Journal
JOURNAL OF COMBINATORIAL CHEMISTRY
Volume 10, Issue 5, Pages 700-703Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cc800067g
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Funding
- Research Council of Shahid Beheshti University
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A novel one-pot tandem synthesis of 2-styryl-4(3H)-quinazolinones in an acidic ionic liquid is reported. In this procedure isatoic anhydride, a primary aniline or ammonium acetate, and triethylorthoacetate are reacted in the presence of imidazolium trifluoroacetate [Hmim]TFA. Subsequently an aromatic aldehyde is added to the mixture to afford the title compounds in high to excellent yields.
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