Article
Biochemistry & Molecular Biology
Beilun Zhao, Peter M. van Bodegom, Krijn Trimbos
Summary: Environmental DNA (eDNA) approaches are increasingly used for species identifications in biomonitoring and ecosystem assessments. However, information regarding age and health state of the population, crucial for species monitoring, has been inaccessible from eDNA. This study investigates the methylation patterns of eDNA and tissue DNA (tDNA) of Lymnaea stagnalis at different life stages. The results show that eDNA methylation varies with age and can differentiate between age classes. Furthermore, eDNA exhibits higher global methylation levels compared to tDNA. These findings suggest that eDNA release may be regulated through DNA methylation and highlight the potential of eDNA methylation analysis in assessing age classes and understanding population dynamics.
MOLECULAR ECOLOGY RESOURCES
(2023)
Review
Neurosciences
Ellen A. Wood, Sylwia A. Stopka, Linwen Zhang, Sara Mattson, Gabor Maasz, Zsolt Pirger, Akos Vertes
Summary: The great pond snail Lymnaea stagnalis is a well-established model organism with a simple central nervous system that has been extensively used to study neural functioning. Through electrophysiological experiments and mass spectrometry techniques, researchers have mapped neuronal connections and identified circuits responsible for basic life functions. This combination of techniques has led to increasing insights into the molecular basis of CNS-controlled biological functions.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Clinical Neurology
Elze R. Timmers, Martijn van Faassen, Marenka Smit, Anouk Kuiper, Ingrid H. Hof, Ido P. Kema, Marina A. J. Tijssen, Klary E. Niezen-Koning, Tom J. de Koning
Summary: This study revealed alterations in dopaminergic and serotonergic metabolism in patients with dystonia, with subtype-specific changes. Low levodopa concentrations, but not serotonin metabolites, were associated with both motor and non-motor symptoms.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Neurosciences
Xuan Wang, Zhenfeng Shu, Quansheng He, Xiaowen Zhang, Luozheng Li, Xiaoxue Zhang, Liang Li, Yujie Xiao, Bo Peng, Feifan Guo, Da-Hui Wang, Yousheng Shu
Summary: This study found that parvalbumin neurons in the striatum have functional autapses, while principal spiny projection neurons do not. The autaptic responses in parvalbumin neurons are mediated by GABA(A) receptors and regulate their spiking activity. These autapses may play important roles in striatal functions.
NEUROSCIENCE BULLETIN
(2023)
Article
Biochemistry & Molecular Biology
Michael Ugrumov, Ekaterina N. Pavlova, Anna A. Kolacheva, Liliya K. Dil'mukhametova, Vsevolod V. Bogdanov, Victor Blokhin, Tatiana S. Pronina
Summary: Research has shown that the hypothalamic periventricular nucleus (PeVN) in rats is one of the largest dopamine-rich centers, containing both dopaminergic and monoenzymatic neurons. Evidence was obtained through double immunostaining and high-performance liquid chromatography, demonstrating the presence of thousands of dopaminergic and monoenzymatic neurons in the PeVN.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Tatiana Pronina, Ekaterina Pavlova, Liliya Dil'mukhametova, Michael Ugrumov
Summary: This study evaluates the development of the periventricular nucleus (PeVN) as a mixed dopaminergic (DAergic) center in rats during the perinatal period. The PeVN contains dopamine-synthesizing neurons and mono-enzymatic neurons expressing tyrosine hydroxylase (TH) or aromatic L-amino acid decarboxylase (AADC). The number of these neurons triples during the perinatal period, with a higher increase in mono-enzymatic neurons. The levels of L-DOPA, the end product of TH neurons, and dopamine, the end product of AADC neurons and DAergic neurons, also increase significantly. Confocal microscopy reveals close relationships between different types of neurons and their processes, suggesting their mutual regulation by L-DOPA and dopamine. These findings suggest the involvement of PeVN in the neuroendocrine regulation of the brain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
A. V. Sidorov, V. N. Shadenko
Summary: This study investigated the rapid responses of key interneurons in the respiratory, locomotor, and cardioregulatory networks of a mollusk Lymnaea stagnalis to different concentrations of D-glucose. The results showed that high glucose concentration led to changes in firing rates of specific neurons, while low concentration had no significant effect. The effects were not associated with increased production of reactive oxygen species and may be due to modification of glucose transporters.
JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Soham Jagtap, Chandrakanta Potdar, Ravi Yadav, Pramod Kumar Pal, Indrani Datta
Summary: This study demonstrated that mutations in the I1371V allele of LRRK2 showed developmental deficits and generated a lower yield/number of TH-immunopositive neurons with impairment in their function and synapse density along with increased alpha-synuclein pathology.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Biology
A. L. Krushinsky, V. S. Kuzenkov, V. E. Dyakonova, V. P. Reutov
Article
Biology
Etsuro Ito, Miki Yamagishi, Dai Hatakeyama, Takayuki Watanabe, Yutaka Fujito, Varvara Dyakonova, Ken Lukowiak
JOURNAL OF EXPERIMENTAL BIOLOGY
(2015)
Article
Biology
Varvara E. Dyakonova, Laszlo Hernadi, Etsuro Ito, Taisia L. Dyakonova, Ilya A. Chistopolsky, Igor S. Zakharov, Dmitri A. Sakharov
JOURNAL OF EXPERIMENTAL BIOLOGY
(2015)
Article
Biology
Tatiana A. Korshunova, Dmitry D. Vorontsov, Varvara E. Dyakonova
JOURNAL OF EXPERIMENTAL BIOLOGY
(2016)
Article
Behavioral Sciences
Hitoshi Aonuma, Yuki Totani, Mugiho Kaneda, Ryota Nakamura, Takayuki Watanabe, Dai Hatakeyama, Varvara E. Dyakonova, Ken Lukowiak, Etsuro Ito
NEUROBIOLOGY OF LEARNING AND MEMORY
(2018)
Article
Multidisciplinary Sciences
Sergei A. Korneev, Dimitris V. Vavoulis, Souvik Naskar, Varvara E. Dyakonova, Ildiko Kemenes, Gyorgy Kemenes
SCIENTIFIC REPORTS
(2018)
Article
Behavioral Sciences
V. E. Dyakonova, A. L. Krushinsky
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
(2013)
Article
Behavioral Sciences
Koichi Mita, Akiko Okuta, Ryuichi Okada, Dai Hatakeyama, Emi Otsuka, Miki Yamagishi, Mika Morikawa, Yuki Naganuma, Yutaka Fujito, Varvara Dyakonova, Ken Lukowiak, Etsuro Ito
NEUROBIOLOGY OF LEARNING AND MEMORY
(2014)
Article
Neurosciences
P. M. Balaban, D. D. Vorontsov, V. E. Dyakonova, T. L. Dyakonova, I. S. Zakharov, T. A. Korshunova, O. Yu Orlov, G. A. Pavlova, Yu V. Panchin, D. A. Sakharov, M. V. Falikman
ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA
(2013)
Article
Multidisciplinary Sciences
T. L. Dyakonova, G. S. Sultanakhmetov, M. Mezheritskiy, D. A. Sakharov, V. E. Dyakonova
SCIENTIFIC REPORTS
(2019)
Review
Biology
Junko Nakai, Yuki Totani, Dai Hatakeyama, Varvara E. Dyakonova, Etsuro Ito
Article
Neurosciences
Yuki Totani, Junko Nakai, Dai Hatakeyama, Varvara E. Dyakonova, Ken Lukowiak, Etsuro Ito
Summary: Nutritional status affects cognitive function in pond snails. Food deprivation can enhance or restore learning ability in snails, depending on the duration of deprivation. The concentration of tryptophan, a precursor to serotonin, in the CNS is affected by food deprivation, while the concentration in the hemolymph is not. Autophagic flux in the CNS and the CNS tryptophan concentration interact to regulate learning ability affected by different durations of food deprivation.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Neurosciences
Yuki Totani, Junko Nakai, Varvara E. Dyakonova, Ken Lukowiak, Manabu Sakakibara, Etsuro Ito
Article
Information Science & Library Science
N. Bazenkov, D. Vorontsov, V. Dyakonova, L. Zhilyakova, I. Zakharov, O. Kuznetsov, S. Kulivets, D. Sakharov
SCIENTIFIC AND TECHNICAL INFORMATION PROCESSING
(2018)
Proceedings Paper
Behavioral Sciences
Nikolay Bazenkov, Varvara Dyakonova, Oleg Kuznetsov, Dmitri Sakharov, Dmitry Vorontsov, Liudmila Zhilyakova
BIOLOGICALLY INSPIRED COGNITIVE ARCHITECTURES (BICA) FOR YOUNG SCIENTISTS
(2018)