Journal
JOURNAL OF COMPUTATIONAL NEUROSCIENCE
Volume 31, Issue 3, Pages 679-684Publisher
SPRINGER
DOI: 10.1007/s10827-011-0332-1
Keywords
Epilepsy; EEG; Mathematical modelling; Spike-wave; Bursting
Funding
- EPSRC
- BBSRC
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Spike-wave discharges are a distinctive feature of epileptic seizures. So far, they have not been reported in spatially extended neural field models. We study a space-independent version of the Amari neural field model with two competing inhibitory populations. We show that this competition leads to robust spike-wave dynamics if the inhibitory populations operate on different time-scales. The spike-wave oscillations present a fold/homoclinic type bursting. From this result we predict parameters of the extended Amari system where spike-wave oscillations produce a spatially homogeneous pattern. We propose this mechanism as a prototype of macroscopic epileptic spike-wave discharges. To our knowledge this is the first example of robust spike-wave patterns in a spatially extended neural field model.
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