Journal
JOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume 532, Issue -, Pages 112-117Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2018.07.125
Keywords
Encapsulation; Microgel; Antimicrobial peptide; Supercritical carbon dioxide; Polymers
Categories
Funding
- European Community
- Interuniversity Attraction Poles [IAP-7/5-FS2]
- Smartdif project [DG06]
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Antimicrobial peptide loaded poly(2-hydroxyethyl methacrylate) particles were synthesized in supercritical carbon dioxide via one-pot free-radical dispersion polymerisation of 2-hydroxyethyl methacrylate and a cross-linker. Discrete particles with a well-defined spherical morphology and a diameter as low as 450 nm have been obtained in mild conditions. The encapsulation and release of the peptide were confirmed by antimicrobial tests that demonstrated for the first time a sustained release of the peptide from poly(2-hydroxyethyl methacrylate) microgels prepared by one-pot dispersion polymerization in supercritical carbon dioxide and then dispersed in water. (C) 2018 Elsevier Inc. All rights reserved.
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