Coupled left-shift of Nav channels: modeling the Na+-loading and dysfunctional excitability of damaged axons

Left-Shifted Nav Channels in Injured Bilayer: Primary Targets for Neuroprotective Nav Antagonists?

(2012) Catherine E. Morris et al.   Frontiers in Pharmacology

Plasma membrane repair and cellular damage control: The annexin survival kit

(2011) Annette Draeger et al.   BIOCHEMICAL PHARMACOLOGY

Characterization of the axon initial segment (AIS) of motor neurons and identification of a para-AIS and a juxtapara-AIS, organized by protein 4.1B

(2011) Amandine Duflocq et al.   BMC BIOLOGY

Clustering and Activity Tuning of Kv1 Channels in Myelinated Hippocampal Axons

(2011) Chen Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Explaining pathological changes in axonal excitability through dynamical analysis of conductance-based models

(2011) Jay S Coggan et al.   Journal of Neural Engineering

Ionic Dynamics Mediate Spontaneous Termination of Seizures and Postictal Depression State

(2011) G. P. Krishnan et al.   JOURNAL OF NEUROSCIENCE

First Node of Ranvier Facilitates High-Frequency Burst Encoding

(2011) Maarten H.P. Kole   NEURON

The paradox of pain from tooth pulp: Low-threshold “algoneurons”?

(2011) Kaj Fried et al.   PAIN

Real-Time CARS Imaging Reveals a Calpain-Dependent Pathway for Paranodal Myelin Retraction during High-Frequency Stimulation

(2011) Terry B. Huff et al.   PLoS One

Pattern of trauma determines the threshold for epileptic activity in a model of cortical deafferentation

(2011) V. Volman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potassium channel blockers as an effective treatment to restore impulse conduction in injured axons

(2011) Riyi Shi et al.   Neuroscience Bulletin

Voltage-Gated Channel Mechanosensitivity: Fact or Friction?

(2011) Catherine E. Morris   Frontiers in Physiology

Modulation of KvAP Unitary Conductance and Gating by 1-Alkanols and Other Surface Active Agents

(2010) Rocio K. Finol-Urdaneta et al.   BIOPHYSICAL JOURNAL

Electrostatic Tuning of Cellular Excitability

(2010) Sara I. Börjesson et al.   BIOPHYSICAL JOURNAL

Riluzole protects against cardiac ischaemia and reperfusion damage via block of the persistent sodium current

(2010) S Weiss et al.   BRITISH JOURNAL OF PHARMACOLOGY

Impaired stretch modulation in potentially lethal cardiac sodium channel mutants

(2010) Umberto Banderali et al.   Channels

Mexiletine suppresses nodal persistent sodium currents in sensory axons of patients with neuropathic pain

(2010) Sagiri Isose et al.   CLINICAL NEUROPHYSIOLOGY

Traumatic Alterations in Consciousness: Traumatic Brain Injury

(2010) Brian J. Blyth et al.   EMERGENCY MEDICINE CLINICS OF NORTH AMERICA

Dendritic alterations after dynamic axonal stretch injury in vitro

(2010) Hubert Monnerie et al.   EXPERIMENTAL NEUROLOGY

Docosahexaenoic Acid Reduces Traumatic Axonal Injury in a Rodent Head Injury Model

(2010) Julian E. Bailes et al.   JOURNAL OF NEUROTRAUMA

Mechanosensitivity of Nav1.5, a voltage-sensitive sodium channel

(2010) Arthur Beyder et al.   JOURNAL OF PHYSIOLOGY-LONDON

Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders

(2010) Massimo Mantegazza et al.   LANCET NEUROLOGY

Binding of sodium channel inhibitors to hyperpolarized and depolarized conformations of the channel

(2010) N. Lenkey et al.   NEUROPHARMACOLOGY

Imbalance of ionic conductances contributes to diverse symptoms of demyelination

(2010) J. S. Coggan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Identity of Dendritic Voltage-Gated Sodium Channels

(2010) A. Lorincz et al.   SCIENCE

Membrane trauma and Na+ leak from Nav1.6 channels

(2009) Jun A. Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Heat opens axon initial segment sodium channels: A febrile seizure mechanism?

(2009) Evan A. Thomas et al.   ANNALS OF NEUROLOGY

Upregulation of persistent sodium conductances in familial ALS

(2009) S. Vucic et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Biochemical, Structural, and Biomarker Evidence for Calpain-Mediated Cytoskeletal Change After Diffuse Brain Injury Uncomplicated by Contusion

(2009) Melissa J. McGinn et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Simulation in Sensory Neurons Reveals a Key Role for Delayed Na+ Current in Subthreshold Oscillations and Ectopic Discharge: Implications for Neuropathic Pain

(2009) Yifat Kovalsky et al.   JOURNAL OF NEUROPHYSIOLOGY

Disruption of the Axon Initial Segment Cytoskeleton Is a New Mechanism for Neuronal Injury

(2009) D. P. Schafer et al.   JOURNAL OF NEUROSCIENCE

Analysis of Astroglial K+ Channel Expression in the Developing Hippocampus Reveals a Predominant Role of the Kir4.1 Subunit

(2009) G. Seifert et al.   JOURNAL OF NEUROSCIENCE

Sodium channelopathy induced by mild axonal trauma worsens outcome after a repeat injury

(2009) Tracy J. Yuen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Neuropathic pain is associated with increased nodal persistent Na+ currents in human diabetic neuropathy

(2009) Sonoko Misawa et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Structure and hydration of membranes embedded with voltage-sensing domains

(2009) Dmitriy Krepkiy et al.   NATURE

The voltage-gated sodium channel Nav1.9 is required for inflammation-based urinary bladder dysfunction

(2009) Amy M. Ritter et al.   NEUROSCIENCE LETTERS

Noise-assisted spike propagation in myelinated neurons

(2009) Anna Ochab-Marcinek et al.   PHYSICAL REVIEW E

Ectopic discharge in Aβ afferents as a source of neuropathic pain

(2009) Marshall Devor   EXPERIMENTAL BRAIN RESEARCH

Modelled temperature-dependent excitability behaviour of a single ranvier node for a human peripheral sensory nerve fibre

(2008) Jacoba E. Smit et al.   BIOLOGICAL CYBERNETICS

Omega-3 polyunsaturated fatty acids inhibit transient outward and ultra-rapid delayed rectifier K+currents and Na+current in human atrial myocytes

(2008) Gui-Rong Li et al.   CARDIOVASCULAR RESEARCH

Nav1.4 Deregulation in Dystrophic Skeletal Muscle Leads to Na+Overload and Enhanced Cell Death

(2008) Carole Hirn et al.   JOURNAL OF GENERAL PHYSIOLOGY

Blebs lead the way: how to migrate without lamellipodia

(2008) Guillaume Charras et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Voltage-dependent K+ channel gating and voltage sensor toxin sensitivity depend on the mechanical state of the lipid membrane

(2008) D. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biophysical Basis for Three Distinct Dynamical Mechanisms of Action Potential Initiation

(2008) Steven A. Prescott et al.   PLoS Computational Biology