Article
Medicine, Research & Experimental
Elias B. Nascimento Jr., R. L. Romero, Marcela M. G. B. Dutra, Bernd L. Fiebich, Igor D. G. Duarte, Marcio M. Coelho
Summary: The activation of 5-HT1D and 5-HT7 receptors plays a role in mechanical allodynia induced by 5-HT in mice, while peripheral 5-HT3 receptors have an inhibitory role in the nociceptive response induced by 5-HT or carrageenan.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Pragathi Balakrishna, Sagila George, Hassan Hatoum, Sarbajit Mukherjee
Summary: Serotonin plays a significant role as a neurotransmitter in the central nervous system and a motility mediator in the gastrointestinal tract, with ongoing research into its role in tumorigenesis in various cancers. Drugs like octreotide and telotristat are being investigated for their potential in treating neuroendocrine cancers, with serotonin receptor antagonists showing anticancer effects in in vitro studies across different cancer types. Further in vivo studies are needed to fully understand serotonin's role in cancer and its potential as an anticancer therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Edward Ofori, Edem K. Onyameh, Uma M. Gonela, Chandrashekhar Voshavar, Barbara Bricker, Tracy L. Swanson, Amy J. Eshleman, Jennifer L. Schmachtenberg, Shelley H. Bloom, Aaron J. Janowsky, Seth Y. Ablordeppey
Summary: We have conducted a study to explore the potential of dual 5-HT1AR and 5-HT7R ligands, resulting in the identification of a new compound with high affinity for these receptors. This compound, designated as 21, shows promising functional characteristics as a potential antidepressant agent.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Sean M. Collins, Christopher J. O'Connell, Evan L. Reeder, Sophia V. Norman, Kainat Lungani, Poornima Gopalan, Gary A. Gudelsky, Matthew J. Robson
Summary: Various forms of TBI are a leading cause of disability in the US, with the generation of neuropsychiatric complications such as depression and anxiety. This study found that mild TBI can lead to selective alterations in cortical 5-HT2A receptor signaling, which may be targeted for the development of pharmacotherapies to alleviate TBI-induced neuropsychiatric disorders.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jelena Nikolic, Katarina Vukojevic, Violeta Soljic, Josip Miskovic, Martina Orlovic Vlaho, Mirna Saraga-Babic, Natalija Filipovic
Summary: We studied the expression of serotonin receptors 5-HT1A, 5-HT2A, and 5-HT3A at different stages of fetal lung development. The receptors were strongly expressed in the epithelium of the proximal airways and vascular walls during early and mid-fetal development. In the later stages, they were also expressed in type I and type II pneumocytes. The expression of 5-HT2A decreased while 5-HT3A expression increased toward the final stage of lung development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
I Erkizia-Santamaria, R. Alles-Pascual, I Horrillo, J. J. Meana, J. E. Ortega
Summary: The study found that psilocin showed similar affinities for 5HT2AR, 5HT2CR, and 5HT1AR in both human and mice brain. Psilocybin induced a dose-dependent head-twitch response (HTR) and affected body temperature, which were both mediated by 5HT2AR, 5HT2CR, and 5HT1AR. These findings provide key insights into the mechanism of action of psilocybin and its therapeutic effects.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Nina K. Popova, Anton S. Tsybko, Vladimir S. Naumenko
Summary: This article reviews the neurobiological links between aggression, depression, and suicidal behavior, focusing on the involvement of different types of 5-HT receptors. It provides evidence that specific 5-HT receptors are associated with depression-related and aggression-related behaviors, and highlights the potential of targeting these receptors for treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Aqeela Imamdin, Emiel P. C. van der Vorst
Summary: Serotonin, a well-known neurotransmitter in the central nervous system, has also been found to have a significant impact on peripheral tissues. It has been shown to influence immune cell responses and contribute to the development of diseases such as atherosclerosis that are caused by immune hyperactivity. This review focuses on the differences in serotonin production between the central nervous system and the periphery, and outlines the role of serotonin in peripheral tissues, particularly its effects on immune cells related to atherosclerosis. Important considerations for future research are also identified.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Natalia Kreshchenko, Nadezhda Terenina, Artem Ermakov
Summary: This study investigates the localization of serotonin and 5-HT7 type serotonin receptors in larvae of parasitic flatworms using immunocytochemical methods and confocal laser scanning microscopy. The results indicate the presence of 5-HT7 immunoreactivity in specific structures of the worms, suggesting its importance in the motor control system of flatworms.
Review
Biochemistry & Molecular Biology
Tomasz Guzel, Dagmara Mirowska-Guzel
Summary: Serotonin is a neurotransmitter that acts in both the central nervous system and peripheral structures, also functioning as a hormone in platelets. It modulates CNS neurons, pain transmission, and platelet aggregation. Serotonin also influences muscle motility in the gut, bronchi, uterus, and vessels. Its synthesis starts with hydroxylation and decarboxylation of tryptophan. 5-HT receptors in the brain and gut are targets for drugs that modify serotonin neurotransmission.
Article
Biochemistry & Molecular Biology
Edem K. Onyameh, Barbara A. Bricker, Suresh V. K. Eyunni, Chandrashekhar Voshavar, Uma M. Gonela, Edward Ofori, Andrea Jenkins, Seth Y. Ablordeppey
Summary: This study aims to investigate the relationship between antipsychotic drugs and their binding affinities at dopamine and serotonin receptor subtypes to potentially develop new drugs with enhanced efficacy. By synthesizing structurally modified compounds, a new analog with moderate binding affinity was identified and demonstrated antipsychotic-like activity in preliminary tests.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Yi Jiang, Jie Zhou, Bai-Lin Song, Yan Wang, Dong-Lin Zhang, Zheng-Tian Zhang, Lai-Fu Li, Ying-Juan Liu
Summary: Social animals self-organize into dominance hierarchies, influenced by the serotonin system in the amygdala. This study explores the role of different 5-HT receptor subtypes in social rank determination and reveals their involvement in the formation and modulation of social hierarchy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Environmental Sciences
Xuanjun Guo, Ruihua Zhang, Qian Jin, Niannian Cao, Jingjing Shi, Xingxing Zong, Xuejun Chen, Chen Wang, Xuefeng Li, Sen Pang, Liqin Li
Summary: In this study, it was observed that azoxystrobin adversely affected courtship and aggressive behavior in zebrafish, possibly by interfering with the kisspeptin-GnIH signaling pathway. This could have profound effects on natural zebrafish populations.
ENVIRONMENTAL POLLUTION
(2023)
Review
Pharmacology & Pharmacy
Rashid Giniatullin
Summary: 5-hydroxytryptamine (5-HT) is considered a key mediator in migraine, but the role of 5-HT3 receptors in pain transmission remains controversial. The applicability of currently available 5-HT3 antagonists in migraine treatment is not clearly supported by clinical data.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Joachim Neumann, Britt Hofmann, Stefan Dhein, Ulrich Gergs
Summary: Serotonin controls human cardiac contractile function solely through 5-HT4-receptors, leading to positive inotropic and chronotropic effects, as well as arrhythmias. This review focuses on the potential effects of 5-HT4-receptors in sepsis, ischemia, and reperfusion. The formation and inactivation of serotonin in the heart, as well as its role in cardiovascular diseases, are discussed. Mechanisms of cardiac signal transduction through 5-HT4-receptors and potential roles in cardiac diseases are addressed, along with future research directions and potential animal models. The potential clinical utility of 5-HT4-receptor agonists or antagonists is also discussed, considering the extensive studies on serotonin over the years.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Tigran P. Norekian, Leonid L. Moroz
JOURNAL OF COMPARATIVE NEUROLOGY
(2019)
Article
Neurosciences
Tigran P. Norekian, Leonid L. Moroz
JOURNAL OF COMPARATIVE NEUROLOGY
(2019)
Article
Neurosciences
Tigran P. Norekian, Leonid L. Moroz
JOURNAL OF COMPARATIVE NEUROLOGY
(2020)
Article
Neurosciences
Tigran P. Norekian, Leonid L. Moroz
JOURNAL OF COMPARATIVE NEUROLOGY
(2020)
Article
Biochemistry & Molecular Biology
Leonid L. Moroz, Dosung Sohn, Daria Y. Romanova, Andrea B. Kohn
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Anatomy & Morphology
Gabrielle C. Winters, Gianluca Polese, Anna Di Cosmo, Leonid L. Moroz
JOURNAL OF MORPHOLOGY
(2020)
Article
Multidisciplinary Sciences
Leonid L. Moroz, Daria Y. Romanova, Mikhail A. Nikitin, Dosung Sohn, Andrea B. Kohn, Emilie Neveu, Frederique Varoqueaux, Dirk Fasshauer
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Daria Y. Romanova, Ivan Smirnov, Mikhail A. Nikitin, Andrea B. Kohn, Alisa Borman, Alexey Y. Malyshev, Pavel M. Balaban, Leonid L. Moroz
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Review
Biology
Leonid L. Moroz, Daria Y. Romanova, Andrea B. Kohn
Summary: Transmitter signalling is the universal chemical language of the nervous system, with origins possibly in secretory cells capable of volume chemical transmission and behavior integration. Different neurotransmitters may have been recruited relatively early or late in animal evolution.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Janos Gyori, Andrea B. Kohn, Daria Y. Romanova, Leonid L. Moroz
Summary: ATP and its ionotropic P2X receptors are components of the most ancient signaling system, with little known about their distribution and function in invertebrates. This study focuses on the cloning, expression, and pharmacological characterization of P2X receptors in the sea slug Aplysia californica, revealing unique expression patterns and functions, especially in development and homeostasis. The findings provide novel insights into the evolution of neurotransmitters.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Daria Y. Romanova, Frederique Varoqueaux, Jean Daraspe, Mikhail A. Nikitin, Michael Eitel, Dirk Fasshauer, Leonid L. Moroz
Summary: Placozoans are among the simplest free-living animals, with bodies consisting of three cell layers and roughly seven major cell types. They lack muscle cells and neurons but are able to move using ciliated surfaces and coordinate food intake. Recent research has revealed a higher level of cell-type diversity in placozoans than previously anticipated.
CELL AND TISSUE RESEARCH
(2021)
Article
Anatomy & Morphology
Tigran P. Norekian, Leonid L. Moroz
Summary: Ctenophores are descendants of an early branching basal metazoan lineage that may have evolved neurons and muscles independently. The neuromuscular system development in Mnemiopsis is similar to Pleurobrachia, but faster. Adult Mnemiopsis exhibits distinct neuronal populations in the feeding lobes and auricles, unique to the Lobata clade.
JOURNAL OF MORPHOLOGY
(2021)
Review
Neurosciences
Leonid L. Moroz, Mikhail A. Nikitin, Pavlin G. Policar, Andrea B. Kohn, Daria Y. Romanova
Summary: Glutamate plays a key role as the primary excitatory transmitter in the mammalian brain, with its origin possibly traced back to primordial nitrogen and carbon metabolic pathways. The versatile chemistry of L-Glu places it at the intersection of cellular biochemistry as one of the most abundant metabolites.
Article
Anatomy & Morphology
Naama Stern-Mentch, Gabriela Winter, Michael Belenky, Leonid Moroz, Binyamin Hochner
Summary: The vertical lobe (VL) in the octopus brain plays a crucial role in learning and memory. Recent studies have discovered more heterogeneity in the VL neurons than previously thought, including glutamatergic and cholinergic neurons, as well as inhibitory and neuromodulatory elements. These findings contribute to a deeper understanding of the efficient learning and memory network.
JOURNAL OF MORPHOLOGY
(2022)
Article
Biology
Marie Drabkova, Kevin M. Kocot, Kenneth M. Halanych, Todd H. Oakley, Leonid L. Moroz, Johanna T. Cannon, Armand Kuris, Ana Elisa Garcia-Vedrenne, M. Sabrina Pankey, Emily A. Ellis, Rebecca Varney, Jan Stefka, Jan Zrzavy
Summary: Dicyemids and orthonectids, traditionally classified as Mesozoa, had uncertain positions within Metazoa. This study used multiple phylogenomic approaches and obtained new transcriptomes and genomes to investigate their placement. The results suggest that Mesozoa is monophyletic and closely related to Platyhelminthes or Gnathifera, but caution is needed due to potential long-branch attraction. The classic hypothesis on monophyletic Mesozoa may need further testing.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)