Article
Engineering, Chemical
Yurui Wang, Jing Zhao, Xiaoran Wang, Rong Zhang, Fei Liang
Summary: A novel injectable bioadhesive chitosan-based hydrogel was developed, inspired by mussels, which showed good sol-gel transition, adhesion to various materials, and biodegradation. The hydrogels also exhibited excellent dry/wet adhesion to tissues and good cytocompatibility, making them promising for biomedical application.
INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES
(2023)
Article
Engineering, Environmental
Shengchang Lu, Xiaohui Zhang, Zuwu Tang, He Xiao, Min Zhang, Kai Liu, Lihui Chen, Liulian Huang, Yonghao Ni, Hui Wu
Summary: The newly designed double-network adhesive hydrogels provide an effective solution for uncontrollable bleeding and wound infection, with rapid hemostatic ability, biocompatibility, and antibacterial properties, suitable for wound healing.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Polymer Science
Guillermo Conejo-Cuevas, Leire Ruiz-Rubio, Virginia Saez-Martinez, Raul Perez-Gonzalez, Oihane Gartziandia, Amaia Huguet-Casquero, Leyre Perez-Alvarez
Summary: Spontaneously formed hydrogels are highly sought after for their potential applications in injectable or wound dressing materials without additional reactions or toxic crosslinking reagents. This study focuses on the covalent modification of hyaluronic acid (HA) and chitosan (CHI) with catechol groups, and the evaluation of their tissue adhesion and film forming capacity. The results show that the adhesiveness of HA-CA hydrogel increases with gelation, while the competitive reactions of quinone in CHI-CA hydrogel slow down tissue adhesion and impair filmogenic properties.
Article
Polymer Science
Yu-Ting Lan, Qian-Pu Cheng, Junpeng Xu, Shih-Ho Lin, Jhih-Min Lin, Shan-hui Hsu
Summary: Mussel-inspired adhesive hydrogels have been developed using catechol-functionalized chitosan, which demonstrated self-healing properties due to hydrogen bonding, cationic-pi interactions, Michael addition, and Schiff base reactions. The gelation mechanism and properties of the catechol-grafted chitosan hydrogels were studied, showing strain-dependent behavior and enhanced adhesive strength after immersion in physiological saline. The research provides insights into utilizing chitosan-catechol for designing hydrogels with tunable mechanical properties in biomedical applications.
Article
Engineering, Environmental
Jung Seung Lee, Yi Sun Choi, Jong Seung Lee, Eun Je Jeon, Soohwan An, Min Suk Lee, Hee Seok Yang, Seung-Woo Cho
Summary: Hydrogels derived from decellularized tissue have shown huge potential in regenerative medicine, but often exhibit weak mechanical properties. In this study, a catechol-modified DT hydrogel with oxidative crosslinking chemistry was developed, showing significantly improved mechanical properties and adhesiveness for effective tissue regeneration. The modified hydrogel demonstrated enhanced osteogenic differentiation of stem cells, accelerated bone formation, and facilitated wound healing through efficient delivery of growth factors. The study supports the applicability of mechanically-reinforced, adhesive DT hydrogel for tissue regeneration.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biophysics
Catia Correia, Rita O. Sousa, A. Catarina Vale, Daniela Peixoto, Tiago H. Silva, Rui L. Reis, Iva Pashkuleva, Natalia M. Alves
Summary: This study describes the development of bioadhesive membranes using marine renewable biomaterials, chitosan and collagen extracted from fish skins. The functionalization of collagen with catechol groups enhances the adhesive and mechanical properties of the membranes, leading to improved cell attachment and proliferation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Polymer Science
Xiang He, Ruyue Liu, Huiqing Liu, Ruixiao Wang, Zhenhao Xi, Yixiang Lin, Jie Wang
Summary: Researchers prepared CS-TBA-Fe hydrogels by mixing chitosan with TBA and FeCl3, showing strong wet tissue adhesion and high biocompatibility. The hydrogel exhibited enhanced wet tissue adhesion strength, robust adhesion to various substrates, controllable physical properties, and antibacterial activity against E. coli.
Article
Engineering, Biomedical
Lin Huang, Wantao Wang, Yiwen Xian, Lei Liu, Jinghao Fan, Hongmei Liu, Zhaomin Zheng, Decheng Wu
Summary: This study reported a rapidly forming injectable chitosan/PEG hydrogel (CSMA-PEGDA-L) that can retard the progression of intervertebral disc (IVD) degeneration. The hydrogel demonstrated strong compressive strength and low cytotoxicity. When implanted on the punctured IVD of rats, it effectively slowed down the degenerative changes.
MATERIALS TODAY BIO
(2023)
Article
Chemistry, Physical
Rebecca I. Randle, Ana M. Fuentes-Caparros, Leide P. Cavalcanti, Ralf Schweins, Dave J. Adams, Emily R. Draper
Summary: The use of small-angle neutron scattering to investigate the aggregation of self-assembling molecules is well established and shows promise in various applications, such as in electrochemistry. Electrochemistry can induce aggregation and can be carried out directly on a sample in the neutron beam to monitor changes in situ.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Polymer Science
Peyman Karami, Naser Nasrollahzadeh, Celine Wyss, Aine O'Sullivan, Martin Broome, Philip Procter, Pierre-Etienne Bourban, Christophe Moser, Dominique P. Pioletti
Summary: This research proposes a new paradigm for designing intrinsically adhesive networks for injectable and photo-curable hydrogels, which not only provide strong adhesive contact, but also have a wide range of physicochemical properties. These adhesive networks are based on a family of polymeric backbones, where chains are modified to be intrinsically adhesive to host tissue while forming a hydrogel network through a hybrid cross-linking mechanism. Adhesion is achieved through a controlled synergy between interfacial chemistry and bulk mechanical properties.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Ximin Yuan, Zhou Zhu, Pengcheng Xia, Zhenjia Wang, Xiao Zhao, Xiao Jiang, Tianming Wang, Qing Gao, Jie Xu, Debin Shan, Bin Guo, Qingqiang Yao, Yong He
Summary: Tough hydrogel is difficult to be used for tissue regeneration due to its poor biocompatibility, nondegradation, and compositional differences from natural tissues. This study proposes a gelatin-based tough hydrogel (GBTH) that overcomes these limitations. GBTH exhibits excellent tensile strength and can be sutured to ruptured tendons, promoting tendon differentiation and allowing quick return to the initial state within eight weeks. This strategy provides a new avenue for highly biocompatible tough hydrogel preparation for tissue regeneration.
Article
Chemistry, Multidisciplinary
Sebastien Baixe, Vincent Ball, Loic Jierry, Sarah Cianferani, Jean-Marc Strub, Youssef Haikel, Marie-Helene Metz-Boutigue, Olivier Etienne
Summary: An antibacterial and adhesive hydrogel was developed for injection into dental implant connections, effectively limiting bacterial growth and showing promise for preventing periimplant diseases.
APPLIED SCIENCES-BASEL
(2021)
Article
Polymer Science
Kummara Madhusudana Rao, Uluvangada Thammaiah Uthappa, Hyeon Jin Kim, Sung Soo Han
Summary: This study developed hydrogels for tissue adhesion that are biocompatible, antioxidant, and antibacterial. Tannic acid (TA) and fungal-derived carboxymethyl chitosan (FCMCS) were incorporated in a polyacrylamide (PAM) network using free-radical polymerization. The concentration of TA greatly influenced the physicochemical and biological properties of the hydrogels. The hydrogels showed excellent adhesive properties, biocompatibility with skin fibroblast cells, and enhanced antibacterial properties against both Gram-positive and Gram-negative bacteria.
Article
Biochemistry & Molecular Biology
Zhicong Lin, Donghao Fan, Guojiao Li, Liming He, Xianyan Qin, Bin Zhao, Qin Wang, Wenlang Liang
Summary: This study developed a hydrogel with tissue adhesivity, conductivity, and antibacterial function, which showed promising results in promoting diabetic wound healing.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Polymer Science
Sumin Kim, Heewon Choi, Donghee Son, Mikyung Shin
Summary: An intrinsically conductive and tissue-adhesive granular hydrogel was fabricated using an electrohydrodynamic spraying method. This hydrogel can be applied in soft and flexible electronics to connect humans and machines.
Article
Chemistry, Multidisciplinary
Mikyung Shin, Ji Hyun Ryu, Joseph P. Park, Keumyeon Kim, Jae Wook Yang, Haeshin Lee
ADVANCED FUNCTIONAL MATERIALS
(2015)
Article
Engineering, Biomedical
Jong Min Lee, Ji Hyun Ryu, Eun Ah Kim, Seongyeon Jo, Byung-Soo Kim, Haeshin Lee, Gun-Il Im
Article
Engineering, Biomedical
Sang Hyeon Hong, Mikyung Shin, Junhee Lee, Ji Hyun Ryu, Suhee Lee, Jae Wook Yang, Wan Doo Kim, Haeshin Lee
ADVANCED HEALTHCARE MATERIALS
(2016)
Article
Engineering, Biomedical
Mihyun Lee, Youngjin Kim, Ji Hyun Ryu, Kyuri Kim, Yong-Mahn Han, Haeshin Lee
ACTA BIOMATERIALIA
(2016)
Review
Nanoscience & Nanotechnology
Ji Hyun Ryu, Philip B. Messersmith, Haeshin Lee
ACS APPLIED MATERIALS & INTERFACES
(2018)
Article
Biochemistry & Molecular Biology
Sang Hyeon Hong, Sunjin Kim, Joseph P. Park, Mikyung Shin, Keumyeon Kim, Ji Hyun Ryu, Haeshin Lee
Article
Materials Science, Biomaterials
Mikyung Shin, Ji Hyun Ryu, Kyuri Kim, Min Jun Kim, Seongyeon Jo, Moon Sue Lee, Dong Yun Lee, Haeshin Lee
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2018)
Article
Materials Science, Biomaterials
Mikyung Shin, Ji Hyun Ryu, Kyuri Kim, Min Jun Kim, Seongyeon Jo, Moon Sue Lee, Dong Yun Lee, Haeshin Lee
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2018)
Article
Materials Science, Biomaterials
Cheong A. Choi, Zihnil Adha Islamy Mazrad, Ji Hyun Ryu, Insik In, Kang Dae Lee, Sung Young Park
JOURNAL OF MATERIALS CHEMISTRY B
(2018)
Review
Chemistry, Multidisciplinary
Jongho Kim, Chaemyeong Lee, Ji Hyun Ryu
Summary: Catechol-containing polymers have shown promise in various biomedical applications such as surgical tissue adhesives and wound dressing, with catechol conjugation enhancing adhesive properties. Specifically, catechol modification significantly improves the mechanical and adhesive properties of hyaluronic acid, enabling its use in diverse medical applications.
APPLIED SCIENCES-BASEL
(2021)
Article
Polymer Science
Sang-woo Lee, Junchul Kim, Xin Cong, Guang-Yan Yu, Ji Hyun Ryu, Kyungpyo Park
Summary: This study investigated the use of surface immobilization of HA derivatives to enhance the survival and bioactivity of eSGM feeder cells, finding that HA-CA showed the highest efficiency in promoting growth of embryonic submandibular gland and enhancing the production of growth factors EGF and FGF7. The clustering of CD44 at cell membrane is identified as a key mechanism for increased EGF expression in eSGM cells.
Review
Chemistry, Multidisciplinary
Gareeballah Osman Adam, Shazid Md Sharker, Ji Hyun Ryu
Summary: Carbon dot-based composite materials have been extensively developed for versatile biomedical applications due to their excellent properties. This review provides an overview of the general aspects, various sources, and versatile biomedical applications of carbon dots and composite materials. Additionally, it highlights the emerging applications of carbon dot-based materials in agricultural systems, COVID-19 theranostics, counterfeit, and security.
APPLIED SCIENCES-BASEL
(2022)
Article
Computer Science, Information Systems
Kwang-Seong Shin, Chungyeon Cho, Ji Hyun Ryu, Dongsik Jo
Summary: Immersive virtual reality is increasingly used in education, but there is still a need for research on improving the learning ability of individuals in 3D immersive environments. This study investigated the effect of different interaction feedback types and found that deformable object feedback had a greater educational effect.
Article
Engineering, Multidisciplinary
Hyun Ho Shin, Ji Hyun Ryu
Summary: This study developed self-healing, shear-thinning, tissue-adhesive hydrogels as sealing materials for surgical suturing. These hydrogels showed excellent adhesive properties and effectively prevented complications caused by leakage from anastomotic sites.
Article
Nanoscience & Nanotechnology
Suyeob Kim, Taewoo Girn, Yeonwoo Jeong, Ji Hyun Ryu, Sung Min Kang
ACS APPLIED MATERIALS & INTERFACES
(2018)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)
