Journal
JOURNAL OF COMPUTATIONAL NEUROSCIENCE
Volume 36, Issue 3, Pages 515-525Publisher
SPRINGER
DOI: 10.1007/s10827-013-0484-2
Keywords
Meso-scale cortical model; Seizure propagation; Optogenetic control
Funding
- US National Science Foundation [CMMI 1031811]
- Directorate For Engineering [1031811] Funding Source: National Science Foundation
- Div Of Civil, Mechanical, & Manufact Inn [1031811] Funding Source: National Science Foundation
Ask authors/readers for more resources
We present a model for the use of open loop optogenetic control to inhibit epileptiform activity in a meso scale model of the human cortex. The meso scale cortical model first developed by Liley et al. (2001) is extended to two dimensions and the nature of the seizure waves is studied. We adapt to the meso scale a 4 state functional model of Channelrhodopsin-2 (ChR2) ion channels. The effects of pulsed and constant illumination on the conductance of these ion channels is presented. The inhibitory cell population is targeted for the application of open loop control. Seizure waves are successfully suppressed and the inherent properties of the optogenetic channels ensures charge balance in the cortex, protecting it from damage.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available