Structural insights for the design of new PPARgamma partial agonists with high binding affinity and low transactivation activity

Discovery of a novel selective PPARγ modulator from (−)-Cercosporamide derivatives

(2010) Akihiro Furukawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological activities of novel indole derivatives as potent and selective PPARγ modulators

(2010) Yann Lamotte et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New Insights on the Mechanism of PPAR-targeted Drugs

(2010) Uwe Grether et al.   ChemMedChem

Design, Synthesis, and Structure−Activity Relationship Studies of Novel 2,4,6-Trisubstituted-5-pyrimidinecarboxylic Acids as Peroxisome Proliferator-Activated Receptor γ (PPARγ) Partial Agonists with Comparable Antidiabetic Efficacy to Rosiglitazone

(2010) Shigeki Seto et al.   JOURNAL OF MEDICINAL CHEMISTRY

New life for antidiabetic drugs

(2010) Riekelt H. Houtkooper et al.   NATURE

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

(2010) Jang Hyun Choi et al.   NATURE

Potential remains for PPAR-targeted drugs

(2010) Dan Jones   NATURE REVIEWS DRUG DISCOVERY

Characterization of New PPARγ Agonists: Benzimidazole Derivatives - the Importance of Position 2

(2009) Matthias Goebel et al.   ChemMedChem

Characterization of New PPARγ Agonists: Analysis of Telmisartan’s Structural Components

(2009) Matthias Goebel et al.   ChemMedChem

Structural Insight into PPARγ Ligands Binding

(2009) A. Farce et al.   CURRENT MEDICINAL CHEMISTRY

Novel Method for Generating Structure-Based Pharmacophores Using Energetic Analysis

(2009) Noeris K. Salam et al.   Journal of Chemical Information and Modeling

Discovery of a Peroxisome Proliferator Activated Receptor γ (PPARγ) Modulator with Balanced PPARα Activity for the Treatment of Type 2 Diabetes and Dyslipidemia

(2009) Weiguo Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Basis for the Design of PPAR-γ Ligands: A Survey on Quantitative Structure- Activity Relationships

(2009) Costas Giaginis et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Highly functionalized 7-azaindoles as selective PPARγ modulators

(2008) Sheryl D. Debenham et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

PPAR Modulators and PPAR Pan Agonists for Metabolic Diseases: The Next Generation of Drugs Targeting Peroxisome Proliferator-Activated Receptors?

(2008) P. Feldman et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Crystal Structure of the Peroxisome Proliferator-Activated Receptor γ (PPARγ) Ligand Binding Domain Complexed with a Novel Partial Agonist: A New Region of the Hydrophobic Pocket Could Be Exploited for Drug Design

(2008) Roberta Montanari et al.   JOURNAL OF MEDICINAL CHEMISTRY