Article
Plant Sciences
M. Rezayian, F. Zarinkamar
Summary: This study investigated the effects of NO on plant metabolism, hormones, and secondary metabolites under salt stress in canola plants. Results showed that exogenous NO improved plant growth, increased antioxidant enzyme activity, promoted hormone balance, and enhanced salt stress tolerance.
Article
Multidisciplinary Sciences
Tuan A. Nguyen, Henry L. Puhl, Kirk Hines, Daniel J. Liput, Steven S. Vogel
Summary: The regulation and modulation of synaptic functions rely on a coordinated choreography of protein conformational changes and interactions, which are influenced by intracellular calcium dynamics. By using time-lapse Forster resonance energy transfer, we can study the dynamics of both conformational changes and protein-protein interactions simultaneously under physiological conditions.
NATURE COMMUNICATIONS
(2022)
Article
Fisheries
Chen Huang, Jie Du, Bairu Ji, Sinan Gong, Chao Geng, Yanyang Miao, Qingchun Shen, Wei Gu, Li Wang, Qingguo Meng
Summary: EsCaMKII is highly transcribed in various tissues of E. sinensis and its over-expression promotes apoptosis and enhances resistance to S. eriocheiris infection, while RNAi knockdown results in increased pathogen copy numbers and crab mortality.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shuhang Dai, Elisa Venturini, Saveg Yadav, Xiaoxuan Lin, Dylan Clapp, Martin Steckiewicz, Angela M. Gocher-Demske, Arthur M. Edelman, D. Grahame Hardie
Summary: This study reveals the important role of CaMKK2 in mediating EGFR signaling in cancer cells, with regulation mechanisms involving both calcium-dependent and calcium-independent pathways. Additionally, CaMKK2 regulates transcription of key genes, impacting cell survival and proliferation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Giovanna Nalesso, Anne-Sophie Thorup, Suzanne Elizabeth Eldridge, Anna De Palma, Amanpreet Kaur, Kiran Peddireddi, Kevin Blighe, Sharmila Rana, Bryony Stott, Tonia Louise Vincent, Bethan Lynne Thomas, Jessica Bertrand, Joanna Sherwood, Antonella Fioravanti, Costantino Pitzalis, Francesco Dell'Accio
Summary: The WNT/CaMKII signaling pathway plays a crucial role in osteoarthritis by affecting the expression of markers such as HMOX1 and Sox-9. Inhibition of CaMKII may exacerbate cartilage damage and bone remodeling, while also upregulating the expression of matrix remodeling enzymes in articular chondrocytes. These findings suggest the potential therapeutic implications of targeting the WNT/CaMKII pathway in osteoarthritis.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Andrew J. Boyle, Carl Schultz, Joseph B. Selvanayagam, Stuart Moir, Richard Kovacs, Nabil Dib, David Zlotnick, Mohammed Al-Omary, Stuart Sugito, Aravinda Selvarajah, Nicholas Collins, Grant McLachlan
Summary: This study found that treatment with NP202 for 3 months after primary PCI for anterior STEMI did not improve LV remodeling in patients with residual LV dysfunction. However, the drug demonstrated good safety and tolerability.
Article
Parasitology
Hai-Jun Gao, Xu-Dong Sun, Yan-Ping Luo, Hua-Sheng Pang, Xing-Ming Ma, Ting Zhang, Tao Jing, Wei Hu, Yu-Juan Shen, Jian-Ping Cao
Summary: The study demonstrated that verapamil has anti-parasitic effects against Echinococcus by downregulating the expression of Ca2+/CaM-CaMKII, indicating that Ca2+/CaM-CaMKII may be a novel drug target for the treatment of echinococcosis.
PARASITES & VECTORS
(2021)
Article
Biochemistry & Molecular Biology
Hyeong-Jae Kim, Peter C. W. Lee, Jeong Hee Hong
Summary: This study reveals the enhancing effect of histamine on lamin-A/C expression in lung cancer cells. This enhancement is dependent on histamine-mediated intracellular calcium signaling and Ca/CaMKII activation. Additionally, histamine stimulation attenuates lung cancer cell motility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Ariel Caviedes, Barbara Maturana, Katherina Corvalan, Alexander Engler, Felipe Gordillo, Manuel Varas-Godoy, Karl-Heinz Smalla, Luis Federico Batiz, Carlos Lafourcade, Thilo Kaehne, Ursula Wyneken
Summary: This study reveals that NMDA receptor overstimulation leads to neuronal death, with NF-kappa B activity selectively enhanced in hippocampal neurons and inhibited through S-nitrosylation in resistant neurons. S-nitrosylation influences different biological processes in susceptible and resistant neurons.
CELL DEATH & DISEASE
(2021)
Article
Plant Sciences
Nana Qi, Ni Wang, Xuemei Hou, Yihua Li, Weibiao Liao
Summary: This study demonstrates the positive roles of nitric oxide (NO) and calcium ion (Ca2+) in promoting tomato seedlings' growth under salt stress. NO and Ca2+ decrease reactive oxygen accumulation, increase the activity of antioxidant enzymes, and upregulate antioxidant enzyme-related genes, thereby alleviating the negative effects of salt stress on plants. Ca2+/CaM may play an important role in the process of NO-alleviated salt stress.
Review
Biochemistry & Molecular Biology
Sofia Beghi, Malgorzata Furmanik, Armand Jaminon, Rogier Veltrop, Nikolas Rapp, Kanin Wichapong, Elham Bidar, Annamaria Buschini, Leon J. Schurgers
Summary: Cardiovascular disease remains a major cause of death worldwide, despite advancements in medication and preventive measures. Calcium plays a vital role in the cardiovascular system, regulating events from action potentials to muscle contraction. Calcium calmodulin pathways are involved in the regulation of cardiac functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Michal Marcinkowski, Tomas Pilzys, Damian Garbicz, Jan Piwowarski, Kaja Przygonska, Maria Winiewska-Szajewska, Karolina Ferenc, Oleksandr Skorobogatov, Jaroslaw Poznanski, Elzbieta Grzesiuk
Summary: FTO is an N-6-methyladenosine demethylase which can remove methyl groups from nucleic acids, forming complexes with other proteins. Research indicates an interaction between FTO and calmodulin (CaM), influencing calcium-binding loops in CaM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agricultural Engineering
Elaheh Samari, Najmeh Ahmadian Chashmi, Faezeh Ghanati, Reza H. Sajedi, Andrea A. Gust, Farnaz Haghdoust, Mohsen Sharifi, Elisabeth Fuss
Summary: Chitosan can regulate lignan biosynthesis through the activation of various signaling pathways. Calcium ions, hydrogen peroxide, and nitric oxide, as well as salicylic acid and mitogen-activated protein kinase 6, are involved in this process.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Riku Kaneshige, Satomi Ohtsuka, Yuhei Harada, Issei Kawamata, Masaki Magari, Naoki Kanayama, Naoya Hatano, Hiroyuki Sakagami, Hiroshi Tokumitsu
Summary: This study reveals that the RP-domain is required for CaMKK isoforms to recognize and phosphorylate downstream kinases, potentially providing a promising target for specific CaMKK inhibitors.
Article
Biochemistry & Molecular Biology
Sasa Liu, Rui Qi, Juan Zhang, Chang Zhang, Liming Chen, Zhi Yao, Wenyan Niu
Summary: This study identified the CaMKII-Kalirin-Rac1 signaling pathway involved in contraction-stimulated glucose uptake in skeletal muscle.
