One-Pot Multicomponent Synthesis of 1-Aryl-5-methyl-N-R2-1H-1,2,3-triazole-4-carboxamides: An Easy Procedure for Combinatorial Chemistry

A convenient synthetic protocol was elaborated for creation of combinatorial libraries of 1-(R-1-phenyl)-5-methyl-N-R-2-1H-1,2,3-triazole-4-carboxamides. As starting materials, commercially available or readily prepared azides, amines, and diketene were selected for the reaction which has proceeded in a one-pot system with high yields and in short time.