, especially hydroxyl radicals. The results demonstrate that CNDs can alleviate liver damage, suppress the inflammatory response, and inhibit apoptosis triggered by liver ischemia/reperfusion operation.
ACS APPLIED NANO MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)
