Article
Biochemistry & Molecular Biology
Shreyas B. Rao, Nadia Skauli, Nenad Jovanovic, Shirin Katoozi, Antonio Frigeri, Stanley C. Froehner, Marvin E. Adams, Ole Petter Ottersen, Mahmood Amiry-Moghaddam
Summary: The study reveals the interdependence between astrocytic AQP4 and gap junctions, with limited impact on AQP4 isoform expression from deletion of beta 1-syntrophin, but with increased astrocytic gap junctions from double knockout of alpha 1- and beta 1-syntrophin. It highlights the importance of syntrophins in organizing specialized functional domains of brain astrocytes.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2021)
Article
Neurosciences
Nadia Skauli, Ekaterina Savchenko, Ole Petter Ottersen, Laurent Roybon, Mahmood Amiry-Moghaddam
Summary: This study suggests that the canonical BMP-signaling pathway may play a role in regulating the expression of AQP4 and the subcellular compartmentation of the associated DAP complex, thereby impacting the development of neurological conditions.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Matthew Simon, Marie Xun Wang, Ozama Ismail, Molly Braun, Abigail G. Schindler, Jesica Reemmer, Zhongya Wang, Mariya A. Haveliwala, Ryan P. O'Boyle, Warren Y. Han, Natalie Roese, Marjorie Grafe, Randall Woltjer, Detlev Boison, Jeffrey J. Iliff
Summary: This study found that the loss of perivascular localization of AQP4 is associated with the development of A beta plaques and cognitive decline in subjects with Alzheimer's disease (AD). Rodent studies also showed that loss of AQP4 localization leads to abnormal distribution of CSF tracer and increased levels of amyloid beta.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Critical Care Medicine
Daniel C. Lu, Zsolt Zador, Jinghua Yao, Farbod Fazlollahi, Geoffrey T. Manley
Summary: This study demonstrates a protective role of AQP4 in post-traumatic seizure susceptibility by promoting astrogliosis, formation of a glial scar, and preventing microgliosis.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Clinical Neurology
Sabahat Iqbal, Jose E. Leon-Rojas, Marian Galovic, Sjoerd B. Vos, Alexander Hammers, Jane de Tisi, Matthias J. Koepp, John S. Duncan
Summary: The volume of the piriform cortex is related to the clinical characteristics of refractory temporal lobe epilepsy. The right piriform cortex is usually larger than the left, and the volume is smaller in patients with longer duration of epilepsy and bilateral hippocampal sclerosis.
Article
Neurosciences
Cloe Moelo, Alicia Quillevere, Lucas Le Roy, Serge Timsit
Summary: Cerebral edema is a deadly complication of ischemic stroke for which there is no current pharmaceutical treatment. This study found that the cyclin-dependent kinase inhibitor (S)-roscovitine was able to reduce cerebral edema and modulate the interaction between Aquaporin-4 (AQP4) and alpha 1-syntrophin, suggesting its potential as a treatment for cerebral edema in ischemic stroke and other neurological diseases.
Article
Neurosciences
Yong-Zhen Guo, Yan-Mei Ma, Xiao-Peng Zhang, Ling-Di Dong, Li Jing, Jian-Zhong Zhang
Summary: Brain edema is a major cause of death in patients who suffer an ischemic stroke. Diabetes aggravates brain edema after cerebral ischemia-reperfusion, with different effects observed in various brain regions. Hyperglycemia can significantly impact the distribution of aquaporin 4 and increase the number of swelling cells in the striatal penumbra compared to the cortical penumbra.
NEUROSCIENCE LETTERS
(2021)
Article
Neurosciences
Marco de Curtis, Laura Librizzi, Laura Uva
Summary: Seizures affecting the limbic regions, such as the hippocampus, are common and often resistant to medication. This study examines the network mechanisms involved in the generation of olfactory-limbic epileptiform patterns and discusses the potential relevance of these findings for human focal epilepsy. The interactions within olfactory-limbic circuits, including region-specific seizure-like events and cortical control, are investigated using in vitro preparations and pro-convulsive drugs.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Neurosciences
Andrew Sheriff, Guinevere Pandolfi, Vivian S. Nguyen, Leslie M. Kay
Summary: The study reveals widespread interactions among nasal respiration, olfactory bulb, piriform cortex, and hippocampus in awake freely moving rats, supporting the piriform cortex as an integrator of respiratory and theta activity.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Aida Maziar, Tristian N. R. H. Y. Critch, Sourav Ghosh, Vishaal Rajani, Cassandra M. Flynn, Tian Qin, Camila Reinhardt, Kwun Nok Mimi Man, Amy Lee, Johannes W. Hell, Qi Yuan
Summary: Aging is linked to cognitive decline and memory loss. In rats, aging leads to changes in neuronal excitability in the piriform cortex and hippocampus, affecting learning abilities.
Article
Clinical Neurology
Valeri Borger, Motaz Hamed, Majd Bahna, Attila Racz, Inja Ilic, Anna-Laura Potthoff, Tobias Baumgartner, Theodor Rueber, Albert Becker, Alexander Radbruch, Florian Mormann, Rainer Surges, Hartmut Vatter, Matthias Schneider
Summary: This study aimed to evaluate the impact of piriform cortex (PiC) resection on long-term seizure outcome in patients with mesial temporal lobe epilepsy (mTLE) treated with selective amygdalo-hippocampectomy (tsSAHE). The results showed that the extent of PiC resection strongly correlated with long-term seizure outcome, suggesting PiC to be a key target volume in tsSAHE for achieving long-term seizure freedom.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Review
Neurosciences
Carolyn Twible, Rober Abdo, Qi Zhang
Summary: The article discusses the impact of epilepsy on approximately 50 million people worldwide, with 60% of adult epilepsies having a focal onset. It delves into the role of astrocytes in temporal lobe epilepsy (TLE), particularly focusing on histopathological diagnosis, mossy fiber sprouting, and the potential contribution of astrocytes to cellular alterations in TLE patients. The review highlights proposed signaling pathways, cellular mechanisms, histological observations, and clinical correlations in human patients.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Zhong-fang Shi, Qing Fang, Ye Chen, Li-xin Xu, Min Wu, Mei Jia, Yi Lu, Xiao-xuan Wang, Yu-jiao Wang, Xu Yan, Li-ping Dong, Fang Yuan
Summary: Methylene blue attenuates brain edema by inhibiting AQP4 expression via the ERK1/2 pathway, suggesting its potential as a treatment option for brain edema.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Biology
Shu Liu, Heung Yan Wong, Li Xie, Zafar Iqbal, Zhuogui Lei, Zhongqi Fu, Yuk Yan Lam, Aruna Surendran Ramkrishnan, Ying Li
Summary: Background schema is formed through the neural circuit between the anterior cingulate cortex (ACC) and hippocampus (HPC). The recruitment of CA1-ACC projection neurons decreases gradually while ACC neurons show a peak of excitation in the middle stage of schema establishment. Activation of CA1 astrocytes disrupts the development of memory schema and inhibits the assimilation of new information.
Review
Neurosciences
Jenny I. Szu, Devin K. Binder
Summary: This review evaluates the role of AQP4 dysregulation and mislocalization in epilepsy, highlighting their significant impact on neuronal hyperexcitability. Research has shown that the mislocalization of AQP4 can greatly affect the excitability of neurons, playing a crucial role in the development of epilepsy.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)