Journal
JOURNAL OF COMBINATORIAL CHEMISTRY
Volume 10, Issue 4, Pages 534-540Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cc800038r
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Funding
- NIGMS NIH HHS [P50 GM067041] Funding Source: Medline
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The chemistry of 5,6,7,8-tetrahydro-1,6-naphthyridine scaffolds, synthesized by intramolecular cobalt-catalyzed [2 + 2 + 2] cyclizations, has been exploited for library synthesis. Urea, amide, and sulfonamide formations were used in the synthesis of a 101-membered library. Screening of the library for antituberculosis activity revealed three lead compounds.
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